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Articles tagged "Rejection"

  • 2016 American Transplant Congress

    Diffuse Extent of Peritubular Capillaritis in Late Antibody Mediated Rejection Is Associated with More Severe Chronic Allograft Damage.

    Z. Kikić,1 F. Eskandary,1 H. Herkner,2 R. Oberbauer,1 G. Bond,1 H. Regele,3 G. Böhmig,1 N. Kozakowski.3

    1Nephrology and Dialysis, Medical University of Vienna, Vienna, Austria; 2Emergency Medicine, Medical University of Vienna, Vienna, Austria; 3Institute of Clinical Pathology, Medical University of Vienna, Vienna, Austria.

    Peritubular capillaritis (ptc) is a widely accepted histologic criterion of antibody-mediated rejection (ABMR), and while the ptc score is incorporated in current diagnostic recommendations, the…
  • 2016 American Transplant Congress

    Acute Rejection by Belatacept (Bela) Dosing Frequency: Results from a Phase II Study of Kidney Transplant Recipients.

    F. Vincenti,1 G. Blancho,2 A. Durrbach,3 G. Grannas,4 J. Grinyó,5 U. Meier-Kriesche,6 M. Polinsky,6 H. Zhao,6 C. Larsen.7

    1UCSF, San Francisco, CA; 2University Hospital of Nantes, Nantes, France; 3University Hôpital of Bicêtre, Le Kremlin-Bicêtre, France; 4Medizinische Hochschule Hannover, Hannover, Germany; 5University Hospital of Bellvitge, Bellvitge, Spain; 6Bristol-Myers Squibb, Lawrenceville, NJ; 7Emory University Transplant Center, Atlanta, GA.

    Background: At 1 year post transplant in IM103-100 (NCT00035555), bela-treated patients had similar acute rejection (AR) rates and significantly improved renal function vs cyclosporine A…
  • 2016 American Transplant Congress

    Kidney Transplant Recipient Adherence Measured by Proportion of Days Covered Is Associated with Late Biopsy Proven Acute Rejection.

    B. Hofmeyer, K. Look, J. Fose, A. Pulvermacher, A. Djamali, D. Hager.

    UW Health, Madison, WI.

    While medication non-adherence is a known risk factor for late “biopsy proven acute rejection (BPAR),” the Pharmacy Quality Alliance definition of “proportion of days covered…
  • 2016 American Transplant Congress

    Fecal Microbiota Transplant Results in Durable Changes to Host Microbiota That Correlate with Allograft Outcome.

    C. Brinkman, L. Hittle, W. Fricke, E. Mongodin, J. Bromberg.

    CVID and IGS, University of Maryland School of Medicine, Baltimore, MD.

    Hypothesis: We previously presented highly significant differences in the bacterial community structures of human renal allograft recipients over time. Likewise, murine normal, colitic, and pregnant…
  • 2016 American Transplant Congress

    Profiling Immunologic Risk for Acute Rejection in Liver Transplantation: Recipient Age Is a Robust Risk Factor.

    M. Kueht, R. Cotton, C. O'Mahony, J. Goss, A. Rana.

    Surgery, Division of Abdominal Transplantation and Hepatobiliary Surgery, Balyor College of Medicine, Houston, TX.

    Profiling the immunologic risk for acute rejection in liver transplantation (OLT) may allow for selection immunosuppression (IS) target ranges appropriate to risk levels, all with…
  • 2016 American Transplant Congress

    Composite Score to Define the Risk of Allograft Loss After Standard-of-Care Treatment of Antibody-Mediated Rejection in Kidney Transplantation.

    D. Viglietti,1 A. Loupy,2 J. Duong Van Huyen,2 J. Verine,1 A. Zeevi,3 C. Legendre,2 D. Glotz,1 C. Lefaucheur.1

    1Saint-Louis Hospital, Paris, France; 2Necker Hospital, Paris, France; 3University of Pittsburgh Medical Center, Pittsburgh.

    The development of a reliable surrogate endpoint for allograft survival after AMR treatment is a current unmet need in clinical transplantation (FDA AMR Workshop). We…
  • 2016 American Transplant Congress

    mRNA Expression of BAFF and APRIL Receptors Increases in Acute Rejection in Kidney Transplant Recipients.

    M. Minz,1 R. Dhital,1 R. Minz,2 A. Sharma,1 R. Nada,3 S. Singh,1 D. Kenwar.1

    1Renal Transplant Surgery, Post Graduate Institute of Medical Education and Research, Chandigarh, India; 2Immunopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India; 3Histopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

    Introduction:BAFF and APRIL are known survival and growth of B- cells.BAFF and APRIL share two receptors i-TACI and ii- BCMA. Additionally, BAFF has strong affinity…
  • 2016 American Transplant Congress

    Early De Novo DSA with T Cell Mediated Rejection (TCMR) Is Associated with Allograft Dysfunction with Chronic Injury.

    A. Cherukuri, R. Mehta, P. Sood, A. Zeevi, S. Hariharan, D. Rothstein.

    UPMC, Pittsburgh.

    De novo anti-donor HLA specific antibody (DSA) detected post-renal transplantation is associated with adverse outcomes. However, the relationship between early de novo DSA and subsequent…
  • 2016 American Transplant Congress

    Acute Rejection Profoundly Impacts Graft Survival in Young but Not in Old Kidney Transplant Recipients.

    C. Denecke,1,3 M. Biebl,1,3 J. Fritz,2 A. Brandl,1,4 S. Weiss,1,4 T. Dziodzio,1,3 F. Aigner,1,3 R. Sucher,1,3 C. Bösmüller,1 J. Pratschke,1,3,4 R. Öllinger.1,3

    1Visceral, Transplantation and Thoracic Surgery, Medical University, Innsbruck, Austria; 2Medical Statistics, Informatics and Health Economics, Medical University, Innsbruck, Austria; 3General, Visceral and Transplantation Surgery, Charité Universitätsmedizin, Campus Virchow, Berlin, Germany; 4General, Visceral, Vascular and Thoracic Surgery, Charite Universitätsmedizin, Campus Mitte, Berlin, Germany.

    Background: The proportion of marginal grafts and elderly recipients awaiting kidney transplantation is ever increasing. The correlation of age with DGF and acute rejection determines…
  • 2016 American Transplant Congress

    Delayed Graft Function Is an Independent Risk Factor for Renal Allograft Rejection.

    T. Dienemann, S. Weber, J. Jacobi, K.-U. Eckardt, A. Weidemann.

    Nephrology and Hypertension, Universitaetsklinikum Erlangen, Universiaet Erlangen Nuernberg, Erlangen, Germany.

    Background: Numerous risk factors for delayed graft function (DGF) after kidney transplantation (KTx) have been identified. However the effect of DGF as an independent risk…
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