The First 48 Months of an Australian Renal and Liver Organ Transplant Dermatology Database.
1Department of Dermatology, Royal Prince Alfred Hospital, Sydney, NSW, Australia
2Faculty of Medicine, University of Sydney, Sydney, NSW, Australia.
Meeting: 2016 American Transplant Congress
Abstract number: B299
Keywords: Kidney, Liver, Post-transplant malignancy
Session Information
Date: Sunday, June 12, 2016
Session Name: Poster Session B: PTLD/Malignancies: All Topics
Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Halls C&D
Purpose
There have been few studies of non-melanoma skin cancers in the Australian cohort, a population unique for its high ambient UV radiation and sun-long lifestyle. Further research is crucial to facilitate local evidence based practice.
Methods
297 SOTRs attended the Royal Prince Alfred Hospital transplant dermatology clinic from August 2011 to August 2015. Data obtained prospectively from patients was collated in a Filemaker Pro database, specifically designed to sequentially record patient information for subsequent analysis.
Results
182 renal and 115 liver transplant patients are included in the database. At baseline entry into the database, 25% have a history of at least one squamous cell carcinoma (SCC), 21% have a history of at least one basal cell carcinoma (BCC) and 3% have had a melanoma.
Since August 2011, there were 251 histopathology proven SCCs, 162 BCCs, 11 keratoacanthomas (KAs) and 5 melanomas. The overall SCC:BCC ratio was 1.6:1.
The SCC:BCC ratio for renal transplant patients is 1.7:1 and the SCC:BCC ratio for liver transplant patients is 1.3:1. The mean SCC tumor accrual (SCCs/patient/year) was similar for liver and renal transplant patients (0.33 and 0.35/patient/year). The mean BCC tumor accrual (BCCs/patient/year) was also similar for liver and renal transplant patients (0.25 and 0.20/patient/year). More than 50% of patients currently on azathioprine or cyclosporine had developed a NMSC since transplant. The majority of NMSCs occurred in patients of Australian, English, Scottish, Irish or Northern European background.
Conclusion
SOTRs have a high incidence of non-melanoma skin cancers, particularly SCCs. Liver and renal transplant recipients have similar tumor accrual rate. Carcinogenic immunosuppressants such as azathioprine and cyclosporine, are associated with a greater risk of NMSC. Further research in the Australian SOTR population will ensure optimal evidence-based practice.
CITATION INFORMATION: Ge L, Lowe P. The First 48 Months of an Australian Renal and Liver Organ Transplant Dermatology Database. Am J Transplant. 2016;16 (suppl 3).
To cite this abstract in AMA style:
Ge L, Lowe P. The First 48 Months of an Australian Renal and Liver Organ Transplant Dermatology Database. [abstract]. Am J Transplant. 2016; 16 (suppl 3). https://atcmeetingabstracts.com/abstract/the-first-48-months-of-an-australian-renal-and-liver-organ-transplant-dermatology-database/. Accessed September 16, 2019.« Back to 2016 American Transplant Congress