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Articles tagged "Post-transplant diabetes"

  • 2017 American Transplant Congress

    Impact of NODAT on Post-Transplant Survival – An Analysis of UNOS Data.

    N. Sarabu, S. Deo, S. Park.

    University Hospital Cleveland Medical Center, Cleveland

    Background: New Onset Diabetes After Transplantation (NODAT) is common and may adversely affect long-term patient survival. Impact of NODAT on patient survival in heart transplantation…
  • 2017 American Transplant Congress

    Glucose Tolerance After Kideney Transplant Is Affected by Systemic Insulin Sensitivity Rather Than Usage of Tacrolimus.

    D. Iwami,1 A. Nakamura,2 K. Hotta,1 H. Sasaki,1 T. Hirose,1 H. Higuchi,1 Y. Takada,1 H. Miyoshi,2 N. Shinohara.1

    1Urology, Hokkaido University Hospital, Sapporo, Hokkaido, Japan; 2Internal Medicine II, Hokkaido University Hospital, Sapporo, Hokkaido, Japan

    Introduction and Objective: Tacrolimus and steroid can affect insulin secretion and insulin sensitivity, resulting in worsened glucose tolerance after kidney transplant (KTx). However, the effect…
  • 2017 American Transplant Congress

    The Impact of De Novo Post-Transplant Diabetes on Hepatic Steatosis and Liver Transplant Outcomes.

    C. Reuter,1 R.-A. Lee,1 R. Watkins,3 S. Lieber,2 K. Szempruch,1 D. Gerber,4 G. DeCherney,2 A. Barritt IV.2

    1Department of Pharmacy, UNC Health Care, Chapel Hill, NC; 2Department of Medicine, UNC Health Care, Chapel Hill, NC; 3UNC Center for Transplant Care, UNC Health Care, Chapel Hill, NC; 4Department of Surgery, UNC Health Care, Chapel Hill, NC

    Introduction: As the prevalence of diabetes (DM) increases in the general population, it is also increasing in the transplant (Tx) population. Post-transplant diabetes (PTDM) has…
  • 2016 American Transplant Congress

    Gut Dysbiosis and Metabolic Disorders in Kidney Transplant Recipients.

    M. Lecronier,1 P. Tashk,1 J. Aron-Wisnewsky,2,3,4 E. Denamur,1 O. Tenaillon,1 B. Barrou,4,5 J. Tourret.1,4,5

    1IAME, UMR 1137, INSERM, Paris, France; 2Institute of Cardiometabolism and Nutrition, ICAN, Service de Nutrition, GH Pitié-Salpêtrière Charles Foix, AP-HP, Paris, France; 3UMR_S U1166, équipe NutriOmics, INSERM, Paris, France; 4Sorbonne Universités, Université Pierre et Marie Curie, Paris, France; 5AP-HP, Département d'Urologie, Néphrologie et Transplantation, GH Pitié-Salpêtrière Charles Foix, Paris, France.

    IntroductionGut microbiota modifications (dysbiosis) have been observed in obese and/or diabetic patients. Kidney transplant recipients (KTR) are particularly exposed to the development of metabolic disorders,…
  • 2016 American Transplant Congress

    Can We Predict New-Onset Diabetes After Transplantation Previously?

    R. Imamura,1 K. Tsutahara,2 S. Nakazawa,1 Y. Kakuta,1 T. Abe,1 T. Takao,2 N. Ichimaru,3 S. Yamaguchi,2 S. Takahara,3 N. Nonomura.1

    1Urology, Osaka University Graduate School of Medicine, Suita, Japan; 2Urology, Osaka General Medical Center, Osaka, Japan; 3Advanced Technology for Transplantation, Osaka University Graduate School of Medicine, Suita, Japan.

    Objectives: New-onset diabetes after transplantation (NODAT), one of the important complications after kidneytransplantation, leads to reduce graft survival rate and increase patient morbidity and mortality.…
  • 2016 American Transplant Congress

    Positive Impact of a Pilot Pharmacist-Run Diabetes Pharmacotherapy Clinic in Solid Organ Transplant Recipients.

    D. Newland, A. Edwards, R. Hall, P. Maxwell.

    University Transplant Center, University Health System and The University of Texas Health Science Center at San Antonio, San Antonio, TX.

    Background: Post-transplant diabetes mellitus (PTDM) can lead to significant morbidity and cardiovascular death with a functioning graft. A paucity of literature exists regarding glycemic control…
  • 2016 American Transplant Congress

    A Genome Wide Association Study of New Onset Diabetes After Transplant in Kidney Transplantation.

    A. Giri,1 M. Sanders,2 D. Velez Edwards,1 T. Ikizler,3 D. Roden,3 K. Birdwell.3

    1Epidemiology, Vanderbilt University Medical Center, Nashville, TN; 2Medicine, University of Iowa, Iowa City, IA; 3Medicine, Vanderbilt University Medical Center, Nashville, TN.

    Purpose: New-onset diabetes after transplantation (NODAT) is associated increased mortality. Using a DNA biobank linked to electronic medical records (EMR) at Vanderbilt University (BioVU), we…
  • 2016 American Transplant Congress

    Higher Functional Capacity Prior to Kidney Transplant Confers Lower Risk of New Onset Diabetes After Transplantation.

    I. Qaqish, S. Behmen, R. Heilman, H. Khamash, J. Huskey, S. Nair, H. Chakkera.

    Mayo Clinic, Phoenix, AZ.

    Background: New onset diabetes after transplantation (NODAT) adversely impacts both allograft function and patient survival. We hypothesize that higher functional capacity prior to kidney transplant…
  • 2016 American Transplant Congress

    Cardiovascular Prognosis and Adverse Cardiac Events After Orthotopic Liver Transplantation.

    L. Potena, V. Manfredini, P. Prestinenzi, R. Alabrese, V. Bertuzzo, L. Borgese, M. Masetti, C. Morelli, F. Grigioni, A. Pinna.

    University of Bologna, Bologna, Italy.

    Cardiovascular (CV) disease is a major cause of morbidity and mortality among transplant candidate and recipients of noncardiac organs. Aiming to analyze the impact of…
  • 2016 American Transplant Congress

    Tacrolimus (Tac), Rather Than Cyclosporine (CsA), Interacts with Insulin Resistance (IR) to Alter Key Transcription Factors for β-Cell Identity & Function without Altering NFAT Localization.

    J. Triñanes,1 A. Rodriguez,2 E. de Koning,1 J. de Fijter,1 F. Carlotti,1 A. Torres,2 A. de Vries,1 E. Porrini.2

    1Nephrology, Leiden University Medical Center, Leiden, Netherlands; 2CIBICAN, University of La Laguna, Tenerife, Spain.

    Inhibiting the calcineurin(CN)/NFAT-pathway in β-cells may contribute to posttransplant diabetes. The presumed higher diabetogenicity of Tac is thought to owe to an IC50 for CN…
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