ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Pig"

  • 2021 American Transplant Congress

    Triple-Knockout Pig Red Blood Cells Are a Potential Alternative Source for Clinical Blood Transfusion

    T. Yamamoto1, M. H. Bikhet1, H. Q. Nguyen1, M. Javed1, D. Ayares2, H. Iwase1, H. Hara1, D. K. Cooper1

    1Xenotransplantation Program, Surgery, The University of Alabama at Birmingham, Birmingham, AL, 2Revivicor, Blacksburg, VA

    *Purpose: Triple-knockout (TKO) pig RBCs (pRBCs) may be an alternative source for clinical blood transfusion because almost humans have no preformed antibody to TKO pRBCs.…
  • 2021 American Transplant Congress

    Composition of Ex Vivo Lung Perfusion Solutions and Kinetics Define Differential Cytokine and Chemokine Secretion in a Porcine Cardiac Arrest Model of Lung Preservation

    L. M. Radomsky1, A. Koch2, C. Olbertz2, J. F. Kuehne1, Y. Liu2, J. Keil1, K. Beushausen1, U. Rauen3, C. S. Falk1, M. Kamler2

    1Institute of Transplant Immunology, Hannover Medical School, Hannover, Germany, 2Thoracic Transplantation, Department of Thoracic and Cardiovascular Surgery, University Hospital Essen, Essen, Germany, 3Institute of Physiological Chemistry, University Hospital Essen, Essen, Germany

    *Purpose: Ex vivo lung perfusion is an innovative technique to evaluate marginal lung organs especially after DCD. Normothermic continuous perfusion should reduce ischemic damage and…
  • 2020 American Transplant Congress

    Experimental Porcine Pancreatic Allotransplantation after Hypothermic Perfusion

    T. Prudhomme1, D. Kervella1, K. Renaudin2, V. Gauttier1, S. Le Bas-Bernardet3, D. Minault3, J. Hervouet3, D. Cantarovich1, G. Karam1, G. Blancho1, J. Branchereau1

    1Institut de Transplantation Urologie Néphrologie (ITUN), CHU Nantes, Nantes, France, 2Département d’Anatomie et de Cytologie Pathologique, CHU Nantes, Nantes, France, 3Centre de Recherche en Transplantation et Immunologie, UMR1064, INSERM, Université de Nantes, Nantes, France

    *Purpose: The main objective of this study was to compare the different preservation techniques (static cold storage (SCS) and hypothermic pulsatile perfusion (HPP)) in a…
  • 2020 American Transplant Congress

    XIAP Enhances Xenoislet Survival: Novel Models to Evaluate Pretransplantation Gene Modifications

    G. R. Devi1, Z. Fitch1, M. Song1, M. Ribeiro1, A. McGowan1, X. Luo2, B. H. Collins1, A. D. Kirk1

    1Department of Surgery, Duke Univesity School of Medicine, Durham, NC, 2Division of Nephrology, Duke Univesity School of Medicine, Durham, NC

    *Purpose: Porcine islet xenotransplantation offers a reliable and near limitless supply of islets for the treatment of type 1 diabetes. Intraportal infusion of cells exposes…
  • 2020 American Transplant Congress

    Hepatic Microenvironment: Molecular and Chemical Changes Associated with Preconditioning Maneuvers

    I. Lies, C. Watkins, M. Em, J. D. Eason, C. Eynard, T. Rousselle, V. R. Mas, D. Maluf

    Dept of Surgery, Transplant Research Institute, James D. Eason Transplant Institute, University of Tennessee Health Science Center, Memphis, TN

    *Purpose: Liver preconditioning has been described to protect liver from ischemia injury and trigger liver regeneration. Hereby, we aimed to assess the effect of preconditioning…
  • 2020 American Transplant Congress

    Abdominal Multiorgan Retrieval from Pigs in a Slaughterhouse: A Reliable and Efficient Donation after Circulatory Death Model for Ex Vivo Organ Perfusion

