2016 American Transplant Congress
Deceased Donor Kidney Transplantation in the Setting of Positive Donor-Specific Antibodies.
1Johns Hopkins University, Baltimore; 2University of Michigan, Ann Arbor.
Recent changes to the kidney allocation system favor highly sensitized transplant candidates, resulting in these patients receiving more offers for deceased donor (DD) kidneys. Despite…2016 American Transplant Congress
HCV, Acute Rejection, and the New Direct-Acting Antivirals in Deceased Donor Kidney Transplant Recipients.
The association between hepatitis C virus (HCV) seropositivity and acute rejection (AR) in kidney transplant donors and recipients is unclear, and may have changed with…2016 American Transplant Congress
The Early Outcomes of Bortezomib Therapy in Patients with Late Antibody Mediated Rejection in Renal Transplantation.
Although several strategies for treating antibody mediated rejection (AMR) in renal transplants have been investigated, the formation of donor-specific antibodies (DSA) and ongoing AMR contribute…2016 American Transplant Congress
Preoperative Cytokine Storm in High MELD Patients Accentuates Incidence of Rejection Following Liver Transplantation.
Abdominal Transplant Surgery, Columbia University, NY, NY.
IntroductionAcute Cellular Rejection (ACR) affects 30 percent of all liver transplants. Histologically it is characterized by cellular inflammation in the veins, bile ducts and portal…2016 American Transplant Congress
IL-17-Producing CCR6+CD4+ Th17 Cells Drive Intestinal Allograft Rejection in Humans.
MedStar Georgetown Transplant Institute, Washington DC.
A. Allograft rejection remains a significant source of mortality and morbidity in intestinal transplant (ITx) recipients. However, the underlying mechanisms remain unclear. The purpose of…2016 American Transplant Congress
Allo-Specific Memory B Cell Recall Responses Are Dependent on B Cell Autophagy.
B cells, and in particular, memory B cells (Bmem) are sources of donor specific antibodies (DSA) that cause allograft injury. Understanding requirements for Bmem function/survival…2016 American Transplant Congress
Tailored Rabbit Anti-Thymocyte Globulin Induction (rATG) Dosing for Kidney Transplantation.
1MMC, Portland, ME; 2MGMC, Augusta, ME.
Purpose: Although rATG is the most commonly used induction immunotherapy for kidney transplantation (KT), optimal dosing remains unknown. In order to minimize adverse effects and…2016 American Transplant Congress
A Molecular Biopsy Test for Probability of Non-Adherence.
Afferent arteriolar hyalinosis (ah-score) in renal transplant biopsies increases with time of biopsy-post-transplant (TxBx), reflecting calcineurin inhibitor drug effects, donor aging, and progressive glomerular diseases.…2016 American Transplant Congress
Immunogenic HLA-DR Eplet Mismatches as Predictors of Transplant Glomerulopathy.
BackgroundThe number of HLA-DR eplet mismatches (eplet load) is a risk factor for the development of anti-HLA antibodies and transplant glomerulopathy (TG). In the case…2016 American Transplant Congress
Human B Cell Cytokines Predict Renal Allograft Rejection and Early Transplant Outcomes.
In renal transplantation, non-invasive biomarkers that are predictive and allow for early intervention are limited. Here we report findings from a prospective longitudinal study of…
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