ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Preservation"

  • 2021 American Transplant Congress

    Recovery After Extended Static Cold Storage Preservation Using Subnormothermic Machine Perfusion in VCA

    M. Goutard1, R. J. de Vries1, A. G. Lellouch1, E. Lupon1, C. Pendexter1, S. N. Tessier1, M. A. Randolph1, L. Lantieri2, C. L. Cetrulo1, K. Uygun1

    1Massachusetts General Hospital, Harvard Medical School, Shriners Hospitals for Children, Boston, MA, 2Hôpital Européen Georges Pompidou, Paris, France

    *Purpose: Vascularized composite allografts (VCA) are more sensitive to cold ischemia than solid organ transplants due to the remaining metabolism in skeletal muscle cells. In…
  • 2021 American Transplant Congress

    Segmental Susceptibility of Intestinal Stem Cells to Cold Storage Preservation Injury in a Porcine Model

    E. K. Ludwig1, N. Abraham2, D. Sudan2, A. Barbas2, C. Schaaf1, J. Freund1, A. S. Stewart1, B. Veerasammy1, L. M. Gonzalez1

    1North Carolina State University, Raleigh, NC, 2Duke University, Durham, NC

    *Purpose: Cold storage (CS) is the current gold standard preservation method for small bowel (SB) prior to transplantation. However, CS can cause epithelial detachment, sloughing,…
  • 2021 American Transplant Congress

    Impact of Machine Perfusion of the Heart on Abdominal Organ Procurement from Donation After Cardiac Death Donors

    C. Feizpour, C. Hwang, A. Shubin, J. Shah, L. DeGregoria, S. Hanish, P. Vagefi, M. MacConmara

    Department of Surgery, Division of Surgical Transplantation, University of Texas Southwestern Medical Center, Dallas, TX

    *Purpose: Superior preservation with normothermic machine perfusion devices has been demonstrated in thoracic and abdominal allografts, especially DCD donation, where clinical utilization of DCD hearts…
  • 2021 American Transplant Congress

    Superior Post-transplant Clinical Outcomes Using Portable Normothermic Perfusion and Assessment with the Organ Care System (ocs) Liver System: 1-year Outcomes of the Ocs Liver Protect Randomized Controlled Trial

    J. Markmann1, M. Abouljoud2, M. Ghobrial3, C. Bhati4, S. Pelletier5, J. Magliocca6, T. Pruett7, A. Lu8, M. Rizzari9, S. Ottmann10, T. Klair11, C. Eymard12, G. Roll13, G. Reyes14, S. Black15, S. Florman16, S. Mirani17, C. Marsh18, G. Schnickel19, M. Kinkhabwala20, A. Demetris21, H. Yeh22, P. Vagefi23, M. MacConmara23

    1MGH, Boston, MA, 2Henry Ford, Detroit, MI, 3Houston Methodist, Houston, TX, 4Virginia Commonwealth, Richmond, VA, 5UVA, Charlottesville, VA, 6Emory, Atlanta, GA, 7U. Minnesota, Minneapolis, MN, 8Tampa General, Tampa, FL, 9Henry Ford, Detriot, MI, 10Johns Hopkins, Baltimore, MD, 11University of Texas HSC, San Antonio, TX, 12University of Tennessee HSC, Memphis, TN, 13UCSF, San Francisco, CA, 14U. Washington, Seattle, WA, 15Ohio State, Columbus, OH, 16Mt. Sinai, New York, NY, 17U. Nebraska, Omaha, NE, 18Scripps Clinic, San Diego, CA, 19U. San Diego, San Diego, CA, 20Montefiore, New York, MA, 21UPMC, Pittsburgh, PA, 22Massachusetts General Hospital, Boston, MA, 23UT Southwestern, Dallas, TX

    *Purpose: The OCS Liver PROTECT Trial was the first U.S. randomized controlled trial for liver perfusion and was designed to evaluate the impact of portable…
  • 2021 American Transplant Congress

    Cross-Circulation for Extracorporeal Liver Support in a Swine Model

    W. K. Wu1, A. Tumen1, J. W. Stokes2, R. Ukita2, A. E. Hozain3, C. R. Flynn2, M. J. Lee3, J. R. Talackine2, N. L. Cardwell2, J. A. Reimer3, M. Pinezich3, C. Benson2, G. Vunjak-Novakovic3, S. P. Alexopoulos2, M. Bacchetta2

