ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Pig"

  • 2021 American Transplant Congress

    Combined CD11b/CD40 Blockade is Superior to CD40 Blockade Alone in Prolonging Survival in Pig-to-Nonhuman Primate Renal Xenotransplantation

    D. A. Faber1, B. Lovasik1, A. Matar1, C. Breeden1, S. Kim1, A. Adams2

    1Surgery, Emory University School of Medicine, Atlanta, GA, 2Surgery, University of Minnesota, Minneapolis, MN

    *Purpose: Blockade of the CD40/CD154 pathway is highly effective in preventing rejection in pig-to-nonhuman primate (NHP) xenotransplantation models. Clinical translation of anti-CD154 mAbs, however, has…
  • 2021 American Transplant Congress

    Complement Blockade Improves Renal Xenograft Survival in Primates in the Absence of Transgenic Complement Regulatory Proteins

    D. A. Faber1, B. Lovasik1, A. Matar1, C. Breeden1, A. B. Farris2, M. Tector3, A. Tector3, A. Adams4

    1Surgery, Emory University School of Medicine, Atlanta, GA, 2Pathology, Emory University School of Medicine, Atlanta, GA, 3Surgery, University of Miami, Miami, FL, 4Surgery, University of Minnesota, Minneapolis, MN

    *Purpose: Complement activation is a major contributor to xenograft rejection. To minimize xenograft injury, complement suppression via insertion of human complement-regulatory transgenes into the donor…
  • 2020 American Transplant Congress

    Old World Monkeys Are Not Ideal Transplantation Models for Testing CMAHKO (TKO or GTKO/CMAHKO) Pig Kidneys

    T. Yamamoto1, H. Iwase1, D. Patel1, A. Jagdale1, J. Foote1, D. Ayares2, D. Anderson1, D. E. Eckhoff1, D. K. Cooper1, H. Hara1

    1University of Alabama at Birmingham, Birmingham, AL, 2Revivicor, Blacksburg, VA

    *Purpose: Triple-knockout (TKO) pigs are likely to be an optimal source of organs for transplantation into human recipients, many of whom do not have natural…
  • 2020 American Transplant Congress

    Enumeration of Platelets by Flow Cytometry Reveals Human Erythrocyte Fragmentation During Pig Organ Xenoperfusion Studies

    Z. Abady1, K. M. Petitpas1, L. Burdorf1, S. G. Pratts1, B. M. Cerel1, S. Sendil2, M. R. Connolly1, W. Qin3, Y. Kan3, J. Layer3, M. Youd3, W. Westlin3, L. Yang3, R. N. Pierson III1, A. M. Azimzadeh1

    1Surgery, Massachusetts General Hospital and Harvard School of Medicine, Boston, MA, 2Surgery, University of Maryland School of Medicine, Baltimore, MD, 3eGenesis, Cambridge, MA

    *Purpose: Human or baboon platelet sequestration and activation occurs during pig organ xenograft perfusion, although the mechanism remains poorly understood. To evaluate an apparent “rebound”…
  • 2020 American Transplant Congress

    Immuno-Modulation of Primed Xenogeneic T Cell Response by mTOR Blockade of T Cells and Porcine Endothelial Cells

    S. Li, A. Kirk, H. Xu

    Surgery, Duke University, Durham, NC

    *Purpose: Porcine vascular endothelial cells (PECs) play a central role in xeno-recognition and costimulation. The objectives of this study were to characterize the immuno-phenotype of…
  • 2020 American Transplant Congress

    Expression of Multiple Human Complement Regulatory Proteins Results in Prolonged Heterotopic Xenoheart Survival in an NHP Model

    K. Ahrens1, J. M. O1, W. Sommer2, D. Becerra1, P. M. Patel1, A. Dehnadi1, Y. Kan3, J. Layer3, J. Morrissette1, T. Costa1, I. M. Hanekamp1, J. S. Allan4, M. Youd3, R. N. Pierson5, W. Qin3, L. Burdorf5, A. M. Azimzadeh1, W. Westlin3, L. Yang3, J. C. Madsen5

