ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Preservation"

  • 2021 American Transplant Congress

    The Edge of Glory: Determinants of Success and Failure for Prolonged Cold Ischemia in Kidney Transplantation

    A. Turner1, M. Hamidi1, V. Ariyamuthu2, R. Harland1, B. Tanriover2

    1Surgery, Banner University of Arizona Medical Center, Tucson, AZ, 2Medicine, Banner University of Arizona Medical Center, Tucson, AZ

    *Purpose: Prolonged cold ischemia time (CIT>30 hours) is associated with an increased risk of primary non-function and early graft loss in kidney transplantation, although this…
  • 2021 American Transplant Congress

    Ex Situ Heart Perfusion and Standard of Care Cold Storage Differentially Affect the Ischemic Secretome of Donor Hearts in Perfusates but Not the Reperfusion Response in Recipient Plasma

    E. Chichelnitskiy1, B. Wiegmann2, N. Ledwoch1, F. Ius2, F. Wandrer1, J. Kühne1, K. Beushausen1, J. Keil1, S. V. Rojas2, W. Sommer2, C. Kühn2, I. Tudorache2, M. Avsar2, A. Haverich2, G. Warnecke2, C. S. Falk1

    1MHH, Institute of Transplant Immunology, Hannover, Germany, 2MHH, Department for Cardiothoracic, Transplantation and Vascular Surgery, Hannover, Germany

    *Purpose: Various allograft preservation procedures influence the donor organ status that may be reflected by the cytokine/chemokine microenvironment in heart transplant (HTx) recipients. In addition,…
  • 2021 American Transplant Congress

    Combined Liver and Lung Transplantation with Extended Normothermic Liver Preservation Using Transmedics Organ Care System (OCS)TM Liver: A Single Center Experience

    J. Konel1, M. Shamaa2, O. Shamaa2, A. Elsabbagh2, T. Kitajima2, T. Ivanics2, K. Delvecchio2, A. Mohamed2, S. Yeddula2, K. Collins2, A. Yoshida2, M. Abouljoud2, S. Nagai2, M. Rizzari2

    1Wayne State University School of Medicine, Detroit, MI, 2Henry Ford Transplant Institute, Detroit, MI

    *Purpose: Combined liver-lung transplantation (CLLT) is indicated in patients who cannot survive single-organ transplantation alone. Ex-situ normothermic machine perfusion (NMP) has been used to increase…
  • 2021 American Transplant Congress

    Mitigating the Adverse Impact of Broader Kidney Sharing with Hospital-based Machine Perfusion

    Y. Yushkov, B. R. Schleich, T. Carrea, V. Wadhera, M. J. Goldstein

    Hackensack University Medical Center, Hackensack, NJ

    *Purpose: The new UNOS kidney allocation changes effective December 2020 will be removing the geographic limits of donation service areas (DSA) and UNOS regions favoring…
  • 2021 American Transplant Congress

    Recovery After Extended Static Cold Storage Preservation Using Subnormothermic Machine Perfusion in VCA

    M. Goutard1, R. J. de Vries1, A. G. Lellouch1, E. Lupon1, C. Pendexter1, S. N. Tessier1, M. A. Randolph1, L. Lantieri2, C. L. Cetrulo1, K. Uygun1

    1Massachusetts General Hospital, Harvard Medical School, Shriners Hospitals for Children, Boston, MA, 2Hôpital Européen Georges Pompidou, Paris, France

    *Purpose: Vascularized composite allografts (VCA) are more sensitive to cold ischemia than solid organ transplants due to the remaining metabolism in skeletal muscle cells. In…
  • 2021 American Transplant Congress

    Segmental Susceptibility of Intestinal Stem Cells to Cold Storage Preservation Injury in a Porcine Model

    E. K. Ludwig1, N. Abraham2, D. Sudan2, A. Barbas2, C. Schaaf1, J. Freund1, A. S. Stewart1, B. Veerasammy1, L. M. Gonzalez1

    1North Carolina State University, Raleigh, NC, 2Duke University, Durham, NC

    *Purpose: Cold storage (CS) is the current gold standard preservation method for small bowel (SB) prior to transplantation. However, CS can cause epithelial detachment, sloughing,…
  • 2021 American Transplant Congress

