Articles tagged "Rejection"

2016 American Transplant Congress
Bile Acid Signaling Affects Metabolism and Prolongs Allograft Survival in Obese Recipients.
M. Quante, A. ElKhal, M. Seyda, J. Schuitenmaker, H. Uehara, S. Tullius.
Division of Transplant Surgery & Transplant Surgery Research Laboratory, Brigham and Women's Hospital / Harvard Medical School, Boston, MA.
Although obesity has been linked to impaired transplant outcomes, underlying mechanisms and consequences of obesity on alloimmunity are only poorly understood.Allogenic skin transplantations were performed…
2016 American Transplant Congress
Susceptibility Patterns of Pre-Transplant Pseudomonas and Post-Lung Transplant Outcomes in Patients with Cystic Fibrosis.
S. Pouch,¹ E. Lease,² T. Bogdanovich,³ D. Ho,⁴ R. Miller,⁵ M. Estabrook,⁶ T. Babu,⁷ C. Kotton,⁷ C. Shaver,⁸ L. Thomas,⁸ S. Aslam,⁹ T. McCarty,¹⁰ J. Garcia-Diaz,¹¹ K. Doucette,¹² S. Kirkby,¹³ D. van Duin.¹⁴
¹Ohio State University, Columbus, OH; ²University of Washington, Seattle, WA; ³University of Pittsburgh, Pittsburgh, PA; ⁴Stanford University, Stanford, CA; ⁵University of Iowa, Iowa City, IA; ⁶Washington University St. Louis, St. Louis, MO; ⁷Massachusetts General Hospital, Boston, MA; ⁸Vanderbilt University, Nashville, TN; ⁹University of California San Diego, San Diego, CA; ¹⁰University of Alabama, Birmingham, AB; ¹¹Ochsner Clinic Foundation, New Orleans, LA; ¹²University of Alberta, Edmonton, AB, Canada; ¹³Nationwide Children's Hospital, Columbus, OH; ¹⁴University of North Carolina, Chapel Hill, NC.
Background: The impact of pre-lung transplant (LT) pan-drug-resistant Pseudomonas aeruginosa (PDR PsA) colonization on post-LT mortality and bronchiolitis obliterans syndrome (BOS) rates in cystic fibrosis…
2016 American Transplant Congress
Treatment of Late Antibody-Mediated Rejection: Observations from Clinical Practice.
G. Einecke,¹ J. Bräsen,² A. Schwarz,¹ H. Haller,¹ F. Njau.¹
¹Nephrology, Medical School of Hannover, Hannover, Germany; ²Pathology, Medical School of Hannover, Hannover, Germany.
Antibody-mediated rejection (AMR) is a major cause of late renal allograft failure. The benefit of treatment of chronic ABMR is unknown. Currently there is no…
2016 American Transplant Congress
Kidney Transplant with Low Level DSA and Low Positive B-Flow Crossmatch: An Underappreciated Option for Highly Sensitized Transplant Candidates.
C. Schinstock, W. Cheungpasitporn, F. Cosio, D. Mitema, M. Gandhi, M. Prieto, P. Dean, M. Stegall.
Transplant Center, Mayo Clinic, Rochester, MN.
Introduction: Avoiding DSA is difficult in sensitized patients. A kidney transplant (KTx) with low level DSA with or without a low level B flow cytometric…
2016 American Transplant Congress
Long Term Outcomes Following Antibody Mediated Rejection (AMR) in Renal Transplant Recipients.
R. Crew, S. Patel, H. Morris, M. Chiles, L. Ratner.
Columbia University, New York.
INTRO: Progress in AMR treatment has improved early graft survival. Since the new kidney allocation system results in more sensitized patients getting transplanted, we expect…
2016 American Transplant Congress
The Effect of Maternal Graft in Early Acute Cellular Rejection After Pediatric Living Donor Liver Transplantation.
Y. Noguchi,¹ T. Ueno,¹ K. Bessho,² Y. Takama,¹ H. Yamanaka,¹ N. Tanaka,¹ Y. Tazuke,¹ H. Okuyama.¹
¹Pediatric Surgery, Osaka University, Suita, Osaka, Japan; ²Pediatrics, Osaka University, Suita, Osaka, Japan.
Objectives: It has been reported that the living donor liver transplantation (LDLT) in which the patients received a maternal graft could be more successful compared…
2016 American Transplant Congress
Development and Validation of a Molecular Microscope Diagnostic System (MMDx) for Heart Transplant Biopsies.
P. Halloran,¹ D. Kim,¹ A. Loupy,² J.-P. Duong Van-Huyen,² P. Bruneval,³ L. Potena,⁴ O. Leone,⁴ J. Reeve.¹
¹University of Alberta, Edmonton, Canada; ²Necker Hospital, Paris, France; ³Hopitaux de Paris, Paris, France; ⁴Bologna University, Bologna, Italy.
The diagnosis of heart transplant rejection by histology in endomyocardial biopsies (EMB) is challenging. A molecular system (MMDx) has been developed to assess both T…
2016 American Transplant Congress
Role of NRP1 in CD4+ T Cell Allo-Activation.
E. Lee, H. Kim, G. Demirci.
Department of Surgery, Boston Children's Hospital, Boston, MA.
Introduction: Neuropilin-1 (NRP1) is a transmembrane glycoprotein that functions as a co-receptor for class III/IV semaphorins, VEGF, and several other growth factors. NRP1 has been…
2016 American Transplant Congress
Avoidance of CNI and Steroids Using Belatacept – A Preliminary Report of CTOT-16.
R. Mannon,¹ P. Stock,² A. Mehta,³ D. Ikle,⁴ N. Watson,⁵ N. Bridges,⁵ M. Robien,⁵ K. Newell.³
¹UAB, Birmingham; ²UCSF, San Francisco; ³Emory, Atlanta; ⁴Rho, Chapel Hill; ⁵NIAID, Bethesda.
CTOT-16 tested the hypothesis that belatacept used as maintenance immunosuppression (IS) in kidney transplantation would allow the long-term avoidance of CNI and corticosteroids. Methods: Primary…
2016 American Transplant Congress
Clinical Significance of Non-HLA Antibodies in the Development of Microcirculation Inflammation in Allograft Tissue After Kidney Transplantation.
J. Min,^1,3 H. Lee,^2,3 B. Chung,^1,3 E.-J. Oh,^2,3 C. Yang.^1,3
¹Division of Nephrology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea; ²Department of Laboratory Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea; ³Transplant Research Center, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
The aim of our study is to determine the clinical significance of pre-transplant non-HLA antibodies, mainly those targeting the angiotenin II type I receptor (AT1R)…