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American Transplant Congress abstracts

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Articles tagged "Preclinical trails"

  • 2020 American Transplant Congress

    Neoadjuvant Gem/Cis Followed by Transarterial Radioembolization for Locally Advanced iCCA with Intent for Curative Resection

    T. Baker, J. Fung, D. Disabato, A. Pillai, O. Ahmed, A. Liao

    Transplantation Institute, The University of Chicago, Chicago, IL

    *Purpose: Locally advanced intrahepatic cholangiocarcinoma (LAiCCA) has a traditionally poor prognosis with few curative surgical options and a high incidence of postop recurrence. The intent…
  • 2020 American Transplant Congress

    Life-Supporting Pig Thymus Plus Kidney Transplantation Leads to Generation of New Baboon T-Cells and Swine-Specific Hyporesponsiveness

    Y. Okumura1, K. Takeuchi1, Y. Ariyoshi1, T. Pomposelli1, L. Boyd1, D. Alper1, K. Miyake1, K. Okubo1, S. Arn1, D. Ayares2, M. Lorber3, M. Sykes1, D. Sachs1, K. Yamada1

    1Columbia Center for Translational Immunology, Columbia University, New York, NY, 2Revivicor Inc., Blacksburg, VA, 3Lung BioTechnology PBC, Silver Spring, MD

    *Purpose: We have achieved greater than 6-month survivals in baboons that received vascularized thymus plus kidney xenotransplants (VT+K XTx). We assessed the thymic function and…
  • 2020 American Transplant Congress

    Prolonged Multitransgenic Pig Lung Survival with Attenuated Pulmonary Vascular Resistance Rise During Human Blood Perfusion

    M. R. Connolly1, L. Burdorf1, S. Pratts1, B. Cerel1, Z. Abady1, W. Quin2, Y. Kan2, J. Layer2, M. Youd2, W. Westlin2, L. Yang2, A. Azimzadeh1, R. N. Pierson III1

    1Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, 2eGenesis, Cambridge, MA

    *Purpose: Physiologic behavior of porcine lungs with multiple xeno-targeted genetic modifications, Pig 2.0, have not previously been evaluated.*Methods: Eight pairs of lungs from Pig 2.0…
  • 2020 American Transplant Congress

    A Nonhuman Primate Model of Intestinal Transplantation – Technical Aspects and Early Outcomes

    R. Schmitz1, J. Yoon1, M. Song1, E. Jelly2, A. P. Wax2, S. J. Knechtle1, D. L. Sudan1, J. Kwun1

    1Department of Surgery, Duke University Medical Center, Durham, NC, 2Department of Biomedical Engineering, Duke University, Durham, NC

    *Purpose: Intestinal transplantation (IT) is the treatment of choice for patients with irreversible intestinal failure that experience complications from total parenteral nutrition. Long-term outcomes after…
  • 2020 American Transplant Congress

    Generation and Long-Term Culturing of AIPCs for Islet Replacement

    J. B. Pollett1, R. Bottino2, S. Bertera2, M. Trucco2, N. Thai2

    1Imagine Pharma, Pittsburgh, PA, 2Allegheny Health Network, Pittsburgh, PA

    *Purpose: Islet transplantation is one of the most promising hopes for a cure for type 1 diabetes, although islet shortage remains a serious concern. A…
  • 2020 American Transplant Congress

    Preclinical Study for Liver Allograft Tolerance after Rapid Immunosuppression Withdrawal Using Cynomolgus Monkeys

    H. Sakai1, E. Berglund1, S. Chaudhry1, Y. Kato1, J. Weiner1, P. Alonso-Guallart1, N. Llore1, K. Bruestle1, F. Fredriksson1, J. Stern1, D. Ekanayake-Alper1, M. Martinez2, G. Pierre1, M. Danton1, S. Kofman1, D. Ordanes1, J. Lefkowitch3, A. Iuga1, T. Kato4, M. Sykes1, A. Griesemer1

