Articles tagged "Preservation"

2016 American Transplant Congress
Can OPTN/UNOS Policies Be Effectively Transferred to Another Country's Healthcare System? Russian Case.
B. Yaremin,¹ A. Mironov,⁴ A. Kolsanov,² A. Navasardyan,¹ R. Akhmetshin,³ A. Starostina.²
¹Samara Regional Ministry of Health, Samara, Russian Federation; ²Operative Surgery Chair, Samara State Medical University, Samara, Russian Federation; ³Moscow Regional Ministry of Health, Moscow, Russian Federation; ⁴Samara Organ Procurement Organisation, Samara State Medical University, Samara, Russian Federation.
US Organ Procurement System known as one of the most advanced systems all over the World. Start of new transplant program in other country always…
2016 American Transplant Congress
Ex Situ Perfusion of a Human Limb for 24 Hours.
N. Werner,¹ F. Alghanem,¹ S. Rakestraw,¹ B. Nicely,² A. Olszewksi,² S. Rudich,² A. Rojas-Pena,¹ J. Magee,¹ K. Ozer.³
¹Transplant Surgery, University of Michigan, Ann Arbor, MI; ²Gift of Life Michigan, Ann Arbor, MI; ³Orthopedic Surgery, University of Michigan, Ann Arbor, MI.
Background: Vascularized composite tissue (limb) allografts are procured and cold stored (4[deg]C) until surgery. This process is time limited as the tissue has to be…
2016 American Transplant Congress
Normothermic Ex-Vivo Perfusion of the Intestine: The Introduction of an Innovative Physiologic Model with Novel Biomarkers.
B. Soliman, T. Okamoto, C. Quintini, Q. Liu, M. Fujiki, A. Khanna, K. Hashimoto, J. Fung, K. Abu-Elmagd.
General Surgery, Transplant Center, Cleveland Clinic Foundation, Cleveland, OH.
Purpose: Ischemia reperfusion injury is a major risk factor for short and long-term functional survival after intestinal transplantation. Normothermic machine perfusion is an emerging biotechnology…
2016 American Transplant Congress
Impact of Machine Perfusion on Long-Term Kidney Transplant Outcomes.
S. Sandal,^1,2 X. Luo,² A. Massie,² M. Cantarovich,¹ D. Segev.²
¹MUHC, Montreal, Canada; ²JHU, Baltimore.
Machine perfusion (MP) has been shown to decrease DGF rates in kidney transplant (KT) recipients when compared with static cold storage (CS). However, there is…
2016 American Transplant Congress
Normothermic Ex Vivo Liver Perfusion (NEVLP) Using Steen Solution as Preservation Technique for Liver Transplantation-First Clinical Results.
M. Selzner, N. Goldaracena, J. Echeverri, I. Linares, M. Kaths, N. Selzner, M. Cattral, E. Renner, A. Ghanekar, L. Lilly, P. Greig, I. McGilvray, D. Grant.
Surgery, Toronto General Hospital, Toronto, Canada.
The European trial investigating NEVLP as preservation technique for liver transplantation uses Gelafusine, a non-FDA approved bovine derived gelatin-based perfusion solution. In contrast, we report…
2016 American Transplant Congress
Is Prolonged Cold Ischemia a Contraindication to Using Kidneys from Acute Kidney Injury Donors?
M. Khan,¹ A. Carrier,¹ H. El-Hennawy,¹ A. Farney,¹ J. Rogers,¹ G. Orlando,¹ A. Reeves-Daniel,² A. Palanisamy,² M. Gautreaux,³ S. Iskandar,³ W. Doares,⁴ S. Kaczmorski,⁴ R. Stratta.¹
¹Surgery, Wake Forest, Winston-Salem, NC; ²Internal Medicine, Wake Forest, Winston-Salem, NC; ³Pathology, Wake Forest, Winston-Salem, NC; ⁴Pharmacy, Wake Forest, Winston-Salem, NC.
