ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Pig"

  • 2021 American Transplant Congress

    Triple-Knockout Pig Red Blood Cells Are a Potential Alternative Source for Clinical Blood Transfusion

    T. Yamamoto1, M. H. Bikhet1, H. Q. Nguyen1, M. Javed1, D. Ayares2, H. Iwase1, H. Hara1, D. K. Cooper1

    1Xenotransplantation Program, Surgery, The University of Alabama at Birmingham, Birmingham, AL, 2Revivicor, Blacksburg, VA

    *Purpose: Triple-knockout (TKO) pig RBCs (pRBCs) may be an alternative source for clinical blood transfusion because almost humans have no preformed antibody to TKO pRBCs.…
  • 2021 American Transplant Congress

    Composition of Ex Vivo Lung Perfusion Solutions and Kinetics Define Differential Cytokine and Chemokine Secretion in a Porcine Cardiac Arrest Model of Lung Preservation

    L. M. Radomsky1, A. Koch2, C. Olbertz2, J. F. Kuehne1, Y. Liu2, J. Keil1, K. Beushausen1, U. Rauen3, C. S. Falk1, M. Kamler2

    1Institute of Transplant Immunology, Hannover Medical School, Hannover, Germany, 2Thoracic Transplantation, Department of Thoracic and Cardiovascular Surgery, University Hospital Essen, Essen, Germany, 3Institute of Physiological Chemistry, University Hospital Essen, Essen, Germany

    *Purpose: Ex vivo lung perfusion is an innovative technique to evaluate marginal lung organs especially after DCD. Normothermic continuous perfusion should reduce ischemic damage and…
  • 2020 American Transplant Congress

    Coagulation and Cd46 Transgene Modification in Neonatal Porcine Islet Xenotransplantation

    M. Song, Z. Fitch, K. Samy, Q. Gao, R. P. Davis, F. Leopard, R. Schmitz, N. Huffman, G. Devi, B. Collins, A. D. Kirk

    Surgery, Duke University, Durham, NC

    *Purpose: Vascular thrombosis is a potential cause for early intraportal xeno-islet loss. To better understand the relationship between coagulation and inflammation in early xeno-islet transplantation,…
  • 2020 American Transplant Congress

    What Happens When You Administer Mesenchymal Stromal Cells During Normothermic Machine Perfusion of Porcine Kidneys: Possible and Helpful or Not?

    K. Rozenberg1, L. Knijff1, J. Sierra-Parraga2, L. Lo Faro1, M. Hoogduijn2, C. Baan2, J. Hunter1, R. Ploeg1

    1Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom, 2Department of Internal Medicine, Nephrology and Transplantation, Erasmus MC, University Medical Center, Rotterdam, Netherlands

    *Purpose: Donation after circulatory death kidneys are widely used to increase the donor pool, despite their inferior quality. Normothermic machine perfusion (NMP) could provide a…
  • 2020 American Transplant Congress

    Normothermic Ex-Vivo Kidney Perfusion is Superior to Anoxic and Oxygenated Hypothermic Machine Perfusion for the Preservation of DCD Porcine Kidney Grafts

    L. Mazilescu1, M. Kaths2, P. Urbanellis1, M. Hamar3, T. Goto1, I. Linares-Cervantes1, Y. Noguchi1, A. Konvalinka1, A. Ghanekar1, D. Bagli4, R. John5, L. Robinson6, M. Selzner1

    1Multi Organ Transplant Program, Toronto General Hospital, Toronto, ON, Canada, 2Department of General, Visceral, and Transplantation Surgery, University Hospital Essen, Essen, Germany, 3Department of Transplantation and Surgery, Semmelweis University, Budapest, Hungary, 4Departments of Surgery(Urology)&Physiology, The Hospital for Sick Children, Toronto, ON, Canada, 5Laboratory Medicine & Pathobiology, Toronto General Hospital, Toronto, ON, Canada, 6Division of Nephrology, The Hospital for Sick Children, Toronto, ON, Canada

    *Purpose: To increase the donor pool, better preservation strategies for the storage of marginal kidney grafts are crucial. Currently, kidney grafts are either stored on…
  • 2020 American Transplant Congress

