ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Protocol biopsy"

  • 2020 American Transplant Congress

    Immunohistochemical and Molecular Detection of NK Cells in Kidney Allografts with Antibody Mediated Rejection

    E. Farkash, J. Barnes, S. Anand

    Pathology, University of Michigan, Ann Arbor, MI

    *Purpose: Molecular signatures specific to Natural Killer (NK) cells are closely associated with antibody mediated rejection (AMR) in transplant biopsies. We have developed an immunohistochemical…
  • 2020 American Transplant Congress

    Assessing Immunosuppression with Immunological Testing and Surveillance Biopsies Late after Liver and Intestine Transplantation (LT, IT)

    L. Remaley, R. Falik, K. Soltys, G. Bond, J. Winnier, P. Kachmar, C. Ashokkumar, A. Ganoza, A. Kepler, A. Khanna, J. Squires, P. McKiernan, J. Rudolph, F. Alissa, G. Mazariegos, R. Sindhi

    Pediatric Transplant, Pittsburgh, PA

    *Purpose: Assessing adequacy of immunosuppression is essential during late allograft surveillance after LT or IT.*Methods: To explain why allograft function tests can be normal despite…
  • 2020 American Transplant Congress

    Analysis of 1000 Protocol Kidney Biopsies: Complications, Benefits, and Predictive Potential of Prior Sensitization

    M. Eslami1, J. Patel2, S. Karzai1, D. T. Collins1, C. Liu1, J. Jonsson1, R. Wali1, J. B. Piper1

    1Surgery, Inova Fairfax Hospital, Falls Church, VA, 2General Surgery, Pennsylvania State University, State College, PA

    *Purpose: Protocol biopsy of kidney transplants can allow for early recognition of treatable findings, both immunologic and non-immunologic. This comes with the risk of biopsy…
  • 2020 American Transplant Congress

    Impact of Variation in Histological Assessments and Their Impact on Clinical Trial Enrollment and Endpoints – Preliminary Report of The Gen04 Study

    W. Park1, M. Ryan2, L. Herrera Hernandez3, M. Smith2, X. Geiger4, T. Sandor5, L. Cornell3, M. Stegall1

    1Transplant Center, Mayo Clinic, Rochester, MN, 2Laboratory Medicine and Pathology, Mayo Clinic, Scottsdale, AZ, 3Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, 4Laboratory Medicine and Pathology, Mayo Clinic, Jacksonville, FL, 5Pathology, University of Szegad, Szegad, Hungary

    *Purpose: Renal allograft histology is often used as inclusion criteria for clinical trials. This includes Gen04, which is an NIH sponsored multi-center clinical trial involving…
  • 2020 American Transplant Congress

    Cost-Effectiveness of Protocol Biopsies in Kidney Transplantation

    C. M. Puttarajappa, S. Hariharan, K. J. Smith

    Medicine, University of Pittsburgh, Pittsburgh, PA

    *Purpose: To perform an economic evaluation of protocol biopsies in kidney transplantation*Methods: We used a Markov decision analytical model (Figure 1) to compare the following…
  • 2020 American Transplant Congress

    The Impact of DSA Screening in Stable Kidney Transplant Recipients in the 1st Year Post-Transplant

    A. Sharma1, D. Jorgensen2, R. Mehta1, P. Sood1, C. Wu1, C. M. Puttarajappa1, A. Tevar1, S. Hariharan1

    1Thomas E. Starzl Transplant Institute, Renal Electrolyte Division, University of Pittsburgh Medical Center, Pittsburgh, PA, 2Thomas E. Starzl Transplant Institute, University of Pittsburgh Medical Center, Pittsburgh, PA

    *Purpose: The importance of Donor Specific Antibody (DSA) as a screening tool within the 1st year post kidney transplant in stable patients remains unclear. We…
  • 2020 American Transplant Congress

    Time-Zero Histology Correlates with Donor Characteristics but Does Not Predict Short-Term Outcomes in Kidney Transplantation

    S. Raza, G. Agarwal, D. Anderson, M. Deierhoi, H. Fatima, M. Hanaway, J. Locke, P. MacLennan, B. Orandi, C. Young, R. Mannon, M. Seifert

    University of Alabama School of Medicine, Birmingham, AL

    *Purpose: Time-zero biopsies provide important information about baseline histology but their clinical utility compared to other non-invasive predictors is unclear. Our center performs universal time-zero…
  • 2020 American Transplant Congress

    Torque Teno Virus Level for Risk Stratification of Subclinical Graft Rejection at 12 Months after Kidney Transplantation – An Prospective Observational Cohort Study

    K. Doberer, E. Puchhammer, G. Böhmig, G. Bond

    Medical University Vienna, Vienna, Austria

    *Purpose: Non-invasive monitoring strategies are insufficient to detect patients at risk for subclinical graft rejection after kidney transplantation. The highly prevalent and non-pathogenic Torque Teno…
  • 2020 American Transplant Congress

    Impact of Focal Cortical Necrosis (CN) in Preimplantation Biopsy (PBx) on Outcomes after Deceased Donor Kidney Transplantation

    S. S. Nair, J. Ninan, R. Heilman, K. Reddy, M. Smith

    Mayo Clinic, Phoenix, AZ

    *Purpose: The data on outcomes of focal CN in PBx after deceased donor transplantation is sparse. We studied the prognostic value of focal CN on…
  • 2020 American Transplant Congress

    1 -Year Protocol Biopsies in Pediatric Kidney Transplant Children: Are Unfavorable Histological Lesions Related to No Adherence?

    M. L. Monteverde1, J. M. Velasco1, V. Solernou2, J. P. Ibanez1, C. Cernadas3, A. B. Chaparro4, Y. L. Marcos5

    1Hospital de Pediatria JP Garrahan, Buenos Aires, Argentina, 2Pathology, Hospital de Pediatria JP Garrahan, Buenos Aires, Argentina, 3Teaching and Investigation, Hospital de Pediatria JP Garrahan, Buenos Aires, Argentina, 4Nephrology, Hospital de Pediatria JP Garrahan, Buenos Aires, Argentina, 5Hemoteraphy, Hospital de Pediatria JP Garrahan, Buenos Aires, Argentina

    *Purpose: In adults with kidney transplantation (KT), histological findings in surveillance biopsies at 1-year post KT are independent correlate to short and long-term graft survival.…
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