ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Pig"

  • 2021 American Transplant Congress

    Initial Experience with Growth Hormone Receptor Knockout in Pig-to-Baboon Kidney Transplantation: Effect on Ureteric Viability and Kidney Growth

    C. Hansen-Estruch1, H. Iwase1, A. Jagdale1, T. Yamamoto1, M. H. Bikhet1, J. Foote2, H. Hara1, D. Anderson1, P. Porrett1, D. Eckhoff1, D. Ayares3, W. Eyestone3, J. Locke1, D. K. Cooper1

    1Xenotransplantation Program, Department of Surgery, University of Alabama at Birmingham, Birmingham, AL, 2Department of Microbiology and Animal Resources Program, University of Alabama at Birmingham, Birmingham, AL, 3Revivicor, Blacksburg, VA

    *Purpose: The purpose of this study was to report outcomes of pig-to-baboon renal transplants using a novel growth hormone receptor knockout (GHRKO) organ-source pig created…
  • 2021 American Transplant Congress

    Anti-pig IgE and IgA Antibodies in Sera of (i) Naïve Primates and (ii) Non-human Primates Sensitized to Pig Xenografts

    H. Hara, Q. Li, H. Iwase, T. Yamamoto, D. Ayares, D. K. Cooper

    University of Alabama at Birmingham, Birmingham, AL

    *Purpose: Anti-pig IgM and IgG antibodies in primates play an important role in xenograft rejection. The possible roles of anti-pig IgE and IgA have not…
  • 2020 American Transplant Congress

    Sialoadhesin Mediates the Adhesion of Human RBC to Porcine Macrophages from Genetically Engineered Pigs

    K. Petitpas1, B. Cerel1, Z. Abady1, L. Burdorf1, D. L. Ayares2, D. M. Magnani3, R. N. Pierson III1, A. M. Azimzadeh1

    1Center for Transplantation Sciences, Massachusetts General Hospital/Harvard Medical School, Boston, MA, 2Revivicor, Blacksburg, VA, 3MassBiologics of UMMS, Boston, MA

    *Purpose: The sequestration of human RBC is prominent after liver and lung xenotransplantation. Rees et al previously implicated porcine sialoadhesin in adhesion of human RBC…
  • 2020 American Transplant Congress

    The Development of an Innovative Training Pathway for Robotic Assisted Renal Transplant Program

    H. Pournik1, J. Castillo2, V. Brown2, J. Collins2, C. Haisch2, D. Leeser2

    1ECU, Greenville, NC, 2Surgery, East Carolina University, Greenville, NC

    *Purpose: To develop and implement a surgeon and team training program for robotic renal transplants utilizing innovative technology and techniques.*Methods: A graduated robotic educational program…
  • 2020 American Transplant Congress

    Using an Ex Vivo Blood-Free Model of Preservation and Reperfusion to Evaluate the Effects of Subnormothermic Perfusion with Hydrogen Sulfide on DCD Porcine Renal Grafts

    S. Juriasingani1, A. Ruthirakanthan1, M. Richard-Mohamed2, M. Zhang1, M. Levine1, E. Sogutdelen1, M. Mandurah1, A. Sener1

    1University of Western Ontario, London, ON, Canada, 2London Health Sciences Centre, London, ON, Canada

    *Purpose: The need for donor blood complicates the clinical translation of normothermic and subnormothermic perfusion for preservation and graft function evaluation. As such, hemoglobin-based oxygen…
  • 2020 American Transplant Congress

    A Large Animal Model of Ex-Vivo Lung Perfusion as a Platform to Deliver Therapeutic Agents to Lungs Before Lung Transplant

    T. M. Egan1, B. Haithcock1, M. H. Ali1, J. W. Blackwell1, B. Masuodi1, S. Shipley2, T. Long3, A. Akerman1, S. Montgomery4, H. Yuan5, P. Stewart6, J. Potenziano7, C. Sekaran7, R. Fitch7

    1Surgery, UNC at Chapel Hill, Chapel Hill, NC, 2Department of Pathology and Laboratory Medicine, UNC at Chapel Hill, Chapel Hill, NC, 3Pathology and Laboratory Medicine,, UNC at Chapel Hill, Chapel Hill, NC, 4Pathology and Laboratory Medicine, UNC at Chapel Hill, Chapel Hill, NC, 5Radiology, UNC at Chapel Hill, Chapel Hill, NC, 6Gillings Global School of Public Health, UNC at Chapel Hill, Chapel Hill, NC, 7Mallinckrodt Pharmaceuticals, Hazelwood, MO

    *Purpose: Ex-vivo lung perfusion (EVLP) has been used to evaluate lung function before lung transplant (LT). We used EVLP to expose lungs recovered 6 hours…
  • 2020 American Transplant Congress

    Experimental Porcine Pancreatic Allotransplantation after Hypothermic Perfusion

    T. Prudhomme1, D. Kervella1, K. Renaudin2, V. Gauttier1, S. Le Bas-Bernardet3, D. Minault3, J. Hervouet3, D. Cantarovich1, G. Karam1, G. Blancho1, J. Branchereau1

    1Institut de Transplantation Urologie Néphrologie (ITUN), CHU Nantes, Nantes, France, 2Département d’Anatomie et de Cytologie Pathologique, CHU Nantes, Nantes, France, 3Centre de Recherche en Transplantation et Immunologie, UMR1064, INSERM, Université de Nantes, Nantes, France

    *Purpose: The main objective of this study was to compare the different preservation techniques (static cold storage (SCS) and hypothermic pulsatile perfusion (HPP)) in a…
  • 2020 American Transplant Congress

    XIAP Enhances Xenoislet Survival: Novel Models to Evaluate Pretransplantation Gene Modifications

    G. R. Devi1, Z. Fitch1, M. Song1, M. Ribeiro1, A. McGowan1, X. Luo2, B. H. Collins1, A. D. Kirk1

    1Department of Surgery, Duke Univesity School of Medicine, Durham, NC, 2Division of Nephrology, Duke Univesity School of Medicine, Durham, NC

    *Purpose: Porcine islet xenotransplantation offers a reliable and near limitless supply of islets for the treatment of type 1 diabetes. Intraportal infusion of cells exposes…
  • 2020 American Transplant Congress

    Hepatic Microenvironment: Molecular and Chemical Changes Associated with Preconditioning Maneuvers

    I. Lies, C. Watkins, M. Em, J. D. Eason, C. Eynard, T. Rousselle, V. R. Mas, D. Maluf

    Dept of Surgery, Transplant Research Institute, James D. Eason Transplant Institute, University of Tennessee Health Science Center, Memphis, TN

    *Purpose: Liver preconditioning has been described to protect liver from ischemia injury and trigger liver regeneration. Hereby, we aimed to assess the effect of preconditioning…
  • 2020 American Transplant Congress

    Abdominal Multiorgan Retrieval from Pigs in a Slaughterhouse: A Reliable and Efficient Donation after Circulatory Death Model for Ex Vivo Organ Perfusion

    F. Neri, F. Dengu, G. Ebeling, L. Knijff, K. Rozemberg, J. Branchereau, P. Friend, R. Ploeg, J. Hunter

    Nuffield Department of Surgical Sciences, Oxford University, Oxford, United Kingdom

    *Purpose: Advances in organ perfusion technology have been driven by the increasing necessity to utilise organs from donors after circulatory death (DCD) and marginal donors.…
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