ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Neutropenia"

  • 2022 American Transplant Congress

    Cytomegalovirus Prevention in Kidney and Pancreas Transplant Recipients: A Successful Pharmacist-Led Multidisciplinary Approach

    J. Geyston, J. Dann, A. Doyle, A. Agarwal, K. Brayman, C. Shoemaker, C. Lester, S. Rao

    University of Virginia Health, Charlottesville, VA

    *Purpose: In response to high cytomegalovirus (CMV) infection and increasing ganciclovir (GCV)-resistance rate, a pharmacist-led multidisciplinary task force was created to manage CMV prophylaxis (ppx).…
  • 2022 American Transplant Congress

    Post-Kidney Transplant Valacyclovir versus Valganciclovir for CMV Prophylaxis: A Randomized Controlled Trial

    P. S. Verghese1, A. Matas2, S. Chinnakotla2, M. Evans3, H. Balfour Jr4

    1Univ of Minnesota Pediatric Nephrology, Minneapolis, MN, 2Surgery, University of Minnesota Medical School, Minneapolis, MN, 3Biostatistics, University of Minnesota, Minneapolis, MN, 4Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN

    *Purpose: Valganciclovir (valG) is an effective CMV prophylactic agent post-kidney transplant (KTx) with significant side effects. Valacyclovir (valA) may be effective for CMV prophylaxis with…
  • 2022 American Transplant Congress

    Burden of Leukopenia/Neutropenia Among Adult Kidney Transplant Recipients: A Systematic Literature Review of Observational Studies

    A. Raval1, K. Kistler2, Y. Tang1, F. Vincenti3

    1Merck & Co., Inc., Kenilworth, NJ, 2Xcenda, Inc, Carrollton, TX, 3University of California, San Francisco, San Francisco, CA

    *Purpose: Leukopenia/neutropenia (L/N) may affect key treatment decisions which could result in poor clinical and economic outcomes among kidney transplant recipients (KTRs). The burden of…
  • 2021 American Transplant Congress

    Clinical Consequences in Patients Experiencing Leukopenia and Neutropenia After Solid Organ Transplant

    A. Diamond1, N. Diehl2, K. Hiryak3, K. Mortia1, J. Au1, C. Ruggia-Check1, H. Clauss4

    1Pharmacy, Temple University Hospital, Philadelphia, PA, 2Pharmacy, UPMC Pinnacle Health, Harrisburg, PA, 3Pharmacy, Temple University School of Pharmacy, Philadelphia, PA, 4Infectious Diseases, Temple University Hospital, Philadelphia, PA

    *Purpose: The incidence of leukopenia and neutropenia in solid organ transplant (SOT) recipients can be influenced by medications required after transplant for immunosuppression and infection…
  • 2021 American Transplant Congress

    Delayed Valganciclovir Initiation and the Incidence of Cytomegalovirus Infection in Liver Transplant Recipients

    S. Shaikh, P. Kawewat-Ho, Y. Genyk, L. Sher, J. Kahn, L. Rivera

    Keck Medical Center of USC, Los Angeles, CA

    *Purpose: Opportunistic infections remain a significant burden after liver transplantation, particularly cytomegalovirus (CMV) infection. With the use of valganciclovir (VGCV), the incidence of CMV infection…
  • 2021 American Transplant Congress

    Outcomes Among CMV Mismatched and Highly Sensitized Kidney Transplant Recipients Who Develop Leukopenia or Neutropenia

    S. Brar1, R. Berry2, A. Raval3, Y. Tang3, F. Vincenti2, N. Skartsis2

    1University of British Columbia, Vancouver, BC, Canada, 2University of California, San Francisco, San Francisco, CA, 3Merck and Co., Inc., Kenilworth, NJ

    *Purpose: Kidney transplant recipients (KTRs) who receive antiproliferative agents for immunosuppression and valganciclovir for CMV prophylaxis are at high risk of developing leukopenia and neutropenia.…
  • 2021 American Transplant Congress

    Outcomes of Granulocyte-Colony Stimulating Factor Use in Pediatric Renal Transplant Recipients: A Pediatric Nephrology Research Consortium Study

    R. M. Engen1, P. L. Weng2, W. Shih3, H. Patel4, K. Richardson5, S. Dowdrick6, I. Ashoor7, J. Misurac8, A. Z. Traum9, M. Semanik10, N. G. Jain11, R. Sreedharan12

    1Northwestern University, Chicago, IL, 2University of California Los Angeles, Los Angeles, CA, 3University of Michigan, Ann Arbor, MI, 4Nationwide Children's Hospital, Columbus, OH, 5Oregon Health & Science University, Portland, OR, 6Penn State Health, Hershey, PA, 7Louisiana State University, New Orleans, LA, 8University of Iowa, Iowa City, IA, 9Harvard University, Boston, MA, 10University of Wisconsin-Madison, Madison, WI, 11Columbia University, New York, NY, 12Medical College of Wisconsin, Milwaukee, WI

    *Purpose: Neutropenia is common after pediatric kidney transplant and is associated with an increased risk of bacterial infection, allograft loss, and death. Granulocyte colony-stimulating factor…
  • 2021 American Transplant Congress

    Systematic Evaluation of Immunosuppressant Drug Tolerability in Lung Transplant Recipients with Short Telomere Syndrome

    R. Patolia1, R. Guzy2, L. Potter1

    1Department of Pharmacy, University of Chicago Medicine, Chicago, IL, 2Department of Medicine, Division of Pulmonology, University of Chicago Medicine, Chicago, IL

    *Purpose: Lung transplant recipients with short telomere syndrome are at high risk of hematologic complications. Consequently, patients with short telomere syndrome may require more frequent…
  • 2021 American Transplant Congress

    Use of Granulocyte Colony Stimulating Factor After Lung Transplantation is Not Associated with Increased Likelihood of Acute Cellular Rejection

    S. Fredrick1, C. Iasella2, L. Sacha3, R. Rivosecchi3, M. Morrell3, P. Sanchez3, J. Pilewski3, M. Snyder3, J. McDyer3, C. Moore3

    1University of Rochester Medical Center, Rochester, NY, 2University of Pittsburgh School of Pharmacy, Pittsburgh, PA, 3University of Pittsburgh Medical Center, Pittsburgh, PA

    *Purpose: The cause of neutropenia in lung transplant recipients is multifactorial, including medications, viral infections, and antecedent disease. Granulocyte colony-stimulating factor (G-CSF) is commonly used…
  • 2021 American Transplant Congress

    Evaluation of a Weight-Based Mycophenolate Mofetil Dosing Protocol for Kidney Transplant Maintenance Immunosuppression

    M. Mahoney1, E. Kincaide1, J. Nelson1, K. Klein1, R. Hall1, S. Bhayana2

    1University Health, San Antonio, Department of Pharmacotherapy and Pharmacy Services, The University of Texas at Austin, Pharmacotherapy Division, College of Pharmacy, San Antonio, TX, 2University Transplant Center, University Health, San Antonio, Department of Nephrology, The University of Texas Health Science Center at San Antonio, San Antonio, TX

    *Purpose: To evaluate the safety and efficacy of a weight-based mycophenolate mofetil (MMF) dosing protocol in adult kidney transplant recipients (KTR).*Methods: This single-center retrospective study…
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