2016 American Transplant Congress
Better Never Than Late: Differences in Outcomes and Risk Factors for Early and Late Rejection After Kidney Transplantation.
Medicine, University Hospitals Case Medical Center, Cleveland, OH.
Background: Late acute rejection (AR) is associated with inferior outcomes relative to early AR after kidney transplantation. We sought to examine the differences in risk…2016 American Transplant Congress
The Effect of Donor Age on Acute Rejection Age – The Clinical Impact of Donor Immuno-Senescence in the Modern Immunosuppressive Era.
Cardiff Transplant Unit, University Hospital of Wales, Cardiff, United Kingdom.
Experimental work has shown that donor age may alter the immune response of the recipient so that older donor grafts elicit a stronger response in…2016 American Transplant Congress
Immunologic Basis for Immunocloaking.
1BREONICS Inc., Watervliet, NY; 2Plastic Surgery, University of Utrecht, Utrecht, Netherlands.
A novel organ-specific immunomodifying therapy referred to as immunocloaking (IC) provides protection from early allograft rejection without immunosuppressive drugs. The IC binds to the surfaces…2016 American Transplant Congress
Biopsies for Delayed Graft Function After Alemtuzumab Induction in Kidney Transplantation: The Incidence of Early Rejection After Alemtuzumab Is Very Low but Not Negligible.
IntroductionUK practice advocates transplant biopsy (Bx) at day 7, then weekly in the presence of delayed graft function (DGF) because if missed, early rejection adversely…2016 American Transplant Congress
Analysis of T Cell Receptor Repertoire in Routine Renal Allograft Biopsy.
Introduction: Diversity and clonality of the T cell repertoire of circulating and tissue-resident T-cells can be assessed by sequencing of recombined T cell receptor (TCR)…2016 American Transplant Congress
Comparison of Transplant Outcomes for Low-Dose and Standard-Dose Tacrolimus in Kidney Transplant Recipients.
Internal Medicine, Kyungpook National University School of Medicine, Daegu, Republic of Korea.
Objectives: There are few studies that compare the effect of different dose of tacrolimus after kidney transplantation. We investigated transplant outcome of low-dose and standard-dose…2016 American Transplant Congress
The Significance of Microvascular Inflammation in Antibody-Mediated Rejection in ABO-Incompatible Kidney Transplantation.
Background: In ABO-incompatible (ABOi) transplantation, the criteria for antibody-mediated rejection (AMR) are controversial, as C4d deposition is common in ABOi. This study examined the impact…2016 American Transplant Congress
Breadth of HLA-Specific B Cell Reactivity and Frequency Assessed by a Novel Multiplex Bead Based Assay Predicts and Correlates with Rejection in Kidney Transplant Recipients.
Northwestern University, Chicago.
Introduction: Recipients with broad sensitization to HLA defined by a high percentage of Panel Reactive Antibodies (PRA) are at higher immunologic risk for poor graft…2016 American Transplant Congress
Impact of Angiotensin II Type I Receptor Antibody Positivity in Highly-HLA Sensitized (HS) Patients Transplanted After Desensitization (DES).
Introduction: Angiotensin II type I receptor antibody (AT1R Ab) is a target for non-HLA antibodies. AT1R ab exert direct effects on endothelial and vascular smooth…2016 American Transplant Congress
Outcomes of Untreated Asymptomatic Bacteriuria in Renal Transplant Recipients: A Single-Center Experience.
University of North Carolina Medical Center, Chapel Hill, NC.
Background. Renal transplant recipients (RTR) with asymptomatic bacteriuria (AB) are often treated with antibiotics. This could lead to complications related to antibiotic treatment including Clostridium…
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