    F. Neri, F. Dengu, G. Ebeling, L. Knijff, K. Rozemberg, J. Branchereau, P. Friend, R. Ploeg, J. Hunter

    Nuffield Department of Surgical Sciences, Oxford University, Oxford, United Kingdom

    *Purpose: Advances in organ perfusion technology have been driven by the increasing necessity to utilise organs from donors after circulatory death (DCD) and marginal donors.…
  • 2020 American Transplant Congress

    Coagulation and Cd46 Transgene Modification in Neonatal Porcine Islet Xenotransplantation

    M. Song, Z. Fitch, K. Samy, Q. Gao, R. P. Davis, F. Leopard, R. Schmitz, N. Huffman, G. Devi, B. Collins, A. D. Kirk

    Surgery, Duke University, Durham, NC

    *Purpose: Vascular thrombosis is a potential cause for early intraportal xeno-islet loss. To better understand the relationship between coagulation and inflammation in early xeno-islet transplantation,…
  • 2020 American Transplant Congress

    What Happens When You Administer Mesenchymal Stromal Cells During Normothermic Machine Perfusion of Porcine Kidneys: Possible and Helpful or Not?

    K. Rozenberg1, L. Knijff1, J. Sierra-Parraga2, L. Lo Faro1, M. Hoogduijn2, C. Baan2, J. Hunter1, R. Ploeg1

    1Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom, 2Department of Internal Medicine, Nephrology and Transplantation, Erasmus MC, University Medical Center, Rotterdam, Netherlands

    *Purpose: Donation after circulatory death kidneys are widely used to increase the donor pool, despite their inferior quality. Normothermic machine perfusion (NMP) could provide a…
  • 2020 American Transplant Congress

    Normothermic Ex-Vivo Kidney Perfusion is Superior to Anoxic and Oxygenated Hypothermic Machine Perfusion for the Preservation of DCD Porcine Kidney Grafts

    L. Mazilescu1, M. Kaths2, P. Urbanellis1, M. Hamar3, T. Goto1, I. Linares-Cervantes1, Y. Noguchi1, A. Konvalinka1, A. Ghanekar1, D. Bagli4, R. John5, L. Robinson6, M. Selzner1

    1Multi Organ Transplant Program, Toronto General Hospital, Toronto, ON, Canada, 2Department of General, Visceral, and Transplantation Surgery, University Hospital Essen, Essen, Germany, 3Department of Transplantation and Surgery, Semmelweis University, Budapest, Hungary, 4Departments of Surgery(Urology)&Physiology, The Hospital for Sick Children, Toronto, ON, Canada, 5Laboratory Medicine & Pathobiology, Toronto General Hospital, Toronto, ON, Canada, 6Division of Nephrology, The Hospital for Sick Children, Toronto, ON, Canada

    *Purpose: To increase the donor pool, better preservation strategies for the storage of marginal kidney grafts are crucial. Currently, kidney grafts are either stored on…
  • 2020 American Transplant Congress

    Improved Survival of Acute Liver Failure by “Off-the-Shelf” Bioartificial Liver Support System Using Immobilized Cryopreserved Hepatocyte Spheroids in Porcine Model

    S. Lee1, J. Lee2, H. Park2, Y. Kim2, J. Noh3, J. Jung3, S. Lee3, H. Shin3, H. Yoon4, D. Lee3, S. Lee1

    1Department of Surgery, Samsung Medical Center, Seoul, Korea, Republic of, 2Stem Cell and Regenerative Medicine Center, Research Institute for Future Medicine, Samsung Medical Center, Seoul, Korea, Republic of, 3Biomedical Research Center, Lifeliver, Co. Ltd., Yongin, Korea, Republic of, 4Biomedical Research Center, Lifeliver, Co. Ltd., Seoul, Korea, Republic of

    *Purpose: Acute liver failure (ALF) has a rapid and unpredictable onset with high mortality. The only current treatment is to transplant a donor organ but…
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