2018 American Transplant Congress
Klotho Enhances FoxO3-Mediated Manganese Superoxide Dismutase Expression by Negatively Regulating PI3K/AKT Pathway during Tacrolimus-Induced Oxidative Stress
Mammalian members of the forkhead box protein O (FoxO) class of transcription factors are implicated in the regulation of oxidative stress, and FoxO proteins are…2017 American Transplant Congress
Signal Inhibitory Regulatory Protein-α Regulates Pathologic Reactive Oxygen Species in Acute Kidney Injury.
Background: Ischemia reperfusion injury (IRI) is mediated by a complex cascade of pro-inflammatory and oxidative processes. We have reported that signal regulatory inhibitory protein (SIRP)-α…2017 American Transplant Congress
The Beneficial Effect of Janus Kinase 3 Inhibitor on Transplanted Islet via Protection from Oxidative Stress-Induced β Cell Death.
Janus kinase 3 (JAK3) is one of the molecules that make up the JAK-STAT signaling pathway that regulates numerous 40 cytokines. Thus, this cascade can…2017 American Transplant Congress
Nox4 and Oxidative Stress Mediate TGF-β1 Induced Human Kidney Proximal Cell Apoptosis in Ischemic Reperfusion Injury.
AimsIschemia/reperfusion injury, resulting from hypoxic damage within a graft, is the leading cause of cell death and graft rejection. In this study, we investigated whether…2017 American Transplant Congress
The Treatment of the Graft and the Recipient with α-Lipoic Acid Improves the Delay Graft Function Severity in the Human Kidney Transplant.
A previous pilot clinic trial had showed that treatment of the donor and recipient with a potent anti-oxidant such as α-lipoc acid (ALA) reduces the…2017 American Transplant Congress
Mitochondrial Dysfunction Is a Common Feature of Injury in Donor Kidneys After Brain and Circulatory Death.
The pro-coagulatory and pro-inflammatory environment in donors after brain death (DBD) and warm ischemia in donors after circulatory death (DCD) can cause injury to target…2016 American Transplant Congress
A Novel Intra-Abdominal Cooling System Prevents Graft Warming During Implantation for Robotic-Assisted Renal Transplantation.
Background and objectiveRobotic kidney transplantation is minimal invasive and leads to decreased surgical site infection. In this stetting, warm ischemia time remains a valid concern.…2016 American Transplant Congress
Metabolic Dysregulation and Mitochondrial Dysfunction Are Key Features of Injury Profiles of Donor Kidneys After Brain Death.
Donation after brain death (DBD) organ donors remain an important source for kidney transplantation. However, brain death affects donor organs rendering them susceptible to ischemia…2016 American Transplant Congress
Role of TGF-β in Ischemia and Reperfusion Injury Induced Renal Fibrosis in Human Proximal Tubular Epithelial Cells.
Institute of Cellular Medicine, Newcastle University, Newcastle Upon Tyne, United Kingdom.
Ischemia-reperfusion injury (IRI) leads to an irreversible damage to the tubular epithelium and promotes acute kidney injury (AKI) that is associated with progressive loss of…2015 American Transplant Congress
Proteasome Activation During Renal Cold Storage and Transplantation: A Novel Pathway for Mitochondrial Destruction?
Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR.
Purpose: Renal cold storage (CS) is considered to be an alloantigen-independent risk factor for long-term transplant outcome. The precise molecular mechanisms responsible for CS-related renal…
American Transplant Congress abstracts