ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Pig"

  • 2020 American Transplant Congress

    Experimental Porcine Pancreatic Allotransplantation after Hypothermic Perfusion

    T. Prudhomme1, D. Kervella1, K. Renaudin2, V. Gauttier1, S. Le Bas-Bernardet3, D. Minault3, J. Hervouet3, D. Cantarovich1, G. Karam1, G. Blancho1, J. Branchereau1

    1Institut de Transplantation Urologie Néphrologie (ITUN), CHU Nantes, Nantes, France, 2Département d’Anatomie et de Cytologie Pathologique, CHU Nantes, Nantes, France, 3Centre de Recherche en Transplantation et Immunologie, UMR1064, INSERM, Université de Nantes, Nantes, France

    *Purpose: The main objective of this study was to compare the different preservation techniques (static cold storage (SCS) and hypothermic pulsatile perfusion (HPP)) in a…
  • 2020 American Transplant Congress

    XIAP Enhances Xenoislet Survival: Novel Models to Evaluate Pretransplantation Gene Modifications

    G. R. Devi1, Z. Fitch1, M. Song1, M. Ribeiro1, A. McGowan1, X. Luo2, B. H. Collins1, A. D. Kirk1

    1Department of Surgery, Duke Univesity School of Medicine, Durham, NC, 2Division of Nephrology, Duke Univesity School of Medicine, Durham, NC

    *Purpose: Porcine islet xenotransplantation offers a reliable and near limitless supply of islets for the treatment of type 1 diabetes. Intraportal infusion of cells exposes…
  • 2020 American Transplant Congress

    Hepatic Microenvironment: Molecular and Chemical Changes Associated with Preconditioning Maneuvers

    I. Lies, C. Watkins, M. Em, J. D. Eason, C. Eynard, T. Rousselle, V. R. Mas, D. Maluf

    Dept of Surgery, Transplant Research Institute, James D. Eason Transplant Institute, University of Tennessee Health Science Center, Memphis, TN

    *Purpose: Liver preconditioning has been described to protect liver from ischemia injury and trigger liver regeneration. Hereby, we aimed to assess the effect of preconditioning…
  • 2020 American Transplant Congress

    Abdominal Multiorgan Retrieval from Pigs in a Slaughterhouse: A Reliable and Efficient Donation after Circulatory Death Model for Ex Vivo Organ Perfusion

    F. Neri, F. Dengu, G. Ebeling, L. Knijff, K. Rozemberg, J. Branchereau, P. Friend, R. Ploeg, J. Hunter

    Nuffield Department of Surgical Sciences, Oxford University, Oxford, United Kingdom

    *Purpose: Advances in organ perfusion technology have been driven by the increasing necessity to utilise organs from donors after circulatory death (DCD) and marginal donors.…
  • 2020 American Transplant Congress

    Coagulation and Cd46 Transgene Modification in Neonatal Porcine Islet Xenotransplantation

    M. Song, Z. Fitch, K. Samy, Q. Gao, R. P. Davis, F. Leopard, R. Schmitz, N. Huffman, G. Devi, B. Collins, A. D. Kirk

    Surgery, Duke University, Durham, NC

    *Purpose: Vascular thrombosis is a potential cause for early intraportal xeno-islet loss. To better understand the relationship between coagulation and inflammation in early xeno-islet transplantation,…
  • 2020 American Transplant Congress

    What Happens When You Administer Mesenchymal Stromal Cells During Normothermic Machine Perfusion of Porcine Kidneys: Possible and Helpful or Not?

