ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Post-transplant diabetes"

  • 2019 American Transplant Congress

    Efficacy and Safety with Empagliflozin in Renal Transplant Recipients with Post-Transplant Diabetes Mellitus

    K. E. Kvitne1, T. S. Halden2, A. Åsberg2, K. Midtvedt2, A. Hartmann2, T. Jenssen2

    1Department of Pharmaceutical Biosciences, School of Pharmacy, University of Oslo, Oslo, Norway, 2Department of Transplantation Medicine, Section of Nephrology, Oslo University Hospital, Rikshospitalet, Oslo, Norway

    *Purpose: Post-transplant diabetes mellitus (PTDM) is a highly prevalent condition following renal transplantation, associated with increased risk of cardiovascular disease and impaired patient survival. Sodium-glucose…
  • 2019 American Transplant Congress

    Belatacept Based Simultaneous Calcineurin Inhibitor Avoidance/Early Corticosteroid Withdrawal is Associated with Low New Onset Diabetes Risk

    A. R. Shields1, P. West-Thielke2, E. S. Woodle1, D. B. Kaufman3, J. Lipscomb4, J. P. Leone5, A. Wiseman6, E. King4, A. J. Matas7, R. R. Alloway for the BEST Study Group4

    1Transplant Surgery, U of Cincinnati, Cincinnati, OH, 2UIC, Chicago, IL, 3Transplant Surgery, U of Wisconsin, Madison, WI, 4U of Cincinnati, Cincinnati, OH, 5Tampa General, Tampa, FL, 6U of Colorado, Denver, CO, 7U Minnesota, Minneapolis, MN

    *Purpose: Calcineurin inhibitor (CNI) and/or corticosteroid (CCS) therapy are associated with significant risk of new onset diabetes after transplantation (NODAT). An important consideration for simultaneous…
  • 2019 American Transplant Congress

    Comparison of Two Glucagon-Like-Peptide-1 Analogs (GLP -1) Dulaglutide vs Liraglutide for the Management of Diabetes in Solid Organ Transplant (SOT)

    P. Singh, M. Taufeeq, T. E. Pesavento, K. Washburn, D. Walsh, S. Meng

    Ohio State University, Columbus, OH

    *Purpose: Poorly controlled Type-2 diabetes is an important contributor to graft dysfunction, and cardiovascular morbidity in the SOT. GLP-1-analog has been widely used in the…
  • 2019 American Transplant Congress

    TDCA/Valine Reverse Obesity and Ameliorate Alloimmune Responses through a Decreased Hypothalamic Expression of MCH

    A. ElKhal1, M. Markus Quante1, T. Heinbokel1, Y. Nian1, K. Minami1, R. Maenosono1, J. Iske1, B. Desai2, A. Banks2, E. Maratos-Flier2, A. Elkhal1, S. G. Tullius1

    1Brigham and Women's Hospital, Boston, AL, 2Beth Israel Deaconess Medical Center, Boston, AL

    *Purpose: Obesity is associated with low grade inflammation and bariatric surgery is the only effective treatment in reducing excess weight both pre- and post-transplant.*Methods: Here,…
  • 2019 American Transplant Congress

    Association Of Lymphocyte-depleting Antibody And Steroids Induction With The Risk And Outcomes Of Post-transplant Diabetes: Analysis Of Deceased-donor Kidney Transplants

    A. Santos1, J. Gregg2, U. L. Akanit3, K. Alquadan1, H. Bejjanki1, K. L. Womer1

    1Div. of Nephrology, Hypertension & Renal Transplantation, University of Florida, Gainesville, FL, 2University of Florida, Gainesville, FL, 3Ubon Ratchathani University, Ubonratchathani, Thailand

    *Purpose: We aimed to determine the risk and outcomes of post-transplant diabetes(PTDM) associated with combined lymphocyte-depleting antibody (LDA) [anti-thymocyte globulin (ATG) or alemtuzumab (ALM)] and…
  • 2019 American Transplant Congress

    Impact of Hepatitis C Viremia on Post-Transplant Diabetes Mellitus Development in Liver Transplant Recipients

    K. Klein1, J. Nelson2, B. Crowther1, C. Guerra3, E. Kincaide1, K. V. Speeg4, N. Alkhouri5, R. Hall1

    1University Health System, The University of Texas at Austin, College of Pharmacy, Pharmacotherapy Division, Austin, TX, The University of Texas Health Science Center at San Antonio, San Antonio, TX, 2University Health System, San Antonio, TX, 3The University of Texas Health Science Center at San Antonio, University of the Incarnate Word Feik School of Pharmacy, San Antonio, TX, 4University Health System, The University of Texas Health Science Center at San Antonio, San Antonio, TX, 5University Health System, The University of Texas Health Science Center at San Antonio, Texas Liver Institute, San Antonio, TX

    *Purpose: Compare incidence of post-transplant diabetes mellitus (PTDM) in hepatitis C virus (HCV) patients with and without viremia at the time of orthotopic liver transplantation…
  • 2019 American Transplant Congress

    Pharmacist-Led Management of Post-Transplant Hyperglycemia Reduces Hospitalizations

    V. H. Do1, I. Figueroa2, A. Elshafie3, R. Belfort De Aguiar3, D. Haakinson3, E. Cohen1

    1Yale New Haven Hospital, New Haven, CT, 2Western New England School of Pharmacy, Springfield, MA, 3Yale School of Medicine, New Haven, CT

    *Purpose: Renal transplant recipients (RTRs) are at risk of developing post-transplant hyperglycemia (PTHG), defined as blood glucose > 180 mg/dL within the first 45 days…
  • 2019 American Transplant Congress

    Serum Apolipoproteins B and A1 Predict the Development of Late Post-Transplant Diabetes Mellitus in Prevalent Adult Kidney Transplant Recipients

    R. Malyala, L. Rapi, M. Nash, G. Prasad

    St Michael's Hospital, University of Toronto, Toronto, ON, Canada

    *Purpose: Post-transplant diabetes mellitus (PTDM) increases adverse outcomes. The risk factors for PTDM have not been fully delineated. Glucose metabolism links closely to cholesterol metabolism.…
  • 2019 American Transplant Congress

    Tacrolimus Activated BMP Signaling Acts in Synergy with Stress-Activated FOXO1 to Induce Loss of Beta-Cell Function and Identity

    J. Trinañes1, P. ten Dijke2, T. J. Rabelink3, E. J. de Koning4, F. Carlotti1, A. P. de Vries1

    1Transplant Center, Leiden University Medical Center, Leiden, Netherlands, 2Molecular Cell Biology, Leiden University Medical Center, Leiden, Netherlands, 3of Nephrology, Leiden University Medical Center, Leiden, Netherlands, 4Nephrology, Leiden University Medical Center, Leiden, Netherlands

    *Purpose: Tacrolimus, the most widely used immunosuppressive drug, is known to be highly diabetogenic. It is thought to trigger β-cell death through inhibition of the…
  • 2019 American Transplant Congress

    Successful Kidney Transplant Improves Glucose Tolerance – A Paradoxical Report From A Single Center

    A. Mitsuke, H. Harada, H. Higuchi, N. Fukuzawa, H. Tanaka, T. Hirano, T. Sekii

    Kidney Transplantation Surgery, Sapporo City General Hospital, Sapporo, Japan

    *Purpose: Kidney recipients tend to impair glucose tolerance because of several factors such as post-operative obesity, and chronic exposure of some diabetogenic immunosuppressants like calcineurin…
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