Evolution of Body Composition and Associations to Glucose Metabolism During the First Year After Kidney Transplantation.
1Department of Transplantation Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway
2Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway
3School of Pharmacy, University of Oslo, Oslo, Norway
4Department of Endocrinology, Oslo University Hospital, Rikshospitalet, Oslo, Norway
5Metabolic and Renal Research Group, University of Tromsø, Tromsø, Norway.
Meeting: 2016 American Transplant Congress
Abstract number: 490
Keywords: Kidney transplantation, Metabolic complications, Post-transplant diabetes
Session Information
Date: Tuesday, June 14, 2016
Session Name: Concurrent Session: Diabetes and Obesity in Kidney Transplantation
Session Time: 4:30pm-6:00pm
Presentation Time: 4:42pm-4:54pm
Location: Room 302
Background. The evolution and association between body composition and glucose haemostasis after kidney transplantation has not been elucidated.
Methods. We investigated 150 consecutive patients without suspected diabetes 8-10 weeks after kidney transplantation and subsequently after one year. Oral glucose-tolerance tests and dual-energy x-ray absorptiometry (DXA) scans were performed. Body mass composition including VAT assessments were measured from DXA scans with a novel validated software.
Insulin levels in plasma were measured and resistance indexes (HOMA-IR) and insulin release indexes (HOMA-ß) were calculated.
Results. Median body weight increased from 74,5 to 76,9 kg (P<0.001) and total fat mass increased from 22,4kg to 25,0kg to (P<0.001) whereas bone mass and visceral fat mass remained unchanged (P <0.638 and P<0.13, respectively). Glucose metabolism improved after one year despite an increase in body fat and BMI . At baseline 13% of patients had PTDM, 19% had IGT and 68% had NGT. After one year 9% of patients had PTDM, 11% had IGT and 80% NGT. Insulin resistance index, HOMA-IR and insulin release index, HOMA-ß index remained unchanged.We addressed demographic and other baseline data that were potentially associated with a normal glucose tolerance after one year in a multivariate model. VAT percentage of fat <5% (HR=3.1, P=0.013), prednisolone dose <10 mg day (HR 3.9, P=0.013), age in the lower quartile (HR 3.2, P=0.047), and HOMA-IR index in lower quartile (HR=3.0, P= 0.04) were significant factors for prediction of normal glucose tolerance after one year. Body weight, BMI, sex, tacrolimus concentration, HOMA-ß index, use of live donor and preemptive transplantation were not significant predictors.
Conclusions. The body composition of non-diabetes kidney transplant recipients is changed during the first year with weight gain due to increased fat mass without a change in lean body mass. However, visceral fat content is not increased and glucose metabolism is generally improved.
CITATION INFORMATION: von Düring M, Hartmann A, Bollerslev J, Åsberg A, Godang K, Eide I, Dahle D, Jenssen T. Evolution of Body Composition and Associations to Glucose Metabolism During the First Year After Kidney Transplantation. Am J Transplant. 2016;16 (suppl 3).
To cite this abstract in AMA style:
Düring Mvon, Hartmann A, Bollerslev J, Åsberg A, Godang K, Eide I, Dahle D, Jenssen T. Evolution of Body Composition and Associations to Glucose Metabolism During the First Year After Kidney Transplantation. [abstract]. Am J Transplant. 2016; 16 (suppl 3). https://atcmeetingabstracts.com/abstract/evolution-of-body-composition-and-associations-to-glucose-metabolism-during-the-first-year-after-kidney-transplantation/. Accessed March 4, 2021.« Back to 2016 American Transplant Congress