Articles tagged "Rejection"

2016 American Transplant Congress
Rare Presentation of PTLD as Parotitis.
R. Pullalarevu, A. Posadas Salas, G. Mour, T. Srinivas, N. Salazar, P. Mohan.
Medicine, MUSC, Charleston, SC.
28y/o AAF w/ hx of CAH, HTN, and ESRD, was on HD for 3 yrs. Pt was EBV seronegative prior to transplant (tx). She received…
2016 American Transplant Congress
Urine IP-10 as the Biomarker for ABMR in Kidney Transplant Recipient with DGF.
N. Townamchai,¹ A. Leelahavanichakul,² J. Supapol,³ S. Wattanatorn,¹ Y. Avihingsanon,¹ K. Praditpornsilpa.¹
¹Department of Medicine, Division of Nephrology, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Bangkok, Thailand; ²Department of Microbiology, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Bangkok, Thailand; ³Department of Surgery, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Bangkok, Thailand.
Background: In the setting of DGF in kidney transplantation (KT), early acute ABMR, which needs early treatment, has to be differentiated from simple ischemic acute…
2016 American Transplant Congress
C1q Donor Specific Antibody Associates with Post Transplant Biopsy Findings in Highly Sensitized Kidney Transplant Recipients.
S. Kuppachi,¹ D. Holanda,² S. Gallegos,³ E. Field.^3,4
¹Nephrology, University of Iowa Hospitals and Clinics, Iowa City, IA; ²Pathology, University of Iowa Hospitals and Clinics, Iowa City, IA; ³Iowa Regional Histocompatibility and Immunogenetics Laboratory, Veteran Affairs Medical Center, Iowa City, IA; ⁴Immunology, University of Iowa Hospitals and Clinics, Iowa City, IA.
We performed monitoring of conventional donor specific antibodies (DSA) and C1q binding DSA (C1q DSA) to correlate levels with pathology findings in protocol kidney biopsies…
2016 American Transplant Congress
Monocyte Recruitment to HLA Class I Antibody-Activated Endothelial Cells Is Dependent Upon mTOR.
S. Salehi, E. Reed.
Pathology & Laboratory Medicine, UCLA, Los Angeles, CA.
Aim: Antibody-mediated rejection (AMR) is a major issue affecting solid organ transplants, manifesting with recruitment of monocytes to the endothelium of the allograft. The purpose…
2016 American Transplant Congress
Clinical Significance of Mycophenolic Acid Therapeutic Drug Monitoring in Kidney Transplant Recipients.
C.-D. Kim, J.-H. Cho, K. Kim, M. Kim, W. Do, Y. Yang, T. Yim, I. Hwang, J.-H. Lee, H.-Y. Jung, J.-Y. Choi, S.-H. Park, Y.-L. Kim.
Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea.
Background: Mycophenolic acid (MPA) is a widely used immunosuppressant to prevent acute rejection in kidney transplant recipients (KTRs). However, clinical significance of MPA therapeutic drug…
2016 American Transplant Congress
Impact of Early Acute Rejection (AR) on Pancreas Transplant (PT) Outcomes.
V. Kirchner, T. Dunn, A. Kukla, R. Kandaswamy, E. Finger.
University of Minnesota, Minneapolis.
Background: The role of early AR in long-term PT outcomes remains unclear. Despite reported high rate of AR (up to 40% in PTA), graft survival…
2016 American Transplant Congress
Mechanistic Insights into How Targeting of HDAC10 Promotes Foxp3+ Treg Cell Suppressive Activity, Gene Expression and Metabolism, and Enhances Allograft Survival.
S. Dahiya,¹ L. Wang,¹ U. Beier,^1,2 A. Angelin,¹ R. Han,¹ D. Wallace,^1,2 W. Hancock.^1,2
¹Children's Hospital of Philadelphia, Philadelphia; ²University of Pennsylvania, Philadelphia.
Foxp3+ T-regulatory (Treg) cells are key regulators of immune responses that can result in unwarranted inflammation and promote allograft rejection. From a theoretical perspective, targeting…
2016 American Transplant Congress
Comparison of Clinical Outcomes of Belatacept- and Tacrolimus-Based Immunosuppression in Renal Transplant Recipients.
X. Wen,¹ M. Casey,¹ A. Santos,¹ A. Hartzema,² K. Womer.¹
¹Department of Medicine, University of Florida, Gainesville, FL; ²Department of Pharmaceutical Outcomes and Policy, University of Florida, Gainesville, FL.
To examine the utilization and clinical outcomes of belatacept in the real clinical setting, a retrospective cohort study was conducted using SRTR data that compared…
2016 American Transplant Congress
Malignancies Contribute to Presensitization with Alloreactive T-Cells in Kidney Transplant Recipients.
T. Schachtner,^1,2 M. Stein,² P. Reinke.^1,2
¹Nephrology and Internal Intensive Care, Charite Campus Virchow Clinic, Berlin, Germany; ²Berlin-Brandenburg Center for Regenerative Therapies, Charite Campus Virchow Clinic, Berlin, Germany.
Alloreactive T-cells have been suggested to impact allograft outcome due to a higher incidence of acute rejection in the initial period after kidney transplantation. Knowledge…
2016 American Transplant Congress
Interaction Between Kidney Tissue Proteome and Humoral Immunity in Antibody Mediated Rejection.
A. Konvalinka,¹ A. Chruscinski,² S. Kim,¹ K. Tinckam,¹ I. Jurisica,³ R. John.⁴
¹Medicine/Division of Nephrology, Toronto General Hospital, Toronto, ON, Canada; ²Medicine/Division of Cardiology, Toronto General Hospital, Toronto, ON, Canada; ³Medical Biophysics and Computational Science, University of Toronto, Toronto, ON, Canada; ⁴Pathology, Toronto General Hospital, Toronto, ON, Canada.
PURPOSE: Antibody-mediated rejection (AMR) is caused by antibodies against human leukocyte antigens (HLA) on graft endothelium, and non-HLA antibodies that target endothelial and epithelial proteins.…