ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Post-transplant lymphoproliferative disorder (PTLD)"

  • 2020 American Transplant Congress

    Evaluation of Infectious and Malignant Complications in Elderly Renal Transplant Recipients Receiving Alemtuzumab Compared to Basiliximab

    K. Lang1, J. Shulte1, K. Cunningham1, C. D'Agostino1, M. Kapugi1, C. Kane1, A. Novak1, J. Leventhal2

    1Department of Pharmacy, Northwestern Memorial Hospital, Chicago, IL, 2Division of Transplant Surgery, Northwestern Memorial Hospital, Chicago, IL

    *Purpose: The choice of induction immunosuppression can affect several outcomes after kidney transplant (KTx), especially for elderly recipients. For this population, there is limited data…
  • 2020 American Transplant Congress

    Epstein-Barr Virus-Specific Cytotoxic T Lymphocyte Precursors (EBV-CTLp) after Tab-cel Correlates with Response & Survival in Rituximab Relapsing or Refractory Ebv+ Posttransplant Lymphoproliferative Disease (PTLD)

    R. Shen1, N. Guzman-Becerra1, Y. Sun1, F. Forozan1, S. Prockop2, E. Doubrovina2, R. O'Reilly2, X. Li1, M. Hiremath3, L. Gamelin1, W. Navarro1, B. Aftab1

    1Atara Biotherapeutics, Thousand Oaks, CA, 2Memorial Sloan Kettering Cancer Center, New York, NY, 3Atara Biotherapeutics, South San Francisco, CA

    *Purpose: EBV+ PTLD is often a fatal disease. Tab-cel is an investigational off-the-shelf, allogeneic T-cell immunotherapy specific for EBV antigens. Functional in vivo expansion approximated…
  • 2020 American Transplant Congress

    Transplant Monitoring and PTLD Detection with B Cell Receptor Repertoire Analysis in a Large Prospective Pediatric Cohort

    K. Jackson1, O. Martinez2, S. Krams2, M. Robien3, M. Lapasaran2, B. Armstrong4, C. Twist5, K. Weinberg6, D. Gratzinger1, B. Tam1, M. Sever4, M. Brown3, D. Bernstein6, C. Esquivel2, S. D. Boyd1

    1Department of Pathology, Stanford Univ School of Med, Stanford, CA, 2Department of Surgery/Division of Abdominal Transplantation, Stanford Univ School of Med, Stanford, CA, 3NIAID, NIH, Bethesda, MD, 4Rho, Chapel Hill, NC, 5Roswell Park, Buffalo, NY, 6Department of Pediatrics, Stanford Univ School of Med, Stanford, CA

    *Purpose: Post-transplant lymphoproliferative disorder (PTLD) remains a serious problem in the pediatric transplant population. The Clinical Trials of Organ Transplantation in Children (CTOT-C)-06 is a…
  • 2020 American Transplant Congress

    Outcomes of Kidney Retransplantation after Post-Transplant Lymphoproliferative Disorders: An Analysis of the UNOS/OPTN Database (1998 to 2019)

    W. Cheungpasitporn1, C. Thongprayoon2, C. C. Jadlowiec3, W. J. Chon4, L. S. Cummings4, S. R. Katari4, N. Leeaphorn4

    1Nephrology, University of Mississippi Medical Center, Jackson, MS, 2Nephrology and Hypertension, Mayo Clinic, Rochester, MN, 3Transplant Surgery, Mayo Clinic, Phoenix, AZ, 4Renal Transplant Program, University of Missouri-Kansas City School of Medicine/Saint Luke's Health System, Kansas City, MO

    *Purpose: Post-transplant lymphoproliferative disease (PTLD) is a serious, potentially fatal complication after kidney transplantation. Existing literature on outcomes of kidney retransplantation in patients with prior…
  • 2020 American Transplant Congress

    Patterns of Belatacept Use and Risk of Post-Transplant Lymphoproliferative Disorder (PTLD) in US Kidney Transplant Recipients – Analysis of Organ Procurement and Transplantation Network (OPTN) Database

    W. S. Cherikh1, T. Kou2, J. Foutz1, A. Gomez-Caminero2

    1United Network for Organ Sharing (UNOS), Richmond, VA, 2Bristol-Myers Squibb, Princeton, NJ

