Articles tagged "Rat"

2018 American Transplant Congress
The Preclinical Application of the Tactile Discrimination Task in Rat Models
S-.H. Wu,^1,2 C-.J. Wen,^1,2 J-.J. Huang,^1,2,3 Y-.C. Pei,^1,2,3 C-.H. Lin,^1,2,4,5 H. Cheng,¹ Z-.L. Peng,^1,4,5 H-.I. Yang,⁶ F-.C. Wei.^1,2,5
¹Center for Vascularized Composite Allotransplantation, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan; ²College of Medicine, Chang Gung University, Taoyuan, Taiwan; ³Department of Physical Medicine & Rehabilitation, Taoyuan Chang Gung Memorial Hospital, Taoyuan, Taiwan; ⁴Division of Trauma and Emergency Plastic Surgery, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan; ⁵Division of Plastic Reconstructive Microsurgery, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan; ⁶Department of Electronic Engineering, National Taipei University of Technology, Taipei, Taiwan.
Nerve reinnervation is an important issue in the field of vascularized composite allotransplantation (VCA). However, nowadays the effective treatment for enhancing the reinnervation after the…
2018 American Transplant Congress
Long-Term HIF-1α Stabilization is Associated with Fibrosis in Rat Lung Allografts
K. Freischlag,¹ B. Ezekian,¹ P. Schroder,¹ J. Everitt,¹ J. Yoon,¹ M. Swiderska-Syn,³ W. Parker,¹ A. Diehl,¹ J. Kwun,¹ S. Knechtle.¹
¹Duke Transplant Center, Duke University, Durham, NC; ²Medical University of South Carolina, Charleston, SC.
Introduction: HIF-1α is a subunit of a heterodimeric transcription factor hypoxia-inducible factor 1 (HIF-1) and functions as a master transcriptional regulator of cellular and developmental…
2018 American Transplant Congress
Functional Reconstruction of Urogenital Tissue Defects Using VCA: A Novel Microsurgical Penis Transplant Model and Clinical & Histological Rejection Classification
S. Fidder,^1,4 G. Furtmüller,¹ B. Simons,² B. Kern,¹ D. Lough,¹ B. Oh,¹ M. Chicco,¹ C. Brayton,³ W. Lee,¹ D. Cooney,¹ R. Redett,¹ G. Brandacher.¹
¹Dept of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore; ²Dept of Urology, JHU SOM, Baltimore; ³Dept of Molecular & Comparative Pathobiology, JHU SOM, Baltimore; ⁴Plastic and Reconstructive Surgery, Erasmus University Medical Center, Rotterdam, Netherlands.
Background: Defects of male urogenital structures subsequent to major trauma are associated with severely reduced function and quality-of-life. As of recent, penis transplantation represents an…
2018 American Transplant Congress
Ex-Vivo Subnormothermic Oxygenated Machine Perfusion of Rodent Hindlimb: Feasibility Study to Elongate Preservation Time of Vascularized Composite Allograft
L. Burlage,^1,2 A. Lellouch,^3,4 S. Tessier,¹ C. Pendexter,¹ S. Cronin,¹ M. Schol,³ M. Randolph,³ R. Porte,² L. Lantieri,⁴ C. Cetrulo,³ K. Uygun.¹
¹Surgery, Massachusetts General Hospital/Harvard Medical School, Boston; ²Surgery, University Medical Center Groningen, Groningen, Netherlands; ³Plastic Surgery, Massachusetts General Hospital/Harvard Medical School, Boston; ⁴Plastic Surgery, European George Pompidou Hospital, Paris, France.
PURPOSE: A pressing challenge in the field of VCA is adequate tissue preservation. Static cold preservation, successfully used in field of solid organ transplantation, greatly…
2018 American Transplant Congress
BLyS^-/- Rats to Prevent Alloantibody Production
N. Bath,¹ B. Verhoven,¹ N. Wilson,¹ S. Reese,² L. Coons,¹ S. Panzer,² A. Djamali,² R. Redfield.¹
¹Surgery, University of Wisconsin, Madison, WI; ²Medicine, University of Wisconsin, Madison, WI.