    Impact of Machine Perfusion of the Heart on Abdominal Organ Procurement from Donation After Cardiac Death Donors

    C. Feizpour, C. Hwang, A. Shubin, J. Shah, L. DeGregoria, S. Hanish, P. Vagefi, M. MacConmara

    Department of Surgery, Division of Surgical Transplantation, University of Texas Southwestern Medical Center, Dallas, TX

    *Purpose: Superior preservation with normothermic machine perfusion devices has been demonstrated in thoracic and abdominal allografts, especially DCD donation, where clinical utilization of DCD hearts…
  • 2021 American Transplant Congress

    Superior Post-transplant Clinical Outcomes Using Portable Normothermic Perfusion and Assessment with the Organ Care System (ocs) Liver System: 1-year Outcomes of the Ocs Liver Protect Randomized Controlled Trial

    J. Markmann1, M. Abouljoud2, M. Ghobrial3, C. Bhati4, S. Pelletier5, J. Magliocca6, T. Pruett7, A. Lu8, M. Rizzari9, S. Ottmann10, T. Klair11, C. Eymard12, G. Roll13, G. Reyes14, S. Black15, S. Florman16, S. Mirani17, C. Marsh18, G. Schnickel19, M. Kinkhabwala20, A. Demetris21, H. Yeh22, P. Vagefi23, M. MacConmara23

    1MGH, Boston, MA, 2Henry Ford, Detroit, MI, 3Houston Methodist, Houston, TX, 4Virginia Commonwealth, Richmond, VA, 5UVA, Charlottesville, VA, 6Emory, Atlanta, GA, 7U. Minnesota, Minneapolis, MN, 8Tampa General, Tampa, FL, 9Henry Ford, Detriot, MI, 10Johns Hopkins, Baltimore, MD, 11University of Texas HSC, San Antonio, TX, 12University of Tennessee HSC, Memphis, TN, 13UCSF, San Francisco, CA, 14U. Washington, Seattle, WA, 15Ohio State, Columbus, OH, 16Mt. Sinai, New York, NY, 17U. Nebraska, Omaha, NE, 18Scripps Clinic, San Diego, CA, 19U. San Diego, San Diego, CA, 20Montefiore, New York, MA, 21UPMC, Pittsburgh, PA, 22Massachusetts General Hospital, Boston, MA, 23UT Southwestern, Dallas, TX

    *Purpose: The OCS Liver PROTECT Trial was the first U.S. randomized controlled trial for liver perfusion and was designed to evaluate the impact of portable…
  • 2021 American Transplant Congress

    Cross-Circulation for Extracorporeal Liver Support in a Swine Model

    W. K. Wu1, A. Tumen1, J. W. Stokes2, R. Ukita2, A. E. Hozain3, C. R. Flynn2, M. J. Lee3, J. R. Talackine2, N. L. Cardwell2, J. A. Reimer3, M. Pinezich3, C. Benson2, G. Vunjak-Novakovic3, S. P. Alexopoulos2, M. Bacchetta2

    1co-first authors, Vanderbilt University Medical Center, Nashville, TN, 2Vanderbilt University Medical Center, Nashville, TN, 3Columbia University Medical Center, New York, NY

    *Purpose: Although machine perfusion has gained momentum as an organ preservation strategy in liver transplantation, significant organ shortages and waitlist mortality persist, highlighting unmet needs…
  • 2021 American Transplant Congress

    Successful Long Term Survival of Vascularized Composite Allografts After Extended Preservation at Subzero Temperatures Using Bioinspired Next Generation Cryoprotectants

    M. Kline1, S. Fidder2, A. Callegari1, A. Matoso2, B. Oh2, K. Lombardo2, J. Etra2, D. Vasilic3, A. Childs1, R. Redett2, G. Brandacher2, X. Wei1

    1X-Therma Inc., Richmond, CA, 2Johns Hopkins University School of Medicine, Baltimore, MD, 3Erasmus MC, Rotterdam, Netherlands

    *Purpose: Vascularized composite allotransplantation (VCA) is a viable reconstructive option for patients with devastating tissue defects. However, the field is constrained by short tolerable ischemia…
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