Articles tagged "Rejection"

2016 American Transplant Congress
Human B Cell Cytokines Predict Renal Allograft Rejection and Early Transplant Outcomes.
A. Cherukuri, R. Mehta, S. Ogunde, S. Hariharan, D. Rothstein.
UPMC, Pittsburgh.
In renal transplantation, non-invasive biomarkers that are predictive and allow for early intervention are limited. Here we report findings from a prospective longitudinal study of…
2016 American Transplant Congress
Skin as a Harbinger of Rejection of Underlying Structures in Vascularized Composite Allografts: Concordance or Discordance?
L. Cendales,¹ M. Levine,² S. Bartlett,³ J. Cheeseman,¹ C. Drachenberg,³ W. Hancock,⁴ M. Joshi,¹ A. Kirk,¹ F. Leoopardi,¹ S. Levin,² M. Uluer,³ A. Selim,⁵ M. Song,¹ W. Twaddell,³ L. Wang,⁴ Z. Wang,² R. Barth.³
¹Surgery, Duke University, Durham, NC; ²University of Pennsylvania, Philadelphia, PA; ³University of Maryland School of Medicine, Baltimore, MD; ⁴Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA; ⁵Pathology, Duke University, Durham, NC.
Vascularized composite allografts (VCA) are composed of multiple tissue types. It has not been determined as to whether there is an immune hierarchy or differential…
2016 American Transplant Congress
The Impact of Treating Borderline Cellular Rejections.
R. Mustafa,¹ Y. Al Azzi,¹ J. Crew,¹ G. Dube,¹ H. Morris,¹ M. Chiles,¹ J. Chang,¹ H. Fernandez,¹ D. Cohen,¹ I. Batal,² E. Campenot,² S. Mohan.¹
¹Nephrology, Columbia University Medical Center, New York, NY; ²Pathology, Columbia University Medical Center, New York, NY.
Introduction: Histological findings that meet the criteria for Borderline rejection (BR) as defined by the Banff Classification are frequently seen. The clinical significance of a…
2016 American Transplant Congress
Profiling of T Cell Subsets in a Primate Cardiac Transplant Model.
N. O'Neill, T. Zhang, G. Braileanu, W. Sun, X. Cheng, C. Evans, R. Pierson, A. Azimzadeh.
Surgery, University of Maryland, Baltimore, MD.
Purpose: Costimulation blockade prolongs graft survival but does not induce tolerance in primates, and mechanisms of rejection are incompletely understood. Here we evaluate changes in…
2016 American Transplant Congress
Higher Pre-Transplant HDL Levels Are Associated with Decreased Acute Rejection Following Kidney Transplant.
J. Hagopian,¹ D. Brennan,² K. Lentine,³ T. Horwedel.¹
¹Barnes Jewish Hospital, St. Louis; ²Washington University, St. Louis; ³Saint Louis University Center for Transplant Research, St. Louis.
Purpose: Dyslipidemia is a common comorbidity in patients on the transplant waitlist and post-transplant, and hyperlipidemia has been associated with more robust immune response, possibly…
2016 American Transplant Congress
Antibody-Mediated Rejection Can Be Assessed by Histology When DSA Is Unknown or Negative.
J. Reeve,¹ P. Halloran.²
¹Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada; ²Department of Medicine, University of Alberta, Edmonton, AB, Canada.
Diagnosis of antibody-mediated rejection (ABMR) in kidney transplants currently requires the presence of donor-specific antibody (DSA) and histologic lesions above somewhat arbitrary cutoffs. DSA is…
2016 American Transplant Congress
The Phenotypic Diversity of Late Silent Antibody-Mediated Rejection.
F. Eskandary,^1,2 J. Reeve,^1,3 H. Regele,⁴ L. Hidalgo,^1,3 D. Yoo,¹ N. Kozakowski,⁴ K. Famulski,¹ G. Böhmig,² P. Halloran.^1,5
¹Alberta Transplant Applied Genomics Centre, University of Alberta, Edmonton, AB, Canada; ²Division of Nephrology and Dialysis, Medical University of Vienna, Vienna, Austria; ³Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada; ⁴Department of Clinical Pathology, Medical University of Vienna, Vienna, Austria; ⁵Department of Medicine, Division of Nephrology and Transplant Immunology, University of Alberta, Edmonton, AB, Canada.
Study purpose: ABMR is a driving force of long-term allograft loss in organ transplantation. The present study was designed to characterize the phenotypic diversity of…
2016 American Transplant Congress
Graft Survival in Sensitized and Non-Sensitized Patients: Role of the Combination of Donor-Specific Antibodies and Acute Rejection.
P. Souza,¹ A. Aguirre,¹ G. Bezerra,² H. Rodrigues,² F. Agena,¹ D. David,¹ F. de Paula,¹ E. David-Neto,¹ M. Castro.¹
¹Renal Transplant Service, Hospital das Clínicas de São Paulo, Sao Paulo, Brazil; ²Immunology Laboratory, Instituto do Coração (InCor), Sao Paulo, Brazil.
Background: Sensitized (S) patients have higher risk for acute rejection (AR), especially ABMR. DSA is a risk fator for ABMR, however, its impact on AR…
2016 American Transplant Congress
A Model to Explore the Potential Budget Impact of a Novel Screening Tool for the Detection of Subclinical Rejection Among Kidney Transplant Patients.
K. Jaglinski,¹ H. Uchida,¹ T. Inocencio,² K. Hughes.²
¹Immucor, Inc, Waukesha, WI; ²Avalare Health, LLC, Washington, DC.
Background: Acute rejection among kidney transplant patients is common, with ~10% of individuals experiencing acute rejection within the first year and rising to 16-17% at…
2016 American Transplant Congress
Pediatric Heart Transplantation Across a Positive Cross-Match Is Associated with High Rates of AMR but No Difference in Short Term Graft Loss, Dysfunction and Death (CTOTC-04 study).
S. Webber,¹ L. Addonizio,² E. Blume,³ A. Dipchand,⁴ R. Shaddy,⁵ B. Feingold,⁶ C. Canter,⁷ D. Hsu,⁸ W. Mahle,⁹ A. Zeevi,⁶ K. Much,¹⁰ D. Ikle,¹⁰ H. Diop,¹¹ J. Odim, MD, PhD, for CTOTC-04 Investigators.¹¹
¹Vanderbilt, Nashville; ²Columbia Univ., NYC; ³Boston Children's, Boston; ⁴Sick Kids, Toronto, Canada; ⁵CHOP, Philadelphia; ⁶CHP of UPMC, Pittsburgh; ⁷Washington Univ., St. Louis; ⁸Children's Hospital, Montefiore, NYC; ⁹CHOA, Atlanta; ¹⁰Rho, Chapel Hill; ¹¹NIAID/NIH, Bethesda.
Sensitization is common in pediatric heart transplant (HT) candidates. Waitlist mortality is high if a prospective -ve CDC-crossmatch (XM) is required, but HT across a…