Articles tagged "Nuclear factor-kappa B (NF-kB)"

2020 American Transplant Congress
Gingival Mesenchymal Stem Cells (GMSCs) Mitigate Liver Ischemia-Reperfusion Injury by Regulating Macrophage Polarization Through miR-199a-3p
Y. Zhang, M. Chen, W. Ju, T. Wang, Z. Chen, C. Huang, R. Xie, Q. Zhao, Z. Guo, X. He
Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
*Purpose: Mesenchymal stromal cells (MSCs) have been increasingly studied in organ ischemia-reperfusion injury, but the mechanism is still unclear. This study explored the immunoregulatory effects…
2020 American Transplant Congress
XIAP Enhances Xenoislet Survival: Novel Models to Evaluate Pretransplantation Gene Modifications
G. R. Devi¹, Z. Fitch¹, M. Song¹, M. Ribeiro¹, A. McGowan¹, X. Luo², B. H. Collins¹, A. D. Kirk¹
¹Department of Surgery, Duke Univesity School of Medicine, Durham, NC, ²Division of Nephrology, Duke Univesity School of Medicine, Durham, NC
*Purpose: Porcine islet xenotransplantation offers a reliable and near limitless supply of islets for the treatment of type 1 diabetes. Intraportal infusion of cells exposes…
2020 American Transplant Congress
Hypothermia Attenuates Renal Fibrosis after Renal Ischemia Reperfusion in Mice
D. Choi¹, D. Kim², E. Kim², J. Jeong², J. Kim¹, Y. Ham¹, Y. Chang³, K. Na¹, K. Lee¹
¹Nephrology, Chungnam National University, Daejeon, Korea, Republic of, ²Department of Medical Science, Chungnam National University, Daejeon, Korea, Republic of, ³Nephrology, Catholic University of Korea, Daejeon, Korea, Republic of
*Purpose: Recently, acute kidney injury is a important cause of chronic kidney injury, characterized by glomerular sclerosis and tubular fibrosis. Hypothermia attenuates the acute kidney…
2020 American Transplant Congress
PD-1 Signals Murine and Human Treg for Enhanced Migration
W. Piao¹, Y. Xiong¹, L. Li¹, K. Hippen², Y. Zhang², V. Saxena¹, C. Paluskievicz¹, M. WillsonShirkey¹, B. Blazar³, L. Riella⁴, J. Bromberg⁵
¹Surgery, U of Maryland, Baltimore, MD, ²U of Minnesota, Minneapolis, MN, ³Surgery, U of Minnesota, Minneapolis, MN, ⁴Harvard U, Boston, MA, ⁵Surgery and Microbiology and Immunology, U of Maryland, Baltimore, MD
*Purpose: Programmed death-1 (PD-1) attenuates immune responses. Engagement of PD-1 by its ligands PD-L1 or PD-L2 regulates T cell development, proliferation, cytokine production, and apoptosis.…
2020 American Transplant Congress
Treg Lymphotoxin Signals Promote Cancer Metastatic Migration: Mechanisms for Treg-Cancer Interaction
W. Piao¹, R. Oakes², C. Paluskievicz¹, Y. Xiong¹, L. Li¹, V. Saxena¹, M. WillsonShirkey¹, C. Jewell², J. Bromberg¹
¹Surgery, U of Maryland, Baltimore, MD, ²U of Maryland, College Park, MD
*Purpose: Immune suppressive therapy can be complicated by malignancy. Regulatory T cells (Treg) control immune tolerance for graft survival but cause to immune suppression in…
2019 American Transplant Congress
Role of NF-kB in Release of Isletokines via Exosomes in Response to Islet Stress
P. Saravanan¹, M. Kanak¹, J. Kalivarathan¹, M. Lawrence², M. Levy¹, B. Naziruddin³
¹Department of Surgery, Virginia Commonwealth University, VCU Health, Richmond, VA, ²Islet Cell Lab, Baylor Scott and White Research Institute, Dallas, TX, ³Simmons Transplant Institute, Baylor Scott and White Medical Center, Dallas, TX
*Purpose: Human islets are exposed to a range of inflammatory stimuli upon transplantation that leads to poor graft survival. Identifying the various signaling events may…
2019 American Transplant Congress
Lymphotoxin Signaling Regulates T Cell Lymphatic Trafficking
W. Piao¹, L. Li², V. Saxena², Y. Xiong², M. WillsonShirkey², C. Paluskievicz², J. Bromberg³
¹Microbiology and Immunology, U. Maryland, Baltimore, baltimore, MD, ²Surgery, U. Maryland, Baltimore, Baltimore, MD, ³Microbiology and Immunology, U. Maryland, Baltimore, Baltimore, MD
*Purpose: Lymphotoxin (LT) α1β2 is crucial for lymphatic organ development and orchestration of immune responses. LTα1β2 is preferentially expressed by regulatory T cells (Treg) for…
2019 American Transplant Congress
Analysis of Islet Exosomal miRNAs Released Post-Transplant in Response to Inflammation
P. Saravanan¹, M. Kanak¹, G. Yoshimatsu², C. Darden², M. Lawrence², M. Levy¹, B. Naziruddin³
¹Department of Surgery, Virginia Commonwealth University, VCU Health, Richmond, VA, ²Islet Cell Lab, Baylor Scott and White Research Institute, Dallas, TX, ³Simmons Transplant Institute, Baylor Scott and White Research Center, Dallas, TX
*Purpose: Islets release miRNAs and other non-coding RNAs via exosomes under various pathological conditions, which are capable of regulating the genes of neighboring and/or distant…
2018 American Transplant Congress
Identification of Exosomal Isletokines Released by Pancreatic Islets in Response to Inflammatory Stress
P. Saravanan,¹ G. Yoshimatsu,¹ R. Bhattacharjee,¹ C. Chang,¹ C. Darden,¹ B. Naziruddin,² M. Lawrence.¹
¹Islet Cell Lab, Baylor Scott & White Research Institute, Dallas, TX; ²Transplantation, Baylor Simmons Transplant Institute, Dallas, TX.
Purpose: To identify isletokines released by exosomes from human islets that have been exposed to hypoxic or inflammatory conditions and define stress signaling pathways that…
2018 American Transplant Congress
Clinical Significance and Therapeutic Potential of Orosomucoid 1 for Chronic Active Antibody Mediated Rejection in Kidney Transplant Recipients
H. Higuchi,^1,2 K. Hotta,¹ D. Iwami,¹ J-.J. Jiang,² D. Kamimura,² Y. Arima,² T. Atsumi,² Y. Takada,^1,2 H. Harada,³ M. Murakami,² N. Shinohara.¹
¹Department of Renal and Genitourinary Surgery, Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan; ²Division of Molecular Psychoimmunology, Institute for Genetic Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan; ³Department of Kidney Transplant Surgery, Sapporo City General Hospital, Sapporo, Hokkaido, Japan.
［Background］We reported a molecular mechanism to develop chronic inflammation (CI), called the inflammation amplifier (IA). IA is activated by concomitant activation of NFkB and STAT3…