ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Non-invasive diagnosis"

  • 2022 American Transplant Congress

    dd-cfDNA Varies Among Diagnostics Groups of Pulmonary AMR

    D. Levine1, C. Giner1, C. Pham2, R. Woodward3, A. Roux4

    1University of Texas Health System San Antonio, San Antonio, TX, 2CareDX, South San Francisco, CA, 3CareDx, South San Francisco, CA, 4Pneumology, Adult CF Center and Lung Transplantation Department, Foch Hospital, Suresnes, France

    *Purpose: Antibody mediated rejection (AMR) in lung transplant remains complex, with differential diagnosis often overlapping with other causes of lung dysfunction. Diagnostic certainty declines to…
  • 2022 American Transplant Congress

    The Unique Course of dd-cfDNA After Lung Transplant

    D. Levine1, C. Giner1, C. Pham2, R. Woodward3, A. Roux4

    1University of Texas Health System San Antonio, San Antonio, TX, 2CareDX, South San Francisco, CA, 3CareDx, South San Francisco, CA, 4Pneumology, Adult CF Center and Lung Transplantation Department, Foch Hospital, Suresnes, France

    *Purpose: The time necessary for dd-cfDNA to reach baseline levels following transplantation has been reported in kidney, heart, and liver as 14-21 days. We explored…
  • 2022 American Transplant Congress

    Urinary Cell mRNA Profile Diagnosis of Borderline TCMR in Kidney Allografts

    T. Salinas1, C. Li1, C. Snopkowski1, K. Chen1, S. Albakry1, S. P. Salvatore2, S. Seshan2, J. R. Lee1, M. Thangamani1, D. Dadhania1, M. Suthanthiran1

    1Nephrology, Weill Cornell-NYPH, New York, NY, 2Pathology, Weill Cornell-NYPH, New York, NY

    *Purpose: Borderline T cell-mediated rejection (BR) is associated with inferior outcomes. In the multicenter CTOT-04 study, we discovered and validated a urinary cell three-gene signature…
  • 2022 American Transplant Congress

    Clinical Validation of Automated Urinary Chemokine Assays for Non-Invasive Detection of Kidney Transplant Rejection: A Large Prospective Cohort Study

    E. Van Loon1, C. Tinel1, J. Callemeyn1, M. Coemans1, A. Van Craenenbroeck1, T. Vaulet2, D. Anglicheau3, M. Naesens1

    1Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium, 2ESAT STADIUS Center for Dynamical Systems, KU Leuven, Leuven, Belgium, 3Department of Nephrology and Kidney Transplantation, Necker Hospital, Paris, France

    *Purpose: Non-invasive diagnostic markers for kidney transplant rejection can provide useful information but often do not reach the clinical implementation stage. The chemokines CXCL9 and…
  • 2022 American Transplant Congress

    Development and Validation of a Machine Learning Based Virtual Biopsy System in Kidney Transplant Patients

    D. Yoo1, G. Divard1, M. Raynaud1, A. Bentall2, M. Stegall3, M. Naesens4, I. Batal5, S. Coley6, J. Gill7, M. Mengel8, L. Cornell3, M. P. Alexander2, T. Coates9, C. Legendre10, P. Reese11, c. lefaucheur12, O. Aubert1, A. Loupy1

    1Paris Transplant Group, Paris, France, 2-, -, AL, 3Mayo Clinic, Rochester, MN, 4Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium, 5Columbia University Medical Center, Scarsdale, NY, 6Columbia University, New York, NY, 7University of British Columbia, Vancouver, BC, Canada, 8University of Alberta, Edmonton, AB, Canada, 9University of Adelaide, Adelaide, Australia, 10Hopital Necker, Paris, France, 11University of Pennsylvania, Philadelphia, PA, 12Hôpital Saint-Louis, Paris, France

    *Purpose: In kidney TX, day-zero biopsies are used to assess organ quality and discriminate lesions inherited from the donor or acquired after transplantation. However, many…
  • 2022 American Transplant Congress

    Urinary Cell CTOT-04 Signature is Diagnostic of Glomerulitis in Kidney Allograft Biopsies

    T. Salinas1, C. Li1, C. Snopkowski1, K. Chen1, S. Albakry1, S. Salvatore2, S. Seshan2, J. R. Lee1, M. Thangamani1, D. Dadhania1, M. Suthanthiran1

    1Nephrology, Weill Cornell-NYPH, New York, NY, 2Pathology, Weill Cornell-NYPH, New York, NY

    *Purpose: Antibody mediated rejection is a significant complication after kidney transplantation and is an important cause of allograft failure. In the multicenter CTOT-04 study, we…
  • 2022 American Transplant Congress

    Correlation of Donor-Derived Cell-Free DNA with Histology and Molecular Diagnoses of T-cell Mediated Rejection in Kidney Transplant Biopsies

    D. Kumar1, I. Moinuddin1, L. Kamal1, M. Shinbashi1, N. Raju1, R. Minniti1, F. Moran1, P. Halloran2, G. Gupta1

    1Virginia Commonwealth University, Richmond, VA, 2University of Alberta, Edmonton, AB, Canada

    *Purpose: We have reported the correlation of donor-derived cell-free DNA (dd-cfDNA) with histologic and molecular diagnosis (MMDx) of kidney transplant biopsies (Gupta et al, Transplantation…
  • 2022 American Transplant Congress

    Diagnostic Performance of Donor-Derived Cell-Free DNA Assay (AlloSure®) in Kidney Transplant Recipients with Graft Dysfunction: A Single Center Study

    M. S. Naseer1, H. Shokouh-Amiri2, T. Creamer1, R. McMillan2, S. Tandukar1, D. Aultman1, G. B. Zibari1, N. Singh1

    1Transplant, John C. McDonald Regional Transplant Center - Willis Knighton Health System, Shreveport, LA, 2John C. McDonald Regional Transplant Center - Willis Knighton Health System, Shreveport, LA

    *Purpose: Circulating donor-derived cell-free DNA (dd-cf-DNA) is a non-invasive biomarker of kidney allograft injury with a high negative predictive value for ruling out active rejection…
  • 2022 American Transplant Congress

    Can dd-cf DNA Eliminate Unnecessary Biopsies? The Answer is Yes!

    K. Andreoni, Y. Chalicheemala, M. Debroy, M. Maklad, K. Zhao, M. Aeder, A. Jittirat, D. Ecabert, A. Bixby, C. Burrelli, K. Chavin

    University Hospitals Cleveland Medical Center, Cleveland, OH

    *Purpose: Historically our center has been one that routinely performs biopsies. We perform them pre-perfusion, for slowly recovering allografts between day 10-14, and routinely at…
  • 2022 American Transplant Congress

    Interleukin-31 (IL-31) and Leukemia Inhibitory Factor (LIF) Are Upregulated in Acute Rejection of Kidney Allograft

    I. Striz, L. Krupickova, M. Fialova, M. Novotny, E. Cecrdlova, O. Viklicky

    Institute for Clinical and Experimental Medicine, Praha, Czech Republic

    *Purpose: Interleukin-31 (IL-31) and leukemia inhibitory factor (LIF) belong to the IL-6 cytokine family clustered by their pro-inflammatory properties and a shared signaling pathway of…
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