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The First 48 Months of an Australian Renal and Liver Organ Transplant Dermatology Database.

L. Ge,1,2 P. Lowe.1,2

1Department of Dermatology, Royal Prince Alfred Hospital, Sydney, NSW, Australia
2Faculty of Medicine, University of Sydney, Sydney, NSW, Australia.

Meeting: 2016 American Transplant Congress

Abstract number: B299

Keywords: Kidney, Liver, Post-transplant malignancy

Session Information

Date: Sunday, June 12, 2016

Session Name: Poster Session B: PTLD/Malignancies: All Topics

Session Time: 6:00pm-7:00pm

 Presentation Time: 6:00pm-7:00pm

Location: Halls C&D

Related Abstracts
  • Dermatology Is an Essential Part of Transplant Care: Report of a Two-Year Experience from a Transplant Dermatology Center
  • Chemoprevention of Cutaneous Squamous Cell Carcinoma in Renal Transplant Recipients: A Case-Controlled Analysis.

Purpose

There have been few studies of non-melanoma skin cancers in the Australian cohort, a population unique for its high ambient UV radiation and sun-long lifestyle. Further research is crucial to facilitate local evidence based practice.

Methods

297 SOTRs attended the Royal Prince Alfred Hospital transplant dermatology clinic from August 2011 to August 2015. Data obtained prospectively from patients was collated in a Filemaker Pro database, specifically designed to sequentially record patient information for subsequent analysis.

Results

182 renal and 115 liver transplant patients are included in the database. At baseline entry into the database, 25% have a history of at least one squamous cell carcinoma (SCC), 21% have a history of at least one basal cell carcinoma (BCC) and 3% have had a melanoma.

Since August 2011, there were 251 histopathology proven SCCs, 162 BCCs, 11 keratoacanthomas (KAs) and 5 melanomas. The overall SCC:BCC ratio was 1.6:1.

The SCC:BCC ratio for renal transplant patients is 1.7:1 and the SCC:BCC ratio for liver transplant patients is 1.3:1. The mean SCC tumor accrual (SCCs/patient/year) was similar for liver and renal transplant patients (0.33 and 0.35/patient/year). The mean BCC tumor accrual (BCCs/patient/year) was also similar for liver and renal transplant patients (0.25 and 0.20/patient/year). More than 50% of patients currently on azathioprine or cyclosporine had developed a NMSC since transplant. The majority of NMSCs occurred in patients of Australian, English, Scottish, Irish or Northern European background.

Conclusion

SOTRs have a high incidence of non-melanoma skin cancers, particularly SCCs. Liver and renal transplant recipients have similar tumor accrual rate. Carcinogenic immunosuppressants such as azathioprine and cyclosporine, are associated with a greater risk of NMSC. Further research in the Australian SOTR population will ensure optimal evidence-based practice.

CITATION INFORMATION: Ge L, Lowe P. The First 48 Months of an Australian Renal and Liver Organ Transplant Dermatology Database. Am J Transplant. 2016;16 (suppl 3).

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To cite this abstract in AMA style:

Ge L, Lowe P. The First 48 Months of an Australian Renal and Liver Organ Transplant Dermatology Database. [abstract]. Am J Transplant. 2016; 16 (suppl 3). https://atcmeetingabstracts.com/abstract/the-first-48-months-of-an-australian-renal-and-liver-organ-transplant-dermatology-database/. Accessed March 1, 2021.

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