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American Transplant Congress abstracts

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Articles tagged "Polyma virus"

  • 2022 American Transplant Congress

    Treatment of BK Virus with Weekly Intravenous Immunoglobulin in Adult Kidney Transplant Recipients

    G. Girone1, W. Asch2

    1Department of Pharmacy, Yale New Haven Hospital, New Haven, CT, 2Section of Nephrology, Yale School of Medicine, New Haven, CT

    *Purpose: The typical management of Polyoma BK virus (BKV) in kidney transplant recipients (KTR) includes reducing immunosuppression (IS). Intravenous immunoglobulin (IVIG) has been utilized for…
  • 2022 American Transplant Congress

    Is BK After SPK Okay?: Kidney and Pancreas Transplant Outcomes After BK Viremia

    G. Dube1, K. McCune2, D. Cohen3, L. Ratner2, S. Husain1

    1Columbia University Medical Center, New York, NY, 2Columbia University, New York, NY, 3Columbia University Med Ctr, New York, NY

    *Purpose: BK viremia and BK nephropathy (BKN) are common after kidney transplant alone, occurring in ~15% and ~1-10%, and are associated with an increased risk…
  • 2022 American Transplant Congress

    BK Viremia in Living vs Deceased Donor Renal Transplant Recipients Receiving Alemtuzumab Induction

    J. P. Casale1, D. Pluckrose1, A. Haririan2, T. Sparkes1

    1University of Maryland Medical Center, Baltimore, MD, 2Univ of Maryland Schl of Med, Baltimore, MD

    *Purpose: There is conflicting data regarding the association of donor type and BK viremia in renal transplant recipients. This study sought to compare the incidence…
  • 2022 American Transplant Congress

    High Incidence of BKPyV DNAemia After Simultaneous Pancreas-Kidney Transplantation

    I. Helanterä1, J. Räihä1, S. von Moos2, I. Lautenschlager3, V. Sallinen1, M. Lempinen1, T. Schachtner2

    1Transplantation and Liver Surgery, Helsinki University Hospital, Helsinki, Finland, 2University Hospital Zurich, Zurich, Switzerland, 3Department of Virology and Immunology, Helsinki University Hospital, Helsinki, Finland

    *Purpose: Polyomavirus BK (BKPyV) commonly reactivates after kidney transplantation and causes significant morbidity and increased risk of graft loss. However, data on the burden of…
  • 2022 American Transplant Congress

    Leflunomide in Children with BK Polyomavirus Viremia After Kidney Transplant

    J. Hewlett1, K. Le Palma1, L. Galea1, J. Savant1, S. Lopez1, J. V. Rosano2, A. Strong1, B. Viteri1, C. LaRosa1, S. Amaral1, B. Laskin1

    1The Children's Hospital of Philadelphia, Philadelphia, PA, 2Yale New Haven Health, New Haven, CT

    *Purpose: Studies examining the use of leflunomide in treating BK polyomavirus (BKPyV) viremia in children after kidney transplant are limited to case reports with small…
  • 2022 American Transplant Congress

    Single-Cell RNA Sequencing Highlights the Role of Epithelial-Immune Dual Feature of Proximal Tubule Cells in BK Virus Nephropathy

    G. Huang, F. Yang, X. Chen, G. Zhao, H. Zhang, J. Luo, S. Yang, L. Zhou

    Organ Transplant Center, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China

    *Purpose: BK virus nephropathy (BKVN) may cause renal allograft dysfunction and failure. However, a specific antiviral agent for BK virus does not exist. Increasing evidence…
  • 2022 American Transplant Congress

    Non-Invasive Metabolite-Based Urine Signature Detects Over-Immunosuppression in Renal Transplant Recipients

    S. Raghavendra Rao1, C. Honrao1, L. O. Rodrigues1, C. Dong1, K. Sonkar1, J. Wolf1, E. M. O'Day1, D. R. Kuypers2

    1Olaris, Inc., Framingham, MA, 2Department of Nephrology and Renal Transplantation, University Hospitals, Leuven, Belgium

    *Purpose: Managing complications related to over-immunosuppression represents a growing challenge in post-transplant care, with infections accounting for the second leading cause of death with functioning…
  • 2021 American Transplant Congress

    Immunosuppression Reduction Strategies for Polyoma BK Viremia in Kidney Transplant Patients on Belatacept-Based Immunosuppression

    O. Roe1, E. Meredith1, A. Reid2, A. Basu3

    1Emory University Hospital, Atlanta, GA, 2University of California San Francisco Medical Center, San Francisco, CA, 3Emory Transplant Center, Atlanta, GA

    *Purpose: The mainstay of treatment for BK infection is immunosuppression (IS) reduction, however limited literature provides guidance for treatment of patients with a belatacept-based IS…
  • 2021 American Transplant Congress

    Development of De Novo Antibody in Renal Transplant Recipients with BK Viremia Managed with Immunosuppression Reduction

    R. Hod Dvorai1, R. Lee2, P. Muluhngwi2, M. Raijmakers3, A. Shetty2, A. Tambur2, M. Ison2

    1SUNY Upstate Medical University, Syracuse, NY, 2Northwestern University, Chicago, IL, 3University of Santiago, Santiago, Chile

    *Purpose: To evaluate development of de novo donor specific antibodies (dnDSA) in Renal Transplant Recipients (RTR) with immunosuppression (IS) modulation due to BK viremia (BKV)…
  • 2021 American Transplant Congress

    Association of Donor Hepatitis C Virus Infection Status and Risk of Bk Polyomavirus Viremia After Kidney Transplantation

    V. S. Potluri1, D. E. Schaubel1, M. E. Sise2, B. P. Concepcion3, R. C. Forbes1, E. A. Blumberg1, D. Goldberg4, P. P. Reese1, R. Bloom1, D. Shaffer3, R. Chung2, D. Sawinski1, I. Strohben2, N. Elias2, A. Azhar5, M. Shah1, J. Eason5, L. A. Binari3, M. Talwar5, V. Balaraman5, A. Bhalla5, B. Besharatian1, M. Z. Molnar5

    1University of Pennsylvania, Philadelphia, PA, 2Massachusetts General Hospital, Boston, MA, 3Vanderbilt University Medical Center, Nashville, TN, 4University of Miami Miller School of Medicine, Miami, FL, 5Methodist University Hospital, Memphis, TN

    *Purpose: Transplantation of kidneys from deceased donors with hepatitis C virus (HCV) infection into HCV-negative recipients has become more common, but some studies have suggested…
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