Articles tagged "Pancreas"

2021 American Transplant Congress
Achilles Heel No Longer: Marked Decline in Early Relaparotomy and Allograft Pancreatectomy Rates Following Simultaneous Kidney-Pancreas Transplantation in the Contemporary Era
B. Sharda¹, K. Gurung², R. Stratta², A. Farney², G. Orlando², C. Jay², A. Reeves-Daniel³, A. Mena-Gutierrez³, N. Sakhovskaya³, W. Doares⁴, S. Kaczmorski⁴, M. Magid⁴, J. Rogers²
¹Wake Forest Baptist Medical Center, Winston Salem, NC, ²Department of Surgery, Wake Forest Baptist Medical Center, Winston-Salem, NC, ³Internal Medicine, Wake Forest Baptist Medical Center, Winston-Salem, NC, ⁴Department of Pharmacy, Wake Forest Baptist Medical Center, Winston-Salem, NC
*Purpose: Technical complications requiring early relaparotomy (relap) and allograft pancreatectomy (AP) have long been the Achilles heel of simultaneous kidney-pancreas transplantation (SKPT).*Methods: Single center retrospective…
2020 American Transplant Congress
Early Tacrolimus-LCP Conversion Due to Adverse Effects in Pancreas Transplant Recipients Improves Tolerance But Not Graft Survival
J. L. Descourouez, M. R. Jorgenson, D. C. Felix, J. Wiegel, G. E. Leverson, D. A. Mandelbrot, R. R. Redfield, J. S. Odorico
UW Health, Madison, WI
*Purpose: Tacrolimus-LCP (LCPT) is an extended release formulation of tacrolimus which has been shown to have fewer adverse drug effects (ADE) than immediate release tacrolimus…
2020 American Transplant Congress
Outcomes of Simultaneous Pancreas-Kidney vs. Kidney Alone Transplants in Type 2 Diabetic Recipients: A Multivariate Analysis of U.S. Transplants
S. M. Riad¹, S. Jackson², D. Keys¹, V. Humphereville³, L. Caramori¹, R. Kandaswamy³
¹Medicine, University of Minnesota, Minneapolis, MN, ²Complex Care Analytics, Fairview Health Services, Minneapolis, MN, ³Surgery, University of Minnesota, Minneapolis, MN
*Purpose: The impact of simultaneous pancreas-kidney (SPK) transplants in uremic, non-obese, insulin-treated type 2 diabetic (T2DM) recipients is not well described. We analyzed the SRTR…
2020 American Transplant Congress
Management of Pancreatic Cancer after Liver Transplantation: A 27-Year Single-Center Experience
I. A. Ziogas, M. A. Rauf, L. K. Matsuoka, M. I. Montenovo, M. Izzy, S. P. Alexopoulos
Vanderbilt University Medical Center, Nashville, TN
*Purpose: The occurrence of de novo cancer after liver transplant (LT) is a leading cause of post-LT mortality and can be partially attributed to the…
2020 American Transplant Congress
Pancreatic Mesenchymal Stromal Cells (MSC) Contain a Subset of Islet Progenitor Cells Capable of Regenerating Islets and Reversing Diabetes
C. M. Darden¹, S. Vasu², K. Kumano¹, Y. Liu², P. Saravanan³, B. Naziruddin², M. Lawrence²
¹Institute of Biomedical Studies, Waco, TX, ²Baylor University Medical Ctr, Dallas, TX, ³Transplant Surgery Department, VCU, Richmond, VA
*Purpose: To identity islet precursor cells residing in pancreatic MSC culture preparations that contribute to islet regeneration and restoration of islet cell function in both…
2020 American Transplant Congress
Construction of Three-Dimensional Vascularized Functional Beta-Cells Tissues Using a Layer-by-Layer Cell Coating Technique
S. Takaichi¹, T. Akagi², Y. Tomimaru¹, S. Kobayashi¹, Y. Iwagami¹, H. Akita¹, T. Noda¹, K. Gotoh¹, Y. Doki¹, M. Akashi², H. Eguchi¹
¹Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita, Japan, ²Building Block Science Joint Research Chair, Graduate School of Frontier Biosciences, Osaka University, Suita, Japan
*Purpose: Regenerative therapy for type I Diabetes Mellitus has been expected to be a promising treatment. A subcutaneous site is an ideal candidate for stem…
2020 American Transplant Congress
High Laminin Alpha 5 Expression is Observed in the Pancreas of Chronic Pancreatitis Patients and Correlates with Poor Autologous Islet Transplant Outcome
Y. Liu, K. Kumano, S. Vasu, C. M. Darden, M. Lawrence, B. Naziruddin
Baylor University Medical Ctr, Dallas, TX
*Purpose: During chronic pancreatitis (CP), the extracellular matrix (ECM) of the pancreas is destroyed by a vicious cycle of parenchymal autodigestion by digestive exocrine enzymes…
2020 American Transplant Congress
Evaluation of US Doppler Examination of Portal Flow Dynamics in Patients with Total Pancreatectomy and Autologous Islet Cell Transplant
B. M. Williams, X. Baldwin, J. S. Vonderau, C. S. Desai
University of North Carolina, Chapel Hill, NC
*Purpose: The aim of this study is to evaluate US doppler flow dynamics following total pancreatectomy and autologous islet cell transplant (TPAIT) and establish any…
2020 American Transplant Congress
A Three-Decade Analysis of Pancreatic Adenocarcinoma Following Liver Transplantation
O. Y. Mousa¹, J. E. Corral², K. Wijarnpreecha², R. Shah³, V. S. Louwagie⁴, M. J. Bartel⁵, B. Brahmbhatt²
¹Mayo Clinic, Rochester, MN, ²Mayo Clinic, Jacksonville, FL, ³Emory University, Atlanta, GA, ⁴Mayo Clinic Health System, Mankato, MN, ⁵Fox Chase Cancer Center, Philadelphia, PA
*Purpose: Liver transplant (LT) recipients are at risk of serious long term complications, including a higher risk of de novo malignancies compared to the general…
2020 American Transplant Congress
Can Autologous Islet Cell Transplant Be a Comparable Choice to Parenchymal Preserving Surgery for Patients with Chronic Pancreatitis with Respect to Glycemic Control?
B. M. Williams, X. Baldwin, J. S. Vonderau, M. Hanson, C. S. Desai
University of North Carolina, Chapel Hill, NC
*Purpose: The aim of this study is to examine the difference in glycemic outcomes between total pancreatectomy and autologous islet cell transplant (TPAIT) and parenchymal…