2016 American Transplant Congress
Durable Clinical and Immunologic Advantage of Living Donor Liver Transplantation (LDLT) in Children.
1Columbia University Medical Center, New York, NY; 2Weill Cornell Medical College, New York, NY.
Purpose:Despite good results, only 10% of liver transplants in children in the US are from living donors. In addition to optimal timing and graft quality,…2016 American Transplant Congress
Characterization of Human Islet Transplant Specific Exosomes in a Xenoislet Transplantation Model.
Department of Surgery, University of Pennsylvania, Philadelphia, PA.
Background: There is a critical need for biomarker platforms for monitoring transplant rejection. We propose that transplant tissues release donor specific exosomes into recipient blood/…2016 American Transplant Congress
Macrophage Specific Deletion of RhoA Impedes Macrophage Functions and Abrogates Chronic Rejection of Cardiac Allograft.
Surgery, The Houston Methodist, Houston, TX.
Objective. Chronic rejection of transplanted organs remains the main obstacle in the long-term success of organ transplantation. Chronic rejection occurs in 40-45% of recipients at…2016 American Transplant Congress
Blockade of HLA Antibody-Triggered Classical Complement Activation by High-Affinity Humanized Monoclonal Anti-C1s Antibody TNT009 – Results of a First-in-Human Phase 1 Trial.
Study purpose: Classical complement may play a key role in ABMR. A promising therapeutic approach could be complement inhibition at the level of key component…2016 American Transplant Congress
Association of Ultrastructural Changes in Renal Allograft Biopsies with Antibody-Mediated Rejection (AMR) and Graft Outcomes.
The role of electron microscopy (EM) in diagnosis of AMR is not well-defined. We sought to examine the EM findings in 796 biopsies from 622…2016 American Transplant Congress
The Effect of Donor-Recipient Relationship on the Immunologic Outcome in Living Kidney Transplantation.
Nephrology, Charite Campus Mitte, Berlin, Germany.
Background. Presensitization and degree of HLA-matching influences immunologic outcome and kidney graft survival. Thus the donor-recipient relationship may influence incidence of immunologic events and outcome…2016 American Transplant Congress
A2 Kidneys into B Recipients: Is Postoperative Anti-A1 Titer Monitoring Useful?
Kidney and Pancreas Transplantation, Vanderbilt University Medical Center, Nashville, TN.
Background: Since the introduction of the new Kidney Allocation System in December 2014, our center implemented a protocol for transplanting A2 kidneys into B recipients…2016 American Transplant Congress
Transcriptome Profiles in Peripheral Blood of Kidney Graft Recipients.
The discovery of sensitive noninvasive diagnosis and the development of immune management in the renal allograft recipients are required for long-term graft survival. Although the…2016 American Transplant Congress
Eomesodermin Expression by CD8+ Alloreactive T Cells in Human and Nonhuman Primate Allograft Recipients.
Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA.
Background:The transcription factor Eomesodermin (Eomes) is critical in the maintenance of antigen-specific memory T cells (Tmem). We have shown previously that prolonged kidney allograft survival…2016 American Transplant Congress
Pre-Existing Diabetes Mellitus Type 2 and Insufficiently Controlled Post-Transplant HbA1c in Kidney Transplantation.
Nephrology, Charité University, Berlin, Germany.
Background Limited data have been reported on the outcomes of kidney transplant recipients (KTR) with pre-existing diabetes mellitus type 2 (preDM) at time of transplantation…
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