2020 American Transplant Congress
Alum Elicited MDSCs Delay the Rejection of Fully Mistmatched Islets in Mice
1Boston Children's Hospital, Boston, MA, 2Massachusetts General Hospital, Boston, MA
*Purpose: Myeloid derived suppressor cells (MDSCs) have been demonstrated to be critical for the induction of tumor induced T cell tolerance and have also been…2019 American Transplant Congress
The Role of Neutrophil Extracellular Traps in Kidney Acute Antibody-Mediated Rejection
*Purpose: Previously our group assessed the spontaneous and lipopolysaccharide-induced NETosis with confocal microscopy in kidney transplant recipients (KTR). We found an enhanced spontaneous NETosis regardless…2019 American Transplant Congress
Soluble Fibrinogen-Like Protein 2 Regulates MDSCs Differentiation and Function in Allograft Immunity
Urology, Zhongshan Hospital, Fudan University, Shanghai, China
*Purpose: Soluble fibrinogen-like protein 2 (sFGL2) is a novel immunoregulatory molecule, secreted mainly by regulatory T cells. CD11b+ Gr1+ myeloid-derived suppressor cells (MDSCs) are an…2019 American Transplant Congress
Human Neutrophil Function against Pathogens in Solid Organ and Stem Cell Transplant Recipients
Transplant Infectious Diseases, Massachusetts General Hospital, Boston, MA
*Purpose: The effects of solid organ (SOT) and allogeneic stem cell transplantation (SCT) on the neutrophil function is not well described. In this study, we…2018 American Transplant Congress
The Role of CD46 in Early Islet Engraftment in a Dual Transplant Model
Department of Surgery, Duke University School of Medicine, Durham, NC.
IntroductionMembrane cofactor protein (CD46) is known to attenuate the complement cascade by facilitating cleavage of C3b and C4b. In solid organ xenotransplantation, organs expressing CD46…2018 American Transplant Congress
Recipient HO-1 Deficiency Decreases Post-Transplant Graft HO-1 Expression and Exacerbates Liver Transplant Damage
1Surgery, Liver Transplantation, UCLA, Los Angeles, CA; 2Pathology, UCLA, Los Angeles, CA.
Many preclinical studies on protective functions of heme oxygenase-1 (HO-1; hsp32) in orthotopic liver transplantation (OLT) have encouraged application of HO-1 inducing regimens in clinical…2018 American Transplant Congress
Inhibition of Neutrophil Recruitment and Activation Protects Airway Epithelium after Transplantation
Background: Obliterative bronchiolitis (OB) is the major obstacle limiting long-term allograft survival of lung transplantation. Airway epithelium is the primary target in obliterative airway diseases.…2018 American Transplant Congress
Is the NETos Increased in Acute Antibody Mediated Rejection?
Neutrophils can promote graft inflammation through a form of programmed cell death termed "NETosis". How alloantibodies contribute to neutrophil responses in grafts is not clear…2018 American Transplant Congress
The Neutrophil to Lymphocyte Ratio is Confounded by MELD in Hepatocellular Carcinoma Patients Undergoing Liver Transplantation
Department of General Surgery Digestive Disease Institute, Cleveland Clinic, Cleveland, OH.
Background: Biological markers such as the pre-operative neutrophil to lymphocyte ratio (NLR) have been suggested to be valuable indicators of recurrence and overall survival after…2018 American Transplant Congress
Myeloid Derived Suppressor Cells Are Induced after Transplantation and Home to the Transplanted Kidney
Surgery and Immunology, University of Maryland, Baltimore, MD.
BACKGROUND: Myeloid-derived suppressor cells (MDSCs) are a naturally occurring, heterogeneous population of highly immunosuppressive cells which expand in response to inflammatory conditions such as cancer.…
American Transplant Congress abstracts