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Articles tagged "Post-transplant lymphoproliferative disorder (PTLD)"

  • 2020 American Transplant Congress

    Outcomes of Kidney Retransplantation after Post-Transplant Lymphoproliferative Disorders: An Analysis of the UNOS/OPTN Database (1998 to 2019)

    W. Cheungpasitporn1, C. Thongprayoon2, C. C. Jadlowiec3, W. J. Chon4, L. S. Cummings4, S. R. Katari4, N. Leeaphorn4

    1Nephrology, University of Mississippi Medical Center, Jackson, MS, 2Nephrology and Hypertension, Mayo Clinic, Rochester, MN, 3Transplant Surgery, Mayo Clinic, Phoenix, AZ, 4Renal Transplant Program, University of Missouri-Kansas City School of Medicine/Saint Luke's Health System, Kansas City, MO

    *Purpose: Post-transplant lymphoproliferative disease (PTLD) is a serious, potentially fatal complication after kidney transplantation. Existing literature on outcomes of kidney retransplantation in patients with prior…
  • 2020 American Transplant Congress

    Patterns of Belatacept Use and Risk of Post-Transplant Lymphoproliferative Disorder (PTLD) in US Kidney Transplant Recipients – Analysis of Organ Procurement and Transplantation Network (OPTN) Database

    W. S. Cherikh1, T. Kou2, J. Foutz1, A. Gomez-Caminero2

    1United Network for Organ Sharing (UNOS), Richmond, VA, 2Bristol-Myers Squibb, Princeton, NJ

    *Purpose: Belatacept, a selective T-cell costimulation blocker, was approved in 2011 for the prophylaxis of organ rejection in Epstein-Barr virus (EBV)-seropositive kidney transplant recipients. PTLD…
  • 2020 American Transplant Congress

    Long-Term Outcomes of Patients with Epstein-barr Virus-Driven Post-Transplant Lymphoproliferative Disease Following Solid Organ Transplant or Allogeneic Hematopoietic Cell Transplant Treated with Tabelecleucel in an Expanded Access Program Study

    S. Prockop1, R. Reshaf2, D. Tsai3, N. Bunin4, R. Abu-Arja5, K. Mahadeo6, W. Weng7, K. Van Besien8, D. Loeb9, S. Dwivedy Nasta10, E. Nemecek11, M. Hiremath12, S. Yue12, Y. Sun12, W. Navarro12, S. Nikiforow13

    1Memorial Sloan Kettering Cancer Center, New York, NY, 2Columbia University Irving Medical Center, New York, NY, 3Loxo Oncology, Stamford, CT, 4The Children's Hospital of Philadelphia, Philadelphia, PA, 5Nationwide Children's Hospital, Columbus, OH, 6MD Anderson Cancer Center, Houston, TX, 7Stanford University School of Medicine, California, CA, 8Weill Cornell Medical College, New York, NY, 9Children's Hospital at Montefiore, Bronx, NY, 10University of Pennsylvania, Philadelphia, PA, 11Oregon Health & Science University, Portland, OR, 12Atara Biotherapeutics, New York, NY, 13Dana Farber Cancer Institute, Boston, MA

    *Purpose: There is a need for effective, well‑tolerated therapies in pts who develop Epstein-Barr virus-driven post-transplant lymphoproliferative disease (EBV+ PTLD) after solid organ (SOT) or…
  • 2020 American Transplant Congress

    Evaluation of Host Immune Responses to Epstein-Barr Virus in Lung Transplant Recipients

    L. Zaffiri1, J. E. Messinger2, J. Yi2, K. J. Weinhold2, G. Ferrari2, M. Luftig2, S. M. Palmer1

    1Pulmonary and Critical Care, Duke University, Durham, NC, 2Duke University, Durham, NC

