2020 American Transplant Congress
Gingival Mesenchymal Stem Cells (GMSCs) Mitigate Liver Ischemia-Reperfusion Injury by Regulating Macrophage Polarization Through miR-199a-3p
Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
*Purpose: Mesenchymal stromal cells (MSCs) have been increasingly studied in organ ischemia-reperfusion injury, but the mechanism is still unclear. This study explored the immunoregulatory effects…2020 American Transplant Congress
XIAP Enhances Xenoislet Survival: Novel Models to Evaluate Pretransplantation Gene Modifications
*Purpose: Porcine islet xenotransplantation offers a reliable and near limitless supply of islets for the treatment of type 1 diabetes. Intraportal infusion of cells exposes…2020 American Transplant Congress
Hypothermia Attenuates Renal Fibrosis after Renal Ischemia Reperfusion in Mice
*Purpose: Recently, acute kidney injury is a important cause of chronic kidney injury, characterized by glomerular sclerosis and tubular fibrosis. Hypothermia attenuates the acute kidney…2020 American Transplant Congress
PD-1 Signals Murine and Human Treg for Enhanced Migration
*Purpose: Programmed death-1 (PD-1) attenuates immune responses. Engagement of PD-1 by its ligands PD-L1 or PD-L2 regulates T cell development, proliferation, cytokine production, and apoptosis.…2020 American Transplant Congress
Treg Lymphotoxin Signals Promote Cancer Metastatic Migration: Mechanisms for Treg-Cancer Interaction
1Surgery, U of Maryland, Baltimore, MD, 2U of Maryland, College Park, MD
*Purpose: Immune suppressive therapy can be complicated by malignancy. Regulatory T cells (Treg) control immune tolerance for graft survival but cause to immune suppression in…2019 American Transplant Congress
Role of NF-kB in Release of Isletokines via Exosomes in Response to Islet Stress
*Purpose: Human islets are exposed to a range of inflammatory stimuli upon transplantation that leads to poor graft survival. Identifying the various signaling events may…2019 American Transplant Congress
Lymphotoxin Signaling Regulates T Cell Lymphatic Trafficking
*Purpose: Lymphotoxin (LT) α1β2 is crucial for lymphatic organ development and orchestration of immune responses. LTα1β2 is preferentially expressed by regulatory T cells (Treg) for…2019 American Transplant Congress
Analysis of Islet Exosomal miRNAs Released Post-Transplant in Response to Inflammation
*Purpose: Islets release miRNAs and other non-coding RNAs via exosomes under various pathological conditions, which are capable of regulating the genes of neighboring and/or distant…2018 American Transplant Congress
Identification of Exosomal Isletokines Released by Pancreatic Islets in Response to Inflammatory Stress
Purpose: To identify isletokines released by exosomes from human islets that have been exposed to hypoxic or inflammatory conditions and define stress signaling pathways that…2018 American Transplant Congress
Clinical Significance and Therapeutic Potential of Orosomucoid 1 for Chronic Active Antibody Mediated Rejection in Kidney Transplant Recipients
[Background]We reported a molecular mechanism to develop chronic inflammation (CI), called the inflammation amplifier (IA). IA is activated by concomitant activation of NFkB and STAT3…