ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Pig"

  • 2022 American Transplant Congress

    Fibrin Deposition in Ischemic Damaged Liver Grafts and Reconditioning with Thrombolytic Therapy During Normothermic Machine Perfusion

    T. Goto, Y. Noguchi, S. Ganesh, B. Arulratnam, M. Kawamura, C. Parmentier, S. Ray, T. Reichman, N. Selzner, M. Selzner

    Ajmera Transplant Program, Department of Surgery, Toronto General Hospital, University Health Network, Toronto, ON, Canada

    *Purpose: Normothermic ex situ perfusion (NMP) is a novel technique for the storage and assessment of marginal livers retrieved from donors after circulatory death (DCD).…
  • 2022 American Transplant Congress

    Perfusate Cell-Free DNA Content is a Potential Marker of Cellular Injury During Hypothermic Machine Perfusion of Porcine Kidneys Subject to Prolonged Warm Ischemia

    V. Boominathan1, M. Willman1, N. Battula2, A. Zarrinpar1, S. Duarte1

    1University of Florida, Gainesville, FL, 2University of Oklahoma, Oklahoma City, OK

    *Purpose: Despite the potential benefits and expanding use of advanced dynamic perfusion systems in clinical practice, to date there is no robust and non-invasive method…
  • 2022 American Transplant Congress

    Utility of Porcine Kidneys in Transplantation Model for Training General Surgery Residents

    O. Eletta, V. Putatunda, D. Walls, C. Antwi-Buosiako, B. Perry, N. Maloney Patel, R. Pelletier, A. Bongu

    Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ

    *Purpose: We sought to increase the opportunities for general surgery residents to hone their vascular anastomosis skills. Accordingly, we created a kidney transplant model using…
  • 2022 American Transplant Congress

    Local Mesenchymal Stem Cell Therapy for the Ex Vivo Preservation of a Porcine Vascularized Composite Allograft with 24-hour Normothermic Machine Perfusion

    A. Bernal1, J. Hinshaw1, J. Pena1, C. Hinshaw1, D. Wood1, K. Zimmern2, N. McMahon2, J. Ling2, W. Zhang1, E. Weitzel1

    1US Army Institute of Surgical Research/59th MDW, San Antonio, TX, 2Southwest Research Institute, San Antonio, TX

    *Purpose: Given therapeutic limitations in limb salvage, we sought to demonstrate the efficacy of combining local mesenchymal stem cells (MSCs) infusion with fresh whole blood…
  • 2022 American Transplant Congress

    Critical Care of the Brain-Dead Recipient of a Pig-to-Human Renal Transplant

    G. L. Piper1, P. Sommer2, J. M. Stern1, B. Sullivan1, E. Weldon1, N. Lawson1, B. Lonze1, R. Dieter2, G. Boulton1, R. Montgomery1

    1NYU Langone Transplant Institute, New York, NY, 2NYU Langone Health, New York, NY

    *Purpose: The care of a brain dead (BD) patient undergoing xenotransplantation in a non-clinical environment poses unique challenges. Selection of an appropriate decedent, stabilization of…
  • 2022 American Transplant Congress

    Triple-Knockout Pig Red Blood Cells as Potential Sources for Blood Transfusion in Alloimmunized Patients with Sickle Cell Disease

    T. Yamamoto1, M. H. Bikhet2, H. Q. Nguyen2, Y. Cui2, M. Javed2, S. S. Raza2, D. Ayares3, H. Iwase2, H. Hara2, D. K. Cooper1

    1Center for Transplantation Sciences, Massachusetts General Hospital/Harvard Medical School, Boston, MA, 2Xenotransplantation Program, Department of Surgery, University of Alabama at Birmingham, Birmingham, AL, 3Revivicor, Blacksburg, VA

    *Purpose: Blood transfusion remains important in the treatment of patients with sickle cell disease (SCD). However, alloimmunization after multiple blood transfusions is associated with patient…
  • 2022 American Transplant Congress

    Implementation of Infectious Disease Surveillance in Recently Deceased Human Xenograft Study

    S. J. Cawthon, E. P. Weldon, N. S. Lawson, B. E. Lonze, R. A. Montgomery, S. A. Mehta

    NYU Langone Transplant Institute, New York, NY

    *Purpose: Xenotransplantation is a promising solution for the ongoing organ shortage but has been slow to develop because of both immunological challenges and potential risk…
  • 2022 American Transplant Congress

    Manufactured Organ Procurement Facility Collaboration and Authorization Approach for Xenotransplant Research

    E. P. Weldon, N. S. Lawson, B. E. Sullivan, B. S. Parent, C. L. Deterville, R. A. Dieter, R. A. Montgomery

    NYU Langone Health-Transplant Institute, New York, NY

    *Purpose: A Manufactured Organ Research Facility (MORF) was created at our institution to provide a safe environment for testing xenograft organs in deceased brain dead…
  • 2022 American Transplant Congress

    Enhancing Early Nerve Regeneration from Reconstruction of a Segmental Nerve Injury with Polyethylene Glycol

    A. Bernal1, C. Hinshaw1, J. Hinshaw1, C. Yang2, S. Margaux1, W. Zhang1, J. Nuelle1, C. Sabbag1, G. Bittner2, J. Shores3, E. Weitzel1, J. Alderete1

    1RESTOR FUSE Nerve Reconstruction Consortium, US Army Institute of Surgical Research/59th MDW, San Antonio, TX, 2University of Texas at Austin, Austin, TX, 3John Hopkins University, Baltimore, MD

    *Purpose: Despite advancements in understanding and treating peripheral nerve injuries (PNIs), restoration of lost motor and sensory functions remain poor using current methods of clinical…
  • 2022 American Transplant Congress

    Long-Term (>1 Year) Rejection Free Graft Survival of Kidney Xenografts with Triple Xenoantigen Knockout and Multiple Human Transgenes in Cynomolgus Monkeys

    T. Hirose1, G. Lassiter1, D. Ma1, A. D'Attilio1, I. Rosales1, D. Cloonan1, R. Matheson1, R. Colvin1, W. Qin2, Y. Kan2, J. Layer2, R. Anand2, V. Paragas2, L. Queroz2, X. Tan2, I. Kohnle2, K. Stiede2, K. Hall2, M. Youd2, M. Curtis2, J. Markmann1, T. Kawai1

    1Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, 2eGenesis Inc, Cambridge, MA

    *Purpose: Pigs with deletion of 3 carbohydrate xenoantigens (triple knock-out, TKO) are expected to be optimal donors for human xenotransplantation. We have previously shown that…
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