ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Pig"

  • 2019 American Transplant Congress

    Balance between Low DNA Concentration and Structural Damage of Extracellular Matrix during Recellularization Procedure as a Key to Successful Recellularization

    A. Berman, A. Adamiok, G. Tynicki, L. Kaczynski, M. Gomolka, M. Klak, M. Wszola

    Foundation of Research and Science Development, Warsaw, Poland

    *Purpose: Recellularization is considered to be a potential way to solve the problem of organ shortage for transplantation. One of the conditions for the use…
  • 2019 American Transplant Congress

    Near-Infrared Fluorescence Imaging with ZW800-1 Dye to Assess Donor Kidneys While on Ex-Vivo Normothermic Machine Perfusion

    A. S. Arykbaeva1, K. M. Rozenberg2, M. L. Lo Faro2, J. Hunter2, J. B. Doppenberg1, A. R. Valentijn3, A. G. Terwisscha van Scheltinga3, H. Putter4, I. P. Alwayn1, J. V. Frangioni5, J. Burggraaf6, A. L. Vahrmeijer1, R. J. Ploeg2, V. A. Huurman1

    1Department of Surgery, Leiden University Medical Center, Leiden, Netherlands, 2Nuffield Department of Surgical Sciences, Oxford, United Kingdom, 3Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, Netherlands, 4Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, Netherlands, 5Curadel, LCC, Marlborough, MA, 6Centre for Human Drug Research, Leiden, Netherlands

    *Purpose: At present, more older and higher risk donor kidneys are accepted resulting in increased uncertainty about quality. This may result in unjustified discard of…
  • 2019 American Transplant Congress

    The Effect of Intravenous Immunoglobulin on Human Complement-Dependent Cytotoxicity of Pig Cells: Benefit? Or Harm?

    T. Yamamoto1, Q. Li1, A. Banks1, H. Iwase1, D. Ayares2, D. K. Cooper1, H. Hara1

    1Xenotransplantation Program, Department of Surgery, University of Alabama at Birmingham, Birmingham, AL, 2Revivicor, Blacksburg, VA

    *Purpose: Xenoreactive antibodies and complement play an important role in pig xenograft rejection. Intravenous immunoglobulin (IVIG) is widely used in desensitization protocols and for the…
  • 2019 American Transplant Congress

    Donor Derived Neoplasia: Will It Be a Risk after Clinical Pig Organ Xenotransplantation?

    A. Jagdale1, H. Iwase1, E. Klein2, D. Cooper1

    1Surgery, University of Alabama at Birmingham, Birmingham, AL, 2Surgery, University of Pittsburgh, Pittsburgh, PA

    *Purpose: The survival of the nonhuman primates with life-supporting pig kidney grafts has increased substantially (to >1 year). As clinical pig organ xenotransplantation draws closer,…
  • 2019 American Transplant Congress

    Urine Recirculation Maintains Hemodynamics and Enhances Function in Normothermic Kidney Perfusion

    A. Weissenbacher1, C. D. Ceresa2, D. Voyce3, J. Hunter2, R. Ploeg2, C. C. Coussios4, P. Friend2

    1Visceral, Transplant and Thoracic Surgery, Innsbruck Medical University, Innsbruck, Austria, 2Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom, 3OrganOx Limited, Oxford, United Kingdom, 4Oxford Institute of Biomedical Engineering, University of Oxford, Oxford, United Kingdom

    *Purpose: The purpose was to compare urine recirculation (URC) and urine replacement with Ringer’s lactate in a porcine normothermic kidney perfusion (NKP) model using a…
  • 2019 American Transplant Congress

    Correlation between Gene Expression and Cardiac Function in Ex Vivo Perfused Porcine Hearts

    S. Rotich, N. Herbers, S. Hatami, J. Nagendran, M. Mengel, D. Freed, B. Adam

    University of Alberta, Edmonton, AB, Canada

    *Purpose: Cardiac transplantation is a life-saving intervention for advanced heart failure but it is limited by a shortage of suitable donor organs. Ex vivo heart…
  • 2019 American Transplant Congress

    Indicators of Impending Pig Organ Xenograft Failure: Relevance to Clinical Xenotransplantation

    H. Iwase1, A. Jagdale1, T. Yamamoto1, G. Zhang1, Q. Li1, J. Foote1, D. Ayares2, H. Hara1, D. K. Cooper1

    1University of Alabama at Birmingham, Birmingham, AL, 2Revivicor, Inc., Blacksburg, VA

    *Purpose: In pig-to-baboon organ xenotransplantation, coagulation dysfunction and inflammation have been suggested to be associated with acute humoral xenograft rejection. We have evaluated platelet counts,…
  • 2019 American Transplant Congress

    CD46 Transgene Modification and Thrombosis in Neonatal Porcine Islet Xenotransplantation

    M. Song, K. Samy, Q. Gao, R. P. Davis, F. Leopard, Z. Fitch, C. Bennett, G. R. Devi, B. H. Collins, A. D. Kirk

    Surgery, Duke University, Durham, NC

    *Purpose: Vascular thrombosis activation is an important cause for early xeno-islet loss. To better understand the thrombosis process in islet xenotransplantation and the effect of…
  • 2019 American Transplant Congress

    TMA Development in Kidney and Heart Xenografts Treated with Anti-CD40 or Anti-CD154 Antibodies

    D. H. Ma1, H. Sasaki1, J. M. O1, K. Ahrens1, D. Becerra1, C. G. Rickert1, D. M. Detelich1, T. Oura1, W. Somer1, I. Rosales2, R. N. Pierson1, J. Markmann1, J. C. Madsen1, T. Kawai1

    1Surgery, MGH, Boston, MA, 2Pathology, MGH, Boston, MA

    *Purpose: Genetically modified Galactose-α 1,3-galactose knockout transgenic swine expressing human CD55 (GTKO.hCD55) are resistant to hyperacute rejection of xenografts. We compare anti-CD154 and anti-CD40 antibody-based…
  • 2019 American Transplant Congress

    The Role of CD47/SIRPα and CD47/TSP-1 Pathways in Pig-to-Baboon Kidney Transplantation Using hCD47 Transgenic Kidneys

    K. Takeuchi1, Y. Ariyoshi1, T. Pomposelli1, L. Boyd1, D. Ekanayake-Alper1, S. Arn1, R. Hawley1, D. Ayares2, M. Lorber3, M. Sykes1, D. Sachs1, R. Johnson4, K. Yamada1

    1CCTI/Surgery, Columbia University Medical Center, New York, NY, 2Revivicor Inc., Blacksburg, VA, 3Lung BioTechnology PBC, Silver Spring, MD, 4Division of Renal Diseases and Hypertension, University of Colorado, Aurora, CO

    *Purpose: We have recently reported that both CD80 upregulation and the degradation of SMPDL-3b on glomerular podocytes are involved in the development of post kidney…
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