Articles tagged "Pig"

2019 American Transplant Congress
Effects of Static Subnormothermic Preservation of Extended Warm Ischemic Porcine Kidneys Assessed by Ex-Vivo Machine Perfusion and Renal Transplant Model
H. Sahara, Y. Ariyoshi, M. Sekijima, T. Iwanaga, A. Shimizu, K. Yamada
Center for Advanced Biomedical Science and Swine Research, Kagoshima University, Kagoshima, Japan
*Purpose: The donation after circulatory death (DCD) donors has the potential to match the increasing need for transplantable organs, however, DCD kidneys have a higher…
2019 American Transplant Congress
Expression of Prostaglandin E2 Receptors Track with Rejection in Porcine Kidney Transplants
A. Harner¹, Y. Wang², X. Fang², R. Lassiter¹, T. D. Merchen¹, S. Ho³, S. Nahman Jr²
¹Surgery, Augusta University, Augusta, GA, ²Nephrology, Augusta University, Augusta, GA, ³Gift of Life Michigan, Ann Arbor, MI
*Purpose: Prostaglandin E2 (PGE2) is generated from arachidonic acid via cyclooxygenase-2 (COX2) and is known to modulate the immune response via its receptors: EP1, EP2,…
2019 American Transplant Congress
Optimizing a Protocol for Extended Ex-Vivo Extremity Perfusion
C. J. Stewart¹, M. T. Buchko², X. Wang¹, G. Brandacher³, A. Ladak⁴, D. H. Freed², J. Nagendran²
¹Surgery, University of Alberta, Edmonton, AB, Canada, ²Cardiac Surgery, University of Alberta, Edmonton, AB, Canada, ³Plastic and Reconstruction Surgery, Johns Hopkins University, Baltimore, MD, ⁴Plastic Surgery, University of Alberta, Edmonton, AB, Canada
*Purpose: Our objective is to demonstrate that Ex-Vivo Extremity Perfusion (EVEP) of a Vascularized Composite Allograft (VCA) is as effective, or superior, to standard cold…
2019 American Transplant Congress
Oral Preconditioning of Donors after Brain Death with Calcineurin Inhibitors vs. Inhibitors of Mammalian Target for Rapamycin in Pig Kidney Transplantation
S. Abbasi Dezfouli¹, M. Golriz¹, O. Ghamarnejad¹, E. Khajeh¹, S. Mohammadi¹, M. Nikdad¹, A. Majlesara¹, M. Sabagh¹, P. Fathi¹, S. Shafiei¹, M. Kentar², A. Younsi², C. Eckert³, T. Poth³, A. Mehrabi¹, A. Nickkholgh¹
¹Department of General, Visceral, and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany, ²Department of Neurosurgery, University of Heidelberg, Heidelberg, Germany, ³Department of Pathology, University of Heidelberg, Heidelberg, Germany
*Purpose: The systemic inflammatory cascade triggered in donors after brain death (DBD) enhances the ischemia-reperfusion injury (IRI) after organ transplantation. Data regarding donor preconditioning with…
2019 American Transplant Congress
Balance between Low DNA Concentration and Structural Damage of Extracellular Matrix during Recellularization Procedure as a Key to Successful Recellularization
A. Berman, A. Adamiok, G. Tynicki, L. Kaczynski, M. Gomolka, M. Klak, M. Wszola
Foundation of Research and Science Development, Warsaw, Poland
*Purpose: Recellularization is considered to be a potential way to solve the problem of organ shortage for transplantation. One of the conditions for the use…
2019 American Transplant Congress
Near-Infrared Fluorescence Imaging with ZW800-1 Dye to Assess Donor Kidneys While on Ex-Vivo Normothermic Machine Perfusion
A. S. Arykbaeva¹, K. M. Rozenberg², M. L. Lo Faro², J. Hunter², J. B. Doppenberg¹, A. R. Valentijn³, A. G. Terwisscha van Scheltinga³, H. Putter⁴, I. P. Alwayn¹, J. V. Frangioni⁵, J. Burggraaf⁶, A. L. Vahrmeijer¹, R. J. Ploeg², V. A. Huurman¹
¹Department of Surgery, Leiden University Medical Center, Leiden, Netherlands, ²Nuffield Department of Surgical Sciences, Oxford, United Kingdom, ³Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, Netherlands, ⁴Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, Netherlands, ⁵Curadel, LCC, Marlborough, MA, ⁶Centre for Human Drug Research, Leiden, Netherlands
*Purpose: At present, more older and higher risk donor kidneys are accepted resulting in increased uncertainty about quality. This may result in unjustified discard of…
2019 American Transplant Congress
The Effect of Intravenous Immunoglobulin on Human Complement-Dependent Cytotoxicity of Pig Cells: Benefit? Or Harm?
T. Yamamoto¹, Q. Li¹, A. Banks¹, H. Iwase¹, D. Ayares², D. K. Cooper¹, H. Hara¹
¹Xenotransplantation Program, Department of Surgery, University of Alabama at Birmingham, Birmingham, AL, ²Revivicor, Blacksburg, VA
*Purpose: Xenoreactive antibodies and complement play an important role in pig xenograft rejection. Intravenous immunoglobulin (IVIG) is widely used in desensitization protocols and for the…
2019 American Transplant Congress
Donor Derived Neoplasia: Will It Be a Risk after Clinical Pig Organ Xenotransplantation?
A. Jagdale¹, H. Iwase¹, E. Klein², D. Cooper¹
¹Surgery, University of Alabama at Birmingham, Birmingham, AL, ²Surgery, University of Pittsburgh, Pittsburgh, PA
*Purpose: The survival of the nonhuman primates with life-supporting pig kidney grafts has increased substantially (to >1 year). As clinical pig organ xenotransplantation draws closer,…
2019 American Transplant Congress
Urine Recirculation Maintains Hemodynamics and Enhances Function in Normothermic Kidney Perfusion
A. Weissenbacher¹, C. D. Ceresa², D. Voyce³, J. Hunter², R. Ploeg², C. C. Coussios⁴, P. Friend²
¹Visceral, Transplant and Thoracic Surgery, Innsbruck Medical University, Innsbruck, Austria, ²Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom, ³OrganOx Limited, Oxford, United Kingdom, ⁴Oxford Institute of Biomedical Engineering, University of Oxford, Oxford, United Kingdom
*Purpose: The purpose was to compare urine recirculation (URC) and urine replacement with Ringer’s lactate in a porcine normothermic kidney perfusion (NKP) model using a…
2019 American Transplant Congress
Correlation between Gene Expression and Cardiac Function in Ex Vivo Perfused Porcine Hearts
S. Rotich, N. Herbers, S. Hatami, J. Nagendran, M. Mengel, D. Freed, B. Adam
University of Alberta, Edmonton, AB, Canada
*Purpose: Cardiac transplantation is a life-saving intervention for advanced heart failure but it is limited by a shortage of suitable donor organs. Ex vivo heart…

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