Articles tagged "Preservation"

2016 American Transplant Congress
Ex Vivo Perfusion of Porcine Forelimbs to Prolong Allowable Ischemia Time.
N. Krezdorn,¹ M. Kueckelhaus,² A. Dermietzel,² M. Alhefzi,¹ M. Aycart,¹ S. Fischer,³ T.-S. Win,¹ H. Kiwanuka,¹ E. Bueno,¹ B. Pomahac.¹
¹Department of Surgery, Division of Plastic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston; ²Department of Plastic Surgery, Burn Center, Sarcoma Reference Center, BG University Hospital Bergmannsheil, Bochum, Germany; ³Department of Hand, Plastic and Reconstructive Surgery, Burn Trauma Center, BG Trauma Center Ludwigshafen, Heidelberg, Germany.
PurposeSuccessful replantation in patients suffering from traumatic amputation of one or more extremities is limited by the muscle ischemia time of 4-6h, which also holds…
2016 American Transplant Congress
Replacing Cold Storage with Normothermic Ex Vivo Kidney Perfusion Improves Function of Grafts Retrieved After Circulatory Death (DCD).
J. Kaths,^1,2 Y.-M. Chun,¹ D. Cen,¹ J. Echeverri,¹ I. Linares,¹ P. Yip,³ R. John,³ D. Bagli,⁴ I. Mucsi,⁵ A. Ghanekar,¹ D. Grant,¹ L. Robinson,² M. Selzner.¹
¹Department of Surgery, Multi Organ Transplant Program, Toronto General Hospital, University Health Network, Toronto, ON, Canada; ²Division of Nephrology, The Hospital for Sick Children, Toronto, ON, Canada; ³Laboratory Medicine & Pathobiology, Toronto General Hospital, Toronto, ON, Canada; ⁴Departments of Surgery (Urology) & Physiology, The Hospital for Sick Children, Toronto, ON, Canada; ⁵Department of Medicine, Multi Organ Transplant Program, Toronto General Hospital, University Health Network, Toronto, ON, Canada.
Normothermic ex vivo kidney perfusion (NEVKP) and avoidance of static cold storage (SCS) is an attractive strategy to minimize injury of DCD kidney grafts. We…
2016 American Transplant Congress
Hydrogen Sulfide Treatment Mitigates Donor Tissue Necrosis During Prolonged Cold Storage and Improves Survival Following Allogeneic Renal Transplantation.
I. Lobb,^1,3 W. Liu,² J. Jiang,³ D. Lian,³ A. Sener.^1,3,4
¹Microbiology and Immunology, Western University Canada, London, ON, Canada; ²Pathology, Western University Canada, London, ON, Canada; ³Matthew Mailing Centre for Translational Transplant Studies, London Health Sciences Centre, London, ON, Canada; ⁴Surgery, Western University Canada, London, ON, Canada.
Organ procurement is inherently associated with ischemia-reperfusion injury (IRI), resulting from loss and subsequent restoration of blood flow, which is detrimental to short- and long-term…
2016 American Transplant Congress
Prolonged Normothermic Ex Vivo Kidney Perfusion Is a Safe Preservation Technique for Kidney Transplantation: A New Opportunity for the Storage, Assessment and Repair of Kidney Grafts.
J. Kaths,^1,2,3 J. Echeverri,¹ N. Goldaracena,¹ K. Louis,¹ Y.-M. Chun,¹ I. Linares,^1,3 A. Wiebe,¹ P. Yip,⁵ R. John,⁵ I. Mucsi,⁶ A. Ghanekar,¹ D. Bagli,^7,3 D. Grant,¹ L. Robinson,^2,3 M. Selzner.^1,3
¹Department of Surgery, Multi Organ Transplant Program, Toronto General Hospital, University Health Network, Toronto, ON, Canada; ²Division of Nephrology, The Hospital for Sick Children, Toronto, ON, Canada; ³Institute of Medical Science, University of Toronto, Toronto, ON, Canada; ⁴Department of General, Visceral, and Transplant Surgery, University Medical Center Mainz, Mainz, Germany; ⁵Laboratory Medicine & Pathobiology, Toronto General Hospital, University Health Network, Toronto, ON, Canada; ⁶Department of Medicine, Toronto General Hospital, University Health Network, Toronto, ON, Canada; ⁷Departments of Surgery (Urology) & Physiology, The Hospital for Sick Children, Toronto, ON, Canada.
