ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Rat"

  • 2018 American Transplant Congress

    Long-Term HIF-1α Stabilization is Associated with Fibrosis in Rat Lung Allografts

    K. Freischlag,1 B. Ezekian,1 P. Schroder,1 J. Everitt,1 J. Yoon,1 M. Swiderska-Syn,3 W. Parker,1 A. Diehl,1 J. Kwun,1 S. Knechtle.1

    1Duke Transplant Center, Duke University, Durham, NC; 2Medical University of South Carolina, Charleston, SC.

    Introduction: HIF-1α is a subunit of a heterodimeric transcription factor hypoxia-inducible factor 1 (HIF-1) and functions as a master transcriptional regulator of cellular and developmental…
  • 2018 American Transplant Congress

    Functional Reconstruction of Urogenital Tissue Defects Using VCA: A Novel Microsurgical Penis Transplant Model and Clinical & Histological Rejection Classification

    S. Fidder,1,4 G. Furtmüller,1 B. Simons,2 B. Kern,1 D. Lough,1 B. Oh,1 M. Chicco,1 C. Brayton,3 W. Lee,1 D. Cooney,1 R. Redett,1 G. Brandacher.1

    1Dept of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore; 2Dept of Urology, JHU SOM, Baltimore; 3Dept of Molecular & Comparative Pathobiology, JHU SOM, Baltimore; 4Plastic and Reconstructive Surgery, Erasmus University Medical Center, Rotterdam, Netherlands.

    Background: Defects of male urogenital structures subsequent to major trauma are associated with severely reduced function and quality-of-life. As of recent, penis transplantation represents an…
  • 2018 American Transplant Congress

    Ex-Vivo Subnormothermic Oxygenated Machine Perfusion of Rodent Hindlimb: Feasibility Study to Elongate Preservation Time of Vascularized Composite Allograft

    L. Burlage,1,2 A. Lellouch,3,4 S. Tessier,1 C. Pendexter,1 S. Cronin,1 M. Schol,3 M. Randolph,3 R. Porte,2 L. Lantieri,4 C. Cetrulo,3 K. Uygun.1

    1Surgery, Massachusetts General Hospital/Harvard Medical School, Boston; 2Surgery, University Medical Center Groningen, Groningen, Netherlands; 3Plastic Surgery, Massachusetts General Hospital/Harvard Medical School, Boston; 4Plastic Surgery, European George Pompidou Hospital, Paris, France.

    PURPOSE: A pressing challenge in the field of VCA is adequate tissue preservation. Static cold preservation, successfully used in field of solid organ transplantation, greatly…
  • 2018 American Transplant Congress

    BLyS-/- Rats to Prevent Alloantibody Production

    N. Bath,1 B. Verhoven,1 N. Wilson,1 S. Reese,2 L. Coons,1 S. Panzer,2 A. Djamali,2 R. Redfield.1

    1Surgery, University of Wisconsin, Madison, WI; 2Medicine, University of Wisconsin, Madison, WI.

    Introduction: Antibody mediated rejection (AMR) is a major cause of kidney allograft failure. APRIL (A Proliferation Inducing Ligand) and BLyS (B Lymphocyte Stimulator) are two…
  • 2018 American Transplant Congress

    Noninvasive Quantization of Intra-Renal Allograft C4d Deposition with Targeted Ultrasound Imaging

    T. Liao,1 Y. Zhang,1 J. Ren,2 H. Zheng,1 H. Zhang,2 X. Liu,1 T. Yin,2 Q. Sun.1

    1Organ Transplantation Research Institute, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China; 2Department of Medical Ultrasound, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.

    Antibody-mediated rejection (AMR) has emerged as the major cause of renal allograft dysfunction. C4d, a specific marker of AMR diagnosis, was strongly recommended for routine…
  • 2018 American Transplant Congress

    The Preclinical Application of the Tactile Discrimination Task in Rat Models

    S-.H. Wu,1,2 C-.J. Wen,1,2 J-.J. Huang,1,2,3 Y-.C. Pei,1,2,3 C-.H. Lin,1,2,4,5 H. Cheng,1 Z-.L. Peng,1,4,5 H-.I. Yang,6 F-.C. Wei.1,2,5

    1Center for Vascularized Composite Allotransplantation, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan; 2College of Medicine, Chang Gung University, Taoyuan, Taiwan; 3Department of Physical Medicine & Rehabilitation, Taoyuan Chang Gung Memorial Hospital, Taoyuan, Taiwan; 4Division of Trauma and Emergency Plastic Surgery, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan; 5Division of Plastic Reconstructive Microsurgery, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan; 6Department of Electronic Engineering, National Taipei University of Technology, Taipei, Taiwan.

    Nerve reinnervation is an important issue in the field of vascularized composite allotransplantation (VCA). However, nowadays the effective treatment for enhancing the reinnervation after the…
  • 2017 American Transplant Congress

    Dual Treatment of Suboptimal Doses of CsA and MSC Infusion Fully Prevents Acute Rejection in an Allogenic Model of Renal Transplantation.

    L. de Ramon,1 A. Merino,1 E. Ripoll,1 N. Bolaños,1 M. Gomà,3 J. Cruzado,1,2 J. Grinyó,1,2 J. Torras.1,2

    1Experimental Nephrology, IDIBELL-UB, Hospitalet Llobregat, Barcelona, Spain; 2Nephrology, Hospital Universitari de Bellvitge, Hospitalet Llobregat, Barcelona, Spain; 3Pathology, Hospital Universitari de Bellvitge, Hopitalet Llobregat, Barcelona, Spain

    The immunomodulatory characteristics of mesenchymal stem cells (MSCs) may lead to multifaceted strategies in rejection of organ transplantation. This study was designed to investigate the…
  • 2017 American Transplant Congress

    Tolerogenic Potential, Migratory Pathways, Engraftment and Long-Term Survival of Human Hematopoietic Chimeric Cells – A Novel Strategy to Induce Tolerance in Transplantation.

    M. Siemionow, E. Bryndza Tfaily, E. Szilagyi, J. Cwykiel, S. Uygur, M. Czerwinski.

    Department of Orthopaedics, University of Illinois at Chicago, Chicago, IL

    Background: Cell-based therapies represent a new promising strategy for tolerance induction in transplantation. One of the methods for immune response modulation in solid organ and…
  • 2017 American Transplant Congress

    Decellularized Rat Liver Scaffolds Support Survival and Metabolic Function of Multilineage Allogenic Cells.

    W. Hassanein, A. Werdesheim, A. Cimeno, B. Buckingham, A. Khalifeh, M. Uluer, J. Harrison, D. Parsell, C. Drachenberg, R. Barth, J. LaMattina.

    University of Maryland School of Medcine, Baltimore, MD

    Background:Organ bioengineering has the potential to completely eliminate the donor organ shortage. Here, we examine the feasibility of a decellularized liver construct to support the…
  • 2017 American Transplant Congress

    Cell-Subset Diversity in Adipose Derived Regenerative Cells Used in Renal Ischemic Reperfusion Injury Treatment.

    R. Lathan,1 R. Ghita,1,2 D. Hillyard,1 P. Mark,1,2 M. Clancy.1,2

    1Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom; 2School of Medicine, Dentistry and Nursing, Queen Elizabeth University Hospital, Glasgow, United Kingdom

    Studies in our novel hybrid model of transplantion/ischemic reperfusion injury (IRI) in rat has demonstrated significant improvement in kidney function post injection of adipose-derived regenerative…
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