Articles tagged "Polyma virus"

2022 American Transplant Congress
BK Polyomavirus Infection is Not Associated with a Meaningful Increase in Donor-Derived Cell-Free DNA
J. Fisher¹, K. Vieira¹, R. Burke², R. Gohh¹, R. Rogers¹
¹Warren Alpert Medical School of Brown University, Providence, RI, ²CareDx, Brisbane, CA
*Purpose: Donor-derived cell-free DNA (dd-cfDNA) is a non-invasive measure of early allograft injury that has been clinically validated as a surveillance tool to detect antibody…
2022 American Transplant Congress
Kinetic Analysis of Post-Clearance Phase Inflammation in Kidney Biopsies After BK Viremia
M. Vincent¹, J. T. Rajagopal¹, E. Farkash²
¹University of Michigan, Ann Arbor, MI, ²Dept. of Pathology, University of Michigan, Ann Arbor, MI
*Purpose: During the post-clearance phase of BK polyomavirus nephropathy, tubulointerstitial inflammation can persist despite resolution of BK viremia. This inflammation is indistinguishable from low grade…
2022 American Transplant Congress
Dd-cfdna Correlates With Acute Rejection In The Setting Of Bk Viremia After Kidney Transplantation
N. M. Ali¹, J. Miles², V. Tatapudi¹, R. Chand¹, R. Montgomery¹
¹NYU Langone Transplant Institute, New York, NY, ²CareDx, Brooklyn, NY
*Purpose: BK virus reactivation is common among kidney transplant recipients (KTRs) and is a risk factor for allograft loss. Currently, there is no clearly established…
2022 American Transplant Congress
BK Polyomavirus and Cytomegalovirus Infections in Kidney Transplantation from Hepatitis C Positive Donors to Uninfected Recipients
I. Yakubu, V. Amrutiya, I. Moinuddin, M. Levy, G. Gupta, A. Azhar
Virginia Commonwealth University, Richmond, VA
*Purpose: Transplantation of hepatitis C viremic (HCV) donor kidneys into uninfected recipients (D+/R-) is becoming more common in the United States. However, the long-term risks…
2022 American Transplant Congress
Posoleucel as Preemptive Therapy for BKV Infection in Kidney Transplant Recipients: Safety and Tolerability in a Phase 2 Trial
R. K. Wali¹, M. Singh², D. Wojciechowski³, M. J. Ansari⁴, B. Lonze⁵, V. Nair⁶, A. Sharma⁷, S. Knechtle⁸, F. Cardarelli⁹, A. Chandraker¹⁰
¹Inova Transplant Center, Falls Church, VA, ²U. of Pittsburg Medical Center, Harrisburg, PA, ³UT Southwestern Medical Center, Dallas, TX, ⁴Northwestern U. Feinberg School of Medicine, Chicago, IL, ⁵NYU Langone Transplant Institute, New York, NY, ⁶Northwell Health, Manhasset, NY, ⁷U. of Pittsburgh Medical Center, Pittsburgh, PA, ⁸Duke U. School of Medicine, Durham, NC, ⁹AlloVir, Cambridge, MA, ¹⁰Brigham & Women's Hospital, Boston, MA
*Purpose: Kidney transplant (KT) recipients with BK viremia are at risk for BK virus (BKV) nephropathy and graft loss. There are no approved therapies for…
2022 American Transplant Congress
Early Tacrolimus Exposure is Associated with BK-Viremia in Kidney Transplant Recipients
S. Meziyerh, A. L. van Rijn, D. van der Helm, P. J. van der Boog, T. van Gelder, A. C. Kroes, J. W. de Fijter, D. J. Moes, J. I. Rotmans, M. C. Feltkamp, A. P. de Vries
LUMC, Leiden, Netherlands
*Purpose: There is scant evidence to what extent maintenance immunosuppression is quantitatively associated with BK viremia. We investigated the association between tacrolimus (tac) whole blood…
2022 American Transplant Congress
RBBP7 as a Novel Biomarker for the Molecular Diagnosis of BK Virus-Associated Nephropathy
W. Yicun, W. Yuxuan, H. Xiaopeng
Department of Urology, Beijing Chaoyang Hospital, Beijing, China
*Purpose: BK virus-associated nephropathy (BKVN) remains a major infectious complication of kidney transplantation, and its histologic appearance can mimic rejection, leading to a diagnostic dilemma…
2021 American Transplant Congress
Dissecting the Intrarenal Immune Response to Viral Infected Cells in Pediatric BK Virus-associated Nephropathy (BKVAN)
D. M. Okamura¹, S. W. Jackson¹, V. R. Dharnidharka², J. M. Smith¹
¹Pediatric Nephrology, Seattle Children's Hospital & Research Institute, Seattle, WA, ²Pediatric Nephrology, 2St. Louis Children’s Hospital, Washington University School of Medicine, St. Louis, MO
*Purpose: BKVAN is not only a cause of acute renal allograft injury but is a recognized cause of chronic allograft disease and in some patients,…
2021 American Transplant Congress
BKV-Associated Urothelial Carcinoma in Patients After Renal and Extrarenal Carcinoma
A. Schwarz¹, J. Schmitz², J. Gottlieb³, C. Bara⁴, H. Haller¹, J. Braesen²
¹Nephrology Department, Hannover Medical School, Hannover, Germany, ²Institute of Pathology, Hannover Medical School, Hannover, Germany, ³Department of Pneumology, Hannover Medical School, Hannover, Germany, ⁴Department of Thoracic Surgery, Hannover Medical School, Hannover, Germany
*Purpose: Polyomavirus BK (BKV) reactivation or transmission is a wellknown problem in renal transplant (TX) patients with BKV nephropathy and interstitial cystitis. The role of…
2021 American Transplant Congress
Polyomavirus BK-Associated Nephropathy in Patients After Renal and Extrarenal Transplantation
A. Schwarz¹, J. Schmitz², J. Braesen², C. Bara³, M. Sauer⁴, H. Haller¹, J. Gottlieb⁵
¹Nephrology Department, Hannover Medical School, Hannover, Germany, ²Institute of Pathology, Hannover Medical School, Hannover, Germany, ³Department of Thoracic Surgery, Hannover Medical School, Hannover, Germany, ⁴Department of Pediatric Hematology, Hannover Medical School, Hannover, Germany, ⁵Deparment of Pneumology, Hannover Medical School, Hannover, Germany
*Purpose: Patients with non-renal organ transplantation (TX) may suffer BK-viral nephropathy (BKVN) of their own orthotopic kidneys. We aimed to know if these patients with…