ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Reactive oxygen species"

  • 2022 American Transplant Congress

    Final Report of the Use of α-Lipoic Acid in Liver Transplantation to Prevent Ischemia Reperfusion Injury

    P. C. Casciato1, N. Ambrosi2, F. Caro2, L. Oliveira1, F. Zalazar1, A. Garmendia1, M. Bonifacio1, M. Padilla1, J. Paladini1, J. Di Menno1, J. Pekjol1, E. de Santibañes1, M. de Santibañes1, G. Adrian1, C. Incardona1, E. Chuluyan2

    1Hospital Italiano, Buenos Aires, Argentina, 2CEFYBO, Buenos Aires, Argentina

    *Purpose: The ischemia and reperfusion injury contributs to grafts deterioration and adverse post-transplant outcomes. The aim of the present study was to evaluate the safety…
  • 2022 American Transplant Congress

    Disulfide HMGB1 Reprograms Macrophages to Induce Alloimmunity via TLR4 and TLR9 Pathways Following Ischemia-Reperfusion Injury in Human Orthotopic Liver Transplantation

    A. Q. Terry1, R. A. Sosa1, F. Kaldas2, R. Busuttil3, D. Gjertson1, J. Kupiec-Weglinski1, E. Reed1

    1Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA, 2University of California Los Angeles (Multi-organ), Los Angeles, CA, 3Surgery, University of California, Los Angeles, Los Angeles, CA

    *Purpose: Human hepatocellular damage caused by ischemia reperfusion injury (IRI) generates the disulfide form of HMGB1 (diS HMGB1), eliciting myeloid cell activation and proinflammatory cytokine…
  • 2021 American Transplant Congress

    Accelerated Bronchiolitis Obliterans After Lung Transplant Promoted by an ATG16L1 Mutation is Coupled to Mitochondrial Damage and Metabolic Alterations in Monocyte-derived Antigen Presenting Cells

    M. Cano1, D. Zhou1, D. Kreisel1, C. Chen2, K. Pugh1, D. Byers1, R. Hachem1, A. Gelman1

    1Washington University, Saint Louis, MO, 2UT Southwestern Medical Center, Dallas, TX

    *Purpose: Bronchiolitis obliterans (BOS) remains a major cause of death for lung transplant recipients, and the mechanisms that drive BOS remain poorly understood. It is…
  • 2021 American Transplant Congress

    The Contribution of Disulfide-hmgb1 Released During Ischemia-reperfusion Injury to Pro-inflammatory Macrophage Polarization Following Liver Transplantation

    A. Q. Terry, R. A. Sosa, M. Rossetti, J. Nevarez-Mejia, B. V. Naini, F. Kaldas, V. Groysberg, S. Younan, R. Busuttil, D. W. Gjertson, J. W. Kupiec-Weglinski, E. Reed

    Pathology and Lab Medicine, UCLA, Los Angeles, CA

    *Purpose: Ischemia-reperfusion injury (IRI) during liver transplantation (LT) is a pro-inflammatory response linked to poorer outcomes, including increased alloimmunity, post-LT. We previously showed that post-reperfusion…
  • 2020 American Transplant Congress

    A Novel Polymer Product, APP-103, Reduces IRI-Induced Damage and Promotes Functional Improvement in Syngeneic Models of Renal Transplantation

    K. Minami1, S. Bae2, H. Uehara1, J. Iske1, J. Reder3, H. Azuma4, A. Weins1, E. Van Keuren5, B. Houser3, A. El-Khal1, P. Kang2, S. Tullius1

    1Brigham and Women's Hospital, Boston, MA, 2Beth Israel Deaconess Medical Center, Boston, MA, 3Celdara Medical, Lebanon, NH, 4Osaka Medical College, Osaka, Japan, 5Georgetown University, Washington DC, DC

    *Purpose: Our data introduce APP-103 as a novel, non-toxic and site-activating therapeutic approach that effectively ameliorates the consequences of ischemia/reperfusion injury in solid organ transplantation.*Methods:…
  • 2020 American Transplant Congress

    Accelerated Bronchiolitis Obliterans after Lung Transplant Promoted by the ATG16L1 rs2241880 Mutation is Coupled to Mitochondrial Damage and Metabolic Alterations in Monocyte-Derived Alveolar Macrophages

    M. Cano1, D. Zhou2, D. Kreisel3, C. Chen4, K. Pugh2, D. Byers1, R. Hachem1, A. E. Gelman3

    1Pulmonary and Critical Care, Washington University, Saint Louis, MO, 2Surgery, Washington University, Saint Louis, MO, 3Surgery and Pathology and Immunology, Washington University, Saint Louis, MO, 4Pulmonary and Critical Care, Southwestern Medical Center, Dallas, TX

    *Purpose: Bronchiolitis obliterans (BOS) remains a major cause of death for lung transplant recipients, and the mechanisms that drive BOS remain poorly understood and require…
  • 2020 American Transplant Congress

    Oral Administration of Nano-Sized Silicon Particles Regulates Gene Expression Related to Oxidative Stress and Attenuates Rat Renal Ischemia Reperfusion Injury

    M. Kawamura1, R. Imamura1, Y. Kobayashi2, A. Taniguchi1, S. Nakazawa1, T. Kato1, T. Abe1, H. Kobayashi2, N. Nonomura1

    1Department of Urology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan, 2The Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Osaka, Japan

    *Purpose: Organ ischemia reperfusion injury (IRI) is unavoidable in kidney transplantation and induces reactive oxygen species and causes organ damage. Although the effectiveness of hydrogen…
  • 2020 American Transplant Congress

    Induction of Transplant Tolerance by Modulating the Metabolic Stress Pathways

    X. Xiao, L. Zhang, Y. Ying, Y. Wang, P. Arnold, Z. Zhang, X. Li

    Houston Methodist Research Institute, Houston, TX

    *Purpose: T cell activation and effector differentiation precede graft rejection, and this process is associated with robust metabolic burst to meet the energy demand of…
  • 2019 American Transplant Congress

    New Reactive Oxygen Species Scavenger Prevents Injury in Ischemia-Reperfusion Injury Model

    N. Bath, W. Fahl, R. Redfield III

    University of Wisconsin, Madison, WI

    *Purpose: Despite the success of preservation solutions, Ischemia-Reperfusion (IR) injury remains a significant problem for all solid organ transplants. As a result, an important, unmet…
  • 2019 American Transplant Congress

    Ceria-Zirconia Nanoparticles as an Enhanced Antioxidant Attenuates Apoptosis of Human Kidney Proximal Tubular Epithelial Cells in Hypoxia

    S. Yoon1, K. Yoon2, S. Hong3, S. Yun1, W. Hwang1, J. Moon4, J. Lee1, H. Jeon1

    1Nephrology, Konyang University Hospital, Daejeon, Korea, Republic of, 2Hannam University, Daejeon, Korea, Republic of, 3Chemistry, Hannam University, Daejeon, Korea, Republic of, 4General Surgery, Konyang University Hospital, Daejeon, Korea, Republic of

    *Purpose: Ischemia/reperfusion injury, resulting from hypoxic damage within a graft, is the leading cause of delayed graft function and graft rejection. Various mechanisms have been…
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