    1co-first authors, Vanderbilt University Medical Center, Nashville, TN, 2Vanderbilt University Medical Center, Nashville, TN, 3Columbia University Medical Center, New York, NY

    *Purpose: Although machine perfusion has gained momentum as an organ preservation strategy in liver transplantation, significant organ shortages and waitlist mortality persist, highlighting unmet needs…
  • 2021 American Transplant Congress

    Successful Long Term Survival of Vascularized Composite Allografts After Extended Preservation at Subzero Temperatures Using Bioinspired Next Generation Cryoprotectants

    M. Kline1, S. Fidder2, A. Callegari1, A. Matoso2, B. Oh2, K. Lombardo2, J. Etra2, D. Vasilic3, A. Childs1, R. Redett2, G. Brandacher2, X. Wei1

    1X-Therma Inc., Richmond, CA, 2Johns Hopkins University School of Medicine, Baltimore, MD, 3Erasmus MC, Rotterdam, Netherlands

    *Purpose: Vascularized composite allotransplantation (VCA) is a viable reconstructive option for patients with devastating tissue defects. However, the field is constrained by short tolerable ischemia…
  • 2021 American Transplant Congress

    Patterns and Inhibition of Cell Death During Static Cold Storage of Human Kidneys

    J. R. DiRito1, G. Chickering2, J. T. Langford1, D. Stern1, S. Hosgood3, M. L. Nicholson3, E. Gavathiotis4, R. N. Kitsis5, M. Saltzman2, J. S. Pober6, G. T. Tietjen7

    1Surgery, Yale School of Medicine, New Haven, CT, 2Biomedical Engineering, Yale University, New Haven, CT, 3Surgery, University of Cambridge, Cambridge, United Kingdom, 4Biochemistry and Medicine, Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine, Bronx, NY, 5Surgery, Albert Einstein College of Medicine, Bronx, NY, 6Immunobiology, Yale University, New Haven, CT, 7Surgery and Biomedical Engineering, Yale School of Medicine, New Haven, CT

    *Purpose: As the donor population continues to age and accumulate co-morbidities, more marginal kidneys are being retrieved for transplantation. However, estimates suggest that more than…
  • 2021 American Transplant Congress

    The Harmful Effect of Retained Peripheral Cells During Flushing and Static Cold Storage in Rat Liver Normothermic Machine Perfusion

    O. Haque1, C. A. Pendexter2, J. F. Markmann2, K. Uygun2, H. Yeh2, S. N. Tessier2

    1Surgery, Beth Israel Deaconess Medical Center, Boston, MA, 2Massachusetts General Hospital, Boston, MA

    *Purpose: Retained donor blood in a liver graft can cause damage to resident cells that is exacerbated by static cold storage (SCS), leading to platelet…
  • 2021 American Transplant Congress

    Combining Oxygenated Cold Perfusion with Normothermic Ex-vivo Perfusion Improves the Outcome of DCD Porcine Kidney Transplantation

    L. I. Mazilescu1, T. Goto1, R. Rosales1, Y. Noguchi1, P. Urbanellis1, L. A. Robinson2, M. Selzner1

    1Ajmera Transplant Program, Toronto General Hospital, Toronto, ON, Canada, 2Department of Nephrology, The Hospital for Sick Children, Toronto, ON, Canada

    *Purpose: Ex-vivo machine perfusion is a novel preservation technique for the storage and assessment of marginal kidney grafts. Normothermic (NEVKP) as well as hypothermic machine…
  • 2021 American Transplant Congress

    Determining Endpoint Criteria in Ex Vivo Normothermic Limb Perfusion (EVNLP)

    S. K. Pandey1, A. Meyers1, P. Sadeghi1, V. Kopparthy1, T. Xia1, H. Brunengraber2, S. Dasarathy3, A. Rampazzo1, B. Bassiri Gharb1

    1Plastic Surgery, Cleveland Clinic, Cleveland, OH, 2Department of Nutrition, School of Medicine, Case Western Reserve University, Cleveland, OH, 3Department of Gastroenterology, Cleveland Clinic, Cleveland, OH

    *Purpose: There are no established criteria for discontinuing EVNLP before irreversible muscle and endothelial cell damage occur. This study aimed to evaluate weight gain as…
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