Articles tagged "Non-invasive diagnosis"

2016 American Transplant Congress
MicroRNAs in Urinary Sediments as Non-Invasive Tool to Detect Acute Rejection After Kidney Transplantation.
E. Gielis,^1,2 J. Anholts,² H. de Fijter,³ I. Bajema,⁴ F. Claas,² M. Eikmans.²
¹Laboratory of Experimental Medicine and Pediatrics, University of Antwerp, Antwerp, Belgium; ²Immunohematology, LUMC, Leiden, Netherlands; ³Nephrology, LUMC, Leiden, Netherlands; ⁴Pathology, LUMC, Leiden, Netherlands.
MicroRNAs in urine are suitable targets for non-invasive detection of acute rejection (AR), since they represent relatively stable analytes. Indeed, we found that PCR signals…
2016 American Transplant Congress
NanoString Detection of Gene Signatures in Urine During Acute Cellular Rejection of Kidney Grafts.
K. Keslar,¹ A. Zmijewska,² J. Andriga,² K. Newell,³ R. Mannon,² P. Heeger,⁴ R. Fairchild.¹
¹Cleveland Clinic, Cleveland; ²UAB, Birmingham; ³Emory, Atlanta; ⁴MSSM, New York.
Considerable effort has focused on identification of gene expression patterns that may assist in diagnosis of acute cellular rejection. The NanoString platform offers a novel…
2016 American Transplant Congress
Transcriptome Profiles in Peripheral Blood of Kidney Graft Recipients.
J.-W. Seo,¹ H. Moon,¹ Y.-G. Kim,¹ K.-H. Jeong,¹ S.-J. Ihm,² J.-Y. Moon,¹ S.-H. Lee.¹
¹Division of Nephrology, Department of Internal Medicine, Kyung Hee University College of Medicine, Seoul, Republic of Korea; ²Department of Pathology, Kyung Hee University College of Medicine, Seoul, Republic of Korea.
The discovery of sensitive noninvasive diagnosis and the development of immune management in the renal allograft recipients are required for long-term graft survival. Although the…
2016 American Transplant Congress
Clinical Significance of Solitary Pulmonary Nodules in Liver Transplant Recipients with Hepatocellular Carcinoma.
O. Serrano,¹ A. Bangdiwala,² D. Vock,² V. Kirchner,¹ K. Yadav,¹ A. Pugalendhi,¹ E. Minja,¹ T. Dunn,¹ E. Finger,¹ A. Matas,¹ R. Kandaswamy,¹ W. Payne,¹ T. Pruett,¹ S. Chinnakotla.¹
¹Surgery, Univ. of Minnesota, Minneapolis, MN; ²Biostatistics and Bioinformatics Core, Masonic Cancer Center, Minneapolis, MN; ³Biostatistics, Univ. of Minnesota, Minneapolis, MN.
PURPOSE: Currently, there are no guidelines for the management of solitary pulmonary nodules (SPN) in hepatocellular carcinoma (HCC) patients being evaluated for liver transplantation (LT).…
2016 American Transplant Congress
Identification of MicroRNAs in EBV⁺ B Cell Lymphomas and Secreted Exosomes.
V. Kaul, A. Harris-Arnold, C. Esquivel, O. Martinez, S. Krams.
Division of Abdominal Transplantation, Dept. of Surgery, Stanford University, Stanford.
Introduction Post-transplant lymphoproliferative disorder (PTLD) is a potentially fatal complication of organ transplantation commonly associated with Epstein Barr virus (EBV) infection. EBV viral loads are…
2015 American Transplant Congress
BK Virus-Specific Polyfunctional CD8+ T Cells Predicts Successful Control of BK Viremia After Kidney Transplantation
J. Schaenman,¹ Y. Korin,² T. Sidwell,² F. Kandarian,² N. Harre,² P.-T. Pham,³ S. Bunnapradist,³ G. Danovitch,³ J. Veale,⁴ H. Gritsch,⁴ E. Reed.²
¹Medicine/Infectious Diseases, David Geffen School of Medicine (DGSOM) at UCLA, Los Angeles, CA; ²UCLA Immunogenetics Center, DGSOM at UCLA, Los Angeles, CA; ³Medicine/Nephrology, DGSOM at UCLA, Los Angeles, CA; ⁴Urology, DGSOM at UCLA, Los Angeles, CA.
Introduction: BK Virus associated nephropathy (BKN) remains an important cause of graft loss after kidney transplantation. We hypothesized that analysis of the anti-BK virus immune…
2015 American Transplant Congress
Non-Invasive Imaging Modalities for Immune Monitoring of Vascularized Composite Allografts Using a Translational Large Animal Model
G. Furtmüller,¹ N. Crane,² R. Luthra,² E. Swanson,¹ H.-T. Cheng,¹ B. Oh,¹ M. Fryer,¹ E. Elster,² W. Lee,¹ G. Brandacher.¹
¹Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD; ²Department of Regenerative Medicine, Naval Medical Research Center, Silver Spring, MD.
Purpose: To evaluate imaging modalities such as 3CCD and infrared (IR) technology as a means of non-invasive monitoring of graft acceptance and rejection in the…
2015 American Transplant Congress
Urinary CXCL10 Independently Improves the Noninvasive Diagnosis of Antibody-Mediated Kidney Allograft Rejection
M. Rabant,^1,2 L. Amrouche,^2,3 X. Lebreton,³ F. Aulagnon,³ A. Benon,² V. Sauvaget,² R. Bonifay,² L. Morin,³ A. Scemla,³ M. Delville,³ F. Martinez,³ M. Timsit,⁴ J. Duong Van Huyen,¹ C. Legendre,³ F. Terzi,² D. Anglicheau.^2,3
¹Pathology Department, Necker Hospital, Paris, France; ²INSERM U1151, Necker Hospital, Paris, France; ³Kidney Transplant Center, Necker Hospital, Paris, France; ⁴Urology Department, Necker Hospital, Paris, France.
The urinary levels of CXCL9 and CXCL10 can noninvasively diagnose T cell-mediated rejection (TCMR) of renal allografts. Their performance as diagnostic/prognostic markers of antibody-mediated rejection…
2015 American Transplant Congress
Constitutively Upregulated Expression of Complement and Matrix Transcripts in Kidney Transplant Recipients Who Develop Acute Rejection
K. Keslar,¹ J. Reid-Adam,⁴ E. Kwon,⁴ D. Hricik,⁵ E. Poggio,^2,3 P. Heeger,⁴ R. Fairchild.^1,3
¹Immunology, Cleveland Clinic; ²Nephrology, Cleveland Clinic; ³Glickman Urological Institute and Transplant Center, Cleveland Clinic, Cleveland, OH; ⁴Icahn School of Medicine, Mount Sinai, New York, NY; ⁵Nephrology, UH Case Medical Center, Cleveland, OH.
Identification of kidney transplants at elevated risk of acute rejection (AR) and/or chronic injury prior to loss of kidney function (GFR) could guide therapies to…
2015 American Transplant Congress
Predictive Value of Regadenoson Scans After Heart Transplant
J. Kawano, M. Kittleson, J. Patel, B. Azarbal, F. Liou, S. Siddiqui, D. Wong, D. Chang, D. Ramzy, L. Czer, J. Kobashigawa.
Cedars-Sinai Heart Institute, Los Angeles, CA.
Purpose: Cardiac allograft vasculopathy (CAV) is one of the major factors limiting long-term survival after heart transplantation. The use of annual coronary angiograms is an…