    1Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, 2Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany, 3eGenesis Inc., Cambridge, MA, 4Center for Transplantation Sciences, Division of Thoracic Surgery, Massachusetts General Hospital, Boston, MA, 5Center for Transplantation Sciences, Division of Cardiac Surgery, Massachusetts General Hospital, Boston, MA

    *Purpose: Advances in genome engineering technology allow for multiplex genetic modifications in pigs designed to address immunologic and coagulation incompatibilities in order to facilitate xenotransplantation.…
  • 2020 American Transplant Congress

    Sialoadhesin Mediates the Adhesion of Human RBC to Porcine Macrophages from Genetically Engineered Pigs

    K. Petitpas1, B. Cerel1, Z. Abady1, L. Burdorf1, D. L. Ayares2, D. M. Magnani3, R. N. Pierson III1, A. M. Azimzadeh1

    1Center for Transplantation Sciences, Massachusetts General Hospital/Harvard Medical School, Boston, MA, 2Revivicor, Blacksburg, VA, 3MassBiologics of UMMS, Boston, MA

    *Purpose: The sequestration of human RBC is prominent after liver and lung xenotransplantation. Rees et al previously implicated porcine sialoadhesin in adhesion of human RBC…
  • 2020 American Transplant Congress

    The Development of an Innovative Training Pathway for Robotic Assisted Renal Transplant Program

    H. Pournik1, J. Castillo2, V. Brown2, J. Collins2, C. Haisch2, D. Leeser2

    1ECU, Greenville, NC, 2Surgery, East Carolina University, Greenville, NC

    *Purpose: To develop and implement a surgeon and team training program for robotic renal transplants utilizing innovative technology and techniques.*Methods: A graduated robotic educational program…
  • 2020 American Transplant Congress

    Using an Ex Vivo Blood-Free Model of Preservation and Reperfusion to Evaluate the Effects of Subnormothermic Perfusion with Hydrogen Sulfide on DCD Porcine Renal Grafts

    S. Juriasingani1, A. Ruthirakanthan1, M. Richard-Mohamed2, M. Zhang1, M. Levine1, E. Sogutdelen1, M. Mandurah1, A. Sener1

    1University of Western Ontario, London, ON, Canada, 2London Health Sciences Centre, London, ON, Canada

    *Purpose: The need for donor blood complicates the clinical translation of normothermic and subnormothermic perfusion for preservation and graft function evaluation. As such, hemoglobin-based oxygen…
  • 2020 American Transplant Congress

    A Large Animal Model of Ex-Vivo Lung Perfusion as a Platform to Deliver Therapeutic Agents to Lungs Before Lung Transplant

    T. M. Egan1, B. Haithcock1, M. H. Ali1, J. W. Blackwell1, B. Masuodi1, S. Shipley2, T. Long3, A. Akerman1, S. Montgomery4, H. Yuan5, P. Stewart6, J. Potenziano7, C. Sekaran7, R. Fitch7

    1Surgery, UNC at Chapel Hill, Chapel Hill, NC, 2Department of Pathology and Laboratory Medicine, UNC at Chapel Hill, Chapel Hill, NC, 3Pathology and Laboratory Medicine,, UNC at Chapel Hill, Chapel Hill, NC, 4Pathology and Laboratory Medicine, UNC at Chapel Hill, Chapel Hill, NC, 5Radiology, UNC at Chapel Hill, Chapel Hill, NC, 6Gillings Global School of Public Health, UNC at Chapel Hill, Chapel Hill, NC, 7Mallinckrodt Pharmaceuticals, Hazelwood, MO

    *Purpose: Ex-vivo lung perfusion (EVLP) has been used to evaluate lung function before lung transplant (LT). We used EVLP to expose lungs recovered 6 hours…
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