ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Protocol biopsy"

  • 2019 American Transplant Congress

    Impact Of Subclinical Bk Virus-associated Nephropathy In High-risk Recipients

    M. E. Seifert, E. P. Kasik, M. Bernard, G. Agarwal, H. Fatima, R. Gaston, B. Julian, C. Kew, V. Kumar, S. Mehta, S. Ong, F. Rosenblum, G. Towns, R. B. Mannon

    University of Alabama, Birmingham, AL

    *Purpose: BK virus-associated nephropathy (BKVAN) is a major contributor to kidney transplant failure. Surveillance of serum and urine for the BKV genome has been incorporated…
  • 2019 American Transplant Congress

    Surveillance Biopsy Utilization Reported Higher In Transplant Centers Performing Over 100 Kidney Transplants Per Year.

    D. M. Lee1, R. First1, S. Rose1, M. Abecassis2

    1Transplant Genomics Inc, Mansfield, MA, 2Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, IL

    *Purpose: To assess the frequency of surveillance biopsies in kidney transplant patients in transplant centers performing greater than 100 transplants per year, and to compare…
  • 2019 American Transplant Congress

    Subclinical Rejection by Biopsy or Gene Expression Profile Predicts Long Term Kidney Function in Patients in the CTOT08 Trial

    R. Heilman1, D. Taber2, K. Guo3, S. Brietigam3, j. charette3, S. Kurian4, M. Abecassis3, J. Friedewald3

    1Mayo Clinic AZ, Scottsdale, AZ, 2MUSC, Charleston, SC, 3Northwestern University, Chicago, IL, 4Scripps, La Jolla, CA

    *Purpose: The CTOT08 trial showed that either histological subAR or positive gene expression profile (GEP) in the blood associated with histological subAR correlated with a…
  • 2019 American Transplant Congress

    Use of TruGraf Serial Testing for Confirming Stability in Kidney Transplant Patients with Stable Renal Function

    V. Peddi1, C. Schieve2, S. Rose2, M. First2

    1California Pacific Med Ctr, San Francisco, CA, 2Transplant Genomics Inc, Mansfield, MA

    *Purpose: The objectives of this study were to model serial TruGraf testing in stable kidney transplant recipients and to demonstrate the potential clinical utility of…
  • 2018 American Transplant Congress

    IgA Recurrence in a Single Center with a Protocol Biopsy Program

    M. Merzkani, N. Lepori, M. El Ters, F. Cosio, H. Amer.

    Mayo Clinic, Rochester, MN.

    The objective of this study was to determine the rate of recurrence of IgA nephropathy in our program aided by protocol biopsies and protocol driven…
  • 2018 American Transplant Congress

    A Substantial Fraction of Surveillance Transplant Biopsies Have Clinically Actionable Findings

    A. Shammout,1 A. Naik,2 M. Samaniego,2 E. Farkash.1

    1Pathology, Michigan Medicine, Ann Arbor; 2Nephrology, Michigan Medicine, Ann Arbor.

    Background: Surveillance biopsies in renal transplant recipients may detect subclinical disease that affects graft longevity. At our transplant center, most patients with stable allograft function…
  • 2018 American Transplant Congress

    Protocol Biopsies after Paediatric Kidney Transplantation: A Single Centres' 17 Year Experience

    T. Alsulaimi,1 M. Aloufi,2 S. Grisaru,1 S. Samuel,1 L. Hamiwka.1

    1Paediatric Nephrology, University of Calgary, Calgary, AB, Canada; 2Pediatric Nephrology, Prince Sultan Military Medical City, Riyadh, Saudi Arabia.

    PURPOSE: Standard laboratory measures are not sensitive indicators of kidney dysfunction following transplantation and may be less reliable in paediatric recipients. Early graft surveillance may…
  • 2018 American Transplant Congress

    Sub-Clinical Acute Rejection (subAR) Detected by Both Surveillance Biopsy (SBx) and a Peripheral Blood Molecular Biomarker Correlates with De Novo Donor Specific Antibody (dnDSA) Following Kidney Transplant (KT)

    R. Heilman,1 J. Friedewald,2 K. Kurian,5 T. Whisemant,5 E. Poggio,3 C. Marsh,5 P. Baliga,7 N. Bridges,4 J. Odim,4 M. Brown,4 D. Ikle,3 B. Armstrong,3 L. Zhao,2 D. Salomon,5 M. Abecassis.2

    1Mayo Clinic, Phoenix; 2Northwestern University, Chicago; 3Rho Federal Systems, Chapel Hill; 4National Institute of Allergy and Infectious Disease, Bethesda; 5Scripps Health, La Jolla; 6Cleveland Clinic, Cleveland; 7Medical University of South Carolina, Charleston.

    AIMWe investigated the correlation between subAR diagnosed by SBx or by a newly-defined biomarker, and the development of dnDSA.METHODS307 KT patients enrolled into a multi-center…
  • 2018 American Transplant Congress

    Impact of Direct Antiviral Therapy for Hepatitis C on Acute Rejection and DSA Formation in Kidney Transplant Recipients

    Z. Zaky, S. Armanyous, L. Herlitz, E. Poggio, J. Augustine.

    Cleveland Clinic, Cleveland, OH.

    Background: Hepatitis C virus infection (HCV) has historically portended a poor outcome after kidney transplantation. With recent advent of direct antiviral agents (DAA), there has…
  • 2018 American Transplant Congress

    Subclinical Borderline Rejection: More Than Meets the Eye?

    M. Bernard, G. Agarwal, H. Fatima, B. Julian, C. Kew, V. Kumar, S. Mehta, S. Ong, A. Patel, G. Towns, M. Seifert, R. Mannon.

    UAB School of Medicine, Birmingham.

    Purpose: Surveillance biopsies can detect subclinical T cell mediated rejection (SC-TCMR) or subclinical borderline rejection (SC-B-TCMR) in patients with normal/stable creatinine, but the impact on…
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