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American Transplant Congress abstracts

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Articles tagged "Rejection"

  • 2016 American Transplant Congress

    Kidney Transplantation in HIV Patients: Effect of Race on the Choice of Anti-Thymocyte Globulin Induction Immunosuppression.

    M. Casey, T. Aijaz, X. Wen, S. Rehman, A. Santos, E. Thomas, K. Andreoni, K. Womer.

    University of Florida, Gainesville, FL.

    Introduction: HIV positive status is a well-known risk factor for acute rejection (AR) in kidney transplant recipients (KTR). In the United States, the majority of…
  • 2016 American Transplant Congress

    Blockade of HLA Antibody-Triggered Classical Complement Activation by High-Affinity Humanized Monoclonal Anti-C1s Antibody TNT009 – Results of a First-in-Human Phase 1 Trial.

    J. Mühbacher,1 B. Jilma,2 M. Wahrmann,3 L. Marinova,3 F. Eskandary,3 J. Gilbert,4 S. Panicker,4 G. Böhmig.3

    1Department of Surgery, Medical University of Vienna, Vienna, Austria; 2Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria; 3Division of Nephrology and Dialysis, Department of Medicine III, Medical University of Vienna, Vienna, Austria; 4True North Therapeutics, Inc., South San Francisco, CA.

    Study purpose: Classical complement may play a key role in ABMR. A promising therapeutic approach could be complement inhibition at the level of key component…
  • 2016 American Transplant Congress

    Association of Ultrastructural Changes in Renal Allograft Biopsies with Antibody-Mediated Rejection (AMR) and Graft Outcomes.

    A. Haririan,1 M. Chaudhry,2 J. Papadimitriou,2 N. Costa,1 B. Thomas,1 M. Mavanur,1 R. Ugarte,1 C. Cangro,1 C. Drachenberg.2

    1Dept of Medicine, Unniversity of Maryland, Baltimore, MD; 2Dept of Pathology, University of Maryland, Baltimore, MD.

    The role of electron microscopy (EM) in diagnosis of AMR is not well-defined. We sought to examine the EM findings in 796 biopsies from 622…
  • 2016 American Transplant Congress

    The Effect of Donor-Recipient Relationship on the Immunologic Outcome in Living Kidney Transplantation.

    D. Khadzhynov, F. Halleck, L. Lehner, M. Duerr, J. Waiser, K. Budde, O. Staeck.

    Nephrology, Charite Campus Mitte, Berlin, Germany.

    Background. Presensitization and degree of HLA-matching influences immunologic outcome and kidney graft survival. Thus the donor-recipient relationship may influence incidence of immunologic events and outcome…
  • 2016 American Transplant Congress

    A2 Kidneys into B Recipients: Is Postoperative Anti-A1 Titer Monitoring Useful?

    A. DeMers, R. Forbes, D. Moore, K. Smith, D. Shaffer.

    Kidney and Pancreas Transplantation, Vanderbilt University Medical Center, Nashville, TN.

    Background: Since the introduction of the new Kidney Allocation System in December 2014, our center implemented a protocol for transplanting A2 kidneys into B recipients…
  • 2016 American Transplant Congress

    Transcriptome Profiles in Peripheral Blood of Kidney Graft Recipients.

    J.-W. Seo,1 H. Moon,1 Y.-G. Kim,1 K.-H. Jeong,1 S.-J. Ihm,2 J.-Y. Moon,1 S.-H. Lee.1

    1Division of Nephrology, Department of Internal Medicine, Kyung Hee University College of Medicine, Seoul, Republic of Korea; 2Department of Pathology, Kyung Hee University College of Medicine, Seoul, Republic of Korea.

    The discovery of sensitive noninvasive diagnosis and the development of immune management in the renal allograft recipients are required for long-term graft survival. Although the…
  • 2016 American Transplant Congress

    Eomesodermin Expression by CD8+ Alloreactive T Cells in Human and Nonhuman Primate Allograft Recipients.

    A. Perez-Gutierrez, L. Lu, A. Zahorchak, Y. Ono, A. Thomson, M. Ezzelarab.

    Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA.

    Background:The transcription factor Eomesodermin (Eomes) is critical in the maintenance of antigen-specific memory T cells (Tmem). We have shown previously that prolonged kidney allograft survival…
  • 2016 American Transplant Congress

    Pre-Existing Diabetes Mellitus Type 2 and Insufficiently Controlled Post-Transplant HbA1c in Kidney Transplantation.

    F. Halleck, D. Khadzhynov, L. Lehner, E. Schrezenmeier, M. Duerr, A. Kleinsteuber, K. Budde, O. Staeck.

    Nephrology, Charité University, Berlin, Germany.

    Background Limited data have been reported on the outcomes of kidney transplant recipients (KTR) with pre-existing diabetes mellitus type 2 (preDM) at time of transplantation…
  • 2016 American Transplant Congress

    The Bacterial Enzyme IdeS, Inhibits HLA Antibody-Mediated NK Cell Activation and Cell Cytotoxicity (ADCC) In Vitro.

    S. Ge, M. Chu, J. Choi, S. Jordan, M. Toyoda.

    Transplant Immunology Laboratory, Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles.

    Background: Antibody-mediated rejection (ABMR) is a major obstacle for successful transplantation in HLA-sensitized patients. ADCC is one of the primary mechanisms for ABMR. IdeS cleaves…
  • 2016 American Transplant Congress

    The Combined Effect of Acute Rejection and De Novo Donor-Specific Antibodies on Kidney Allograft Survival.

    S. Davis, J. Gralla, A. Wiseman, J. Cooper.

    Division of Renal Diseases and Hypertension, University of Colorado, Aurora, CO.

    While dnDSA is associated with graft loss in multiple studies, the clinical context in which dnDSA develops and contributes to graft loss is less well…
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