    *Purpose: Belatacept, a selective T-cell costimulation blocker, was approved in 2011 for the prophylaxis of organ rejection in Epstein-Barr virus (EBV)-seropositive kidney transplant recipients. PTLD…
  • 2020 American Transplant Congress

    Long-Term Outcomes of Patients with Epstein-barr Virus-Driven Post-Transplant Lymphoproliferative Disease Following Solid Organ Transplant or Allogeneic Hematopoietic Cell Transplant Treated with Tabelecleucel in an Expanded Access Program Study

    S. Prockop1, R. Reshaf2, D. Tsai3, N. Bunin4, R. Abu-Arja5, K. Mahadeo6, W. Weng7, K. Van Besien8, D. Loeb9, S. Dwivedy Nasta10, E. Nemecek11, M. Hiremath12, S. Yue12, Y. Sun12, W. Navarro12, S. Nikiforow13

    1Memorial Sloan Kettering Cancer Center, New York, NY, 2Columbia University Irving Medical Center, New York, NY, 3Loxo Oncology, Stamford, CT, 4The Children's Hospital of Philadelphia, Philadelphia, PA, 5Nationwide Children's Hospital, Columbus, OH, 6MD Anderson Cancer Center, Houston, TX, 7Stanford University School of Medicine, California, CA, 8Weill Cornell Medical College, New York, NY, 9Children's Hospital at Montefiore, Bronx, NY, 10University of Pennsylvania, Philadelphia, PA, 11Oregon Health & Science University, Portland, OR, 12Atara Biotherapeutics, New York, NY, 13Dana Farber Cancer Institute, Boston, MA

    *Purpose: There is a need for effective, well‑tolerated therapies in pts who develop Epstein-Barr virus-driven post-transplant lymphoproliferative disease (EBV+ PTLD) after solid organ (SOT) or…
  • 2019 American Transplant Congress

    Lower Rates of Epstein-Barr Virus Viremia and Post-Transplant Lymphoproliferative Disease in Pediatric Solid Organ Transplant Recipients Who Received Valganciclovir Prophylaxis

    E. A. Moulton1, M. Karandikar2, S. Bond3, S. Burchett2, T. Sharma2, F. M. Marty3

    1Baylor College of Medicine, Houston, TX, 2Boston Children's Hospital, Boston, MA, 3Brigham and Women's Hospital, Boston, MA

    *Purpose: Antiviral prophylaxis to prevent post-transplant lymphoproliferative disease (PTLD) remains controversial, but some data suggest that valganciclovir or ganciclovir use in Epstein-Barr virus (EBV) high-risk…
  • 2019 American Transplant Congress

    Regulation of Host microRNA Expression by Natural Variants of Epstein Barr Virus (EBV) Latent Membrane Protein 1 (LMP1)

    O. Hatton1, A. Harris-Arnold2, A. Hui2, E. Maloney2, S. M. Krams2, O. M. Martinez2

    1Molecular Biology, Colorado College, Colorado Springs, CO, 2Program in Immunology and Department of Surgery, Stanford University, Stanford, CA

    *Purpose: Malignancies attributable to EBV, such as post-transplant lymphoproliferative disorder (PTLD), represent 1.8% of global cancer deaths. PTLD occurs in 1-20% of transplant recipients and…
  • 2019 American Transplant Congress

    Mass Cytometry-Based Characterization of Adaptive Immunity in Transplant Recipients with Self-Limiting or Chronic EBV Viremia

    V. H. Ferreira1, C. J. Guidos2, A. Humar1, D. Kumar1

    1UHN, Toronto, ON, Canada, 2SickKids Research Inst, Toronto, ON, Canada

    *Purpose: SOT recipients are at high risk for EBV-associated PTLD. EBV viremia is a risk factor for PTLD. In some patients viremia is self-limited while…
  • 2019 American Transplant Congress

    Ex-Vivo Perfusion Mediated Delivery of Rituximab to Clear Latent Epstein-Barr Virus

    T. Ku, M. Cypel, R. V. Ribeiro, V. H. Ferreira, D. Kumar, A. Humar

    UHN, Toronto, ON, Canada

    *Purpose: Post-transplant lymphoproliferative disorder (PTLD) can manifest as a B-cell malignancy associated with Epstein-Barr virus (EBV) infection. Risk of PTLD is greatest in EBV D+/R-…
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