Articles tagged "Protective genes"

2022 American Transplant Congress
The Role of HNF4α in Renal Ischemia Reperfusion Injury
A. D. Saha
Toronto General Hospital Research Institute, Toronto, ON, Canada
*Purpose: Ischemia reperfusion injury (IRI) affects all solid organ transplants and impairs renal graft function. However, the mechanisms by which IRI affects grafts are incompletely…
2022 American Transplant Congress
Myeloid Molecular Signature of Ischemia-Reperfusion Injury in Human Liver Transplantation
R. A. Sosa¹, R. Ahn², A. Terry¹, Z. Qian², F. Li¹, S. Sen¹, T. Ito³, B. V. Naini¹, F. Kaldas³, A. Hoffmann², R. W. Busuttil³, D. W. Gjertson¹, J. Kupiec-Weglinski³, E. F. Reed¹
¹Pathology and Lab Medicine, UCLA, Los Angeles, CA, ²Microbiology, Immunology and Molecular Genetics, UCLA, Los Angeles, CA, ³Surgery, UCLA, Los Angeles, CA
*Purpose: Ischemia reperfusion injury (IRI) is well-appreciated as a significant clinical concern for recipients of liver transplantation, yet there are still no diagnostic or therapeutic…
2020 American Transplant Congress
Prolonged Multitransgenic Pig Lung Survival with Attenuated Pulmonary Vascular Resistance Rise During Human Blood Perfusion
M. R. Connolly¹, L. Burdorf¹, S. Pratts¹, B. Cerel¹, Z. Abady¹, W. Quin², Y. Kan², J. Layer², M. Youd², W. Westlin², L. Yang², A. Azimzadeh¹, R. N. Pierson III¹
¹Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ²eGenesis, Cambridge, MA
*Purpose: Physiologic behavior of porcine lungs with multiple xeno-targeted genetic modifications, Pig 2.0, have not previously been evaluated.*Methods: Eight pairs of lungs from Pig 2.0…
2020 American Transplant Congress
IL-33 is a Potent Injury Signal That Programs Graft Macrophage Metabolism Toward That Required for Reparative and Regulatory Functions
T. Li¹, Z. Zhang¹, Q. Liu¹, J. Bartolacci², M. Velayutham¹, G. Hussey², J. Dziki², L. Mathews¹, Y. Lee³, G. Dwyer¹, H. Dai¹, A. Roessing¹, S. Shiva⁴, M. Oberbarnscheidt¹, S. Badylak², H. Turnquist¹
¹Starzl Transplant Inst. and Dept. Surgery, University of Pittsburgh, Pittsburgh, PA, ²McGowan Inst. and Dept. of Surgery, University of Pittsburgh, Pittsburgh, PA, ³Bioengineering, University of Pittsburgh, Pittsburgh, PA, ⁴Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA
*Purpose: Sequestered self-molecules, such as HMGB1 or haptoglobin, are appreciated to stimulate the pro-inflammatory response of infiltrating innate immune cells by targeting TLR4 after their…
2020 American Transplant Congress
Improved Platelet Sequestration with Humanization of Von Willebrand Factor in Pig Xenogeneic Lung Perfusion Model
M. R. Connolly¹, L. Burdorf¹, Z. Abady¹, S. Sendil², E. Redding², B. Cerel¹, S. Pratts¹, C. Phelps³, W. Eyestone³, D. Ayares³, A. Azimzadeh¹, R. N. Pierson III¹
¹Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ²University of Maryland, Baltimore, Baltimore, MD, ³Revivicor, Blacksburg, VA
*Purpose: Von Willebrand factor (vWF) is an important element of hemostasis and when activated, mediates platelet adhesion and promotes platelet aggregation under shear stress conditions.…
2020 American Transplant Congress
Normothermic Machine Perfusion of Genetically Modified Pig Livers with Human Blood
D. Detelich¹, T. M. Coe², C. G. Rickert², C. Carroll², N. Serifis², R. Matheson², I. Rosales², W. Qin³, Y. Kan³, J. Layer³, M. Youd³, W. Westlin³, S. Kimura², A. Azimzadeh², L. Yang³, J. F. Markmann²
¹Tufts Medical Center, Boston, MA, ²Massachusetts General Hospital, Boston, MA, ³eGenesis, Cambridge, MA
*Purpose: Barriers to pig-to-human liver xenotransplantation remain, including profound thrombocytopenia, coagulopathy, and rejection. We utilized ex-vivo liver xenoperfusion with human blood to study the human…
2019 American Transplant Congress
Shroom3 Regulates Glomerular Hypertrophy after Uninephrectomy via mTOR
K. Banu, F. Garzon, C. Wei, Z. Yi, W. Zhang, C. He, B. Murphy, M. C. Menon
Mount Sinai School of Medicine, New York, NY
*Purpose: A Shroom3 intronic risk locus & Shroom3 protein have been associated with increased fibrosis but reduced albuminuria in recipients of allografts with the risk…
2019 American Transplant Congress
Hypothermic Machine Perfusion Protects Donation After Cardiac Deathliver Graft Through Gstm1-mediated Cytochrome P450 Exogenous Substance Metabolism Pathway
W. Liang, S. Ye, Z. Zhong, Q. Hu, Y. Wang, Q. Ye
Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases, Wuhan, China
*Purpose: Donation after cardiac death (DCD) is the mainly resource to relieve organ-transplantation shortage. Our previous research have confirmed that the function of DCD liver…
2018 American Transplant Congress
Klotho, HMGB-1 and Kynurenine as Marker for Injury and Function in Renal Transplantation
M. Stangl,¹ D. Abendroth.²
¹Transplant Center Munich, Klinikum Großhadern, LMU Munich, Munich, Germany; ²Surgery, University of Ulm, Ulm, Germany.
Brain death is associated with immune activation and tissue injuries, counter regulated by activation of the tryptophan pathway producing kynurenine (Kyn). High mobility group box…
2017 American Transplant Congress
TIE'ing Statins to Microvascular Stability and Endothelial Cell Immunogenicity.
C. Ghosh,¹ A. Mak,¹ M. McGourty,¹ S. Parikh,² X. Chen,² S. Goldberg,¹ J. Wedel,¹ D. Briscoe.¹
¹Transplant Research Program, Boston Children's Hospital, Boston, MA; ²Division of Nephrology, Beth Israel Deaconess Medical Center, Boston, MA
Graft microvascular endothelial cells (EC) represent a critical interface between the recipient and the donor. Stable/quiescent EC support immunoregulation in part via the expression of…