ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Primates"

  • 2018 American Transplant Congress

    Combination Proteasome Inhibition and Anti-BAFF Therapy Permits Highly Sensitized Rhesus Kidney Transplantation

    B. Ezekian, J. Kwun, M. Manook, P. Schroder, J. Yoon, M. Mulvihill, K. Freischlag, J. Park, J. Cochran, K. Kroning, J. Yi, S. Knechtle.

    Duke Transplant Center, Duke University Medical Center, Durham, NC.

    Purpose:HLA-sensitization is a significant immunologic barrier to successful kidney transplantation (KT). We have shown that proteasome inhibition (PI) in insolation reduces plasma cells (PCs), but…
  • 2018 American Transplant Congress

    Mechanisms of Vascularized Bone Marrow Graft Protection of Vascularized Composite Allografts

    E. Buckingham, N. Shockcor, W. Hassanein, C. Drachenberg, A. Nam, S. Bartlett, R. Barth.

    Surgery, University of Maryland, Baltimore, MD.

    Background Co-transplantation of vascularized bone marrow (VBM) promotes vascularized composite allograft (VCA) survival with standard immunosuppression in a non-human primate (NHP) model. We investigated mechanisms…
  • 2018 American Transplant Congress

    Targeted Donor Complement Blockade after Brain-Death Prevents Delayed Graft Function but Not Progression to Antibody-Mediated Rejection in a Non-Human Primate Model of Kidney Allo-Transplantation

    J. Danobeitia,1 T. Zens,1 L. Zitur,1 P. Chlebeck,1 J. Torrealba,3 D. Burguete, E. Van Amersfoort,2 A. Relan,2 A. D'Alessandro,1 L. Fernandez.1

    1Surgery, University of Wisconsin-Madison, Madison, WI; 2Pharming Group N.V, Leiden, Netherlands.

    Introduction: Donor brain death (BD) triggers a complement-mediated inflammatory response linked to renal injury which has been associated to delayed graft function (DGF) and the…
  • 2018 American Transplant Congress

    Preemptive B Cell Depletion Modulates Pathogenic Alloimmunity Associated with Selective Non-Activating CD28 Blockade

    N. O'Neill,1 T. Zhang,1 W. Sun,1 G. Braileanu,1 X. Cheng,1 I. Tatarov,1 W. Hassanein,1 Z. Habibabady,1 B. Cerel,1 K. Reimann,2 A. Azimzadeh,1 R. Pierson.1

    1Surgery, University of Maryland School of Medicine, Baltimore, MD; 2University of Massachusetts Medical School, Boston, MA.

    Purpose: Because anti-donor alloantibody (alloAb) elaboration is associated with chronic allograft rejection, peri-transplant B cell depletion is being explored to modulate pathogenic alloimmunity. Here, we…
  • 2018 American Transplant Congress

    CD8-Expressing Transitional B Cells Dominate B Cell Reconstitution in Transplanted Monkeys Receiving Mixed Chimerism Conditioning

    K. Pruner, J. Paster, S. Wiebke, O. Jane, H. Isabel, D. Abbas, B. Gilles, M. Joren.

    Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA.

    IntroductionTolerance of heart or lung allografts have been achieved for the first time in nonhuman primates (NHPs) using a mixed chimerism conditioning regimen. However, the…
  • 2018 American Transplant Congress

    Humoral Immunity to CMV Remains Intact after Dual Targeting Desensitization in Allosensitized Nonhuman Primates

    P. Schroder, B. Ezekian, F. Saccoccio, J. Yoon, M. Dennis, K. Freischlag, J. Kwun, S. Permar, S. Knechtle.

    Department of Surgery, Duke University Medical Center, Durham, NC.

    Desensitization to remove donor specific antibody (DSA) is a way to expand the pool of potential donors for sensitized patients. This study compared the effects…
  • 2017 American Transplant Congress

    Trafficking of Donor Leukocytes and Recipient Cells Cross-Dressed with Donor MHC Molecules After Transplantation of Cardiac Allografts in Monkeys.

    J. Marino, K. Robinson, J. Paster, I. Hanekamp, J. Madsen, G. Benichou.

    Center for Transplantation Sciences, Massachusetts General Hospital / Harvard Medical School, Boston, MA

    Activation of recipient T cells recognizing allogeneic MHC molecules displayed on donor leukocytes is known to trigger acute allograft rejection (direct allorecognition). Recently, we have…
  • 2017 American Transplant Congress

    Effective Targeting Plasma Cells with Daratumumab (Anti-CD38) and Mozobil (Anti-CXCR4) in a Sensitized Non-Human Primate Model.

    J. Kwun,1 B. Ezekian,1 M. Manook,1 E. Branum,1 V. Curfman,1 J. Park,1,2 K. Freishlag,1 J. Yoon,1 S. Knechtle.1

    1Surgery, Duke Transplant Center, Durham, NC; 2Surgery, Samsung Medical Center, Seoul, Korea

    [Introduction] The presence of donor-specific antibodies (DSA) leads to antibody-mediated rejection (AMR) and decreased graft survival. Therefore efforts continue to be made to reduce DSA…
  • 2017 American Transplant Congress

    Measurement of Dissolved Oxygen by 19F MRI of Microcapsules Implanted IP in Non-Human Primates.

    S. Safley,1 M. Graham,2 M. Garwood,3 K. Papas,5 B. Weegman,3,4 G. Barber,1 E. Lin,1 J. Leisen,7 A. Sambanis,6 B. Hering,2 C. Weber.1

    1Surgery, Emory University, Atlanta, GA; 2Surgery, University of Minnesota, Minneapolis, MN; 3Radiology, University of Minnesota, Minneapolis, MN; 4Sylvatica Biotech, Inc., Charleston, SC; 5Surgery, University of Arizona, Tucson, AZ; 6School of Chemical and Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA; 7School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA

    Since our encapsulated NHP islet allografts and porcine islet xenografts fail after i.p. transplantation in immunosuppressed NHPs without a cellular or humoral immune response, we…
  • 2017 American Transplant Congress

    Induction of Proliferative Responses in B Cell and Plasma Cell Populations Following Proteasome Inhibitor Desensitization Treatment in Rhesus Macacques and Humans.

    J. Driscoll,1 S. Knechtle,2 J. Kwun,2 S. Tremblay,1 N. Salomonis,3 S. Potter,3 B. Aronow,3 M. Manook,2 R. Alloway,1 H. Singh,3 E. Woodle.1

    1U of Cincinnati, Cincinnati; 2Duke, Durham; 3Cincinnati Childrens, Cincinnati

    Proteasome inhibitor (PI)-based desensitization (DS) in humans has demonstrated variable reduction in HLA antibody levels that is often associated with variable rebound following treatment cessation.The…
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