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Articles tagged "Protocol biopsy"

  • 2017 American Transplant Congress

    Early Introduction of Oral Paricalcitol in Renal Transplant Recipients. An Open-Label Randomized Study.

    H. Pihlstrøm,1 F. Gatti,2 C. Hammarstrom,2 I. Eide,1 M. Kasprzycka,2 J. Wang,2 G. Haraldsen,2 M. Svensson,3 K. Midtvedt,1 A. Hartmann,1 G. Mjøen,1 D. Dahle,1 H. Holdaas.1

    1Department of Surgery, Inflammation Medicine and Transplantation, Oslo University Hospital Rikshospitalet, Oslo, Norway; 2Department of Pathology, Oslo University Hospital Rikshospitalet, Oslo, Norway; 3Department of Nephrology, Akershus University Hospital, Oslo, Norway

    In stable renal transplant recipients with hyperparathyroidism, the vitamin D agonist paricalcitol reduces level of proteinuria. Animal studies indicate possible anti-fibrotic and anti-inflammatory effects. The…
  • 2016 American Transplant Congress

    Baseline Donor Specific Antibody (DSA) More Predictive of Chronic Antibody Mediated Rejection (CAMR) Than the Change in DSA Over Time.

    D. Mitema,1 W. Cheungpasitporn,1 M. Stegall,1 F. Cosio,1 M. Gandhi,2 C. Schinstock.1

    1Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN; 2Division of Transfusion Medicine, Mayo Clinic, Rochester, MN.

    Introduction: Although therapies are available to at least temporarily reduce DSA, the change in DSA naturally post-transplant remains unknown. We aim to study the serial…
  • 2016 American Transplant Congress

    De Novo Proliferative Glomerulonephritis with Monoclonal IgG Deposits of the IgG1κ Subtype in a Kidney Allograft: Protocol Biopsy Findings.

    T. Tsuji,1 M. Miura,2 M. Yanai,1 H. Itami,1 Y. Ishii,1 M. Akimoto,1 Y. Fukasawa.1

    1Department of Pathology, Sapporo City General Hospital, Sapporo, Japan; 2Departments of Renal Transplant Surgery and Urology, Sapporo Hokuyu Hospital, Sapporo, Japan.

    Proliferative glomerulonephritis with monoclonal immunoglobulin G (IgG) deposits (PGNMID) has recently been described in cases with glomerular disease. Only a dozen cases of recurrent or…
  • 2016 American Transplant Congress

    Surveillance Renal Allograft Biopsies Prognosticate Graft Function.

    J. Thompson, D. Taber, P. Baliga, K. Chavin, T. Srinivas.

    MUSC, Charleston, SC.

    Background: Surveillance biopsy of the renal allograft provides a window into the health of the allograft and could allow prognostication of function by affording better…
  • 2016 American Transplant Congress

    A Systematic Over View of Five Year Results of Serial Protocol Kidney Transplant Biopsies.

    A. Geraedts, M. Tavakol, F. Vincenti, S. Chandran, Z. Laszik, B. Lee, J. Roberts, M. Sarwal.

    Surgery, UCSF, San Francisco, CA.

    Background: Protocol biopsies can detect sub-clinical rejection. With declining rates of clinical acute rejection, a systematic review of protocol biopsies can provide clues about other…
  • 2016 American Transplant Congress

    Detecting Renal Allograft Inflammation Using Quantitative Urine Metabolomics and CXCL10.

    J. Ho,1 A. Sharma,2 R. Mandal,3 D. Wishart,3 C. Wiebe,1 L. Storsley,1 M. Karpinski,1 I. Gibson,4 P. Nickerson,1 D. Rush.1

    1Internal Medicine, University of Manitoba, Winnipeg, MB, Canada; 2Pediatrics & Child Health, University of Manitoba, Winnipeg, MB, Canada; 3Biological Sciences, University of Alberta, Edmonton, AB, Canada; 4Pathology, University of Manitoba, Winnipeg, MB, Canada.

    Background. We studied urine metabolomics (UM) alone or combined with urine CXCL10 to non-invasively detect cellular infiltrates in renal allograft biopsies.Methods. Urines (n=137) were obtained…
  • 2016 American Transplant Congress

    Human B Cell Cytokines Predict Renal Allograft Rejection and Early Transplant Outcomes.

    A. Cherukuri, R. Mehta, S. Ogunde, S. Hariharan, D. Rothstein.

    UPMC, Pittsburgh.

    In renal transplantation, non-invasive biomarkers that are predictive and allow for early intervention are limited. Here we report findings from a prospective longitudinal study of…
  • 2016 American Transplant Congress

    Delayed Graft Function (DGF) Does Not Accelerate Progression of Fibrosis During the First Year After Deceased Donor Kidney Transplantation.

    R. Heilman, I. Qaqish, M. Smith, H. Khamash, B. Kaplan, K. Reddy.

    Mayo Clinic, Phoenix, AZ.

    BackgroundOur aim was to study the impact of DGF on the progression of interstitial fibrosis during the first post-transplant year.MethodsWe included all patients who received…
  • 2016 American Transplant Congress

    Sequential and Long-Term Protocol Biopsy Is Useful for the Detection of Subclinical Lesions of Clinical Interest in Kidney Allografts.

    M. Miura,1 H. Higashiyama,1 T. Tsuji,2 Y. Fukasawa.2

    1Department of Urology and Renal Transplantation Surgery, Sapporo Hokuyu Hospital, Sapporo, Japan; 2Department of Pathology, Sapporo City General Hospital, Sapporo, Japan.

    Objectives: Detection of subclinical lesions is important to overcome the obstacles to improve long-term graft survival after kidney transplantation. The aim of this study was…
  • 2016 American Transplant Congress

    Comparison of Once-Daily and Twice-Daily Low-Dose Tacrolimus in Living Related Kidney Transplantation – Prospective Trial of Once-Daily vs. Twice-Daily Tac – 5 Years Second Report.

    T. Tsuchiya, H. Ishida, T. Nozaki, H. Shirakawa, T. Shimizu, K. Omoto, M. Okumi, K. Tanabe.

    Department of Urology, Tokyo Women's Medical University, Tokyo, Japan.

    Background; Previously, we reported a comparison of the safety and pharmacokinetics between a prolonged-release formulation of Tacrolimus (Tac-QD) and twice-daily tacrolimus (Tac-BD) in the early…
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