Articles tagged "Polyma virus"

2022 American Transplant Congress
Clinical Relevance of Absolute BK Polyoma Viral Load Kinetics in Patients with Biopsy Proven BK Polyomavirus Associated Nephropathy
H. Omic¹, J. P. Kläger¹, H. Herkner¹, S. W. Aberle¹, H. Regele¹, L. Weseslindtner¹, T. A. Schrag¹, G. Bond¹, K. Hohenstein¹, B. Watschinger¹, J. Werzowa², R. Strassl¹, M. Eder¹, Z. Kikic¹
¹Medical University of Vienna, Vienna, Austria, ²Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital of WGKK and AUVA Trauma Centre Meidling, 1st Medical Department, Hanusch Hospital, Vienna, Austria
*Purpose: The absolute BK viral load is an important diagnostic surrogate for BK polyomavirus associated nephropathy (PyVAN) after renal transplant (KTX) and serial assessment of…
2022 American Transplant Congress
De-Novo Belatacept Therapy is Associated with Higher Levels of BK Viremia and Lower Rates of BK Clearance in Kidney Transplantation Patients
G. Petrossian¹, J. Ortiz², K. Addonizio¹, L. Teixeira¹, A. Hsiao¹, R. James³, N. Koizumi³, S. Patel⁴, D. Conti², R. Plews²
¹Albany Medical Center, Albany, NY, ²Division of Renal and Pancreatic Transplant Services, Albany Medical Center, Albany, NY, ³George Mason University, Fairfax, VA, ⁴UMC Las Vegas, Las Vegas, NV
*Purpose: To compare the incidence and severity of BK viremia in kidney transplantation patients with a de-novo belatacept (bela) vs. a no-bela maintenance immunosuppression regimen.*Methods:…
2022 American Transplant Congress
Combined Metagenomic Viral Detection and Donor-Derived Cell-Free DNA Quantification for Solid Organ Transplant Recipients
R. Sinha¹, C. Rebello², E. Bixler¹, A. Al-Turck¹, A. Berg¹, J. Friedewald², S. Kleiboeker¹
¹Eurofins Viracor, Lees Summit, MO, ²Northwestern University, Chicago, IL
*Purpose: Solid organ transplant recipients are predisposed to opportunistic infections, and current viral diagnostic methods focus on sensitive detection of single pathogens by qPCR. However,…
2022 American Transplant Congress
Use of Viral Specific T Cell Therapy in Solid Organ Transplant Recipients – A Single Center Experience
G. McGraw¹, N. Patel², K. Patel¹, S. Bumb³, A. Govil⁴, M. Anand¹
¹University of Cincinnati, Cincinnati, OH, ²Nephrology, University of Cincinnati, Cincinnati, OH, ³Nephrology, Internal Medicine, University of Cincinnati Medical Center, Blue Ash, OH, ⁴Univ of Cincinnati, Cincinnati, OH
*Purpose: Viral infections such as BK virus (BKV), cytomegalovirus (CMV) and adenovirus after kidney transplantation negatively impact outcomes in solid organ transplant (SOT) recipients despite…
2022 American Transplant Congress
Characterization of Kidney Allograft Pathology Using the Histomap Gene Expression Profile (GEP) and Formalin Fixed Paraffin Embedded (FFPE) Tissue
N. Garg¹, K. Degner², H. Zhang³, W. Tian³, F. Aziz⁴, S. Parajuli², W. Zhong², N. Wilson², S. Panzer¹, A. Djamali²
¹University of Wisconsin Madison, Madison, WI, ²University of Wisconsin, Madison, WI, ³CareDx, Brisbane, CA, ⁴University of Wsiconsin, Madison, WI
*Purpose: The new Banff Human Organ Transplant (B-HOT) gene panel assessed on nCounter system has been created through a collaboration between NanoString and the Banff…
2022 American Transplant Congress
Impact of Cytomegalovirus and BK Virus Infection on Clinical Outcomes in Kidney Transplant Recipients
W. Park, J. Yang, J. Kwon, J. Lim, Y. Kim, J. Paek, K. Jin, S. Han
Division of Nephrology, Department of Internal Medicine, Keimyung University School of Medicine, Keimyung University Dongsan Hospital, Daegu, Korea, Republic of
*Purpose: Cytomegalovirus (CMV) or BK virus (BKV) infection is one of the important opportunistic infections in kidney transplant recipients (KTRs). CMV or BKV infection can…
2022 American Transplant Congress
Infections in Kidney Transplant Recipients on Belatacept versus Tacrolimus-Based Immunosuppression
S. Gattis¹, A. Basu²
¹Emory Healthcare, Atlanta, GA, ²Emory University Hospital, Atlanta, GA
*Purpose: Patients 70 years and older with advanced/ end stage kidney disease are increasingly receiving kidney transplants. Immediately post- transplant, our center utilizes Belatacept coupled…
2022 American Transplant Congress
Intensive Antimetabolite Reduction is Not Associated with Increased Risk of Biopsy-Proven Acute Rejection in Kidney Transplant Recipients with BK Virus Infection; a Single Center Experience
J. Marvin¹, D. Malhotra², P. Jethwani², K. Belfield¹, E. Cohen¹
¹Yale New Haven Hospital, New Haven, CT, ²Section of Nephrology, Yale School of Medicine, New Haven, CT
*Purpose: Polyoma BK virus (BKV) is a ubiquitous DNA virus that is capable of reactivation and infection in kidney transplant recipients (KTR). Manifestations of the…
2022 American Transplant Congress
Metastatic BK Virus-Associated Urothelial Carcinoma Originating in Renal Allograft
J. Torrealba¹, H. Jones¹, A. Bhakta², L. Jia¹, D. Wojciechowski²
¹Pathology, UT Southwestern, Dallas, TX, ²Internal Medicine, UT Southwestern, Dallas, TX
*Purpose: Cases of urinary tract carcinoma associated with BK virus have been reported in kidney transplant recipients; therefore, we postulate that BK virus may play…
2022 American Transplant Congress
A Randomized Phase 2 Study Of Mau868 Vs Placebo To Treat Bk Viremia In Kidney Transplant Recipients
S. Jordan¹, A. P. Limaye², B. Fischbach³, P. Sood⁴, S. Collette⁵, L. Gasink⁶, M. W. Fordyce⁷, C. J. Lin⁷, M. Hodges⁶, D. C. Brennan⁸
¹Cedars-Sinai Medical Center, Los Angeles, CA, ²University of Washington, Seattle, WA, ³Dallas Nephrology Associates, Inc, Dallas, TX, ⁴University of Pittsburgh Medical Center, Pittsburgh, PA, ⁵Hôpital Maisonneuve-Rosemont, Montréal, QC, Canada, ⁶previous employee/consultant for Amplyx Pharmaceuticals, San Diego, CA, ⁷Vera Therapeutics, Inc, Brisbane, CA, ⁸Johns Hopkins School of Medicine, Baltimore, MD
*Purpose: To assess the safety and efficacy of MAU868, a BK virus-specific monoclonal antibody, in adult kidney transplant recipients with BK viremia.*Methods: This is a…

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