2020 American Transplant Congress
Prolonged Multitransgenic Pig Lung Survival with Attenuated Pulmonary Vascular Resistance Rise During Human Blood Perfusion
*Purpose: Physiologic behavior of porcine lungs with multiple xeno-targeted genetic modifications, Pig 2.0, have not previously been evaluated.*Methods: Eight pairs of lungs from Pig 2.0…2020 American Transplant Congress
IL-33 is a Potent Injury Signal That Programs Graft Macrophage Metabolism Toward That Required for Reparative and Regulatory Functions
*Purpose: Sequestered self-molecules, such as HMGB1 or haptoglobin, are appreciated to stimulate the pro-inflammatory response of infiltrating innate immune cells by targeting TLR4 after their…2020 American Transplant Congress
Improved Platelet Sequestration with Humanization of Von Willebrand Factor in Pig Xenogeneic Lung Perfusion Model
*Purpose: Von Willebrand factor (vWF) is an important element of hemostasis and when activated, mediates platelet adhesion and promotes platelet aggregation under shear stress conditions.…2020 American Transplant Congress
Normothermic Machine Perfusion of Genetically Modified Pig Livers with Human Blood
*Purpose: Barriers to pig-to-human liver xenotransplantation remain, including profound thrombocytopenia, coagulopathy, and rejection. We utilized ex-vivo liver xenoperfusion with human blood to study the human…2019 American Transplant Congress
Shroom3 Regulates Glomerular Hypertrophy after Uninephrectomy via mTOR
Mount Sinai School of Medicine, New York, NY
*Purpose: A Shroom3 intronic risk locus & Shroom3 protein have been associated with increased fibrosis but reduced albuminuria in recipients of allografts with the risk…2019 American Transplant Congress
Hypothermic Machine Perfusion Protects Donation After Cardiac Deathliver Graft Through Gstm1-mediated Cytochrome P450 Exogenous Substance Metabolism Pathway
Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases, Wuhan, China
*Purpose: Donation after cardiac death (DCD) is the mainly resource to relieve organ-transplantation shortage. Our previous research have confirmed that the function of DCD liver…2018 American Transplant Congress
Klotho, HMGB-1 and Kynurenine as Marker for Injury and Function in Renal Transplantation
Brain death is associated with immune activation and tissue injuries, counter regulated by activation of the tryptophan pathway producing kynurenine (Kyn). High mobility group box…2017 American Transplant Congress
TIE'ing Statins to Microvascular Stability and Endothelial Cell Immunogenicity.
Graft microvascular endothelial cells (EC) represent a critical interface between the recipient and the donor. Stable/quiescent EC support immunoregulation in part via the expression of…2017 American Transplant Congress
GSK3β and VDAC in Endoplasmic Reticulum Stress and Apoptosis Modulation During Orthotropic Liver Transplantation.
Ischemia reperfusion injury(IRI) is a major cause of graft non-function following liver transplantation (LT). Mitochondrial dysfunction plays a central role in preventing liver IRI), associated…2016 American Transplant Congress
Predicting Delayed Kidney Graft Function with Gene Expression in Preimplantation Biopsies.
Aiming to further the investigation of markers in pre-implantation biopsies (PIB) for the prediction of delayed graft function (DGF), we analyzed, in a different cohort…
American Transplant Congress abstracts