Introduction: Antibody mediated rejection (AMR) is a major cause of kidney allograft failure. APRIL (A Proliferation Inducing Ligand) and BLyS (B Lymphocyte Stimulator) are two…
2018 American Transplant Congress
Noninvasive Quantization of Intra-Renal Allograft C4d Deposition with Targeted Ultrasound Imaging
T. Liao,¹ Y. Zhang,¹ J. Ren,² H. Zheng,¹ H. Zhang,² X. Liu,¹ T. Yin,² Q. Sun.¹
¹Organ Transplantation Research Institute, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China; ²Department of Medical Ultrasound, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.
Antibody-mediated rejection (AMR) has emerged as the major cause of renal allograft dysfunction. C4d, a specific marker of AMR diagnosis, was strongly recommended for routine…
2017 American Transplant Congress
The Novel Establishment of Neuroma in Continuity Animal Model Based on Buccal Nerve in Rats.
Y.-H. Hsieh,^1,2 C.-J. Wen,^1,3 C.-H. Lin,^1,2,3,4 F.-C. Wei,^1,2,3 Y.-C. Pei.^3,5
¹Center for Vascularized Composite Allotransplantation, Chang Gung Memorial Hospital, Taoyuan, Taiwan; ²Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan; ³College of Medicine, Chang Gung University, Taoyuan, Taiwan; ⁴Division of Trauma and Emergency Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan; ⁵Department of Physical Medicine & Rehabilitation, Chang Gung Memorial Hospital, Taoyuan, Taiwan
Introduction: Peripheral nerve regeneration is a challenging and a rapid growing field. Its application is no longer restricted to trauma reconstruction but also in vascularized…
2017 American Transplant Congress
Biodistribution of Adipose Derived Regenerative Cells Administered via the Renal Artery in Novel Rat Transplant Model.
R. Ghita,^1,2 R. Lathan,² D. Hillyard,² P. Mark,^1,2 M. Clancy.^1,2
¹Glasgow Renal and Transplant Unit, Queen Elizabeth University Hospital Glasgow, Glasgow, United Kingdom; ²Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom
Introduction:A novel rodent model of ischaemia- reperfusion injury (IRI) has shown significant improvement in renal function and histology after administration of adipose derived regenerative cells…
2017 American Transplant Congress
Lipid Catabolism Provides Alternative Energy Source and Compensates for Mitochondrial Dysfunction in Reperfused Rat Kidneys After Ischaemia.
H. Huang,^1,2 L. van Dullemen,³ M. Akhtar,¹ M. Lo Faro,^1,2 A. Dona,⁴ M. Kaisar,^1,2 H. Leuvenink,³ B. Kessler,² R. Ploeg.¹
¹Oxford Transplant Centre, NDS, University of Oxford, Oxford, United Kingdom; ²Target Discovery Institute, NDM, University of Oxford, Oxford, United Kingdom; ³Department of Surgery, University Medical Center Groningen, Groningen, Netherlands; ⁴Department of Surgery and Cancer, Imperial College London, London, United Kingdom
Introduction: To reduce morbidity and mortality on the wait list for kidney transplantation, centres are required to use older and higher risk organs including unstable…
2017 American Transplant Congress
Dual Treatment of Suboptimal Doses of CsA and MSC Infusion Fully Prevents Acute Rejection in an Allogenic Model of Renal Transplantation.
L. de Ramon,¹ A. Merino,¹ E. Ripoll,¹ N. Bolaños,¹ M. Gomà,³ J. Cruzado,^1,2 J. Grinyó,^1,2 J. Torras.^1,2
¹Experimental Nephrology, IDIBELL-UB, Hospitalet Llobregat, Barcelona, Spain; ²Nephrology, Hospital Universitari de Bellvitge, Hospitalet Llobregat, Barcelona, Spain; ³Pathology, Hospital Universitari de Bellvitge, Hopitalet Llobregat, Barcelona, Spain
The immunomodulatory characteristics of mesenchymal stem cells (MSCs) may lead to multifaceted strategies in rejection of organ transplantation. This study was designed to investigate the…