2017 American Transplant Congress
C3d-Binding Anti-DQ DSA Is Associated with a High Risk for Late ABMR and Graft Failure in Stable Kidney Transplant Recipients.
Introduction:Donor specific anti-HLA antibodies (DSA) are a major cause of antibody-mediated rejection (ABMR) and poor graft outcome in kidney transplant recipients (KTR). Critical issue is…2016 American Transplant Congress
Detecting Renal Allograft Inflammation Using Quantitative Urine Metabolomics and CXCL10.
Background. We studied urine metabolomics (UM) alone or combined with urine CXCL10 to non-invasively detect cellular infiltrates in renal allograft biopsies.Methods. Urines (n=137) were obtained…2016 American Transplant Congress
Human B Cell Cytokines Predict Renal Allograft Rejection and Early Transplant Outcomes.
In renal transplantation, non-invasive biomarkers that are predictive and allow for early intervention are limited. Here we report findings from a prospective longitudinal study of…2016 American Transplant Congress
Delayed Graft Function (DGF) Does Not Accelerate Progression of Fibrosis During the First Year After Deceased Donor Kidney Transplantation.
BackgroundOur aim was to study the impact of DGF on the progression of interstitial fibrosis during the first post-transplant year.MethodsWe included all patients who received…2016 American Transplant Congress
Sequential and Long-Term Protocol Biopsy Is Useful for the Detection of Subclinical Lesions of Clinical Interest in Kidney Allografts.
Objectives: Detection of subclinical lesions is important to overcome the obstacles to improve long-term graft survival after kidney transplantation. The aim of this study was…2016 American Transplant Congress
Comparison of Once-Daily and Twice-Daily Low-Dose Tacrolimus in Living Related Kidney Transplantation – Prospective Trial of Once-Daily vs. Twice-Daily Tac – 5 Years Second Report.
Department of Urology, Tokyo Women's Medical University, Tokyo, Japan.
Background; Previously, we reported a comparison of the safety and pharmacokinetics between a prolonged-release formulation of Tacrolimus (Tac-QD) and twice-daily tacrolimus (Tac-BD) in the early…2016 American Transplant Congress
Replicative Senescence and Arteriosclerosis After Kidney Transplantation.
BackgroundReplicative senescence is associated with telomere shortening. In native kidneys, obtained prior to transplantation, we recently described and validated a significant association between shorter intrarenal…2016 American Transplant Congress
Baseline Donor Specific Antibody (DSA) More Predictive of Chronic Antibody Mediated Rejection (CAMR) Than the Change in DSA Over Time.
Introduction: Although therapies are available to at least temporarily reduce DSA, the change in DSA naturally post-transplant remains unknown. We aim to study the serial…2016 American Transplant Congress
De Novo Proliferative Glomerulonephritis with Monoclonal IgG Deposits of the IgG1κ Subtype in a Kidney Allograft: Protocol Biopsy Findings.
Proliferative glomerulonephritis with monoclonal immunoglobulin G (IgG) deposits (PGNMID) has recently been described in cases with glomerular disease. Only a dozen cases of recurrent or…2016 American Transplant Congress
Surveillance Renal Allograft Biopsies Prognosticate Graft Function.
Background: Surveillance biopsy of the renal allograft provides a window into the health of the allograft and could allow prognostication of function by affording better…
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