Articles tagged "Polyma virus"

2021 American Transplant Congress
Urine Donor-derived Cell-free is Valuable for Predicting BK Polyomavirus-associated Nephropathy in Kidney Transplant Recipients
G. Huang¹, X. Chen¹, Y. Huang¹, J. Li¹, R. Deng¹, W. Chen², J. Qiu¹, S. Deng¹, G. Chen¹, Q. Fu¹, C. Wu¹, J. Fei¹, L. Liu¹, L. Chen¹, C. Wang¹
¹Organ Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, ²Department of Pathology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
*Purpose: Our previous study has proved that urine donor-derived cell-free DNA (dd-cfDNA) can assist in the diagnosis of BK polyomavirus-associated nephropathy (BKPyVAN), but its specificity…
2021 American Transplant Congress
Treatment of Bk Virus With Intravenous Immunoglobulin in Pediatric Kidney Transplant
D. Mohammad, D. Kim, R. Baracco, G. Kapur, A. Jain
Pediatric Nephrology and Transplant Services, Children's Hospital of Michigan, Detroit, MI
*Purpose: To study the prevalence of BK viremia (BKV) and BK Virus Nephropathy (BKVN) utilizing plasma BK quantitative Polymerase Chain Reaction (qPCR) and report outcomes…
2021 American Transplant Congress
VP2 MRNA Distinguishes the Direct Injury and Inflammation Effects of Polyoma Virus (BK) Infection from the Cognate TCMR Response That Follows Immunosuppressive Minimization
P. F. Halloran¹, K. Famulski¹, K. S. Madill-Thomsen¹, G. Böhmig², G. Gupta³, M. Myślak⁴, O. Viklicky⁵, &. the INTERCOMEX Study Group⁶
¹Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, ²Medical University of Vienna, Vienna, Austria, ³Virginia Commonwealth University, Richmond, VA, ⁴Pomeranian Medical University, Szczecin, Poland, ⁵Institute for Clinical and Experimental Medicine, Prague, Czech Republic, ⁶., Edmonton, AB, Canada
*Purpose: BK virus nephropathy (BKN) and T cell-mediated rejection (TCMR) are difficult to distinguish by histology but often coexist due to the necessity for immunosuppression…
2020 American Transplant Congress
Role of Peptide Antigen, Antigen-Presenting Cells and CD4 T Cells in Modulating BK Polyomavirus (BKPyV)-Specific CD8 T Cell Responses In Vitro
M. Wilhelm, A. Kaur, M. Wernli, H. H. Hirsch
Biomedicine, University of Basel, Basel, Switzerland
*Purpose: BKPyV persists as significant cause of premature kidney transplant failure. Current treatment is based on reducing immunosuppression to regain immune control over BKPyV replication…
2020 American Transplant Congress
BK Viremia: A Double Edged Sword – The Impact of Immunosuppression Reduction on Allograft Rejection
A. Szczepanik¹, A. Bixby¹, C. Burrelli¹, A. Padiyar², T. Srinivas², K. Chavin³
¹Pharmacy, University Cleveland Medical Center, Cleveland, OH, ²Nephrology, University Cleveland Medical Center, Cleveland, OH, ³Surgery, University Cleveland Medical Center, Cleveland, OH
*Purpose: BK viremia (BKV) increases the risk of renal allograft loss following transplant. Guidelines recommend reduction of immunosuppression (IS) after BKV diagnosis, however, the ideal…
2020 American Transplant Congress
Molecular Diagnosis and Risk Prediction in BK Virus Nephropathy: Discovery and Multicenter Validation of Novel Intragraft Gene Expression Signatures
B. Adam¹, Z. Kikic², Y. Bouatou³, J. Gueguen³, B. Robin³, G. Reid¹, H. Regele², M. Rabant³, A. Loupy³, M. Mengel¹
¹University of Alberta, Edmonton, AB, Canada, ²Medical University of Vienna, Vienna, Austria, ³Paris Transplant Group, Paris, France
