2018 American Transplant Congress
Targeted Donor Complement Blockade after Brain-Death Prevents Delayed Graft Function but Not Progression to Antibody-Mediated Rejection in a Non-Human Primate Model of Kidney Allo-Transplantation
1Surgery, University of Wisconsin-Madison, Madison, WI; 2Pharming Group N.V, Leiden, Netherlands.
Introduction: Donor brain death (BD) triggers a complement-mediated inflammatory response linked to renal injury which has been associated to delayed graft function (DGF) and the…2018 American Transplant Congress
Preemptive B Cell Depletion Modulates Pathogenic Alloimmunity Associated with Selective Non-Activating CD28 Blockade
Purpose: Because anti-donor alloantibody (alloAb) elaboration is associated with chronic allograft rejection, peri-transplant B cell depletion is being explored to modulate pathogenic alloimmunity. Here, we…2018 American Transplant Congress
CD8-Expressing Transitional B Cells Dominate B Cell Reconstitution in Transplanted Monkeys Receiving Mixed Chimerism Conditioning
Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA.
IntroductionTolerance of heart or lung allografts have been achieved for the first time in nonhuman primates (NHPs) using a mixed chimerism conditioning regimen. However, the…2018 American Transplant Congress
Humoral Immunity to CMV Remains Intact after Dual Targeting Desensitization in Allosensitized Nonhuman Primates
Department of Surgery, Duke University Medical Center, Durham, NC.
Desensitization to remove donor specific antibody (DSA) is a way to expand the pool of potential donors for sensitized patients. This study compared the effects…2018 American Transplant Congress
Carfilzomib and Belatacept Reduces DSA and Prolongs Survival in a Highly Sensitized Rhesus Model of Kidney Transplantation
Duke Transplant Center, Duke University Medical Center, Durham, NC.
Purpose:Sensitized kidney transplant (KT) recipients have poor access to transplantation and inferior outcomes when transplanted. Conventional methods of desensitization remove donor specific antibody (DSA) temporarily,…2018 American Transplant Congress
Ultra Low Dose of IL-2 Produces Long-Term Drug-Free Survival of Cynomolgus Islets Allografts
1Medicine and Surgery, Beth Israel Deaconess Medical Center, Boston, MA; 2Surgery, MGH, Boston, MA.
Therapeutic principles established in non-human transplant models have value for clinical application despite cost related limitations on sample size. We have tested new therapies in…2017 American Transplant Congress
Autologous Expanded Tregs and Porcine Hematopoietic Cells to Prolong Xenogeneic Pig Skin Graft Acceptance in Baboons.
Background: Mixed chimerism (MC) has been shown to induce tolerance to allogeneic organs and has shown promise for application to xenotransplants, although long-term tolerance has…2017 American Transplant Congress
Prolonged Survival with Co-Stimulatory Blockade Based Immunosuppression in Pig-to-Primate Liver Xenotransplantation.
Massachusetts General Hospital, Boston, MA
Background: Since the first attempt in 1968, survival following pig-to-baboon liver xenotransplantation (LXT) has been limited to <9-days due to a lethal coagulopathy. To improve…2017 American Transplant Congress
CD4 Depletion Is Necessary and Sufficient for Long-Term Nonhuman Primate Xenotransplant Survival.
Introduction. Xenotransplantation may alleviate the organ shortage, yet experimental renal xenotransplant has met limited success. We have previously reported the longest surviving pig-to-nonhuman primate (NHP)…2017 American Transplant Congress
CD28 Directed Immunotherapy Is More Potent Than Belatacept in a Nonhuman Primate Xenotransplant Model.
Introduction. Xenotransplantation may alleviate the organ shortage, yet experimental renal xenotransplantation has met limited success. T cell-mediated damage remains a critical problem. Our group has…
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