    Improved Survival of Acute Liver Failure by “Off-the-Shelf” Bioartificial Liver Support System Using Immobilized Cryopreserved Hepatocyte Spheroids in Porcine Model

    S. Lee1, J. Lee2, H. Park2, Y. Kim2, J. Noh3, J. Jung3, S. Lee3, H. Shin3, H. Yoon4, D. Lee3, S. Lee1

    1Department of Surgery, Samsung Medical Center, Seoul, Korea, Republic of, 2Stem Cell and Regenerative Medicine Center, Research Institute for Future Medicine, Samsung Medical Center, Seoul, Korea, Republic of, 3Biomedical Research Center, Lifeliver, Co. Ltd., Yongin, Korea, Republic of, 4Biomedical Research Center, Lifeliver, Co. Ltd., Seoul, Korea, Republic of

    *Purpose: Acute liver failure (ALF) has a rapid and unpredictable onset with high mortality. The only current treatment is to transplant a donor organ but…
  • 2020 American Transplant Congress

    Prolonged In Vivo Perfusion of a Re-Endothelialized Human-Scale Tissue Engineered Kidney Graft

    J. S. Uzarski1, E. E. Russell1, E. C. Beck1, M. Holzner2, V. Wadhera2, D. Adamson2, T. Gilbert1, S. Florman2, D. S. Davidow1, R. Shapiro2, J. Ross1

    1Research & Development, Miromatrix Medical Inc., Eden Prairie, MN, 2Recanati/Miller Institute, Mount Sinai, New York, NY

    *Purpose: Advances are desperately needed to increase the supply of transplantable kidneys for the 100,000 patients on the waiting list. Whole organ engineering is one…
  • 2020 American Transplant Congress

    Xenoantibody Depletion of Human Blood with Normothermic Machine Perfusion of Porcine Kidney and Lung Prior to Liver Perfusion

    T. M. Coe1, N. Serifis1, S. Raigani1, C. Carroll1, C. G. Rickert1, R. Matheson1, D. Detelich2, W. Qin3, Y. Kan3, J. Layer3, M. Youd3, W. Westlin3, L. Yang3, A. Azimzadeh1, J. F. Markmann1

    1Surgery, Massachusetts General Hospital, Boston, MA, 2Surgery, Tufts Medical Center, Boston, MA, 3eGenesis, Cambridge, MA

    *Purpose: Genetic modifications of porcine donors for pig-to-human xenotransplantation have led to significant progress in survival of xenografts in preclinical models. Triple knock-out (TKO) of…
  • 2020 American Transplant Congress

    Old World Monkeys Are Not Ideal Transplantation Models for Testing CMAHKO (TKO or GTKO/CMAHKO) Pig Kidneys

    T. Yamamoto1, H. Iwase1, D. Patel1, A. Jagdale1, J. Foote1, D. Ayares2, D. Anderson1, D. E. Eckhoff1, D. K. Cooper1, H. Hara1

    1University of Alabama at Birmingham, Birmingham, AL, 2Revivicor, Blacksburg, VA

    *Purpose: Triple-knockout (TKO) pigs are likely to be an optimal source of organs for transplantation into human recipients, many of whom do not have natural…
  • 2020 American Transplant Congress

    Enumeration of Platelets by Flow Cytometry Reveals Human Erythrocyte Fragmentation During Pig Organ Xenoperfusion Studies

    Z. Abady1, K. M. Petitpas1, L. Burdorf1, S. G. Pratts1, B. M. Cerel1, S. Sendil2, M. R. Connolly1, W. Qin3, Y. Kan3, J. Layer3, M. Youd3, W. Westlin3, L. Yang3, R. N. Pierson III1, A. M. Azimzadeh1

    1Surgery, Massachusetts General Hospital and Harvard School of Medicine, Boston, MA, 2Surgery, University of Maryland School of Medicine, Baltimore, MD, 3eGenesis, Cambridge, MA

    *Purpose: Human or baboon platelet sequestration and activation occurs during pig organ xenograft perfusion, although the mechanism remains poorly understood. To evaluate an apparent “rebound”…
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