ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Pig"

  • 2019 American Transplant Congress

    Urine Recirculation Maintains Hemodynamics and Enhances Function in Normothermic Kidney Perfusion

    A. Weissenbacher1, C. D. Ceresa2, D. Voyce3, J. Hunter2, R. Ploeg2, C. C. Coussios4, P. Friend2

    1Visceral, Transplant and Thoracic Surgery, Innsbruck Medical University, Innsbruck, Austria, 2Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom, 3OrganOx Limited, Oxford, United Kingdom, 4Oxford Institute of Biomedical Engineering, University of Oxford, Oxford, United Kingdom

    *Purpose: The purpose was to compare urine recirculation (URC) and urine replacement with Ringer’s lactate in a porcine normothermic kidney perfusion (NKP) model using a…
  • 2019 American Transplant Congress

    Correlation between Gene Expression and Cardiac Function in Ex Vivo Perfused Porcine Hearts

    S. Rotich, N. Herbers, S. Hatami, J. Nagendran, M. Mengel, D. Freed, B. Adam

    University of Alberta, Edmonton, AB, Canada

    *Purpose: Cardiac transplantation is a life-saving intervention for advanced heart failure but it is limited by a shortage of suitable donor organs. Ex vivo heart…
  • 2019 American Transplant Congress

    Indicators of Impending Pig Organ Xenograft Failure: Relevance to Clinical Xenotransplantation

    H. Iwase1, A. Jagdale1, T. Yamamoto1, G. Zhang1, Q. Li1, J. Foote1, D. Ayares2, H. Hara1, D. K. Cooper1

    1University of Alabama at Birmingham, Birmingham, AL, 2Revivicor, Inc., Blacksburg, VA

    *Purpose: In pig-to-baboon organ xenotransplantation, coagulation dysfunction and inflammation have been suggested to be associated with acute humoral xenograft rejection. We have evaluated platelet counts,…
  • 2019 American Transplant Congress

    CD46 Transgene Modification and Thrombosis in Neonatal Porcine Islet Xenotransplantation

    M. Song, K. Samy, Q. Gao, R. P. Davis, F. Leopard, Z. Fitch, C. Bennett, G. R. Devi, B. H. Collins, A. D. Kirk

    Surgery, Duke University, Durham, NC

    *Purpose: Vascular thrombosis activation is an important cause for early xeno-islet loss. To better understand the thrombosis process in islet xenotransplantation and the effect of…
  • 2019 American Transplant Congress

    TMA Development in Kidney and Heart Xenografts Treated with Anti-CD40 or Anti-CD154 Antibodies

    D. H. Ma1, H. Sasaki1, J. M. O1, K. Ahrens1, D. Becerra1, C. G. Rickert1, D. M. Detelich1, T. Oura1, W. Somer1, I. Rosales2, R. N. Pierson1, J. Markmann1, J. C. Madsen1, T. Kawai1

    1Surgery, MGH, Boston, MA, 2Pathology, MGH, Boston, MA

    *Purpose: Genetically modified Galactose-α 1,3-galactose knockout transgenic swine expressing human CD55 (GTKO.hCD55) are resistant to hyperacute rejection of xenografts. We compare anti-CD154 and anti-CD40 antibody-based…
  • 2019 American Transplant Congress

    The Role of CD47/SIRPα and CD47/TSP-1 Pathways in Pig-to-Baboon Kidney Transplantation Using hCD47 Transgenic Kidneys

    K. Takeuchi1, Y. Ariyoshi1, T. Pomposelli1, L. Boyd1, D. Ekanayake-Alper1, S. Arn1, R. Hawley1, D. Ayares2, M. Lorber3, M. Sykes1, D. Sachs1, R. Johnson4, K. Yamada1

    1CCTI/Surgery, Columbia University Medical Center, New York, NY, 2Revivicor Inc., Blacksburg, VA, 3Lung BioTechnology PBC, Silver Spring, MD, 4Division of Renal Diseases and Hypertension, University of Colorado, Aurora, CO

    *Purpose: We have recently reported that both CD80 upregulation and the degradation of SMPDL-3b on glomerular podocytes are involved in the development of post kidney…
  • 2019 American Transplant Congress

    Xenorejection of Porcine Islets in Humanized Mice is Dominated by a Human Th17 Cytokine Immune Response

    F. T. Lee1, A. Dangi2, M. Burnette2, B. Hering3, X. Luo2

    1Transplant Surgery, Northwestern University, Chicago, IL, 2Nephrology, Duke University, Durham, NC, 3Diabetes Institute, University of Minnesota, Minneapolis, MN

    *Purpose: We have previously shown that interleukin(IL)-17 producing CD4 T cells (Th17 response) dominate in the early anti-donor immune responses of a pig-to-mouse xenogeneic model…
  • 2019 American Transplant Congress

    Kidney Xenotransplantation from Genetically Engineered Pigs to Baboons with FDA-Approved Immunosuppressive Therapy

    T. Yamamoto1, H. Hara1, J. Foote1, E. C. Klein2, H. J. Schuurman3, L. Wang1, Q. Li1, H. Zhou1, J. Li1, J. A. Tector1, Z. Zhang2, M. Ezzelarab2, R. Lovingood1, D. Ayares4, D. E. Eckhoff1, D. K. Cooper1, H. Iwase1

    1University of Alabama at Birmingham, Birmingham, AL, 2University of Pittsburgh, Pittsburgh, PA, 3Schubiomed Consultancy, Utrecht, Netherlands, 4Revivicor, Blacksburg, VA

    *Purpose: Genetically-engineered pigs might present a solution to the critical shortage of organs for clinical transplantation. The aims of this study were to evaluate the…
  • 2019 American Transplant Congress

    Donor-Specific Tregs Prolong Peripheral Chimerism in Baboons Receiving GalTKO hCD47-tg Porcine Peripheral Blood Stem Cells

    N. P. Llore1, J. Stern1, G. Pierre1, E. Lopes1, D. Ekanayake-Alper1, P. Alonso-Guallart1, K. Bruestle1, H. Sakai1, D. Ayares2, M. Lorber2, R. Hawley1, D. H. Sachs1, M. Sykes1, A. D. Griesemer1

    1Columbia Center for Translational Immunology, New York, NY, 2United Therapeutics, Silver Springs, MD

    *Purpose: We have previously evaluated the ability of transplantation of polyclonal expanded recipient T regulatory cells to prolong xenogeneic chimerism and skin grafts after transplantation…
  • 2019 American Transplant Congress

    Utilizing Ides To Eliminate Residual Antibodies Targeting Xenografts

    C. Rickert, K. Lee, N. Tanimine, J. Lei, A. Cuenca, N. Feeney, K. Deng, H. Yeh, J. F. Markmann

    Massachusetts General Hospital, Boston, MA

    *Purpose: A significant hinderance to the successful use of xenotransplantation has been the presence of preformed antibodies against the donor antigens, known as xenoantigens. Using…
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