    K. Rozenberg1, L. Knijff1, J. Sierra-Parraga2, L. Lo Faro1, M. Hoogduijn2, C. Baan2, J. Hunter1, R. Ploeg1

    1Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom, 2Department of Internal Medicine, Nephrology and Transplantation, Erasmus MC, University Medical Center, Rotterdam, Netherlands

    *Purpose: Donation after circulatory death kidneys are widely used to increase the donor pool, despite their inferior quality. Normothermic machine perfusion (NMP) could provide a…
  • 2020 American Transplant Congress

    Normothermic Ex-Vivo Kidney Perfusion is Superior to Anoxic and Oxygenated Hypothermic Machine Perfusion for the Preservation of DCD Porcine Kidney Grafts

    L. Mazilescu1, M. Kaths2, P. Urbanellis1, M. Hamar3, T. Goto1, I. Linares-Cervantes1, Y. Noguchi1, A. Konvalinka1, A. Ghanekar1, D. Bagli4, R. John5, L. Robinson6, M. Selzner1

    1Multi Organ Transplant Program, Toronto General Hospital, Toronto, ON, Canada, 2Department of General, Visceral, and Transplantation Surgery, University Hospital Essen, Essen, Germany, 3Department of Transplantation and Surgery, Semmelweis University, Budapest, Hungary, 4Departments of Surgery(Urology)&Physiology, The Hospital for Sick Children, Toronto, ON, Canada, 5Laboratory Medicine & Pathobiology, Toronto General Hospital, Toronto, ON, Canada, 6Division of Nephrology, The Hospital for Sick Children, Toronto, ON, Canada

    *Purpose: To increase the donor pool, better preservation strategies for the storage of marginal kidney grafts are crucial. Currently, kidney grafts are either stored on…
  • 2020 American Transplant Congress

    Improved Survival of Acute Liver Failure by “Off-the-Shelf” Bioartificial Liver Support System Using Immobilized Cryopreserved Hepatocyte Spheroids in Porcine Model

    S. Lee1, J. Lee2, H. Park2, Y. Kim2, J. Noh3, J. Jung3, S. Lee3, H. Shin3, H. Yoon4, D. Lee3, S. Lee1

    1Department of Surgery, Samsung Medical Center, Seoul, Korea, Republic of, 2Stem Cell and Regenerative Medicine Center, Research Institute for Future Medicine, Samsung Medical Center, Seoul, Korea, Republic of, 3Biomedical Research Center, Lifeliver, Co. Ltd., Yongin, Korea, Republic of, 4Biomedical Research Center, Lifeliver, Co. Ltd., Seoul, Korea, Republic of

    *Purpose: Acute liver failure (ALF) has a rapid and unpredictable onset with high mortality. The only current treatment is to transplant a donor organ but…
  • 2020 American Transplant Congress

    Prolonged In Vivo Perfusion of a Re-Endothelialized Human-Scale Tissue Engineered Kidney Graft

    J. S. Uzarski1, E. E. Russell1, E. C. Beck1, M. Holzner2, V. Wadhera2, D. Adamson2, T. Gilbert1, S. Florman2, D. S. Davidow1, R. Shapiro2, J. Ross1

    1Research & Development, Miromatrix Medical Inc., Eden Prairie, MN, 2Recanati/Miller Institute, Mount Sinai, New York, NY

    *Purpose: Advances are desperately needed to increase the supply of transplantable kidneys for the 100,000 patients on the waiting list. Whole organ engineering is one…
  • 2020 American Transplant Congress

    Xenoantibody Depletion of Human Blood with Normothermic Machine Perfusion of Porcine Kidney and Lung Prior to Liver Perfusion

    T. M. Coe1, N. Serifis1, S. Raigani1, C. Carroll1, C. G. Rickert1, R. Matheson1, D. Detelich2, W. Qin3, Y. Kan3, J. Layer3, M. Youd3, W. Westlin3, L. Yang3, A. Azimzadeh1, J. F. Markmann1

    1Surgery, Massachusetts General Hospital, Boston, MA, 2Surgery, Tufts Medical Center, Boston, MA, 3eGenesis, Cambridge, MA

    *Purpose: Genetic modifications of porcine donors for pig-to-human xenotransplantation have led to significant progress in survival of xenografts in preclinical models. Triple knock-out (TKO) of…
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