2020 American Transplant Congress
Immunohistochemical and Molecular Detection of NK Cells in Kidney Allografts with Antibody Mediated Rejection
Pathology, University of Michigan, Ann Arbor, MI
*Purpose: Molecular signatures specific to Natural Killer (NK) cells are closely associated with antibody mediated rejection (AMR) in transplant biopsies. We have developed an immunohistochemical…2020 American Transplant Congress
Assessing Immunosuppression with Immunological Testing and Surveillance Biopsies Late after Liver and Intestine Transplantation (LT, IT)
Pediatric Transplant, Pittsburgh, PA
*Purpose: Assessing adequacy of immunosuppression is essential during late allograft surveillance after LT or IT.*Methods: To explain why allograft function tests can be normal despite…2020 American Transplant Congress
Analysis of 1000 Protocol Kidney Biopsies: Complications, Benefits, and Predictive Potential of Prior Sensitization
*Purpose: Protocol biopsy of kidney transplants can allow for early recognition of treatable findings, both immunologic and non-immunologic. This comes with the risk of biopsy…2020 American Transplant Congress
Impact of Variation in Histological Assessments and Their Impact on Clinical Trial Enrollment and Endpoints – Preliminary Report of The Gen04 Study
*Purpose: Renal allograft histology is often used as inclusion criteria for clinical trials. This includes Gen04, which is an NIH sponsored multi-center clinical trial involving…2020 American Transplant Congress
Cost-Effectiveness of Protocol Biopsies in Kidney Transplantation
Medicine, University of Pittsburgh, Pittsburgh, PA
*Purpose: To perform an economic evaluation of protocol biopsies in kidney transplantation*Methods: We used a Markov decision analytical model (Figure 1) to compare the following…2020 American Transplant Congress
The Impact of DSA Screening in Stable Kidney Transplant Recipients in the 1st Year Post-Transplant
*Purpose: The importance of Donor Specific Antibody (DSA) as a screening tool within the 1st year post kidney transplant in stable patients remains unclear. We…2020 American Transplant Congress
Time-Zero Histology Correlates with Donor Characteristics but Does Not Predict Short-Term Outcomes in Kidney Transplantation
University of Alabama School of Medicine, Birmingham, AL
*Purpose: Time-zero biopsies provide important information about baseline histology but their clinical utility compared to other non-invasive predictors is unclear. Our center performs universal time-zero…2020 American Transplant Congress
Torque Teno Virus Level for Risk Stratification of Subclinical Graft Rejection at 12 Months after Kidney Transplantation – An Prospective Observational Cohort Study
Medical University Vienna, Vienna, Austria
*Purpose: Non-invasive monitoring strategies are insufficient to detect patients at risk for subclinical graft rejection after kidney transplantation. The highly prevalent and non-pathogenic Torque Teno…2020 American Transplant Congress
Impact of Focal Cortical Necrosis (CN) in Preimplantation Biopsy (PBx) on Outcomes after Deceased Donor Kidney Transplantation
*Purpose: The data on outcomes of focal CN in PBx after deceased donor transplantation is sparse. We studied the prognostic value of focal CN on…2020 American Transplant Congress
1 -Year Protocol Biopsies in Pediatric Kidney Transplant Children: Are Unfavorable Histological Lesions Related to No Adherence?
*Purpose: In adults with kidney transplantation (KT), histological findings in surveillance biopsies at 1-year post KT are independent correlate to short and long-term graft survival.…
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