Articles tagged "Nuclear factor-kappa B (NF-kB)"

2019 American Transplant Congress
Role of NF-kB in Release of Isletokines via Exosomes in Response to Islet Stress
P. Saravanan¹, M. Kanak¹, J. Kalivarathan¹, M. Lawrence², M. Levy¹, B. Naziruddin³
¹Department of Surgery, Virginia Commonwealth University, VCU Health, Richmond, VA, ²Islet Cell Lab, Baylor Scott and White Research Institute, Dallas, TX, ³Simmons Transplant Institute, Baylor Scott and White Medical Center, Dallas, TX
*Purpose: Human islets are exposed to a range of inflammatory stimuli upon transplantation that leads to poor graft survival. Identifying the various signaling events may…
2019 American Transplant Congress
Lymphotoxin Signaling Regulates T Cell Lymphatic Trafficking
W. Piao¹, L. Li², V. Saxena², Y. Xiong², M. WillsonShirkey², C. Paluskievicz², J. Bromberg³
¹Microbiology and Immunology, U. Maryland, Baltimore, baltimore, MD, ²Surgery, U. Maryland, Baltimore, Baltimore, MD, ³Microbiology and Immunology, U. Maryland, Baltimore, Baltimore, MD
*Purpose: Lymphotoxin (LT) α1β2 is crucial for lymphatic organ development and orchestration of immune responses. LTα1β2 is preferentially expressed by regulatory T cells (Treg) for…
2019 American Transplant Congress
Analysis of Islet Exosomal miRNAs Released Post-Transplant in Response to Inflammation
P. Saravanan¹, M. Kanak¹, G. Yoshimatsu², C. Darden², M. Lawrence², M. Levy¹, B. Naziruddin³
¹Department of Surgery, Virginia Commonwealth University, VCU Health, Richmond, VA, ²Islet Cell Lab, Baylor Scott and White Research Institute, Dallas, TX, ³Simmons Transplant Institute, Baylor Scott and White Research Center, Dallas, TX
*Purpose: Islets release miRNAs and other non-coding RNAs via exosomes under various pathological conditions, which are capable of regulating the genes of neighboring and/or distant…
2018 American Transplant Congress
Identification of Exosomal Isletokines Released by Pancreatic Islets in Response to Inflammatory Stress
P. Saravanan,¹ G. Yoshimatsu,¹ R. Bhattacharjee,¹ C. Chang,¹ C. Darden,¹ B. Naziruddin,² M. Lawrence.¹
¹Islet Cell Lab, Baylor Scott & White Research Institute, Dallas, TX; ²Transplantation, Baylor Simmons Transplant Institute, Dallas, TX.
Purpose: To identify isletokines released by exosomes from human islets that have been exposed to hypoxic or inflammatory conditions and define stress signaling pathways that…
2018 American Transplant Congress
Clinical Significance and Therapeutic Potential of Orosomucoid 1 for Chronic Active Antibody Mediated Rejection in Kidney Transplant Recipients
H. Higuchi,^1,2 K. Hotta,¹ D. Iwami,¹ J-.J. Jiang,² D. Kamimura,² Y. Arima,² T. Atsumi,² Y. Takada,^1,2 H. Harada,³ M. Murakami,² N. Shinohara.¹
¹Department of Renal and Genitourinary Surgery, Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan; ²Division of Molecular Psychoimmunology, Institute for Genetic Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan; ³Department of Kidney Transplant Surgery, Sapporo City General Hospital, Sapporo, Hokkaido, Japan.
［Background］We reported a molecular mechanism to develop chronic inflammation (CI), called the inflammation amplifier (IA). IA is activated by concomitant activation of NFkB and STAT3…
2018 American Transplant Congress
Targeting LTβR Classical NFκB Signaling Facilitates Inflammation Resolution
W. Piao, Y. Xiong, L. Li, V. Saxena, J. Bromberg.
UMB, Baltimore.
Background:Contact hypersensitivity (CHS) is a reliable model to assess the immune cell-mediated cutaneous inflammatory response, which includes the three phases of priming/sensitization, elicitation, and resolution,…
2018 American Transplant Congress
Targeting Lymphotoxin Signaling in Lymphatics Regulates Immune Sensitization, Elicitation, and Resolution
W. Piao, Y. Xiong, L. Li, V. Saxena, J. Bromberg.
UMB, MD.
Background:Contact hypersensitivity (CHS) is a T cell-mediated cutaneous inflammatory response which includes three phases of priming/sensitization, elicitation, and resolution,mirroring many aspects of allogeneic responses. The…
2018 American Transplant Congress
Treg Regulate Distinct Lymphatic NFκB Signaling Pathways to Alter Migration and Immunity
W. Piao, Y. Xiong, L. Li, V. Saxena, J. Bromberg.
UMB, MD.
Background: Treg migration to the graft and draining lymph nodes is crucial for graft survival. Little is known about the molecular cues that regulate the…
2017 American Transplant Congress
Regulation of T Cell Migration by Specifically Targeting Lymphotoxin β Receptor (LTβR)-Mediated Non-Canonical NFkB Signaling.
W. Piao, Y. Xiong, C. Brinkman, J. Bromberg.
UMB, Baltimore
Background:Selective recruitment of regulatory T cells (Treg) to draining lymph nodes is crucial for graft survival, and LTαβ-LTβR signaling is required to direct Treg into…
2017 American Transplant Congress
Lymphotoxin (LT) β Receptor-Mediated Non-Classical NFκB Signaling in Lymphatic Endothelial Eells (LEC) is Required for Homeostatic T Cell Migration.
W. Piao, C. Brinkman, J. Bromberg.
UMB, Baltimore
Background: The selective recruitment of regulatory T cells (Treg) or blockade of memory/effector T cell migration to the graft and draining lymph nodes (dLN) are…