    1Columbia Center for Translational Immunology, Department of Medicine, Columbia University, New York, NY, 2Department of Pediatrics, Columbia University, New York, NY, 3Departments of Pathology and Cell Biology, Columbia University, New York, NY, 4Department of Surgery, Columbia University, New York, NY

    *Purpose: Operational tolerance of liver allografts occurs in highly selected patients but cannot be reliably induced. Herein, we investigated if tolerance to liver can be…
  • 2020 American Transplant Congress

    Outcome of over 65 Years Old ESRD Patients Referred for Pre-Kidney Transplant Evaluation

    A. M. Alabadi1, A. H. Shaqaq1, K. F. Hamawi1, A. A. Alqatari2, M. Alaskar2, B. S. Alsadah2, A. A. Alomran2, K. B. Akkari1

    1Multi Organ Transplant Center, King Fahad Specialist Hospital, Dammam, Saudi Arabia, 2Faculty of Medicine, Imam Abdulrahman bin Faisal University, Dammam, Saudi Arabia

    *Purpose: Potential kidney transplant recipients over the age of 65 years of age form a significant proportion of the total referred for kidney transplant evaluation.…
  • 2020 American Transplant Congress

    A Mouse Model of Non-MHC Mismatches Recapitulates Chronic Allograft Dysfunction and I-IFTA

    V. Pavlov1, F. Garzon1, R. Haroon Al Rasheed2, K. Banu1, F. ElSalem1, L. Li1, E. Cody1, M. Planoutene1, N. Chun1, Z. Zhang1, J. Leventhal1, B. Murphy1, P. Heeger1, M. C. Menon1

    1Medicine, Mount Sinai School of Medicine, New York, NY, 2Pathology, Mount Sinai School of Medicine, New York, NY

    *Purpose: Fibrotic and atrophic changes or IF/TA is an important cause of graft loss. We reported that genome-wide donor-recipient non-HLA mismatches independently correlate with Banff…
  • 2020 American Transplant Congress

    Development and Cell Surface Testing of a Novel Nanofiber Technology for Targeted Delivery of Therapeutic Regulatory T Cells

    J. M. Mathew1, S. Lee2, Y. Sambandam1, L. A. Fraser2, T. D. Clemons2, A. Kolberg2, J. He1, L. C. Palmer2, M. T. McClendon2, Z. J. Zhang1, J. R. Leventhal1, S. I. Stupp2, L. Gallon1

    1Surgery -Transplant, Northwestern University, Chicago, IL, 2Simpson Querrey Institute, Northwestern University, Chicago, IL

    *Purpose: Regulatory CD4+CD25+FOXP3+ T cells (Tregs) have been shown to induce tolerance in transplantation models, and to be increased in their numbers in tolerant human…
  • 2019 American Transplant Congress

    A CMV Vaccine Based on Non-Replicating Lymphocytic Choriomeningitis Virus Vectors Expressing gB and pp65 is Safe and Immunogenic in Healthy Volunteers and Entering a Phase 2 Trial in Kidney Transplant Recipients

    C. N. Kotton1, M. Schwendinger2, G. Thiry3, B. De Vos4, F. De Boever5, G. Leroux-Roels6, A. Lilja7

    1Infectious Diseases Division, Boston, MA, 2Hookipa Biotech AG, Vienna, Austria, 3Hookipa Biotech GmbH, VIenna, Austria, 4Bejamad sprl/bvba, Beersel, Belgium, 5Centrum voor vaccinologie (CEVAC), Gdent, Belgium, 6Centrum voor vaccinologie (CEVAC), Gent, Belgium, 7Hookipa Biotech GmbH, Vienna, Austria

    *Purpose: Cytomegalovirus (CMV) is a significant pathogen in pregnancy and immunocompromised patients. Antiviral prophylaxis is limited by toxicities, recurrent infection, and resistance. A safe and…
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