Hypothermic kidney storage causes preservation injury. We investigated whether SCS can be safely replaced with prolonged normothermic ex vivo kidney perfusion (NEVKP). Right kidneys were…
2016 American Transplant Congress
Signs of a Dying Organ: Beyond Resistance in Subnormothermic Kidney Perfusion.
M. Blum, D. Urcuyo, Q. Liu, B. Soliman, T. Okamoto, D. Goldfarb, C. Quintini.
Cleveland Clinic, Cleveland, OH.
Purpose: In hypothermic machine preservation of the kidney, resistance is often used to assess organ quality. Since no prognostic standard yet exists for subnormothermic ex-vivo…
2016 American Transplant Congress
Ex-Vivo Normothermic Perfusion for Assessment of High Risk Deceased Donor Kidneys for Transplantation.
S. Kabagambe, I. Palma, Y. Smolin, T. Boyer, I. Palma, J. Sageshima, C. Santhanakrishnan, C. Troppmann, J. McVicar, R. Perez.
Surgery, University of California-Davis, Sacramento, CA.
Despite the organ shortage, many procured deceased donor kidneys are deemed too high risk for failure and discarded. Ex-vivo normothermic perfusion (EVNP) may be useful…
2016 American Transplant Congress
The Effect of the Use of a TNF-Alpha Inhibitor in Hypothermic Machine Perfusion on Kidney Function After Transplantation.
P. Diuwe,¹ P. Domagala,¹ R. Kieszek,¹ M. Wszola,¹ M. Serwanska-Swietek,¹ L. Paczek,² M. Durlik,³ A. Chmura,¹ A. Kwiatkowski.¹
¹Department of General Surgery and Transplantology, Medical University of Warsaw, Warsaw, Poland; ²Department of Immunology, Transplantology and Internal Medicine, Medical University of Warsaw, Warsaw, Poland; ³Department of Transplantology and Nephrology, Medical University of Warsaw, Warsaw, Poland.
Organ damage associated with processes occurring during the ischaemic period as well as during and after organ reperfusion is an important problem of transplantation medicine.The…
2016 American Transplant Congress
Kidney Transplants from Anuric Deceased Donors on Renal Replacement Therapy.
W. Bry, J. Bellingham, S. Katznelson, P. Patel, K. Ueda, H. Mahanty, N. Neidlinger, A. Hassoun, V. Peddi.
Transplantation, California Pacific Medical Center, San Francisco, CA.
Transplantation of deceased donor kidneys with Acute Kidney Injury (AKI) has become a generally well accepted practice with excellent results documented in the literature. The…
2016 American Transplant Congress
Storage Kidneys Prior to Transplantation Using First Polish Preservation Solution "Biolasol" – Preliminary Report.
A. Jozwik,¹ P. Domagala,¹ R. Kieszek,¹ M. Wszola,¹ M. Bieniasz,¹ M. Serwanska-Swietek,¹ M. Durlik,² F. Ryszka,³ A. Chmura,¹ A. Kwiatkowski.¹
¹Department of General Surgery and Transplantology, Medical University of Warsaw, Warsaw, Poland; ²Departments of Transplantology and Nephrology, Medical University of Warsaw, Warsaw, Poland; ³BIOCHEFA, Sosnowiec, Poland.
One of the factors affecting function of the transplanted organ is a method of its storage. The aim of the study is to evaluate the…
2016 American Transplant Congress
Cost-Effectiveness of Machine Perfusion Use After Long Cold Ischemic Time in a Kidney Transplantation Program.
A. Matos, D. Malheiros, S. Morgado, L. Requiao-Moura, M. Borrelli, M. Nogueira, M. Durao, E. Tonato, A. Pacheco-Silva.
Renal Transplantation Unit, Hospital Israelita Albert Einstein, Sao Paulo, Brazil.
In Brazil the incidence of DGF is very high (60-70%) mainly due to an inadequate care of the donors and long cold ischemia time. This…