2020 American Transplant Congress
Neoadjuvant Gem/Cis Followed by Transarterial Radioembolization for Locally Advanced iCCA with Intent for Curative Resection
Transplantation Institute, The University of Chicago, Chicago, IL
*Purpose: Locally advanced intrahepatic cholangiocarcinoma (LAiCCA) has a traditionally poor prognosis with few curative surgical options and a high incidence of postop recurrence. The intent…2020 American Transplant Congress
Life-Supporting Pig Thymus Plus Kidney Transplantation Leads to Generation of New Baboon T-Cells and Swine-Specific Hyporesponsiveness
*Purpose: We have achieved greater than 6-month survivals in baboons that received vascularized thymus plus kidney xenotransplants (VT+K XTx). We assessed the thymic function and…2020 American Transplant Congress
Prolonged Multitransgenic Pig Lung Survival with Attenuated Pulmonary Vascular Resistance Rise During Human Blood Perfusion
*Purpose: Physiologic behavior of porcine lungs with multiple xeno-targeted genetic modifications, Pig 2.0, have not previously been evaluated.*Methods: Eight pairs of lungs from Pig 2.0…2020 American Transplant Congress
A Nonhuman Primate Model of Intestinal Transplantation – Technical Aspects and Early Outcomes
*Purpose: Intestinal transplantation (IT) is the treatment of choice for patients with irreversible intestinal failure that experience complications from total parenteral nutrition. Long-term outcomes after…2020 American Transplant Congress
Generation and Long-Term Culturing of AIPCs for Islet Replacement
1Imagine Pharma, Pittsburgh, PA, 2Allegheny Health Network, Pittsburgh, PA
*Purpose: Islet transplantation is one of the most promising hopes for a cure for type 1 diabetes, although islet shortage remains a serious concern. A…2020 American Transplant Congress
Preclinical Study for Liver Allograft Tolerance after Rapid Immunosuppression Withdrawal Using Cynomolgus Monkeys
*Purpose: Operational tolerance of liver allografts occurs in highly selected patients but cannot be reliably induced. Herein, we investigated if tolerance to liver can be…2020 American Transplant Congress
Outcome of over 65 Years Old ESRD Patients Referred for Pre-Kidney Transplant Evaluation
*Purpose: Potential kidney transplant recipients over the age of 65 years of age form a significant proportion of the total referred for kidney transplant evaluation.…2020 American Transplant Congress
A Mouse Model of Non-MHC Mismatches Recapitulates Chronic Allograft Dysfunction and I-IFTA
*Purpose: Fibrotic and atrophic changes or IF/TA is an important cause of graft loss. We reported that genome-wide donor-recipient non-HLA mismatches independently correlate with Banff…2020 American Transplant Congress
Development and Cell Surface Testing of a Novel Nanofiber Technology for Targeted Delivery of Therapeutic Regulatory T Cells
*Purpose: Regulatory CD4+CD25+FOXP3+ T cells (Tregs) have been shown to induce tolerance in transplantation models, and to be increased in their numbers in tolerant human…2019 American Transplant Congress
A CMV Vaccine Based on Non-Replicating Lymphocytic Choriomeningitis Virus Vectors Expressing gB and pp65 is Safe and Immunogenic in Healthy Volunteers and Entering a Phase 2 Trial in Kidney Transplant Recipients
*Purpose: Cytomegalovirus (CMV) is a significant pathogen in pregnancy and immunocompromised patients. Antiviral prophylaxis is limited by toxicities, recurrent infection, and resistance. A safe and…
American Transplant Congress abstracts