2020 American Transplant Congress
Outcomes of Kidney Retransplantation after Post-Transplant Lymphoproliferative Disorders: An Analysis of the UNOS/OPTN Database (1998 to 2019)
*Purpose: Post-transplant lymphoproliferative disease (PTLD) is a serious, potentially fatal complication after kidney transplantation. Existing literature on outcomes of kidney retransplantation in patients with prior…2020 American Transplant Congress
Patterns of Belatacept Use and Risk of Post-Transplant Lymphoproliferative Disorder (PTLD) in US Kidney Transplant Recipients – Analysis of Organ Procurement and Transplantation Network (OPTN) Database
1United Network for Organ Sharing (UNOS), Richmond, VA, 2Bristol-Myers Squibb, Princeton, NJ
*Purpose: Belatacept, a selective T-cell costimulation blocker, was approved in 2011 for the prophylaxis of organ rejection in Epstein-Barr virus (EBV)-seropositive kidney transplant recipients. PTLD…2020 American Transplant Congress
Long-Term Outcomes of Patients with Epstein-barr Virus-Driven Post-Transplant Lymphoproliferative Disease Following Solid Organ Transplant or Allogeneic Hematopoietic Cell Transplant Treated with Tabelecleucel in an Expanded Access Program Study
*Purpose: There is a need for effective, well‑tolerated therapies in pts who develop Epstein-Barr virus-driven post-transplant lymphoproliferative disease (EBV+ PTLD) after solid organ (SOT) or…2020 American Transplant Congress
Evaluation of Host Immune Responses to Epstein-Barr Virus in Lung Transplant Recipients
1Pulmonary and Critical Care, Duke University, Durham, NC, 2Duke University, Durham, NC
*Purpose: After lung transplantation, Epstein-Barr virus (EBV) is a common opportunistic infection. The significance of EBV viremia following solid organ transplantation (SOT) remains unclear. Host…2020 American Transplant Congress
Genome-Wide Analysis of Epstein Barr Virus Identifies Variations in the Latency Gene EBNA3C That Are Associated with Post Transplant Lymphoproliferative Disorder
Stanford University Sch of Med, Stanford, CA
*Purpose: Epstein Barr virus (EBV) is a gamma herpes virus that is associated with a variety of human malignancies including EBV+ B cell lymphomas in…2020 American Transplant Congress
Role of CAR-T Cell Therapy in Post Transplant Lymphoproliferative Disorder
Transplant, Washington University in St. Louis, Saint Louis, MO
*Purpose: Chimeric Antigen Receptor (CAR) T cells are a genetically modified autologous immunotherapy that uses a patient’s own T cells modified with a chimeric antigen…2020 American Transplant Congress
Malignancy Incidence after Pediatric Kidney Transplantation; a Single-Center Experience in Japan
*Purpose: The incidence of malignancy was higher in organ transplant recipients than in the general population, and malignancies are a well-recognized complication of organ transplantation.…2019 American Transplant Congress
Phylogenetic Analysis of the Epstein Barr Virus Nuclear Antigen-1 and Associated Correlates among Canadian Transplant Patients
*Purpose: The effect of the genetic diversity of the Epstein-Barr virus (EBV) on clinical outcomes in the transplant setting is important to study. We examined…2019 American Transplant Congress
Donor Derived Neoplasia: Will It Be a Risk after Clinical Pig Organ Xenotransplantation?
*Purpose: The survival of the nonhuman primates with life-supporting pig kidney grafts has increased substantially (to >1 year). As clinical pig organ xenotransplantation draws closer,…2019 American Transplant Congress
EBV+ PTLD Cell Lines Secrete Exosomes Containing microRNAs That Alter Immune Responses
Stanford Univ School of Med, Stanford, CA
*Purpose: Exosomes are nanometric (50-150nm) membrane vesicles that are released, into blood and other body fluids, by most cell types. Exosomes, which are generated from…
American Transplant Congress abstracts