ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Polyma virus"

  • 2022 American Transplant Congress

    The Prevalence and Morbidity Associated with BK Virus in Heart Transplant Recipients

    A. Nguyen1, Z. Li2, N. F. Rasheed2, J. Cruz2, M. Fei3, G. Kim1, S. Pinney1, N. Uriel4

    1University of Chicago Medicine, Chicago, IL, 2University of Chicago, Chicago, IL, 3CareDx, Brisbane, CA, 4New York Presbyterian, Columbia University Irving Medical Center, New York, NY

    *Purpose: BK polyomavirus (BKV) is a quiescent polyomavirus that is present in approximately 80% of the population and can reactivate in immunocompromised patients and impair…
  • 2022 American Transplant Congress

    Treatment of BK Virus with Weekly Intravenous Immunoglobulin in Adult Kidney Transplant Recipients

    G. Girone1, W. Asch2

    1Department of Pharmacy, Yale New Haven Hospital, New Haven, CT, 2Section of Nephrology, Yale School of Medicine, New Haven, CT

    *Purpose: The typical management of Polyoma BK virus (BKV) in kidney transplant recipients (KTR) includes reducing immunosuppression (IS). Intravenous immunoglobulin (IVIG) has been utilized for…
  • 2022 American Transplant Congress

    Is BK After SPK Okay?: Kidney and Pancreas Transplant Outcomes After BK Viremia

    G. Dube1, K. McCune2, D. Cohen3, L. Ratner2, S. Husain1

    1Columbia University Medical Center, New York, NY, 2Columbia University, New York, NY, 3Columbia University Med Ctr, New York, NY

    *Purpose: BK viremia and BK nephropathy (BKN) are common after kidney transplant alone, occurring in ~15% and ~1-10%, and are associated with an increased risk…
  • 2022 American Transplant Congress

    BK Viremia in Living vs Deceased Donor Renal Transplant Recipients Receiving Alemtuzumab Induction

    J. P. Casale1, D. Pluckrose1, A. Haririan2, T. Sparkes1

    1University of Maryland Medical Center, Baltimore, MD, 2Univ of Maryland Schl of Med, Baltimore, MD

    *Purpose: There is conflicting data regarding the association of donor type and BK viremia in renal transplant recipients. This study sought to compare the incidence…
  • 2022 American Transplant Congress

    High Incidence of BKPyV DNAemia After Simultaneous Pancreas-Kidney Transplantation

    I. Helanterä1, J. Räihä1, S. von Moos2, I. Lautenschlager3, V. Sallinen1, M. Lempinen1, T. Schachtner2

    1Transplantation and Liver Surgery, Helsinki University Hospital, Helsinki, Finland, 2University Hospital Zurich, Zurich, Switzerland, 3Department of Virology and Immunology, Helsinki University Hospital, Helsinki, Finland

    *Purpose: Polyomavirus BK (BKPyV) commonly reactivates after kidney transplantation and causes significant morbidity and increased risk of graft loss. However, data on the burden of…
  • 2022 American Transplant Congress

    Leflunomide in Children with BK Polyomavirus Viremia After Kidney Transplant

    J. Hewlett1, K. Le Palma1, L. Galea1, J. Savant1, S. Lopez1, J. V. Rosano2, A. Strong1, B. Viteri1, C. LaRosa1, S. Amaral1, B. Laskin1

    1The Children's Hospital of Philadelphia, Philadelphia, PA, 2Yale New Haven Health, New Haven, CT

    *Purpose: Studies examining the use of leflunomide in treating BK polyomavirus (BKPyV) viremia in children after kidney transplant are limited to case reports with small…
  • 2022 American Transplant Congress

    Single-Cell RNA Sequencing Highlights the Role of Epithelial-Immune Dual Feature of Proximal Tubule Cells in BK Virus Nephropathy

    G. Huang, F. Yang, X. Chen, G. Zhao, H. Zhang, J. Luo, S. Yang, L. Zhou

    Organ Transplant Center, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China

    *Purpose: BK virus nephropathy (BKVN) may cause renal allograft dysfunction and failure. However, a specific antiviral agent for BK virus does not exist. Increasing evidence…
  • 2022 American Transplant Congress

    Non-Invasive Metabolite-Based Urine Signature Detects Over-Immunosuppression in Renal Transplant Recipients

    S. Raghavendra Rao1, C. Honrao1, L. O. Rodrigues1, C. Dong1, K. Sonkar1, J. Wolf1, E. M. O'Day1, D. R. Kuypers2

    1Olaris, Inc., Framingham, MA, 2Department of Nephrology and Renal Transplantation, University Hospitals, Leuven, Belgium

    *Purpose: Managing complications related to over-immunosuppression represents a growing challenge in post-transplant care, with infections accounting for the second leading cause of death with functioning…
  • 2022 American Transplant Congress

    Concordance of POLQ and PARP-1 Expression and MMEJ Type Viral Integration in the Progression of BKPyV-Associated Diseases

    Y. Wang1, Z. Yan1, Y. Liu2, J. Geng3, W. Deng1, R. Xia1, W. Zeng1, J. Xu1, C. Wu4, Y. Miao1

    1Department of Transplantation, Nanfang Hospital, Southern Medical University, Guangzhou, China, 2Department of Microbiology and Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China, 3Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, China, 4Departments of Urology & Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA

    *Purpose: To reveal the mechanism of the increasing dominant position of integration, especially the microhomology-mediated end joint (MMEJ) form in the development of BK Polyomavirus…
  • 2022 American Transplant Congress

    BK Polyomavirus Infection is Not Associated with a Meaningful Increase in Donor-Derived Cell-Free DNA

    J. Fisher1, K. Vieira1, R. Burke2, R. Gohh1, R. Rogers1

    1Warren Alpert Medical School of Brown University, Providence, RI, 2CareDx, Brisbane, CA

    *Purpose: Donor-derived cell-free DNA (dd-cfDNA) is a non-invasive measure of early allograft injury that has been clinically validated as a surveillance tool to detect antibody…
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