Articles tagged "Polyma virus"

2019 American Transplant Congress
Genome-Wide Profiling of BK Polyomavirus Integration in Urothelial Carcinoma of Kidney Transplant Recipients Reveals a Potential Microhomology or Nonhomologous End Joining Mediated Integration Mechanism
Y. Jin¹, Y. Zhou¹, W. Deng¹, R. Lee², Y. Liu¹, M. Blute³, R. Liu¹, N. Elias⁴, F. Fu¹, B. Guan¹, J. Geng¹, J. Ma⁵, J. Zhou⁵, N. Liu⁵, C. Wu⁶, Y. Miao¹
¹Nanfang Hospital, Southern Medical University, Guangdzhou, China, ²Departments of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ³Departments of Urology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁴Departments of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁵Mygenostics Co., Beijing, China, ⁶Departments of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA
*Purpose: Chronic BK polyomavirus (BKV) infection is recognized as a potential oncogenic factor of urothelial carcinoma (UC) in renal transplant recipients. Besides, a positive correlation…
2019 American Transplant Congress
Incidence, Risk Factors, Outcomes and Clinical Management of BK Viremia in the Modern Era of Kidney Transplantation
J. Kim
Toronto General Hospital, Toronto, ON, Canada
*Purpose: BK viremia is endemic among kidney transplant recipients (KTR). Previous work has not compared the incidence, risk factors, and outcomes of any vs. clinically…
2019 American Transplant Congress
Effects of IVIG Therapy and FcγR Polymorphisms on BK Virus Nephropathy in Kidney Transplant Recipients
D. I. Min¹, Y. Chang², T. Shah³
¹Western Univ of Health Sciences, Los Angeles, CA, ²Mendez National Institute of Transplantation Foundation, Los Angeles, CA, ³St. Vincent Medical Center, Los Angeles, CA
*Purpose: BK Virus Nephropathy (BKVN) is a major complication in kidney transplant patients. Although standard treatment for BKVN is immunosuppression reduction and/or using leflunomide, studies…
2019 American Transplant Congress
Tandem Mass Tags Based Liquid Chromatography/ Mass Spectrometry Analysis of Quantitative Proteomic Changes in Renal Allograft Biopsies with Polyomavirus BK Nephropathy
F. Fang, P. Liu, L. Song, Y. Zhao, G. Zeng, G. Tseng, K. Xiao, P. Randhawa
University of Pittsburgh, Pittsburgh, PA
*Purpose: Transcriptomics analyses have not generated reliable means to distinguish T-cell mediated rejection (TCMR) from BK virus nephropathy (BKVN). Proteomics-based approaches deserve further exploration since…
2019 American Transplant Congress
Successful Use of Hizentra to Address BK Viremia in Pediatric Transplant Population
K. Gruenkemeyer, E. Wood, A. Beck, C. Belsha
Pediatric Nephrology, Saint Louis University, Saint Louis, MO
*Purpose: BK viremia is an important problem in the pediatric renal transplant population leading to increased risk for viral associated nephropathy in the transplant. Early…
2019 American Transplant Congress
Prospective BK Virus Screening in the Early Post-Kidney Transplant Period: A Single Center Experience
N. Parrish¹, S. Stander², M. Anand², B. G. Abu Jawdeh², A. Govil²
¹UC Med Ctr, Cincinnati, OH, ²U Cincinnati, Cincinnati, OH
*Purpose: BK virus screening protocols for the early (up to post-transplant day 90) post kidney transplant (KT) period vary amongst kidney transplant centers. Most commonly,…
2019 American Transplant Congress
Epidemiology and Outcomes of BKV Nephropathy Management by Screening Policy in a Real-Life Setting
V. D. GARCIA¹, F. V. Raupp¹, G. MEINERZ¹, K. Piegas², E. KEITEL¹
¹Nephrology and Kidney and Pancreas Transplant Department, ISCMPA, Porto Alegre, Brazil, ²Pathology Department, ISCMPA, Porto Alegre, Brazil
*Purpose: To verify the frequency of BKVAN in a single center's clinical setting and evaluate the response to immunosuppressive adjustments through graft survival analysis.*Methods: Retrospective…
2019 American Transplant Congress
Development of De Novo Antibody in Renal Transplant Recipients with BK Viremia Managed with Immunosuppression Reduction
M. Raijmakers¹, A. Shetty², R. Hod Dvorai², A. Tambur², M. G. Ison²
¹University of Santiago, Santiago, Chile, ²Northwestern University Comprehensive Transplant Center, Chicago, IL
*Purpose: To determine the development of de novodonor specific antibodies (DSA) in renal transplant recipients with immunosuppression modulation and BK viremia and the associated risk…
2019 American Transplant Congress
Impact Of Subclinical Bk Virus-associated Nephropathy In High-risk Recipients
M. E. Seifert, E. P. Kasik, M. Bernard, G. Agarwal, H. Fatima, R. Gaston, B. Julian, C. Kew, V. Kumar, S. Mehta, S. Ong, F. Rosenblum, G. Towns, R. B. Mannon
University of Alabama, Birmingham, AL
*Purpose: BK virus-associated nephropathy (BKVAN) is a major contributor to kidney transplant failure. Surveillance of serum and urine for the BKV genome has been incorporated…
2019 American Transplant Congress
Late Onset J C Virus Allograft Nephropathy
M. Samra, I. Tang, S. Setty
University of Illinois Health, Chicago, IL
*Purpose: JC virus(JCV) is a member of the Polyomaviridae family. Few studies have been published regarding the replication of JCV in transplant recipients. The incidence…

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