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Articles tagged "Preservation solutions"

  • 2017 American Transplant Congress

    Extended Ex Vivo Kidney Perfusion Using Hemopure as an Oxygen Carrier: A Method to Preserve, Assess and Repair Discarded Organs.

    F. Fontan, M. Aburawi, N. Karimian, K. Uygun, F. Delmonico, H. Yeh, J. Markmann.

    Transplant Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA

    Background: Hypothermic non-oxygenated machine perfusion (HMP) is commonly used in kidney preservation, providing some advantage over static cold storage, as well as flow and resistance…
  • 2016 American Transplant Congress

    Significance of Preservation Fluid Cultures in Solid Organ Transplantation.

    H. Nam, N. Perni, K. Galen, M. Campara, R. Roca-Garcia, V. Yeldandi.

    University of Illinois at Chicago, Chicago.

    Introduction. The study aim was to determine microbiological characteristics of preservation fluid (PF) cultures in solid organ transplant (SOT) patients and to evaluate their impact…
  • 2016 American Transplant Congress

    Storage Kidneys Prior to Transplantation Using First Polish Preservation Solution "Biolasol" – Preliminary Report.

    A. Jozwik,1 P. Domagala,1 R. Kieszek,1 M. Wszola,1 M. Bieniasz,1 M. Serwanska-Swietek,1 M. Durlik,2 F. Ryszka,3 A. Chmura,1 A. Kwiatkowski.1

    1Department of General Surgery and Transplantology, Medical University of Warsaw, Warsaw, Poland; 2Departments of Transplantology and Nephrology, Medical University of Warsaw, Warsaw, Poland; 3BIOCHEFA, Sosnowiec, Poland.

    One of the factors affecting function of the transplanted organ is a method of its storage. The aim of the study is to evaluate the…
  • 2016 American Transplant Congress

    SLPI in the Perfusion Liquid: A Predictor Marker of Short and Long Term Clinical Outcomes.

    A. Dotta,1 F. Caro,2 K. Peña Ponce,1 N. Ambrosi,2 J. Salaberry,2 X. García,1 E. Minué,1 L. León,1 F. Sánchez,2 F. Togniolo,1 C. Incardona,3 E. Chuluyan,2 D. Casadei.1

    1Instituto de Nefrología, Caba, Argentina; 2CEFYBO-UBA, Caba, Argentina; 3Fundación GADOR, Caba, Argentina.

    A lot of efforts have been done to identify the risk factors that tend to diminish the incidence of delayed graft function (DGF). Recently, the…
  • 2015 American Transplant Congress

    Losartan Benefits Are Mediated Through SIRT1 Activation in Rat Reduced Size Orthotopic Liver Transplantation

    E. Pantazi,1 M. Bejaoui,1 M. Zaouali,1 E. Folch-Puy,1 A. Rolo,2,3 A. Panisello,1 C. Palmeira,2 J. Rosello-Catafau.1

    1Experimental Pathology, Institute of Biomedical Research of Barcelona (IIBB-CSIC), Barcelona, Spain; 2Department of Life Sciences, Faculty of Science and Technology, University of Coimbra, Coimbra, Portugal; 3Center for Neurosciences and Cell Biology, Department of Zoology, University of Coimbra, Coimbra, Portugal.

    Background: Silent Information Regulator 1 (SIRT1) is a histone deacetylase that has been associated with protective mechanisms against IRI, but its role in liver transplantation…
  • 2015 American Transplant Congress

    Lifor Organ Preservation Solution Protects Pulmonary Microvasculature in a Rat Model of Ex Vivo Lung Perfusion and Transplantation

    T. Okamoto,1,3 A. Yasuda,1,2 D. Mathisen,1,3 H. Ott.1,3

    1Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA; 2Department of Anesthesiology, Massachuetts General Hospital, Boston, MA; 3Department of Surgery, Massachuetts General Hospital, Boston, MA.

    A. Ex Vivo Lung Perfusion (EVLP) has emerged as an innovative method for lung preservation. Microvascular dysfunction and breakdown of endothelial barrier during EVLP are…
  • 2015 American Transplant Congress

    Preservation Solution Impacts Short- and Long-Term Survival in Orthotopic Heart Transplant Recipients

    C. Lewis,1 S. Jayarajan,1 S. Taghavi,1 S. Kadakia,1 V. Ambur,1 A. Shiose,3 G. Wheatley,3 L. Kaiser,2 T. Guy,3 Y. Toyoda.3

    1Department of Surgery, Temple University Hospital, Philadelphia, PA; 2Division of Thoracic Surgery, Temple University Hospital, Philadelphia, PA; 3Division of Cardiovascular Surgery, Temple University Hospital, Philadelphia, PA.

    Objectives: To examine the effect of three commonly used preservation solutions on short- and long-term survival after orthotopic heart transplantation (OHT) using a large national…
  • 2015 American Transplant Congress

    Targeting Complement Pathways During Ischemia and Reperfusion: Implications for the Prevention of Delayed Graft Function

    Z. Yu,1 S. Qi,2 M. Lasaro,1 K. Bouchard,1 C. Dow,1 K. Moore,1 Z. Wu,2 A. Barama,2 J. Xu,2 K. Johnson,1 A. Marozsan,1 Y. Wang.1

    1Pre-Clinical Sciences, Alexion Pharmaceutical Inc., Cheshire, CT; 2Department of Surgery, Hôpital Notre Dame and Université de Montréal, Montréal, QC, Canada.

    Complement system plays a critical role in ischemia-reperfusion injury (IRI), and contributes to DGF. The aim of this study was to evaluate the effects of…
  • 2015 American Transplant Congress

    Ischemic Cholangiopathy Following Liver Transplantation from Donation After Circulatory Death Donors: Role of Tissue Plasminogen Activator Flush

    C. Kubal,1 R. Mangus,1 J. Fridell,1 M. Wingler,2 S. Nagai,1 B. Ekser,1 J. Tector.1

    1Department of Surgery, Indiana University, Indianapolis, IN; 2Indiana Organ Procurement Organization, Indianapolis, IN.

    Background: Formation of microthrombi within the peribiliary arterial plexus causing necrosis of biliary epithelium may be responsible for ischemic cholangiopathy (IC) after donation after circulatory…
  • 2015 American Transplant Congress

    Can MitoQ Improve Renal and Mitochondrial Function Following Cold Storage and Transplantation?

    L. MacMillan-Crow,1 N. Parajuli,1 D. Borja-Cacho.

    1Pharmacology/Toxicology, Univ. of Arkansas for Medical Sciences, Little Rock, AR; 2Surgery, Univ. of Arkansas for Medical Sciences, Little Rock, AR.

    The overall goal of this study is to further evaluate the effectiveness of a potential new therapy designed to minimize damage during cold preservation, increase…
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