Articles tagged "Rejection"

2016 American Transplant Congress
Association of Genetic Polymorphisms in Complement Independent Pathways with Donor Specific Antibodies in Kidney Allograft Recipients.
Y. Chang,^1,2 T. Shah,^1,3 D. Min.¹
¹Western University of Health Sciences, Pomona, CA; ²Mendez National Institute of Transplantation Foundation, Los Angeles, CA; ³St. Vincent Medical Center, Los Angeles, CA.
Background: It is known that detection of donor specific antibodies (DSA) is associated with antibody mediated rejection (AMR) and poor allograft outcomes. DSA mediates graft…
2016 American Transplant Congress
Focal C4d Staining in Biopsies of Kidney Transplant Recipients Is Not Associated with Antibody Mediated Rejection and Does Not Correlate with Graft Survival.
R. Prashar, M. Goggins, L. Yessayan, A. Patel, M. Goggins.
Transplant Institute, Henry Ford Hospital, Detroit, MI.
Introduction: While diffuse C4d positivity in kidney transplant peritubular capillaries(PTC) strongly co-relates with the presence of antibody mediated rejection(AMR),data on the significance of focal C4d…
2016 American Transplant Congress
Dendritic Cells and Damage-Associated Molecular Patterns in Aging.
M. Seyda, H. Li, G. Liu, M. Quante, H. Uehara, J. Schuitenmaker, A. Elkhal, S. Tullius.
Division of Transplant Surgery and Transplant Surgery Research Laboratory, Brigham and Women's Hospital, Boston.
Recently, it has been shown that Dendritic Cells (DCs) of old organs accelerate graft rejection by orchestrating IL-17A-mediated T cell responses. Moreover, cell-free DNA has…
2016 American Transplant Congress
Concomitant Proton Pump Inhibitor and Mycophenolate Mofetil Use in Renal Transplant Recipients.
K. Patel,¹ B. Stephany,² J. Barnes,¹ S. Bauer,¹ M. Spinner.¹
¹Department of Pharmacy, Cleveland Clinic, Cleveland, OH; ²Department of Nephrology and Hypertension, Cleveland Clinic, Cleveland, OH.
Pharmacokinetic (PK) data show reduced mycophenolic acid levels in transplant recipients taking mycophenolate mofetil (MMF) and proton pump inhibitors (PPIs) concomitantly. MMF dosing is not…
2016 American Transplant Congress
Antibody-Mediated Rejection in Pancreas Transplantation.
O. Serrano,¹ D. Vock,² E. Finger,¹ R. Kandaswamy,¹ D. Sutherland,¹ T. Dunn.¹
¹Surgery, Univ. of Minnesota, Minneapolis, MN; ²Biostatistics, University of Minnesota, Minneapolis, MN.
PURPOSE: The diagnostic criteria for antibody-mediated rejection (AMR) in pancreas transplantation (PTx) is evolving. The incidence and long-term effect of AMR have not been well-described.…
2016 American Transplant Congress
Everolimus in Combination with Reduced Dose Tacrolimus Is Effective as a Prophylaxis of Acute Rejection in Low-to-Moderate Immunologic Risk De Novo Kidney Transplantation Patients.
Y. Qazi, F. Shihab, S. Mulgaonkar, K. MaCague, D. Patel.
University of Southern California, Los Angeles; University of Utah, Salt Lake City; Barnabas Health, West Orange; Novartis Pharmaceuticals Corporation, East Hanover.
The US92 study determined whether, in de novo renal transplant patients (pts), concentration-controlled everolimus (EVR) with reduced dose tacrolimus (RTAC) is non-inferior compared to CellCept®…
2016 American Transplant Congress
Treatment of Hepatitis C Viral Infection with Novel Direct Acting Antivirals in Kidney Transplant Recipients – Single Center Experience.
K. Hatahet,¹ M. Ghanta,¹ A. Gillespie,¹ I. Lee,¹ H. El-Halawany,² K. Qureshi,² K. Lau,³ S. Karhadkar,³ A. Di Carlo,³ S. Constantinescu,¹ S. Rao.¹
¹Nephrology, Temple University, Phildelphia, PA; ²Hepatology, Temple University, Philadelphia, PA; ³Surgery, Temple University, Philadelphia, PA.
Kidney transplant recipients (KTRs) with Hepatitis C virus infection (HCV+ve) have higher proteinuria and inferior patient and graft survival compared to HCV negative KTRs. Due…
2016 American Transplant Congress
Post-Transplant T-Cell Alloreactive Perturbation Precedes the Advent of Humoral Immunity in Kidney Transplant Patients.
E. Crespo,¹ S. Luque,¹ J. Cruzado,² E. Melilli,² J. Grinyo,² M. Lucia,¹ O. Bestard.²
¹Experimental Nephrology Laboratory, IDIBELL, Barcelona, Spain; ²Kidney Transplant Unit, Bellvitge University Hospital, Barcelona, Spain.
Subclinical inflammation in kidney allografts is associated with worse outcome and the activation of humoral alloimmunity. Surveillance allograft biopsies are an accurate tool to diagnose…
2016 American Transplant Congress
Molecular Diagnosis of Antibody-Mediated Rejection in Routine Formalin-Fixed Paraffin-Embedded Nonhuman Primate Renal Allograft Biopsies.
B. Adam,¹ I. Rosales,² T. Oura,² R. Smith,² A. Cosimi,² T. Kawai,² R. Colvin,² M. Mengel.¹
¹University of Alberta, Edmonton, Canada; ²Harvard Medical School and Massachusetts General Hospital, Boston.
Background: In 2013, the Banff classification proposed molecular testing as an adjunct for the diagnosis of antibody-mediated rejection (ABMR) in renal allografts. We analyzed whether…
2016 American Transplant Congress
Recipient Age and KDPI Are Potent Predictors of Early Acute Rejection in the Modern Era of Deceased Donor Kidney Transplantation.
D. Keith, G. Vranic, A. Nishio Lucar.
Medicine, University of Virginia, Charlottesville, VA.
The rate of acute rejection in the first six months after deceased donor (DD) kidney transplant is about 10% in the modern era of immunosuppression.…