ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Primates"

  • 2021 American Transplant Congress

    Interruption of Notch Signaling via Blockade of Delta-Like Ligand 4 Prevents Co-Stimulation Blockade Resistant Allograft Rejection

    A. J. Matar, B. P. Lovasik, Y. Dong, D. A. Faber, J. Habib, C. Breeden, J. Regenold, A. Ghosh, A. Stephenson, W. H. Kitchens, A. B. Adams

    Emory University Department of Surgery, Atlanta, GA

    *Purpose: Co-stimulation blockade (CoB) has emerged as a promising immunosuppression strategy with the advent of Belatacept, a novel CTLA4-Ig fusion protein that blocks CD28-mediated T…
  • 2021 American Transplant Congress

    First Full Reversal of Diabetes in Non-human Primates (nhp) with Stem Cell Derived Islet-like-clusters (sc-ilcs)

    J. Lei1, S. Collins2, H. Deng1, Z. Yang1, A. Zhang1, C. Peters1, J. Zhang2, K. Boulanger2, M. Yu3, M. Rickels3, C. Liu3, R. Pop2, A. Naji3, D. Melton2, J. Markmann1

    1Surgery, Mass General, Boston, MA, 2Harvard Stem Cell Institute, Harvard University, Boston, MA, 3Surgery, Upenn, Philadelphia, PA

    *Purpose: Deceased donor allo-islet transplants (Tx) have demonstrated the ability of cell-based therapy to fully reverse T1D, however, an inadequate donor supply and frequent need…
  • 2021 American Transplant Congress

    P2X7 Receptor Activity Mediates Th17-Specific Self- and Alloreactivity in Non-Human Primates

    C. Little, J. Sullivan, W. Burlingham, D. Kaufman

    Department of Surgery, University of Wisconsin, Madison, WI

    *Purpose: The broadly expressed ATP-binding purinergic receptor, P2X7 (P2X7R) is involved in the Th17 mediated cellular immune response to allo- and select self-antigens (Collagen type…
  • 2021 American Transplant Congress

    Effects of IL-2 and/ or Anti-IL6R Therapy on Long-term Cardiac Allograft Survival in Non-Human Primates (NHPs)

    C. L. Miller, K. J. Ahrens, J. M. O, P. M. Patel, J. A. Morrissette, D. Becerra, T. Costa, A. Dehnadi, I. M. Hanekamp, G. Benichou, J. C. Madsen

    Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA

    *Purpose: Cardiac allograft tolerance in NHPs has been achieved by our group using a mixed chimerism model with allogeneic bone marrow transplant after non-myeloablative conditioning…
  • 2020 American Transplant Congress

    Old World Monkeys Are Not Ideal Transplantation Models for Testing CMAHKO (TKO or GTKO/CMAHKO) Pig Kidneys

    T. Yamamoto1, H. Iwase1, D. Patel1, A. Jagdale1, J. Foote1, D. Ayares2, D. Anderson1, D. E. Eckhoff1, D. K. Cooper1, H. Hara1

    1University of Alabama at Birmingham, Birmingham, AL, 2Revivicor, Blacksburg, VA

    *Purpose: Triple-knockout (TKO) pigs are likely to be an optimal source of organs for transplantation into human recipients, many of whom do not have natural…
  • 2020 American Transplant Congress

    Splenectomy Impedes B Cell Infiltration Associated with Rejection of Neonatal Porcine Islet Xenografts

    Z. W. Fitch, M. Song, R. Schmitz, F. Leopardi, M. Ribeiro, A. Miller, G. Devi, B. Collins, X. Luo, A. D. Kirk

    Duke University, Durham, NC

    *Purpose: Xenotransplantation has historically been frustrated by antibody-mediated rejection. Splenectomy has shown efficacy in mediating humoral immunity. We hypothesized that adding splenectomy to a clinically…
  • 2020 American Transplant Congress

    Expression of Multiple Human Complement Regulatory Proteins Results in Prolonged Heterotopic Xenoheart Survival in an NHP Model

    K. Ahrens1, J. M. O1, W. Sommer2, D. Becerra1, P. M. Patel1, A. Dehnadi1, Y. Kan3, J. Layer3, J. Morrissette1, T. Costa1, I. M. Hanekamp1, J. S. Allan4, M. Youd3, R. N. Pierson5, W. Qin3, L. Burdorf5, A. M. Azimzadeh1, W. Westlin3, L. Yang3, J. C. Madsen5

    1Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, 2Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany, 3eGenesis Inc., Cambridge, MA, 4Center for Transplantation Sciences, Division of Thoracic Surgery, Massachusetts General Hospital, Boston, MA, 5Center for Transplantation Sciences, Division of Cardiac Surgery, Massachusetts General Hospital, Boston, MA

    *Purpose: Advances in genome engineering technology allow for multiplex genetic modifications in pigs designed to address immunologic and coagulation incompatibilities in order to facilitate xenotransplantation.…
  • 2020 American Transplant Congress

    Pig-To-Baboon Liver Xenotransplantation Utilizing Genetically Modified Swine

    D. Detelich1, C. G. Rickert1, T. M. Coe1, S. Kimura1, I. Rosales1, H. Deng1, H. Yeh1, W. Qin2, Y. Kan2, J. Layer2, M. Youd2, W. Westlin2, L. Yang2, J. F. Markmann1

    1Massachusetts General Hospital, Boston, MA, 2eGenesis, Cambridge, MA

    *Purpose: Pig-to-baboon liver xenotransplant (LXT) continues with significant hurdles, including thrombocytopenia, coagulation dysregulation and rejection with the longest reported survival of 29 days utilizing a…
  • 2020 American Transplant Congress

    Successful Long-Term TMA- and Rejection- Free Survival of a Kidney Xenograft with Triple Xenoantigen Knockout Plus Insertion of Multiple Human Transgenes

    D. H. Ma1, H. Sasaki1, T. Hirose1, I. Rosales1, A. Dehnadi1, R. Colvin1, J. F. Markmann1, W. Win2, Y. Kan2, J. Layer2, M. Youd2, W. Westlin2, L. Yang2, T. Kawai1

    1Surgery, MGH, Boston, MA, 2eGenesis Inc., Cambridge, MA

    *Purpose: Recent advances in genome engineering technology allow for the generation of porcine organ donors with multiplex gene edits. Here we evaluated survival of kidneys…
  • 2020 American Transplant Congress

    The Effect of Human Thrombomodulin on Thrombotic Complications in Life Supporting Pig-to-Baboon Cardiac Xenotransplantation

    C. E. Goerlich1, A. Singh1, D. Kaczorowski1, M. Abdullah1, B. Lewis1, I. Tatarov1, A. Hershfeld1, T. Zhang1, P. Odonkor1, E. Strauss1, B. Williams1, D. Ayares2, M. Mohiuddin1

    1Surgery, University of Maryland School of Medicine, Baltimore, MD, 2Revivicor, Blacksburg, VA

    *Purpose: Transplantation of organs from animals to humans (xenotransplantation) has been proposed to address the critical shortage of organs for transplantation. The use of genetically…
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