2016 American Transplant Congress
The Urine Common Rejection Module (uCRM) Is a Sentinal Assay for Graft Rejection.
1Surgery, UCSF, San Francisco, CA; 2Nephrology, Bellevitage Hospital, Barcelona, Spain.
Background: A common rejection module (CRM) consisting of 11 genes are expressed in solid organ transplant rejection in kidney, heart, liver and lung transplantation (Khatri,…2016 American Transplant Congress
CMV-Accelerated Cardiac Allograft Rejection Is Associated with Dysregulation of Sphingolipid Metabolomics.
PurposeCytomegalovirus (CMV) infection accelerates transplant vascular sclerosis (TVS) and chronic rejection (CR) in solid organ transplants. Sphingolipid metabolism plays an immunomodulatory role in transplant rejection,…2016 American Transplant Congress
Effect of Early Tacrolimus Trough Variability on Graft Outcomes in Lung Transplantation.
The Johns Hopkins Hospital, Baltimore, MD.
Background: Recent data suggests that variability in tacrolimus trough levels after lung transplant may be associated with poor long term graft outcomes. The purpose of…2016 American Transplant Congress
Early Onset Acute Antibody Mediated Rejection (ABMR) Is More Common in Female Than in Male Recipients of a Living Unrelated Donor (LURD) Renal Transplant and Is Associated with the Presence of Preformed Donor Specific Antibodies (DSA).
1Nephrology, LUMC, Leiden, Netherlands; 2IHB, LUMC, Leiden, Netherlands.
Introduction: Women who receive a renal graft from their male spouse have a higher risk of early onset acute ABMR. The aim of this study…2016 American Transplant Congress
Detection of Endothelial Cell Specific Molecule-1 According to Allograft Status After Kidney Transplantation.
To investigate urine ESM-1(endothelial cell specific molecule-1) as well as plasma ESM-1 level from renal allograft recipients, we show whether there is the difference of…2016 American Transplant Congress
Elevation of Peripheral IL-6 in Kidney Transplant Recipients with Antibody Mediated Rejection.
University of Wisconsin, Madison.
Background: Despite current therapy, antibody mediated rejection (AMR) remains a major cause of kidney allograft loss. IL-6 is a known survival factor of antibody secreting…2016 American Transplant Congress
Mass Cytometry Reveals NK Cell and T Cell Subsets in Pediatric Liver Transplant Patients with Acute Rejection.
1Pediatrics, Stanford/LPCH, Palo Alto, CA; 2Surgery, Stanford, Palo Alto, CA.
Proper evaluation of the immune status of liver transplant recipients is crucial for appropriate post-transplant management. Current monitoring of graft function relies mainly on non-specific…2016 American Transplant Congress
The Impact of One Year Individual or Dual Organ Rejection in Simultaneous Pancreas-Kidney Transplant on Kidney Graft Survival – A UNOS Registry Analysis 2000-2013.
Background: Early Rejection of either organ in Simultaneous Pancreas-Kidney transplants (SPK) is common within the first 1 year. We studied the impact of within 1…2016 American Transplant Congress
Rapamycin Nanotherapy Delays Heart Transplant Rejection.
Background:In patients, allograft survival requires a cocktail of immunosuppressive drugs, while experimentally antibodies targeting the innate immune system have been shown to induce long-term tolerance,…2016 American Transplant Congress
Novel Function of CD4+ T Cell DEPTOR in Treg Homeostasis and Alloimmunity.
DEPTOR, a recently described modulator of PI-3K/mTOR signaling, is expressed by CD4+ T cells, and functions to modulate CD4+ Teff cell differentiation. Upon CD4+ T…
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