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Articles tagged "Polyma virus"

  • 2018 American Transplant Congress

    Higher Concordance in the Incidence of DGF and Post-Transplant BKV Infection among Recipients Receiving Mate Kidneys from the Same Deceased Donor: A Paired Deceased Donor Kidney Transplant Analysis

    K. Venkatesh,1 C. Wu,1 C. Puttarajappa,1 R. Mehta,1 P. Sood,1 A. Tevar,2 S. Hariharan.1

    1Nephrology Division, Univ of Pittsburgh Medical Center, Pittsburgh, PA; 2Transplant Surgery, Univ of Pittsburgh Medical Center, Pittsburgh, PA.

    Background: This study was undertaken to explore the degree to which donor variables impact rates of DGF, post-transplant CMV and BKV infections using a paired…
  • 2018 American Transplant Congress

    Mycophenolic Acid Reduces BK Polyomavirus Replication in an In Vitro Model of Renal Tubular Epithelial Cells Infection

    E. Favi,1 S. Delbue,2 C. Colico,1 P. Ferrante,2 S. Villani,2 I. Perna,2 N. Mondoni,2 A. Giussani,1 M. Ferraresso.1

    1Kidney Transplantation, Fondazione IRCCS Ca' Granda, Milan, Italy; 2Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy.

    Background. BK virus (BKV) nephropathy is an important cause of allograft failure after kidney transplant. Immunosuppression is a recognized risk factor for BKV replication but…
  • 2018 American Transplant Congress

    Aggressive Immunosuppression Minimization Shortens BK Viremia, Does Not Improve Outcome, but Increases the Risk of De Novo Donor Specific Antibodies in Kidney Recipients

    A. Devresse,1,2 C. Tinel,1 A. Vermorel,1 R. Snanoudj,1 L. Morin,1 V. Avettand-Fenoel,3 L. Amrouche,1 A. Scemla,1 J. Zuber,1 C. Legendre,1 M. Rabant,4 D. Anglicheau.1

    1Nephrology and Kidney Transplantation, Necker Hospital, Paris, France; 2Nephrology, University Hosputal Saint-Luc, Brussels, Belgium; 3Virology, Necker Hospital, Paris, France; 4Pathology, Necker Hospital, Paris, France.

    Background: Immunosuppression (IS) minimization is the gold-standard treatment of BK virus (BKV) viremia in kidney transplant recipients (KTRs). However, the optimal approach to IS reduction…
  • 2018 American Transplant Congress

    Prospective Study of Switching from Tacrolimus to Low-Dose Cyclosporine A Preserving Allograft Function in BK Virus-Associated Nephropathy

    G. Huang, X. Chen, S. Yang, C. Wang.

    Organ Transplant Center/Department of Pathology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

    Background: Tacrolimus(Tac) -mycophenolic acid compared to cyclosporine is an independent risk factor for BK virus-associated nephropathy (BKVAN). Cyclosporine A (CsA) can inhibit BKV replication in…
  • 2018 American Transplant Congress

    BK Nephropathy in Non-Kidney Transplant Patients, a Case Series and Systematic Review of the Literature

    A. Shah,1 V. Kumar,2 B. Laskin,2,3 D. Sawinski,1,2 J. Hogan.1,2

    1Division of Nephrology, Hospital of the University of Pennsylvania, Philadelphia; 2Perelman School of Medicine, Philadelphia; 3Division of Nephrology, Children's Hospital of Philadelphia, Philadelphia.

    Background: BK virus is highly seroprevalent but clinical disease typically occurs only in immunocompromised persons, most notably leading to significant morbidity in patients with kidney…
  • 2017 American Transplant Congress

    Impact of Donor BK-Virus Replication on Posttransplant BKV Replication After Living-Donor Transplantation.

    J. Grellier, A. Del Bello, L. Esposito, A. Hebral, C. Mengelle, N. Kamar.

    Department of Nephrology and Organ Transplantation, Toulouse University Hospital, Toulouse, France

    BK-virus-associated nephropathy (BKVAN) can cause kidney-allograft dysfunction after kidney transplantation: several risk factors for BKV replication after kidney transplantation have been identified. They can be…
  • 2017 American Transplant Congress

    Poor Outcome of Polyomavirus -Associated Nephropathy with Glomerular Parietal Epithelial Cells Infected by Polyomavirus.

    G. Huang,1 W. Chen,2 J. Qiu,1 X. Chen,1 L. Chen,1 C. Wang.1

    1Department of Organ Transplantation, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China; 2Department of Pathology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China

    Background: Bowman's capsular epithelium infected by polyomavirus(Py) in polyomavirus -associated nephropathy (PyVAN) is infrequent and considered as the advanced stage of the disease. The aim…
  • 2017 American Transplant Congress

    Resumption of Standard Dose Immunosuppression Following Resolution of BK Viremia Does Not Lead to Viremia Recurrence.

    K. Alquadan, A. Santos, M. Casey, T. Ozrazgat-Baslanti, S. Bozorgmehri, J. Gregg, K. Womer.

    Medicine, Nephrology, University of Florida, Gainesville, FL

    Introduction: Reduction of immunosuppression (IS) in response to BK viremia following kidney transplantation prevents the development of BK virus nephropathy, with no apparent increase in…
  • 2017 American Transplant Congress

    Defining a BKV Cutt-Off and Profile for Early Detection of BKV Associated Nephropathy.

    C. Nihei,1 F. Agena,1 F. Paula,1 D. David,1 M. Fink,3 L. Pierrotti,2 E. David-Neto.1

    1Renal Transplantation Service, Universidade de São Paulo, São Paulo, SP, Brazil; 2Parasitic and Infectious Diseases Division, Universidade de São Paulo, São Paulo, SP, Brazil; 3Tropical Medicine Institute, Universidade de São Paulo, São Paulo, SP, Brazil

    BK polyomavirus-associated nephropathy (BKPyVAN) represents a challenge to transplant centers. Prevention using early detection of BKPy viremia (BKPyV) and immunosuppression(IS) reduction is the best current…
  • 2017 American Transplant Congress

    Calibration of BK Virus Nucleic Acid Amplification Testing to the 1st WHO International Standard for BK Virus.

    S. Tan,1 S. Milligan,2 M. Sahoo,3 N. Taylor,2 B. Pinsky.1,2,3

    1Department of Medicine, Division of Infectious Diseases, Stanford University School of Medicine, Stanford, CA; 2Clinical Virology Laboratory, Stanford Health Care, Stanford, CA; 3Department of Pathology, Stanford University School of Medicine, Stanford, CA

    Significant inter-assay variability in the quantification of BK virus (BKV) DNA has limited the broad applicability of thresholds for the management of BKV infection in…
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