Articles tagged "Rejection"

2016 American Transplant Congress
Protective Impact of the Kidney in SPK Transplants – Mechanisms for Improved Outcomes Compared with Solitary Transplants.
E. Finger, T. Dunn, A. Kukla, V. Kirchner, R. Kandaswamy.
Surgery, University of Minnesota, Minneapolis, MN.
Purpose: Outcomes for SPK txps are superior to solitary pancreas txps. The basis for this difference is unknown. We sought to identify the biologic mechanism…
2016 American Transplant Congress
Induction Therapy with Depleting Antibodies in Low Immunological Risk Renal Transplant Patients Treated with a Steroid Free Regimen – Comparison of Alemtuzumab vs. Antithymocyte Globulin.
N. Bossini,¹ S. Sandrini,¹ R. Tardanico,² F. Valerio,¹ G. Setti,¹ C. Salviani,¹ S. Possenti,¹ P. Foini,¹ E. Marta,¹ G. Cancarini.¹
¹Division and Chair of Nephrology, A.O "Spedali Civili" and University, Brescia, Italy; ²Division and Chair of II Laboratory of Pathology, A.O "Spedali Civili" and University, Brescia, Italy.
Induction therapy with depleting antibodies reduces rejection rate and potentially improves efficacy of steroid free regimens after renal transplantation.This prospective, single-centre, cohort study evaluated cumulative…
2016 American Transplant Congress
Mapping Heterogeneity in Antibody-Mediated Rejection Using Molecular Phenotypes and Archetype Analysis.
J. Reeve,¹ P. Halloran.^1,2
¹Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada; ²Medicine, University of Alberta, Edmonton, AB, Canada.
Archetype analysis is a method for identifying new relationships among samples without subdividing them into classes, finding a limited number of archetypical cases and calculating…
2016 American Transplant Congress
Randomized Controlled Study Evaluating Adherence Monitoring with Electronic Feedback on Reducing Renal Allograft Rejection.
A. Bodzin, Y. Becker, M. Josephson, P. Witkowski, M. Lockwood, L. Potter, B. Kane, L. Lourenco, J. Millis.
Transplant Center, University of Chicago, Chicago, IL.
Purpose: The negative impact of non-adherence to the immunosuppressant medication (IM) regimen on transplant outcomes is well recognized. In an attempt to improve outcomes, the…
2016 American Transplant Congress
Implications of Subclinical Borderline Acute Cellular Rejection Detected in Protocol Biopsies on Graft Outcomes.
Z. Zaky,¹ C. Yu,¹ N. Elfadawy,² A. Chiesa-Vottero,¹ L. Herlitz,¹ S. Flechner,¹ E. Poggio.¹
¹Glickman Urological and Kidney institute, Cleveland Clinic, Cleveland, OH; ²Internal Medicine, Univ. Hospitals Case Medical Center, Cleveland, OH.
Background: The effects of subclinical borderline acute cellular rejection (BACR-defined as I1T1 per Banff criteria) detected in protocol biopsies (Bx) on subsequent graft function and…
2016 American Transplant Congress
Radiosensitive Cell Population Prolongs Graft Survival of Vascularized Composite Allografts in Non-Human Primates.
M. Uluer, J. Woodall, W. Hassanein, U. Drhu, B. Bojovic, A. Nam, S. Bartlett, R. Barth.
University of Maryland School of Medicine, Baltimore, MD.
Background: Vascularized composite allografts (VCA) containing vascularized bone marrow (VBM) prolong graft survival. To help elucidate this protective immunomodulatory effect, we irradiated donor facial VCA…
2016 American Transplant Congress
Acute Allograft Glomerulopathy: A Distinct Form of Cellular Rejection.
O. AL-Badri, M. Alexander, F. Cosio, L. Cornell.
Mayo Clinic, Rochester, MN.
Background: Acute allograft glomerulopathy (AAG) is an unusual glomerular lesion of allografts with endocapillary hypercellularity, markedly enlarged endothelial cells occluding the capillary lumen, and absence…
2016 American Transplant Congress
Distinct Effects of Chronic Hyperglycemia on Cellular and Humoral Alloresponses In Vivo.
N. Bishop,¹ K. Beard,² R. Gill.²
¹Immunology and Microbiology, University of Colorado Denver, Aurora, CO; ²Surgery, University of Colorado Denver, Aurora, CO; ³Surgery, University of Colorado Denver, Aurora, CO.
Background: Diabetes constitutes a significant problem in the transplant recipient. Diabetes is associated with impaired immunity to pathogens but its effect on alloimmunity remains ambiguous.…
2016 American Transplant Congress
High KDPI Is a Predictor of Acute Rejection in Delayed Graft Function.
B. Muth,¹ J. Turk,¹ S. Parajuli,¹ D. Mandelbrot,¹ M. Mohamed,¹ R. Redfield,² D. Kaufman,² A. Djamali.^1,2
¹Department of Medicine, Division of Nephrology, University of Wisconsin School of Medicine and Public Health, Madison, WI; ²Department of Surgery, Division of Transplantation, University of Wisconsin School of Medicine and Public Health, Madison, WI.
The kidney donor profile index (KDPI) is a prognostic measure for graft function and survival. It is unclear whether it predicts acute rejection in patients…
2016 American Transplant Congress
Deceased Donor Kidney Transplantation in the Setting of Positive Donor-Specific Antibodies.
B. Orandi,¹ J. Montgomery,² E. Kraus,¹ D. Segev,¹ R. Montgomery,¹ N. Alachkar.¹
¹Johns Hopkins University, Baltimore; ²University of Michigan, Ann Arbor.
Recent changes to the kidney allocation system favor highly sensitized transplant candidates, resulting in these patients receiving more offers for deceased donor (DD) kidneys. Despite…