Articles tagged "Pancreas"

2020 American Transplant Congress
Implications for Facilitated Pancreas Transplant Allocation with the Removal of Donor Service Area
R. Forbes¹, R. Urban², A. Fox², J. Odorico³, S. Niederhaus⁴
¹Vanderbilt University Medical Center, Nashville, TN, ²United Network for Organ Sharing, Richmond, VA, ³University of Wisconsin, Madison, WI, ⁴University of Maryland, Baltimore, MD
*Purpose: Facilitated Pancreas (FP) Allocation, modified in August 2016 to be metric-based rather than opt-in, defines an eligible center as one that has transplanted at…
2020 American Transplant Congress
Impact of Sarcopenia on Simultaneous Pancreas and Kidney Transplantation Outcomes: A Retrospective Observational Cohort Study
R. P. Meier, H. Noguchi, Y. Kelly, M. Sarwal, G. Conti, R. Halleluyan, M. Tavakol, P. Stock, C. Freise
Transplant Surgery, University of California San Francisco, San Francisco, CA
*Purpose: Sarcopenia has been identified as a recognized predictive variable for surgical outcomes. We hypothesized that sarcopenia could be a key measure to identify frail…
2020 American Transplant Congress
Lower Extremity Vascular Complications after Simultaneous Pancreas Kidney Transplant
H. J. Braun, D. Amara, T. Sorrentino, J. L. Ramirez, J. Lin, A. Mello, P. G. Stock, J. S. Hiramoto
University of California, San Francisco, San Francisco, CA
*Purpose: Type 1 diabetes mellitus (DM) is the leading indication for simultaneous pancreas kidney transplantation (SPK). Prior work has demonstrated a 2% incidence of lower…
2020 American Transplant Congress
Early Tacrolimus-LCP Conversion Due to Adverse Effects in Pancreas Transplant Recipients Improves Tolerance But Not Graft Survival
J. L. Descourouez, M. R. Jorgenson, D. C. Felix, J. Wiegel, G. E. Leverson, D. A. Mandelbrot, R. R. Redfield, J. S. Odorico
UW Health, Madison, WI
*Purpose: Tacrolimus-LCP (LCPT) is an extended release formulation of tacrolimus which has been shown to have fewer adverse drug effects (ADE) than immediate release tacrolimus…
2020 American Transplant Congress
Outcomes of Simultaneous Pancreas-Kidney vs. Kidney Alone Transplants in Type 2 Diabetic Recipients: A Multivariate Analysis of U.S. Transplants
S. M. Riad¹, S. Jackson², D. Keys¹, V. Humphereville³, L. Caramori¹, R. Kandaswamy³
¹Medicine, University of Minnesota, Minneapolis, MN, ²Complex Care Analytics, Fairview Health Services, Minneapolis, MN, ³Surgery, University of Minnesota, Minneapolis, MN
*Purpose: The impact of simultaneous pancreas-kidney (SPK) transplants in uremic, non-obese, insulin-treated type 2 diabetic (T2DM) recipients is not well described. We analyzed the SRTR…
2020 American Transplant Congress
Management of Pancreatic Cancer after Liver Transplantation: A 27-Year Single-Center Experience
I. A. Ziogas, M. A. Rauf, L. K. Matsuoka, M. I. Montenovo, M. Izzy, S. P. Alexopoulos
Vanderbilt University Medical Center, Nashville, TN
*Purpose: The occurrence of de novo cancer after liver transplant (LT) is a leading cause of post-LT mortality and can be partially attributed to the…
2020 American Transplant Congress
Pancreatic Mesenchymal Stromal Cells (MSC) Contain a Subset of Islet Progenitor Cells Capable of Regenerating Islets and Reversing Diabetes
C. M. Darden¹, S. Vasu², K. Kumano¹, Y. Liu², P. Saravanan³, B. Naziruddin², M. Lawrence²
¹Institute of Biomedical Studies, Waco, TX, ²Baylor University Medical Ctr, Dallas, TX, ³Transplant Surgery Department, VCU, Richmond, VA
*Purpose: To identity islet precursor cells residing in pancreatic MSC culture preparations that contribute to islet regeneration and restoration of islet cell function in both…
2020 American Transplant Congress
Construction of Three-Dimensional Vascularized Functional Beta-Cells Tissues Using a Layer-by-Layer Cell Coating Technique
S. Takaichi¹, T. Akagi², Y. Tomimaru¹, S. Kobayashi¹, Y. Iwagami¹, H. Akita¹, T. Noda¹, K. Gotoh¹, Y. Doki¹, M. Akashi², H. Eguchi¹
¹Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita, Japan, ²Building Block Science Joint Research Chair, Graduate School of Frontier Biosciences, Osaka University, Suita, Japan
*Purpose: Regenerative therapy for type I Diabetes Mellitus has been expected to be a promising treatment. A subcutaneous site is an ideal candidate for stem…
2020 American Transplant Congress
High Laminin Alpha 5 Expression is Observed in the Pancreas of Chronic Pancreatitis Patients and Correlates with Poor Autologous Islet Transplant Outcome
Y. Liu, K. Kumano, S. Vasu, C. M. Darden, M. Lawrence, B. Naziruddin
Baylor University Medical Ctr, Dallas, TX
*Purpose: During chronic pancreatitis (CP), the extracellular matrix (ECM) of the pancreas is destroyed by a vicious cycle of parenchymal autodigestion by digestive exocrine enzymes…
2019 American Transplant Congress
microRNA-375 Provides an Objective Measure of Pancreas Quality in Organ Donors
I. Shapey¹, A. Summers¹, J. O'Sullivan¹, P. Yiannoullou¹, J. Casey², S. Forbes², M. Rosenthal³, P. Johnson⁴, P. Choudhary¹, J. Bushnell⁵, J. Shaw⁶, N. Hanley¹, T. Augustine¹, M. Rutter¹, D. van Dellen¹
¹University of Manchester, Manchester, United Kingdom, ²University of Edinburgh, Edinburgh, United Kingdom, ³Royal Free Hospital, London, United Kingdom, ⁴University of Oxford, Oxford, United Kingdom, ⁵Southmead Hospital, Bristol, United Kingdom, ⁶University of Newcastle, Newcastle, United Kingdom
*Purpose: Donor pancreatic beta cells are at high risk from apoptosis. Objective methods for assessing the quality of donor pancreases for transplantation are limited. We…