ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Neutrophils"

  • 2020 American Transplant Congress

    Influence of the Gut Microbiota on Acute Rejection of Vascular Allografts

    J. C. Choy, K. Rey, W. Enns, T. Van Rossum, F. S. Brinkman

    Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada

    *Purpose: The gut microbiota influences immune responses in many ways but its involvement in transplant rejection is poorly understood. We have examined how changes in…
  • 2020 American Transplant Congress

    FcγRIIIb Inhibits Renal Transplant Rejection by Inducing Neutrophils Apoptosis

    J. Zhang, J. Chen

    Kidney Disease Center, The First Affiliated Hospital of Zhejiang University, Hangzhou, China

    *Purpose: Fcγ receptors (FcγR) have been proposed to be involved in the pathogenesis of acute rejection (AR) after organ transplantation. However, the mechanisms by which…
  • 2020 American Transplant Congress

    Alum Elicited MDSCs Delay the Rejection of Fully Mistmatched Islets in Mice

    A. Cuenca1, N. Feeney2, J. Ge1, K. Deng2, Q. Fu2, G. Huai2, K. Lee2, C. Rickert2, J. Markmann2

    1Boston Children's Hospital, Boston, MA, 2Massachusetts General Hospital, Boston, MA

    *Purpose: Myeloid derived suppressor cells (MDSCs) have been demonstrated to be critical for the induction of tumor induced T cell tolerance and have also been…
  • 2019 American Transplant Congress

    The Role of Neutrophil Extracellular Traps in Kidney Acute Antibody-Mediated Rejection

    R. Villca-Gonzales1, J. Torres-Ruiz2, D. Gomez-Martin2, L. Morales-Buenrostro1, J. Alberu3

    1Nephrology, Instituto Nacional de Ciencias Medicas y Nutrición Salvador Zubiran, Mexico, Mexico, 2Immunology, Instituto Nacional de Ciencias Medicas y Nutrición Salvador Zubiran, Mexico, Mexico, 3Transplantation, Instituto Nacional de Ciencias Medicas y Nutrición Salvador Zubiran, Mexico, Mexico

    *Purpose: Previously our group assessed the spontaneous and lipopolysaccharide-induced NETosis with confocal microscopy in kidney transplant recipients (KTR). We found an enhanced spontaneous NETosis regardless…
  • 2019 American Transplant Congress

    Soluble Fibrinogen-Like Protein 2 Regulates MDSCs Differentiation and Function in Allograft Immunity

    C. Yang

    Urology, Zhongshan Hospital, Fudan University, Shanghai, China

    *Purpose: Soluble fibrinogen-like protein 2 (sFGL2) is a novel immunoregulatory molecule, secreted mainly by regulatory T cells. CD11b+ Gr1+ myeloid-derived suppressor cells (MDSCs) are an…
  • 2019 American Transplant Congress

    Human Neutrophil Function against Pathogens in Solid Organ and Stem Cell Transplant Recipients

    N. Barros, N. Alexander, Z. Dagher, S. Knooihuizen, A. Viens, A. R. Hopke, D. Irimia, M. K. Mansour

    Transplant Infectious Diseases, Massachusetts General Hospital, Boston, MA

    *Purpose: The effects of solid organ (SOT) and allogeneic stem cell transplantation (SCT) on the neutrophil function is not well described. In this study, we…
  • 2018 American Transplant Congress

    The Role of CD46 in Early Islet Engraftment in a Dual Transplant Model

    Q. Gao, K. Samy, R. Davis, M. Song, A. MacDonald, F. Leopardi, T. How, K. Williams, G. Devi, B. Collins, A. Kirk.

    Department of Surgery, Duke University School of Medicine, Durham, NC.

    IntroductionMembrane cofactor protein (CD46) is known to attenuate the complement cascade by facilitating cleavage of C3b and C4b. In solid organ xenotransplantation, organs expressing CD46…
  • 2018 American Transplant Congress

    Recipient HO-1 Deficiency Decreases Post-Transplant Graft HO-1 Expression and Exacerbates Liver Transplant Damage

    S. Kageyama,1 K. Nakamura,1 T. Ito,1 A. Aziz,1 B. Ke,1 R. Sossa,2 E. Reed,2 F. Kaldas,1 R. Busuttil,1 J. Kupiec-Weglinski.1

    1Surgery, Liver Transplantation, UCLA, Los Angeles, CA; 2Pathology, UCLA, Los Angeles, CA.

    Many preclinical studies on protective functions of heme oxygenase-1 (HO-1; hsp32) in orthotopic liver transplantation (OLT) have encouraged application of HO-1 inducing regimens in clinical…
  • 2018 American Transplant Congress

    Inhibition of Neutrophil Recruitment and Activation Protects Airway Epithelium after Transplantation

    R. Zhang,1 H. Fang,1 Q. Chen,2 J. Ochando,3 Y. Ding,1 J. Xu.1

    1Department of Immunology, Capital Medical University, Beijing, China; 2Department of Thoracic Surgery, Chaoyang Hospital, Beijing, China; 3Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.

    Background: Obliterative bronchiolitis (OB) is the major obstacle limiting long-term allograft survival of lung transplantation. Airway epithelium is the primary target in obliterative airway diseases.…
  • 2018 American Transplant Congress

    Is the NETos Increased in Acute Antibody Mediated Rejection?

    R. Villca-Gonzales,1 J. Torres-Ruiz,2 D. Gomez-Martin,2 J. Alberu,3 L. Morales-Buenrostro.1

    1Nephrology, Inst. Nacional de Ciencias Médicas y Nutrición SZ, Mexico City, CDMX, Mexico; 2Immunology, Inst. Nacional de Ciencias Médicas y Nutrición SZ, Mexico City, CDMX, Mexico; 3Transplantation, Inst. Nacional de Ciencias Médicas y Nutrición SZ, Mexico City, CDMX, Mexico.

    Neutrophils can promote graft inflammation through a form of programmed cell death termed "NETosis". How alloantibodies contribute to neutrophil responses in grafts is not clear…
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