Elevated deceased donor (DD) serum creatinine (SCr) levels and prolonged cold ischemia time (CIT) are major independent reasons for kidney discard following organ recovery. Many…
2016 American Transplant Congress
Hypothermic Machine Perfusion Is Also Beneficial for Deceased Donor Kidneys When Cold Ischemic Time Is Short and a Short Cold Ischemic Time Is Also Beneficial When Kidneys Are Machine Perfused.
J. Kox,¹ C. Moers,² D. Monbaliu,³ A. Strelniece,⁴ J.-W. Treckmann,⁵ I. Jochmans,³ H. Leuvenink,² L. van Heurn,¹ J. Pirenne,³ A. Paul,⁵ R. Ploeg.^2,6
¹Dept. of Surgery, Maastricht University Medical Center, Maastricht, Netherlands; ²Dept. of Surgery, University Medical Center Groningen, Groningen, Netherlands; ³Abdominal Transplant Surgery, University Hospital Leuven, Leuven, Belgium; ⁴Eurotransplant, Leiden, Netherlands; ⁵General, Visceral and Transplantation Surgery, University Hospital Essen, Essen, Germany; ⁶Oxford Transplant Centre, Oxford, United Kingdom.
IntroductionHypothermic machine perfusion (HMP) of deceased donor kidneys is associated with better outcome compared to static cold storage (SCS). It is generally assumed that HMP…
2016 American Transplant Congress
Influence of Pancreas Import and Cold Ischemia on Outcomes Following Pancreas Transplantation.
M. Khan,¹ H. El-Hennawy,¹ J. Rogers,¹ A. Farney,¹ G. Orlando,¹ A. Reeves-Daniel,² A. Palanisamy,² R. Stratta.¹
¹Surgery, Wake Forest, Winston-Salem, NC; ²Internal Medicine, Wake Forest, Winston-Salem, NC.
Proposed changes in pancreas transplant (PT) allocation may improve organ sharing but increase cold ischemia time (CIT). Methods: We performed a single center, retrospective study…
2016 American Transplant Congress
Ex Vivo Perfusion of Porcine Forelimbs to Prolong Allowable Ischemia Time.
N. Krezdorn,¹ M. Kueckelhaus,² A. Dermietzel,² M. Alhefzi,¹ M. Aycart,¹ S. Fischer,³ T.-S. Win,¹ H. Kiwanuka,¹ E. Bueno,¹ B. Pomahac.¹
¹Department of Surgery, Division of Plastic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston; ²Department of Plastic Surgery, Burn Center, Sarcoma Reference Center, BG University Hospital Bergmannsheil, Bochum, Germany; ³Department of Hand, Plastic and Reconstructive Surgery, Burn Trauma Center, BG Trauma Center Ludwigshafen, Heidelberg, Germany.
PurposeSuccessful replantation in patients suffering from traumatic amputation of one or more extremities is limited by the muscle ischemia time of 4-6h, which also holds…
2016 American Transplant Congress
Replacing Cold Storage with Normothermic Ex Vivo Kidney Perfusion Improves Function of Grafts Retrieved After Circulatory Death (DCD).
J. Kaths,^1,2 Y.-M. Chun,¹ D. Cen,¹ J. Echeverri,¹ I. Linares,¹ P. Yip,³ R. John,³ D. Bagli,⁴ I. Mucsi,⁵ A. Ghanekar,¹ D. Grant,¹ L. Robinson,² M. Selzner.¹
¹Department of Surgery, Multi Organ Transplant Program, Toronto General Hospital, University Health Network, Toronto, ON, Canada; ²Division of Nephrology, The Hospital for Sick Children, Toronto, ON, Canada; ³Laboratory Medicine & Pathobiology, Toronto General Hospital, Toronto, ON, Canada; ⁴Departments of Surgery (Urology) & Physiology, The Hospital for Sick Children, Toronto, ON, Canada; ⁵Department of Medicine, Multi Organ Transplant Program, Toronto General Hospital, University Health Network, Toronto, ON, Canada.
Normothermic ex vivo kidney perfusion (NEVKP) and avoidance of static cold storage (SCS) is an attractive strategy to minimize injury of DCD kidney grafts. We…