    *Purpose: After lung transplantation, Epstein-Barr virus (EBV) is a common opportunistic infection. The significance of EBV viremia following solid organ transplantation (SOT) remains unclear. Host…
  • 2020 American Transplant Congress

    Genome-Wide Analysis of Epstein Barr Virus Identifies Variations in the Latency Gene EBNA3C That Are Associated with Post Transplant Lymphoproliferative Disorder

    E. Maloney, J. Toh, S. M. Krams, C. O. Esquivel, O. M. Martinez

    Stanford University Sch of Med, Stanford, CA

    *Purpose: Epstein Barr virus (EBV) is a gamma herpes virus that is associated with a variety of human malignancies including EBV+ B cell lymphomas in…
  • 2020 American Transplant Congress

    Role of CAR-T Cell Therapy in Post Transplant Lymphoproliferative Disorder

    S. Krishnamoorthy, A. Malone, R. Delos Santos, H. Murad, T. Alhamad

    Transplant, Washington University in St. Louis, Saint Louis, MO

    *Purpose: Chimeric Antigen Receptor (CAR) T cells are a genetically modified autologous immunotherapy that uses a patient’s own T cells modified with a chimeric antigen…
  • 2020 American Transplant Congress

    Malignancy Incidence after Pediatric Kidney Transplantation; a Single-Center Experience in Japan

    Y. Aoki1, H. Satoh1, R. Hamada2, R. Harada2, M. Muramatsu3, Y. Hamasaki3, S. Shishido3

    1Urology and Kidney Transplantation, Tokyo Metropolitan Children’s Medical Center, Tokyo, Japan, 2Nephrology, Tokyo Metropolitan Children’s Medical Center, Tokyo, Japan, 3Nephrology, Toho University, Faculty of Medicine, Tokyo, Japan

    *Purpose: The incidence of malignancy was higher in organ transplant recipients than in the general population, and malignancies are a well-recognized complication of organ transplantation.…
  • 2020 American Transplant Congress

    Incidence of Skin Cancer – A Long Term Outcome of Immunosuppression in Renal Transplant Recipients Associated with the Usage of Azathioprine

    H. Bheemreddy1, S. Yusuf1, N. Krishnan2, A. Imtiaz3

    1Health and Life Sciences, Coventry University, Coventry, United Kingdom, 2Renal Unit, University Hospital Coventry and Warwickshire NHS Trust, Coventry, United Kingdom, 3Department of Dermatology, University Hospital Coventry and Warwickshire NHS Trust, Coventry, United Kingdom

    *Purpose: The main cause of mortality in Kidney Transplant Recipient’s (KTRs) is malignancy. The cancer incidence is increased by treating with immunosuppressive agents and longer…
  • 2020 American Transplant Congress

    Impact of Immunosuppression Protocol on the Incidence of EBV Viremia and PTLD in Pediatric Kidney Transplant Recipients: A Single Center Experience

    K. Bowers1, V. M. Panzarino1, A. Campos1, J. Buggs2, V. D. Bowers2

    1Pediatrics, USF, Tampa, FL, 2Transplant Surgery, TGH, Tampa, FL

    *Purpose: The purpose of this study was to evaluate the efficacy of an immunosuppression protocol change, which included avoidance of anti-thymocyte globulin for induction and…
  • 2020 American Transplant Congress

    Causal Relationship between Anti-Thymocyte Globulin Induction Therapy and Development of Monomorphic PTLD in Renal Transplant Recipients

    K. Soliman1, H. Ali2, T. Fulop1, A. Osman3, A. Halawa4

    1Medicine, Medical University of South Carolina, Charleston, SC, 2Medicine, Royal Stoke, Royal Stoke, United Kingdom, 3Medicine, Cairo University, Cairo, Egypt, 4Medicine, University of Liverpool, Liverpool, United Kingdom

    *Purpose: The aim of our study is to explore the causality between ATG and different types of post-transplant lymphoproliferative disorder (PTLD) in renal transplant recipients…
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