2022 American Transplant Congress
Enhancing Early Nerve Regeneration from Reconstruction of a Segmental Nerve Injury with Polyethylene Glycol
*Purpose: Despite advancements in understanding and treating peripheral nerve injuries (PNIs), restoration of lost motor and sensory functions remain poor using current methods of clinical…2022 American Transplant Congress
Long-Term (>1 Year) Rejection Free Graft Survival of Kidney Xenografts with Triple Xenoantigen Knockout and Multiple Human Transgenes in Cynomolgus Monkeys
*Purpose: Pigs with deletion of 3 carbohydrate xenoantigens (triple knock-out, TKO) are expected to be optimal donors for human xenotransplantation. We have previously shown that…2022 American Transplant Congress
The Renin Angiotensin System (RAS) After Pig-to-Baboon Kidney Transplantation
*Purpose: Relatively long-term survival after life-supporting pig-to-baboon kidney transplantation has been achieved. However, there are documented episodes of hypovolemia during the post-transplant period from an…2022 American Transplant Congress
Histocompatibility Findings in the First Xenotransplants from a Pig to Deceased Human Recipient
Transplant Institute, NYU Langone Transplant Institute, New York, NY
*Purpose: Humans lack α-1,3-Gal (α-gal) epitopes, and naturally occurring α-gal antibodies (Abs) cause hyperacute rejection of porcine xenografts. We conducted 2 successful xenotransplants in brain-dead…2022 American Transplant Congress
First-in-Human Clinical-Grade Porcine Kidney Xenotransplant
*Purpose: Proof-of-concept xenotransplant work has been performed in pig to non-human primates (NHP), but it is unclear if outcomes can be recapitulated in humans. While…2022 American Transplant Congress
Xenogeneic Cross-Circulation Supports Ex Vivo Human Livers for 24 Hours
*Purpose: Despite increasing use of machine perfusion as an organ preservation and rescue technique in liver transplantation, significant organ shortages and waitlist mortality highlight a…2022 American Transplant Congress
Fibrin Deposition in Ischemic Damaged Liver Grafts and Reconditioning with Thrombolytic Therapy During Normothermic Machine Perfusion
*Purpose: Normothermic ex situ perfusion (NMP) is a novel technique for the storage and assessment of marginal livers retrieved from donors after circulatory death (DCD).…2022 American Transplant Congress
Perfusate Cell-Free DNA Content is a Potential Marker of Cellular Injury During Hypothermic Machine Perfusion of Porcine Kidneys Subject to Prolonged Warm Ischemia
1University of Florida, Gainesville, FL, 2University of Oklahoma, Oklahoma City, OK
*Purpose: Despite the potential benefits and expanding use of advanced dynamic perfusion systems in clinical practice, to date there is no robust and non-invasive method…2022 American Transplant Congress
Utility of Porcine Kidneys in Transplantation Model for Training General Surgery Residents
Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ
*Purpose: We sought to increase the opportunities for general surgery residents to hone their vascular anastomosis skills. Accordingly, we created a kidney transplant model using…2022 American Transplant Congress
Local Mesenchymal Stem Cell Therapy for the Ex Vivo Preservation of a Porcine Vascularized Composite Allograft with 24-hour Normothermic Machine Perfusion
*Purpose: Given therapeutic limitations in limb salvage, we sought to demonstrate the efficacy of combining local mesenchymal stem cells (MSCs) infusion with fresh whole blood…
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