Articles tagged "Non-invasive diagnosis"

2022 American Transplant Congress
Development and Validation of a Machine Learning Based Virtual Biopsy System in Kidney Transplant Patients
D. Yoo¹, G. Divard¹, M. Raynaud¹, A. Bentall², M. Stegall³, M. Naesens⁴, I. Batal⁵, S. Coley⁶, J. Gill⁷, M. Mengel⁸, L. Cornell³, M. P. Alexander², T. Coates⁹, C. Legendre¹⁰, P. Reese¹¹, c. lefaucheur¹², O. Aubert¹, A. Loupy¹
¹Paris Transplant Group, Paris, France, ²-, -, AL, ³Mayo Clinic, Rochester, MN, ⁴Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium, ⁵Columbia University Medical Center, Scarsdale, NY, ⁶Columbia University, New York, NY, ⁷University of British Columbia, Vancouver, BC, Canada, ⁸University of Alberta, Edmonton, AB, Canada, ⁹University of Adelaide, Adelaide, Australia, ¹⁰Hopital Necker, Paris, France, ¹¹University of Pennsylvania, Philadelphia, PA, ¹²Hôpital Saint-Louis, Paris, France
*Purpose: In kidney TX, day-zero biopsies are used to assess organ quality and discriminate lesions inherited from the donor or acquired after transplantation. However, many…
2022 American Transplant Congress
Urinary Cell CTOT-04 Signature is Diagnostic of Glomerulitis in Kidney Allograft Biopsies
T. Salinas¹, C. Li¹, C. Snopkowski¹, K. Chen¹, S. Albakry¹, S. Salvatore², S. Seshan², J. R. Lee¹, M. Thangamani¹, D. Dadhania¹, M. Suthanthiran¹
¹Nephrology, Weill Cornell-NYPH, New York, NY, ²Pathology, Weill Cornell-NYPH, New York, NY
*Purpose: Antibody mediated rejection is a significant complication after kidney transplantation and is an important cause of allograft failure. In the multicenter CTOT-04 study, we…
2022 American Transplant Congress
Correlation of Donor-Derived Cell-Free DNA with Histology and Molecular Diagnoses of T-cell Mediated Rejection in Kidney Transplant Biopsies
D. Kumar¹, I. Moinuddin¹, L. Kamal¹, M. Shinbashi¹, N. Raju¹, R. Minniti¹, F. Moran¹, P. Halloran², G. Gupta¹
¹Virginia Commonwealth University, Richmond, VA, ²University of Alberta, Edmonton, AB, Canada
*Purpose: We have reported the correlation of donor-derived cell-free DNA (dd-cfDNA) with histologic and molecular diagnosis (MMDx) of kidney transplant biopsies (Gupta et al, Transplantation…
2022 American Transplant Congress
Diagnostic Performance of Donor-Derived Cell-Free DNA Assay (AlloSure®) in Kidney Transplant Recipients with Graft Dysfunction: A Single Center Study
M. S. Naseer¹, H. Shokouh-Amiri², T. Creamer¹, R. McMillan², S. Tandukar¹, D. Aultman¹, G. B. Zibari¹, N. Singh¹
¹Transplant, John C. McDonald Regional Transplant Center - Willis Knighton Health System, Shreveport, LA, ²John C. McDonald Regional Transplant Center - Willis Knighton Health System, Shreveport, LA
*Purpose: Circulating donor-derived cell-free DNA (dd-cf-DNA) is a non-invasive biomarker of kidney allograft injury with a high negative predictive value for ruling out active rejection…
2022 American Transplant Congress
Can dd-cf DNA Eliminate Unnecessary Biopsies? The Answer is Yes!
K. Andreoni, Y. Chalicheemala, M. Debroy, M. Maklad, K. Zhao, M. Aeder, A. Jittirat, D. Ecabert, A. Bixby, C. Burrelli, K. Chavin
University Hospitals Cleveland Medical Center, Cleveland, OH
*Purpose: Historically our center has been one that routinely performs biopsies. We perform them pre-perfusion, for slowly recovering allografts between day 10-14, and routinely at…
2022 American Transplant Congress
Interleukin-31 (IL-31) and Leukemia Inhibitory Factor (LIF) Are Upregulated in Acute Rejection of Kidney Allograft
I. Striz, L. Krupickova, M. Fialova, M. Novotny, E. Cecrdlova, O. Viklicky
Institute for Clinical and Experimental Medicine, Praha, Czech Republic
*Purpose: Interleukin-31 (IL-31) and leukemia inhibitory factor (LIF) belong to the IL-6 cytokine family clustered by their pro-inflammatory properties and a shared signaling pathway of…
2022 American Transplant Congress
Can Fibroscan Evaluation Of A Liver Predict Transplantability As Accurately As A Biopsy?
S. J. Sander¹, M. Moncure²
¹Organ Procurement, Midwest Transplant Network, Westwood, KS, ²Midwest Transplant Network, Westwood, KS
*Purpose: Liver transplants are essential procedures that can impact a patient with chronic liver disease’s overall survival. Historically liver biopsies are the gold standard in…
2022 American Transplant Congress
Tissue Engineering Scaffolds for Minimally Invasive Immunosurveillance of Acute Cellular Graft Rejection
R. R. Urie¹, D. Farris², A. Morris¹, E. Lombard¹, J. Z. Li³, D. Goldstein², L. Shea¹
¹Biomedical Engineering, University of Michigan, Ann Arbor, MI, ²Internal Medicine, University of Michigan, Ann Arbor, MI, ³Human Genetics, University of Michigan, Ann Arbor, MI
*Purpose: As there is no assay to predict the risk of acute cellular allograft rejection (ACAR), clinicians rely on protocol graft biopsy and aggressive, one-size-fits-all…
2022 American Transplant Congress
Infection Impacts dd-cfDNA in Lung Transplant Recipients
D. Levine¹, C. Giner¹, C. Pham², R. Woodward², A. Roux³
¹University of Texas Health System San Antonio, San Antonio, TX, ²CareDX, South San Francisco, CA, ³Pneumology, Adult CF Center and Lung Transplantation Department, Foch Hospital, Suresnes, France
*Purpose: Infection is the leading cause of death within 1 year post lung transplant. Graft injury secondary to infection is affected by both source and…
2022 American Transplant Congress
Bone Mineral Density, Bone Micro-Architecture Evolution After Kidney Transplantation: A Prospective Cohort Study
A. Bouquegneau, O. Malaise, L. Seidel, L. Weekers, C. Bonvoisin, F. Jouret, E. Cavalier, P. Delanaye
CHU de Liège, Liege, Belgium
*Purpose: Bone loss and mineral abnormalities are frequent in kidney transplant recipients (KTRs) and associated with a high risk of fracture and cardiovascular mortality. In…

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