Articles tagged "Preclinical trails"

2020 American Transplant Congress
A Nonhuman Primate Model of Intestinal Transplantation – Technical Aspects and Early Outcomes
R. Schmitz¹, J. Yoon¹, M. Song¹, E. Jelly², A. P. Wax², S. J. Knechtle¹, D. L. Sudan¹, J. Kwun¹
¹Department of Surgery, Duke University Medical Center, Durham, NC, ²Department of Biomedical Engineering, Duke University, Durham, NC
*Purpose: Intestinal transplantation (IT) is the treatment of choice for patients with irreversible intestinal failure that experience complications from total parenteral nutrition. Long-term outcomes after…
2020 American Transplant Congress
Generation and Long-Term Culturing of AIPCs for Islet Replacement
J. B. Pollett¹, R. Bottino², S. Bertera², M. Trucco², N. Thai²
¹Imagine Pharma, Pittsburgh, PA, ²Allegheny Health Network, Pittsburgh, PA
*Purpose: Islet transplantation is one of the most promising hopes for a cure for type 1 diabetes, although islet shortage remains a serious concern. A…
2020 American Transplant Congress
Preclinical Study for Liver Allograft Tolerance after Rapid Immunosuppression Withdrawal Using Cynomolgus Monkeys
H. Sakai¹, E. Berglund¹, S. Chaudhry¹, Y. Kato¹, J. Weiner¹, P. Alonso-Guallart¹, N. Llore¹, K. Bruestle¹, F. Fredriksson¹, J. Stern¹, D. Ekanayake-Alper¹, M. Martinez², G. Pierre¹, M. Danton¹, S. Kofman¹, D. Ordanes¹, J. Lefkowitch³, A. Iuga¹, T. Kato⁴, M. Sykes¹, A. Griesemer¹
¹Columbia Center for Translational Immunology, Department of Medicine, Columbia University, New York, NY, ²Department of Pediatrics, Columbia University, New York, NY, ³Departments of Pathology and Cell Biology, Columbia University, New York, NY, ⁴Department of Surgery, Columbia University, New York, NY
*Purpose: Operational tolerance of liver allografts occurs in highly selected patients but cannot be reliably induced. Herein, we investigated if tolerance to liver can be…
2020 American Transplant Congress
Outcome of over 65 Years Old ESRD Patients Referred for Pre-Kidney Transplant Evaluation
A. M. Alabadi¹, A. H. Shaqaq¹, K. F. Hamawi¹, A. A. Alqatari², M. Alaskar², B. S. Alsadah², A. A. Alomran², K. B. Akkari¹
¹Multi Organ Transplant Center, King Fahad Specialist Hospital, Dammam, Saudi Arabia, ²Faculty of Medicine, Imam Abdulrahman bin Faisal University, Dammam, Saudi Arabia
*Purpose: Potential kidney transplant recipients over the age of 65 years of age form a significant proportion of the total referred for kidney transplant evaluation.…
2020 American Transplant Congress
A Mouse Model of Non-MHC Mismatches Recapitulates Chronic Allograft Dysfunction and I-IFTA
V. Pavlov¹, F. Garzon¹, R. Haroon Al Rasheed², K. Banu¹, F. ElSalem¹, L. Li¹, E. Cody¹, M. Planoutene¹, N. Chun¹, Z. Zhang¹, J. Leventhal¹, B. Murphy¹, P. Heeger¹, M. C. Menon¹
¹Medicine, Mount Sinai School of Medicine, New York, NY, ²Pathology, Mount Sinai School of Medicine, New York, NY
*Purpose: Fibrotic and atrophic changes or IF/TA is an important cause of graft loss. We reported that genome-wide donor-recipient non-HLA mismatches independently correlate with Banff…
2020 American Transplant Congress
Development and Cell Surface Testing of a Novel Nanofiber Technology for Targeted Delivery of Therapeutic Regulatory T Cells
J. M. Mathew¹, S. Lee², Y. Sambandam¹, L. A. Fraser², T. D. Clemons², A. Kolberg², J. He¹, L. C. Palmer², M. T. McClendon², Z. J. Zhang¹, J. R. Leventhal¹, S. I. Stupp², L. Gallon¹
¹Surgery -Transplant, Northwestern University, Chicago, IL, ²Simpson Querrey Institute, Northwestern University, Chicago, IL
*Purpose: Regulatory CD4+CD25+FOXP3+ T cells (Tregs) have been shown to induce tolerance in transplantation models, and to be increased in their numbers in tolerant human…
2020 American Transplant Congress
Neoadjuvant Gem/Cis Followed by Transarterial Radioembolization for Locally Advanced iCCA with Intent for Curative Resection
T. Baker, J. Fung, D. Disabato, A. Pillai, O. Ahmed, A. Liao
Transplantation Institute, The University of Chicago, Chicago, IL
*Purpose: Locally advanced intrahepatic cholangiocarcinoma (LAiCCA) has a traditionally poor prognosis with few curative surgical options and a high incidence of postop recurrence. The intent…
2020 American Transplant Congress
Life-Supporting Pig Thymus Plus Kidney Transplantation Leads to Generation of New Baboon T-Cells and Swine-Specific Hyporesponsiveness
Y. Okumura¹, K. Takeuchi¹, Y. Ariyoshi¹, T. Pomposelli¹, L. Boyd¹, D. Alper¹, K. Miyake¹, K. Okubo¹, S. Arn¹, D. Ayares², M. Lorber³, M. Sykes¹, D. Sachs¹, K. Yamada¹
¹Columbia Center for Translational Immunology, Columbia University, New York, NY, ²Revivicor Inc., Blacksburg, VA, ³Lung BioTechnology PBC, Silver Spring, MD
*Purpose: We have achieved greater than 6-month survivals in baboons that received vascularized thymus plus kidney xenotransplants (VT+K XTx). We assessed the thymic function and…
2020 American Transplant Congress
Prolonged Multitransgenic Pig Lung Survival with Attenuated Pulmonary Vascular Resistance Rise During Human Blood Perfusion
M. R. Connolly¹, L. Burdorf¹, S. Pratts¹, B. Cerel¹, Z. Abady¹, W. Quin², Y. Kan², J. Layer², M. Youd², W. Westlin², L. Yang², A. Azimzadeh¹, R. N. Pierson III¹
¹Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ²eGenesis, Cambridge, MA
*Purpose: Physiologic behavior of porcine lungs with multiple xeno-targeted genetic modifications, Pig 2.0, have not previously been evaluated.*Methods: Eight pairs of lungs from Pig 2.0…
2019 American Transplant Congress
Anti- CD154 / CD40 Costimulation Blockade is Superior to Tacrolimus in Prolonging Survival in Pig-to-Nonhuman Primate Renal Xenotransplantation
B. P. Lovasik¹, A. J. Matar¹, C. Breeden¹, J. Jenkins², J. Tector³, S. C. Kim¹, A. B. Adams¹
¹Emory Transplant Center, Emory University, Atlanta, GA, ²Yerkes National Primate Center, Emory University, Atlanta, GA, ³University of Alabama at Birmingham, Birmingham, AL
*Purpose: Costimulation blockade strategies targeting the CD40/CD154 pathway are highly effective in preventing xenograft rejection in pig-to-nonhuman primate (NHP) transplantation models. The aim of this…