Articles tagged "Rejection"

2016 American Transplant Congress
Durable Clinical and Immunologic Advantage of Living Donor Liver Transplantation (LDLT) in Children.
E. Przybyszewski,¹ S. Lobritto,¹ M. Martinez,¹ J. Vittorio,¹ A. Fox,¹ B. Samstein,² T. Kato,¹ A. Griesemer,¹ J. Emond.¹
¹Columbia University Medical Center, New York, NY; ²Weill Cornell Medical College, New York, NY.
Purpose:Despite good results, only 10% of liver transplants in children in the US are from living donors. In addition to optimal timing and graft quality,…
2016 American Transplant Congress
Differential Regulation of the Microvascular Endothelial Cell Mediated Allogeneic CD4+ T Cell Response by Anti-HLA-DR and -DQ Alloantibodies in an Inflammatory Context.
N. Mooney,^1,2 A. Cross,^1,2 J. Lion,^1,2 A. Haziot,^1,2 D. Glotz.^1,2,3
¹INSERM UMRS 1160, Institut Universitaire d'Hématologie, Paris, France; ²Université-Paris-Diderot, Sorbonne Paris Cité, Paris, France; ³Service de Néphrologie et Transplantation, Hôpital Saint Louis, Paris, France.
This study examines the basic mechanisms by which high levels of circulating HLA class II donor-specific-antibodies can contribute to microvasculature damage in chronic antibody mediated…
2016 American Transplant Congress
Kidney Transplantation in HIV Patients: Effect of Race on the Choice of Anti-Thymocyte Globulin Induction Immunosuppression.
M. Casey, T. Aijaz, X. Wen, S. Rehman, A. Santos, E. Thomas, K. Andreoni, K. Womer.
University of Florida, Gainesville, FL.
Introduction: HIV positive status is a well-known risk factor for acute rejection (AR) in kidney transplant recipients (KTR). In the United States, the majority of…
2016 American Transplant Congress
A Molecular Biopsy Test for Probability of Non-Adherence.
P. Halloran,^1,3 G. Einecke,² J. Reeve.¹
¹ATAGC, Edmonton, AB, Canada; ²Hannover Medical School, Hannover, Germany; ³Department of Medicine, University of Alberta, Edmonton, AB, Canada.
Afferent arteriolar hyalinosis (ah-score) in renal transplant biopsies increases with time of biopsy-post-transplant (TxBx), reflecting calcineurin inhibitor drug effects, donor aging, and progressive glomerular diseases.…
2016 American Transplant Congress
Immunogenic HLA-DR Eplet Mismatches as Predictors of Transplant Glomerulopathy.
D. Blum,¹ K. Tinckam,² M. Marrari,³ J. Kim,² R. Sapir-Pichhadze.¹
¹McGill University, Montreal, Canada; ²University Health Network, Toronto, Canada; ³University of Pittsburgh Medical Center, Pittsburgh.
BackgroundThe number of HLA-DR eplet mismatches (eplet load) is a risk factor for the development of anti-HLA antibodies and transplant glomerulopathy (TG). In the case…
2016 American Transplant Congress
Human B Cell Cytokines Predict Renal Allograft Rejection and Early Transplant Outcomes.
A. Cherukuri, R. Mehta, S. Ogunde, S. Hariharan, D. Rothstein.
UPMC, Pittsburgh.
In renal transplantation, non-invasive biomarkers that are predictive and allow for early intervention are limited. Here we report findings from a prospective longitudinal study of…
2016 American Transplant Congress
Skin as a Harbinger of Rejection of Underlying Structures in Vascularized Composite Allografts: Concordance or Discordance?
L. Cendales,¹ M. Levine,² S. Bartlett,³ J. Cheeseman,¹ C. Drachenberg,³ W. Hancock,⁴ M. Joshi,¹ A. Kirk,¹ F. Leoopardi,¹ S. Levin,² M. Uluer,³ A. Selim,⁵ M. Song,¹ W. Twaddell,³ L. Wang,⁴ Z. Wang,² R. Barth.³
¹Surgery, Duke University, Durham, NC; ²University of Pennsylvania, Philadelphia, PA; ³University of Maryland School of Medicine, Baltimore, MD; ⁴Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA; ⁵Pathology, Duke University, Durham, NC.
Vascularized composite allografts (VCA) are composed of multiple tissue types. It has not been determined as to whether there is an immune hierarchy or differential…
2016 American Transplant Congress
The Impact of Treating Borderline Cellular Rejections.
R. Mustafa,¹ Y. Al Azzi,¹ J. Crew,¹ G. Dube,¹ H. Morris,¹ M. Chiles,¹ J. Chang,¹ H. Fernandez,¹ D. Cohen,¹ I. Batal,² E. Campenot,² S. Mohan.¹
¹Nephrology, Columbia University Medical Center, New York, NY; ²Pathology, Columbia University Medical Center, New York, NY.
Introduction: Histological findings that meet the criteria for Borderline rejection (BR) as defined by the Banff Classification are frequently seen. The clinical significance of a…
2016 American Transplant Congress
Eomesodermin Expression by CD8+ Alloreactive T Cells in Human and Nonhuman Primate Allograft Recipients.
A. Perez-Gutierrez, L. Lu, A. Zahorchak, Y. Ono, A. Thomson, M. Ezzelarab.
Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA.
Background:The transcription factor Eomesodermin (Eomes) is critical in the maintenance of antigen-specific memory T cells (Tmem). We have shown previously that prolonged kidney allograft survival…
2016 American Transplant Congress
Pre-Existing Diabetes Mellitus Type 2 and Insufficiently Controlled Post-Transplant HbA1c in Kidney Transplantation.
F. Halleck, D. Khadzhynov, L. Lehner, E. Schrezenmeier, M. Duerr, A. Kleinsteuber, K. Budde, O. Staeck.
Nephrology, Charité University, Berlin, Germany.
Background Limited data have been reported on the outcomes of kidney transplant recipients (KTR) with pre-existing diabetes mellitus type 2 (preDM) at time of transplantation…