ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Reactive oxygen species"

  • 2020 American Transplant Congress

    Accelerated Bronchiolitis Obliterans after Lung Transplant Promoted by the ATG16L1 rs2241880 Mutation is Coupled to Mitochondrial Damage and Metabolic Alterations in Monocyte-Derived Alveolar Macrophages

    M. Cano1, D. Zhou2, D. Kreisel3, C. Chen4, K. Pugh2, D. Byers1, R. Hachem1, A. E. Gelman3

    1Pulmonary and Critical Care, Washington University, Saint Louis, MO, 2Surgery, Washington University, Saint Louis, MO, 3Surgery and Pathology and Immunology, Washington University, Saint Louis, MO, 4Pulmonary and Critical Care, Southwestern Medical Center, Dallas, TX

    *Purpose: Bronchiolitis obliterans (BOS) remains a major cause of death for lung transplant recipients, and the mechanisms that drive BOS remain poorly understood and require…
  • 2020 American Transplant Congress

    Oral Administration of Nano-Sized Silicon Particles Regulates Gene Expression Related to Oxidative Stress and Attenuates Rat Renal Ischemia Reperfusion Injury

    M. Kawamura1, R. Imamura1, Y. Kobayashi2, A. Taniguchi1, S. Nakazawa1, T. Kato1, T. Abe1, H. Kobayashi2, N. Nonomura1

    1Department of Urology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan, 2The Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Osaka, Japan

    *Purpose: Organ ischemia reperfusion injury (IRI) is unavoidable in kidney transplantation and induces reactive oxygen species and causes organ damage. Although the effectiveness of hydrogen…
  • 2020 American Transplant Congress

    Induction of Transplant Tolerance by Modulating the Metabolic Stress Pathways

    X. Xiao, L. Zhang, Y. Ying, Y. Wang, P. Arnold, Z. Zhang, X. Li

    Houston Methodist Research Institute, Houston, TX

    *Purpose: T cell activation and effector differentiation precede graft rejection, and this process is associated with robust metabolic burst to meet the energy demand of…
  • 2020 American Transplant Congress

    A Novel Polymer Product, APP-103, Reduces IRI-Induced Damage and Promotes Functional Improvement in Syngeneic Models of Renal Transplantation

    K. Minami1, S. Bae2, H. Uehara1, J. Iske1, J. Reder3, H. Azuma4, A. Weins1, E. Van Keuren5, B. Houser3, A. El-Khal1, P. Kang2, S. Tullius1

    1Brigham and Women's Hospital, Boston, MA, 2Beth Israel Deaconess Medical Center, Boston, MA, 3Celdara Medical, Lebanon, NH, 4Osaka Medical College, Osaka, Japan, 5Georgetown University, Washington DC, DC

    *Purpose: Our data introduce APP-103 as a novel, non-toxic and site-activating therapeutic approach that effectively ameliorates the consequences of ischemia/reperfusion injury in solid organ transplantation.*Methods:…
  • 2019 American Transplant Congress

    The Effect of the Beneficial Activity of α-Lipoic Acid Treatment Depend on the Quality of the Graft Kidneys

    F. Osella1, N. Ambrosi2, G. Werber1, F. Caro2, S. Beltramino1, I. Cabrera1, G. Hilchenbach1, L. Diaz Alvarez1, C. Incardona3, E. Chuluyan2, D. Casadei1

    1Instituto de Trasplante y Alta Complejidad, Buenos Aires, Argentina, 2CEFYBO, UBA, Buenos Aires, Argentina, 3GADOR S.A., Buenos Aires, Argentina

    *Purpose: In a previous preliminary study, with a small number of patients, we observed that the treatment of the donor and the recipient with the…
  • 2019 American Transplant Congress

    New Reactive Oxygen Species Scavenger Prevents Injury in Ischemia-Reperfusion Injury Model

    N. Bath, W. Fahl, R. Redfield III

    University of Wisconsin, Madison, WI

    *Purpose: Despite the success of preservation solutions, Ischemia-Reperfusion (IR) injury remains a significant problem for all solid organ transplants. As a result, an important, unmet…
  • 2019 American Transplant Congress

    Ceria-Zirconia Nanoparticles as an Enhanced Antioxidant Attenuates Apoptosis of Human Kidney Proximal Tubular Epithelial Cells in Hypoxia

    S. Yoon1, K. Yoon2, S. Hong3, S. Yun1, W. Hwang1, J. Moon4, J. Lee1, H. Jeon1

    1Nephrology, Konyang University Hospital, Daejeon, Korea, Republic of, 2Hannam University, Daejeon, Korea, Republic of, 3Chemistry, Hannam University, Daejeon, Korea, Republic of, 4General Surgery, Konyang University Hospital, Daejeon, Korea, Republic of

    *Purpose: Ischemia/reperfusion injury, resulting from hypoxic damage within a graft, is the leading cause of delayed graft function and graft rejection. Various mechanisms have been…
  • 2019 American Transplant Congress

    The Adapter Protein TSAd Regulates Mitochondrial Lck Activity and is Potent to Enhance Immunoregulation Following Transplantation

    J. Wedel1, M. P. Stack1, T. Seto1, K. Liu1, I. E. Stillman2, D. M. Briscoe1

    1Transplant Research Program, Boston Children's Hospital, Harvard Medical School, Boston, MA, 2Department of Pathology, Beth Israel Deaconess Center, Harvard Medical School, Boston, MA

    *Purpose: T cell Specific Adaptor Protein (TSAd, encoded by the SH2D2A gene) is an intracellular adapter molecule that binds Lck and functions to elicit T…
  • 2018 American Transplant Congress

    Klotho Enhances FoxO3-Mediated Manganese Superoxide Dismutase Expression by Negatively Regulating PI3K/AKT Pathway during Tacrolimus-Induced Oxidative Stress

    S. Lim,1 K. Luo,1 J. Il,1 Y. Shin,1 E. Ko,1,2 B. Chung,1,2 C. Yang.1,2

    1Transplant Research Center, The Catholic University of Korea, Seoul, Republic of Korea; 2Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea.

    Mammalian members of the forkhead box protein O (FoxO) class of transcription factors are implicated in the regulation of oxidative stress, and FoxO proteins are…
  • 2017 American Transplant Congress

    Signal Inhibitory Regulatory Protein-α Regulates Pathologic Reactive Oxygen Species in Acute Kidney Injury.

    N. Rogers,1,2,3 D. Meijles,3 P. Pagano,3 J. Isenberg.3

    1Centre for Transplant and Renal Research, Westmead Institute for Medical Research, Sydney, NSW, Australia; 2Starzl Transplant Institute, University of Pittsburgh, Pittsburgh, PA; 3Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA

    Background: Ischemia reperfusion injury (IRI) is mediated by a complex cascade of pro-inflammatory and oxidative processes. We have reported that signal regulatory inhibitory protein (SIRP)-α…
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