2022 American Transplant Congress
The Renin Angiotensin System (RAS) After Pig-to-Baboon Kidney Transplantation
*Purpose: Relatively long-term survival after life-supporting pig-to-baboon kidney transplantation has been achieved. However, there are documented episodes of hypovolemia during the post-transplant period from an…2022 American Transplant Congress
Histocompatibility Findings in the First Xenotransplants from a Pig to Deceased Human Recipient
Transplant Institute, NYU Langone Transplant Institute, New York, NY
*Purpose: Humans lack α-1,3-Gal (α-gal) epitopes, and naturally occurring α-gal antibodies (Abs) cause hyperacute rejection of porcine xenografts. We conducted 2 successful xenotransplants in brain-dead…2022 American Transplant Congress
First-in-Human Clinical-Grade Porcine Kidney Xenotransplant
*Purpose: Proof-of-concept xenotransplant work has been performed in pig to non-human primates (NHP), but it is unclear if outcomes can be recapitulated in humans. While…2022 American Transplant Congress
Xenogeneic Cross-Circulation Supports Ex Vivo Human Livers for 24 Hours
*Purpose: Despite increasing use of machine perfusion as an organ preservation and rescue technique in liver transplantation, significant organ shortages and waitlist mortality highlight a…2022 American Transplant Congress
Fibrin Deposition in Ischemic Damaged Liver Grafts and Reconditioning with Thrombolytic Therapy During Normothermic Machine Perfusion
*Purpose: Normothermic ex situ perfusion (NMP) is a novel technique for the storage and assessment of marginal livers retrieved from donors after circulatory death (DCD).…2022 American Transplant Congress
Perfusate Cell-Free DNA Content is a Potential Marker of Cellular Injury During Hypothermic Machine Perfusion of Porcine Kidneys Subject to Prolonged Warm Ischemia
1University of Florida, Gainesville, FL, 2University of Oklahoma, Oklahoma City, OK
*Purpose: Despite the potential benefits and expanding use of advanced dynamic perfusion systems in clinical practice, to date there is no robust and non-invasive method…2022 American Transplant Congress
Utility of Porcine Kidneys in Transplantation Model for Training General Surgery Residents
Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ
*Purpose: We sought to increase the opportunities for general surgery residents to hone their vascular anastomosis skills. Accordingly, we created a kidney transplant model using…2022 American Transplant Congress
Local Mesenchymal Stem Cell Therapy for the Ex Vivo Preservation of a Porcine Vascularized Composite Allograft with 24-hour Normothermic Machine Perfusion
*Purpose: Given therapeutic limitations in limb salvage, we sought to demonstrate the efficacy of combining local mesenchymal stem cells (MSCs) infusion with fresh whole blood…2022 American Transplant Congress
Critical Care of the Brain-Dead Recipient of a Pig-to-Human Renal Transplant
1NYU Langone Transplant Institute, New York, NY, 2NYU Langone Health, New York, NY
*Purpose: The care of a brain dead (BD) patient undergoing xenotransplantation in a non-clinical environment poses unique challenges. Selection of an appropriate decedent, stabilization of…2022 American Transplant Congress
Triple-Knockout Pig Red Blood Cells as Potential Sources for Blood Transfusion in Alloimmunized Patients with Sickle Cell Disease
*Purpose: Blood transfusion remains important in the treatment of patients with sickle cell disease (SCD). However, alloimmunization after multiple blood transfusions is associated with patient…
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