Articles tagged "Post-transplant malignancy"

2017 American Transplant Congress
Genomic Diversity of Epstein-Barr Virus in Post-Transplant Lymphoproliferative Disorder.
E. Maloney, O. Martinez.
Program in Immunology, Stanford University School of Medicine, Stanford, CA
Purpose: In transplant recipients, Epstein-Barr Virus (EBV) is associated with the development of B cell lymphomas in post-transplant lymphoproliferative disorder (PTLD). We used next-generation sequencing…
2017 American Transplant Congress
Identification of Kidney Transplant Patients at Risk for Skin Cancer by Differentially Methylated Regions in T Cells.
F. Peters,¹ A. Peeters,¹ P. Mandaviya,² J. van de Wetering,¹ M. Betjes,¹ C. Baan,¹ K. Boer.¹
¹Nephrology and Transplantation, Erasmus MC, University Medical Center, Rotterdam, Netherlands; ²Clinical Chemistry, Erasmus MC, University Medical Center, Rotterdam, Netherlands
Skin cancer, specifically cutaneous squamous cell carcinoma (cSCC), is the most often occurring malignancy in patients after organ transplantation, with an incidence of 100-200 times…
2017 American Transplant Congress
Donor Derived and BK Virus Positive Urologic Cancers After Renal Transplantation.
V. Hellström,¹ G. Tufveson,¹ A. Wallgren,² A. Loskog,² E. Larsson,² T. Töttermann,² M. Bengtsson,² A. Laurell,² C. Lundberg,¹ B. Holmström,¹ G. Enblad,² T. Lorant.¹
¹Department of Surgical Sciences, Uppsala University, Uppsala, Sweden; ²Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
Background. Donor-derived tumours in organ recipients develop from donor tissue with no known pre-existing malignancy in the donor. In addition, polyoma BK virus (BKV) might…
2017 American Transplant Congress
BK Polyoma Virus and Malignancy: Cause or Co-Incidence?
R. Prashar, A. Shah, D. Stewart, S. Williamson, A. Patel.
Henry Ford Transplant Institute, Detroit, MI
BackgroundThe WHO agency for cancer research has classified BKV as "possibly carcinogenic".The etiological role of BKV in human cancer, however,remains controversial.We present 5 cases of…
2017 American Transplant Congress
Outcomes of Renal Disease Related to Monoclonal Gammopathy After Kidney Transplantation: A Single Center Experience.
T. Kaur, E. Poggio, S. Nurko.
Nephrology, Cleveland Clinic, Cleveland
Kidneys are commonly involved in patients with monoclonal gammopathies (MG). However, the role of kidney transplants (KTx) in MG still needs to be more clearly…
2017 American Transplant Congress
10 Years of DTAC Experience with Kaposi's Sarcoma – Not Just Another PTLD!
M. Nalesnik,¹ M. Clark,² S. Tlusty,² M. Michaels,¹ C. Wolfe.¹
¹DTAC, Richmond; ²United Network for Organ Sharing, Richmond
Background:Kaposi's Sarcoma (KS), a tumor derived from the oncogenic virus human herpesvirus-8 (HHV8) is strongly associated with immunodeficiencies. Classically seen with AIDS, it can also…
2016 American Transplant Congress
Outcomes of Solid Organ Transplant Recipients with Pre-Existing Malignancies.
S. Acuna,^1,2,3 R. Sutradhar,^1,2 J. Kim,^1,2,4 N. Baxter.^1,2,3
¹Institute of Health Policy, Management and Education, University of Toronto, Toronto, ON, Canada; ²Institute of Clinical Evaluative Sciences, Toronto, ON, Canada; ³Department of Surgery, St. Michael's Hospital, Toronto, ON, Canada; ⁴Department of Medicine, University Health Network, Toronto, ON, Canada.
Background: Pre-transplant malignancy (PTM) is considered a relative contraindication for transplantation due to the heightened risk of cancer recurrence associated with immunosuppression. However, little has…
2016 American Transplant Congress
Calcineurin Inhibitors Promote Metastasis in Post-Transplant Colorectal Cancer Through Cancer Related- Exosomes Released from Cancer Cells in TGF Beta Independent Epitheilal to Mesenquimal Transition.
V. Tubita,¹ J. Segui-Barber,⁴ M.-J. Ramírez-Bajo,¹ D. Moya-Rull,¹ P. Piselli,³ D. Verdirosi,³ F. Oppenheimer,^1,2,5 D. Serraino,⁶ H. Del Portillo,^4,7 F. Diekmann,^1,2,5 J. Campistol,^1,2,5 I. Revuelta.^1,2,5
¹Experimental Laboratory of Nephrology and Kidney Transplant, IDIBAPS, Barcelona, Spain; ²Department of Nephrology and Kidney Transplant, Hospital Clínic, Barcelona, Spain; ³Dipartamento di Epidemiologia e Ricerca Pre-Clinica, INMI “L. Spallanzani” IRCCC, Rome, Italy; ⁴ISGlobal, CRESIB, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain; ⁵National Network for Kidney Research (REDinREN), Carlos III Royal Institute, Ministry of Health, Madrid, Spain; ⁶IRCCS Centro di Riferimento Oncologico, Aviano, Italy; ⁷Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain.
Introduction: Cancer is one of the major causes of death in kidney transplantation. Despite more mortality in colon cancer (CRC), similar incidence than general population…
2016 American Transplant Congress
Long Term Outcome of Kidney Transplant Recipients Treated with Everolimus: Final 5-Years Results from the Certic Observational Study.
L. Furian,¹ L. Di Maria,² G. Cappelli,³ M. Carmellini,⁴ G. Spagnoletti,⁵ G. Piredda,⁶ P. Todeschini,⁷ S. Chiaramonte,⁸ G. Tisone.⁹
¹AOU di Padova, Padova, Italy; ²AOU Careggi, Firenze, Italy; ³AOUP di Modena, Modena, Italy; ⁴AOU Senese, Siena, Italy; ⁵PU A.Gemelli, Roma, Italy; ⁶AO G.Brotzu, Cagliari, Italy; ⁷AOP S.Orsola-Malpighi, Bologna, Italy; ⁸PO S.Bortolo, Vicenza, Italy; ⁹Fondazione PU Tor Vergata, Roma, Italy.
Everolimus is associated with long-term benefits, such as preserving renal function and reducing the incidence of infections, malignancies and major cardiovascular events (MACE). The Certic…
2016 American Transplant Congress
The First 48 Months of an Australian Renal and Liver Organ Transplant Dermatology Database.
L. Ge,^1,2 P. Lowe.^1,2
¹Department of Dermatology, Royal Prince Alfred Hospital, Sydney, NSW, Australia; ²Faculty of Medicine, University of Sydney, Sydney, NSW, Australia.
PurposeThere have been few studies of non-melanoma skin cancers in the Australian cohort, a population unique for its high ambient UV radiation and sun-long lifestyle.…