2019 American Transplant Congress
Balance between Low DNA Concentration and Structural Damage of Extracellular Matrix during Recellularization Procedure as a Key to Successful Recellularization
Foundation of Research and Science Development, Warsaw, Poland
*Purpose: Recellularization is considered to be a potential way to solve the problem of organ shortage for transplantation. One of the conditions for the use…2019 American Transplant Congress
Near-Infrared Fluorescence Imaging with ZW800-1 Dye to Assess Donor Kidneys While on Ex-Vivo Normothermic Machine Perfusion
*Purpose: At present, more older and higher risk donor kidneys are accepted resulting in increased uncertainty about quality. This may result in unjustified discard of…2019 American Transplant Congress
The Effect of Intravenous Immunoglobulin on Human Complement-Dependent Cytotoxicity of Pig Cells: Benefit? Or Harm?
*Purpose: Xenoreactive antibodies and complement play an important role in pig xenograft rejection. Intravenous immunoglobulin (IVIG) is widely used in desensitization protocols and for the…2019 American Transplant Congress
Donor Derived Neoplasia: Will It Be a Risk after Clinical Pig Organ Xenotransplantation?
*Purpose: The survival of the nonhuman primates with life-supporting pig kidney grafts has increased substantially (to >1 year). As clinical pig organ xenotransplantation draws closer,…2019 American Transplant Congress
Urine Recirculation Maintains Hemodynamics and Enhances Function in Normothermic Kidney Perfusion
*Purpose: The purpose was to compare urine recirculation (URC) and urine replacement with Ringer’s lactate in a porcine normothermic kidney perfusion (NKP) model using a…2019 American Transplant Congress
Correlation between Gene Expression and Cardiac Function in Ex Vivo Perfused Porcine Hearts
University of Alberta, Edmonton, AB, Canada
*Purpose: Cardiac transplantation is a life-saving intervention for advanced heart failure but it is limited by a shortage of suitable donor organs. Ex vivo heart…2019 American Transplant Congress
Indicators of Impending Pig Organ Xenograft Failure: Relevance to Clinical Xenotransplantation
1University of Alabama at Birmingham, Birmingham, AL, 2Revivicor, Inc., Blacksburg, VA
*Purpose: In pig-to-baboon organ xenotransplantation, coagulation dysfunction and inflammation have been suggested to be associated with acute humoral xenograft rejection. We have evaluated platelet counts,…2019 American Transplant Congress
CD46 Transgene Modification and Thrombosis in Neonatal Porcine Islet Xenotransplantation
Surgery, Duke University, Durham, NC
*Purpose: Vascular thrombosis activation is an important cause for early xeno-islet loss. To better understand the thrombosis process in islet xenotransplantation and the effect of…2019 American Transplant Congress
TMA Development in Kidney and Heart Xenografts Treated with Anti-CD40 or Anti-CD154 Antibodies
1Surgery, MGH, Boston, MA, 2Pathology, MGH, Boston, MA
*Purpose: Genetically modified Galactose-α 1,3-galactose knockout transgenic swine expressing human CD55 (GTKO.hCD55) are resistant to hyperacute rejection of xenografts. We compare anti-CD154 and anti-CD40 antibody-based…2019 American Transplant Congress
The Role of CD47/SIRPα and CD47/TSP-1 Pathways in Pig-to-Baboon Kidney Transplantation Using hCD47 Transgenic Kidneys
*Purpose: We have recently reported that both CD80 upregulation and the degradation of SMPDL-3b on glomerular podocytes are involved in the development of post kidney…
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