2022 American Transplant Congress
The Prevalence and Morbidity Associated with BK Virus in Heart Transplant Recipients
*Purpose: BK polyomavirus (BKV) is a quiescent polyomavirus that is present in approximately 80% of the population and can reactivate in immunocompromised patients and impair…2022 American Transplant Congress
Treatment of BK Virus with Weekly Intravenous Immunoglobulin in Adult Kidney Transplant Recipients
*Purpose: The typical management of Polyoma BK virus (BKV) in kidney transplant recipients (KTR) includes reducing immunosuppression (IS). Intravenous immunoglobulin (IVIG) has been utilized for…2022 American Transplant Congress
Is BK After SPK Okay?: Kidney and Pancreas Transplant Outcomes After BK Viremia
*Purpose: BK viremia and BK nephropathy (BKN) are common after kidney transplant alone, occurring in ~15% and ~1-10%, and are associated with an increased risk…2022 American Transplant Congress
BK Viremia in Living vs Deceased Donor Renal Transplant Recipients Receiving Alemtuzumab Induction
1University of Maryland Medical Center, Baltimore, MD, 2Univ of Maryland Schl of Med, Baltimore, MD
*Purpose: There is conflicting data regarding the association of donor type and BK viremia in renal transplant recipients. This study sought to compare the incidence…2022 American Transplant Congress
High Incidence of BKPyV DNAemia After Simultaneous Pancreas-Kidney Transplantation
*Purpose: Polyomavirus BK (BKPyV) commonly reactivates after kidney transplantation and causes significant morbidity and increased risk of graft loss. However, data on the burden of…2022 American Transplant Congress
Leflunomide in Children with BK Polyomavirus Viremia After Kidney Transplant
1The Children's Hospital of Philadelphia, Philadelphia, PA, 2Yale New Haven Health, New Haven, CT
*Purpose: Studies examining the use of leflunomide in treating BK polyomavirus (BKPyV) viremia in children after kidney transplant are limited to case reports with small…2022 American Transplant Congress
Single-Cell RNA Sequencing Highlights the Role of Epithelial-Immune Dual Feature of Proximal Tubule Cells in BK Virus Nephropathy
Organ Transplant Center, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China
*Purpose: BK virus nephropathy (BKVN) may cause renal allograft dysfunction and failure. However, a specific antiviral agent for BK virus does not exist. Increasing evidence…2022 American Transplant Congress
Non-Invasive Metabolite-Based Urine Signature Detects Over-Immunosuppression in Renal Transplant Recipients
*Purpose: Managing complications related to over-immunosuppression represents a growing challenge in post-transplant care, with infections accounting for the second leading cause of death with functioning…2022 American Transplant Congress
Concordance of POLQ and PARP-1 Expression and MMEJ Type Viral Integration in the Progression of BKPyV-Associated Diseases
*Purpose: To reveal the mechanism of the increasing dominant position of integration, especially the microhomology-mediated end joint (MMEJ) form in the development of BK Polyomavirus…2022 American Transplant Congress
BK Polyomavirus Infection is Not Associated with a Meaningful Increase in Donor-Derived Cell-Free DNA
1Warren Alpert Medical School of Brown University, Providence, RI, 2CareDx, Brisbane, CA
*Purpose: Donor-derived cell-free DNA (dd-cfDNA) is a non-invasive measure of early allograft injury that has been clinically validated as a surveillance tool to detect antibody…
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