*Purpose: Novel tools are needed to improve diagnosis and risk prediction in BK virus nephropathy (BKVN). This study aimed to assess the utility of intragraft…
2020 American Transplant Congress
Diligent Prospective BK Virus (BKV) Monitoring and Management Post Kidney Transplant to Mitigate Risk of BK Nephropathy and Rejection: A Single Center Experience
A. Dao¹, M. Madhrira², S. Allam²
¹Medical City Transplant Institute, Fort Worth, TX, ²Tarrant Nephrology Associates, Fort Worth, TX
*Purpose: BK viremia and nephropathy are evolving challenges in post-kidney transplants. Currently, monitoring and management strategies vary across centers. At our program, we prospectively monitor…
2020 American Transplant Congress
Pathogenesis of Polyomavirus BK Nephropathy (BKVN): Insights from Quantitative Proteomics Profiling
P. Randhawa¹, F. Fei², Y. Huang³, G. Tseng⁴, K. Xiao⁵
¹UPMC-Montefiore Hospital, Pittsburgh, PA, ²Pharmacology and Chemical Biology,, University of Pittsburgh, Pittsburgh, PA, ³Univeristy of Pittsburgh, Pittsburgh, PA, ⁴Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, ⁵Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA
*Purpose: Our current understanding of the pathogenesis of BKVN is based primarily on transcriptomics studies. However, proteins are the final effector molecules that mediate tissue…
2020 American Transplant Congress
Reactivation of BK Polyomavirus after Kidney Transplantation: A Multi-Center Collaboration Examining the Impact of Adherence to a Screening Protocol on Clinical Outcomes
R. Rogers¹, F. Cheema², M. Chobanian³, Z. Ebcioglu², H. Gilligan⁴, R. Gohh¹, N. Goyal⁵, M. Pavlakis⁶, N. Rodig⁷, A. Rossi⁸, J. Singh², C. S. Tan⁶
¹Warren Alpert Medical School of Brown University, Providence, RI, ²Hartford Hospital, Hartford, CT, ³Geisel School of Medicine at Dartmouth, Hanover, NH, ⁴Massachusetts General Hospital, Boston, MA, ⁵Tufts University School of Medicine, Boston, MA, ⁶Beth Israel Deaconess Medical Center, Boston, MA, ⁷Boston Children's Hospital, Boston, MA, ⁸Maine Medical Center, Portland, ME
*Purpose: Reactivation of BK polyomavirus (BK) after kidney transplantation (KT) is common and can lead to adverse clinical outcomes such as allograft nephropathy (BKAN). In…
2020 American Transplant Congress
Viral Integration In BK Polyomavirus-Associated Urothelial Carcinoma in Renal-Transplant Recipients: Multistage Carcinogenesis Revealed by Next Generation Virome Capture Sequencing
Y. Wang¹, Y. Liu¹, W. Deng¹, F. Fu¹, S. Yan¹, H. Yang¹, M. Luo², R. Liu¹, J. Geng¹, J. Xu¹, Y. Wu¹, J. Ma³, J. Zhou³, N. Liu³, Y. Jin¹, R. Xia¹, N. Elias⁴, R. J. Lee⁵, A. S. Feldman⁶, M. L. Blute⁶, R. B. Colvin⁷, C. Wu⁷, Y. Miao¹
¹Department of Organ Transplantation, Nanfang Hospital, Southern Medical University, Guangzhou, China, ²State Key Laboratory of Virology, Wuhan Institute of Virology, Wuhan, China, ³Mygenostics Co., Beijing, China, ⁴Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁵Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁶Department of Urology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁷Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA
*Purpose: To elucidate the mechanism of carcinogenesis by BK Polyomavirus (BKV) integration in immunocompromised patients.*Methods: Virome capture sequencing and whole genome sequencing were performed on…

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