Articles tagged "Polyma virus"

2018 American Transplant Congress
Multiplexed Immunofluorescence to Investigate the Immune Response to BK Virus in Pediatric Kidney Transplant Recipients
C. Fajardo,¹ P. Grimm,¹ N. Kambham,² G. Nolan,³ N. Samusik,³ J. Maltzman.³
¹Pediatrics, Stanford, Stanford, CA; ²Pathology, Stanford, Stanford, CA; ³Immunology, Stanford, Stanford, CA.
Background: BK virus-associated nephropathy (BKVN) is a significant complication in renal transplantation that leads to allograft dysfunction or failure. BKV is thought to reactivate as…
2018 American Transplant Congress
Medullary Tissue Sampling in Renal Allograft Biopsy is More Sensitive for Pathologic Diagnosis of PVN
D. Abdelwahab,¹ H. Khamash,¹ S. Kriegshauser,³ R. Heilman,¹ M. Smith.²
¹Nephrology and Transplant, Mayo Clinic, Phoenix; ²Pathology and Laboratory Medicine, Mayo Clinic, Phoenix; ³Radiology, Mayo Clinic, Phoenix.
Background Post-transplant polyoma virus nephropathy (PVN) prevalence is 1-10%. Definitive PVN diagnosis requires polyoma virus presence in infected cells, done with immunohistochemical staining for SV40…
2018 American Transplant Congress
Role of BK Virus-Specific T Cell Immune Monitoring for BK Virus-Associated Nephropathy in Kidney Transplant Recipients
J. Bruminhent,¹ S. Srisala,² C. Klinmalai,³ S. Pinsai,¹ S. Watcharananan,¹ S. Kantachuvessiri,⁵ S. Hongeng,⁴ N. Apiwattanakul.³
¹Division of Infectious Diseases, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; ²Research Center, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; ³Division of Infectious Diseases, Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; ⁴Division of Hematology and Oncology, Department of Pediatrics Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; ⁵Division of Nephrology, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Background: Reduced immunosuppression in a key therapy for BK virus (BKV)-associated nephropathy (BKVAN) in kidney transplant (KT) recipients. A study of immune monitoring against BKV…
2018 American Transplant Congress
Intragraft Gene Expression Differentiates Polyomavirus Nephropathy from T-Cell Mediated Rejection
B. Adam,¹ S. Wagner,¹ J. Bräsen,² V. Bröcker,² V. D'Agati,³ C. Drachenberg,⁴ E. Farkash,⁵ A. Farris,⁶ L. Geldenhuys,⁷ A. Magil,⁸ V. Nickeleit,⁹ P. Randhawa,¹⁰ H. Regele,¹¹ M. Mengel.¹
¹University of Alberta, Edmonton, Canada; ²Hannover Medical School, Hannover, Germany; ³Columbia University, New York; ⁴University of Maryland, College Park; ⁵University of Michigan, Ann Arbor; ⁶Emory University, Atlanta; ⁷Dalhousie University, Halifax, Canada; ⁸University of British Columbia, Vancouver, Canada; ⁹University of North Carolina, Chapel Hill; ¹⁰University of Pittsburgh, Pittsburgh; ¹¹Medical University of Vienna, Vienna, Austria.
Background: Improved immunosuppression protocols have reduced the incidence of T-cell mediated rejection (TCMR) but still carry a significant risk of BK polyomavirus nephropathy (BKVN). Despite…
2018 American Transplant Congress
Association between Donor/Recipient BK Viral Serostatus and Risk of BK Viraemia Post-Transplantation
S. Chong,¹ C. Atkinson,² N. Banga,¹ M. Harber,¹ M. Reeves,² C. Magee.¹
¹Royal Free London NHS Foundation Trust, London, United Kingdom; ²Department of Virology, University College London, London, United Kingdom.
IntroductionThe development of BK viraemia, and subsequently, BK nephropathy is a potentially devastating event associated with kidney transplant loss. In contrast to other clinically important…
2017 American Transplant Congress
Urinary Retention Associated with Polyomavirus (BK) Viruria and Higher Peak Blood BK Following Kidney Transplant (KTx).
W. Cheungpasitporn,¹ H. Amer,² F. Cosio,² C. Schinstock.²
¹Nephrology and Hypertension, Mayo Clinic, Rochester, MN; ²The William J von Liebig Center for Transplantation and Clinical Regeneration, Mayo Clinic, Rochester, MN
BACKGROUND: BK nephropathy is a major risk factor for allograft dysfunction and loss. BK viruria and viremia are early markers of BK nephropathy in KTx…
2017 American Transplant Congress
Role of Chemokines in Resolution of BK Virus-Associated Nephropathy and Chronicity of Pathology Changes in Kidney Transplant Recipients.
J. Zuckerman, F. Palma Diaz, C. Magyar, B. Abdalla, E. Lum, S. Bunnapradist, T. Pham, G. Dannovitch, J. Veale, H. Gritsch, E. Reed, J. Schaenman.
David Geffen School of Medicine at UCLA, Los Angeles, CA
BK virus-associated nephropathy (BKN) remains the most common infectious cause of allograft loss after kidney transplantation. We previously demonstrated increased frequency of polyfunctional T cells…
2017 American Transplant Congress
Nephrectomy of the Failed First Kidney Allograft Predisposes Kidney Transplant Recipients to Presensitization with Alloreactive T-Cells and Inferior Allograft Survival After Retransplantation.
T. Schachtner,^1,2 M. Stein,¹ P. Reinke.^1,2
¹Nephrology and Internal Intensive Care, Charite Campus Virchow Clinic, Berlin, Germany; ²Berlin-Brandenburg Center for Regenerative Therapies, Charite Campus Virchow Clinic, Berlin, Germany
During the last two decades the number of recipients (KTRs) of a previous kidney transplantation being evaluated and waitlisted for a subsequent kidney transplantation has…
2017 American Transplant Congress
Improvement in Inflammatory Response Follows Clearance of BKVN.
E. Abuhelaiqa,¹ S. Salvatore,² J. Lee,¹ J. Lee,¹ T. Muthukumar,¹ S. Seshan,² D. Dadhania.¹
¹Transplant Medicine, Weill Cornell Medicine, NY, NY; ²Dept. of Pathology, Weill Cornell Medicine, NY, NY
Intro: Development of BKV nephropathy (BKVN) is a significant risk factor for graft loss. Proximate cause of graft loss is commonly attributed to acute/chronic rejection…
2017 American Transplant Congress
Donor Derived and BK Virus Positive Urologic Cancers After Renal Transplantation.
V. Hellström,¹ G. Tufveson,¹ A. Wallgren,² A. Loskog,² E. Larsson,² T. Töttermann,² M. Bengtsson,² A. Laurell,² C. Lundberg,¹ B. Holmström,¹ G. Enblad,² T. Lorant.¹
¹Department of Surgical Sciences, Uppsala University, Uppsala, Sweden; ²Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
Background. Donor-derived tumours in organ recipients develop from donor tissue with no known pre-existing malignancy in the donor. In addition, polyoma BK virus (BKV) might…