2020 American Transplant Congress
Effect of Everolimus and Reduced Calcineurin Inhibitors on Biopsy Proven BK Virus Associated Nephropathy
Cleveland Clinic, Cleveland, OH
*Purpose: BK virus-associated nephropathy (BKVAN) is a clinically important entity that contributes to allograft loss in kidney transplant recipients (KTRs). Mammalian target of rapamycin inhibitors…2020 American Transplant Congress
Incidence and Risks Factors of Kidney Allograft Loss Due to BK Virus: UNOS Data Set
*Purpose: BK virus infection can lead to graft dysfunction and loss in kidney transplant patients. Incidence and prevalence of BK Viremia (BKV) and BK Virus…2020 American Transplant Congress
Pretransplant BKV-IgG Serostatus and BKV-Specific ELISPOT Assays for the Prediction of BKV Infection
*Purpose: BK Polyomavirus (BK) can lead to major infectious complications and damage to the graft in kidney transplantation (KT). We investigated whether pretransplant BK serostatus…2020 American Transplant Congress
Treatment of BK Viremia in Kidney Transplant Recipients: A Single-Center Experience
Rush University Medical Center, Chicago, IL
*Purpose: Over the past 10 years, our center has utilized various strategies in managing BK viremia in our kidney transplant recipients. Reducing immunosuppression (IMS) in…2020 American Transplant Congress
Role of Peptide Antigen, Antigen-Presenting Cells and CD4 T Cells in Modulating BK Polyomavirus (BKPyV)-Specific CD8 T Cell Responses In Vitro
Biomedicine, University of Basel, Basel, Switzerland
*Purpose: BKPyV persists as significant cause of premature kidney transplant failure. Current treatment is based on reducing immunosuppression to regain immune control over BKPyV replication…2020 American Transplant Congress
BK Viremia: A Double Edged Sword – The Impact of Immunosuppression Reduction on Allograft Rejection
*Purpose: BK viremia (BKV) increases the risk of renal allograft loss following transplant. Guidelines recommend reduction of immunosuppression (IS) after BKV diagnosis, however, the ideal…2020 American Transplant Congress
Molecular Diagnosis and Risk Prediction in BK Virus Nephropathy: Discovery and Multicenter Validation of Novel Intragraft Gene Expression Signatures
*Purpose: Novel tools are needed to improve diagnosis and risk prediction in BK virus nephropathy (BKVN). This study aimed to assess the utility of intragraft…2020 American Transplant Congress
Diligent Prospective BK Virus (BKV) Monitoring and Management Post Kidney Transplant to Mitigate Risk of BK Nephropathy and Rejection: A Single Center Experience
1Medical City Transplant Institute, Fort Worth, TX, 2Tarrant Nephrology Associates, Fort Worth, TX
*Purpose: BK viremia and nephropathy are evolving challenges in post-kidney transplants. Currently, monitoring and management strategies vary across centers. At our program, we prospectively monitor…2020 American Transplant Congress
Pathogenesis of Polyomavirus BK Nephropathy (BKVN): Insights from Quantitative Proteomics Profiling
*Purpose: Our current understanding of the pathogenesis of BKVN is based primarily on transcriptomics studies. However, proteins are the final effector molecules that mediate tissue…2020 American Transplant Congress
Reactivation of BK Polyomavirus after Kidney Transplantation: A Multi-Center Collaboration Examining the Impact of Adherence to a Screening Protocol on Clinical Outcomes
*Purpose: Reactivation of BK polyomavirus (BK) after kidney transplantation (KT) is common and can lead to adverse clinical outcomes such as allograft nephropathy (BKAN). In…
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