Articles tagged "Neutropenia"

2022 American Transplant Congress
Post-Kidney Transplant Valacyclovir versus Valganciclovir for CMV Prophylaxis: A Randomized Controlled Trial
P. S. Verghese¹, A. Matas², S. Chinnakotla², M. Evans³, H. Balfour Jr⁴
¹Univ of Minnesota Pediatric Nephrology, Minneapolis, MN, ²Surgery, University of Minnesota Medical School, Minneapolis, MN, ³Biostatistics, University of Minnesota, Minneapolis, MN, ⁴Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN
*Purpose: Valganciclovir (valG) is an effective CMV prophylactic agent post-kidney transplant (KTx) with significant side effects. Valacyclovir (valA) may be effective for CMV prophylaxis with…
2022 American Transplant Congress
Burden of Leukopenia/Neutropenia Among Adult Kidney Transplant Recipients: A Systematic Literature Review of Observational Studies
A. Raval¹, K. Kistler², Y. Tang¹, F. Vincenti³
¹Merck & Co., Inc., Kenilworth, NJ, ²Xcenda, Inc, Carrollton, TX, ³University of California, San Francisco, San Francisco, CA
*Purpose: Leukopenia/neutropenia (L/N) may affect key treatment decisions which could result in poor clinical and economic outcomes among kidney transplant recipients (KTRs). The burden of…
2022 American Transplant Congress
Cytomegalovirus Prevention in Kidney and Pancreas Transplant Recipients: A Successful Pharmacist-Led Multidisciplinary Approach
J. Geyston, J. Dann, A. Doyle, A. Agarwal, K. Brayman, C. Shoemaker, C. Lester, S. Rao
University of Virginia Health, Charlottesville, VA
*Purpose: In response to high cytomegalovirus (CMV) infection and increasing ganciclovir (GCV)-resistance rate, a pharmacist-led multidisciplinary task force was created to manage CMV prophylaxis (ppx).…
2021 American Transplant Congress
Systematic Evaluation of Immunosuppressant Drug Tolerability in Lung Transplant Recipients with Short Telomere Syndrome
R. Patolia¹, R. Guzy², L. Potter¹
¹Department of Pharmacy, University of Chicago Medicine, Chicago, IL, ²Department of Medicine, Division of Pulmonology, University of Chicago Medicine, Chicago, IL
*Purpose: Lung transplant recipients with short telomere syndrome are at high risk of hematologic complications. Consequently, patients with short telomere syndrome may require more frequent…
2021 American Transplant Congress
Outcomes of Granulocyte-Colony Stimulating Factor Use in Pediatric Renal Transplant Recipients: A Pediatric Nephrology Research Consortium Study
R. M. Engen¹, P. L. Weng², W. Shih³, H. Patel⁴, K. Richardson⁵, S. Dowdrick⁶, I. Ashoor⁷, J. Misurac⁸, A. Z. Traum⁹, M. Semanik¹⁰, N. G. Jain¹¹, R. Sreedharan¹²
¹Northwestern University, Chicago, IL, ²University of California Los Angeles, Los Angeles, CA, ³University of Michigan, Ann Arbor, MI, ⁴Nationwide Children's Hospital, Columbus, OH, ⁵Oregon Health & Science University, Portland, OR, ⁶Penn State Health, Hershey, PA, ⁷Louisiana State University, New Orleans, LA, ⁸University of Iowa, Iowa City, IA, ⁹Harvard University, Boston, MA, ¹⁰University of Wisconsin-Madison, Madison, WI, ¹¹Columbia University, New York, NY, ¹²Medical College of Wisconsin, Milwaukee, WI
*Purpose: Neutropenia is common after pediatric kidney transplant and is associated with an increased risk of bacterial infection, allograft loss, and death. Granulocyte colony-stimulating factor…
2021 American Transplant Congress
Outcomes Among CMV Mismatched and Highly Sensitized Kidney Transplant Recipients Who Develop Leukopenia or Neutropenia
S. Brar¹, R. Berry², A. Raval³, Y. Tang³, F. Vincenti², N. Skartsis²
¹University of British Columbia, Vancouver, BC, Canada, ²University of California, San Francisco, San Francisco, CA, ³Merck and Co., Inc., Kenilworth, NJ
*Purpose: Kidney transplant recipients (KTRs) who receive antiproliferative agents for immunosuppression and valganciclovir for CMV prophylaxis are at high risk of developing leukopenia and neutropenia.…
2021 American Transplant Congress
Delayed Valganciclovir Initiation and the Incidence of Cytomegalovirus Infection in Liver Transplant Recipients
S. Shaikh, P. Kawewat-Ho, Y. Genyk, L. Sher, J. Kahn, L. Rivera
Keck Medical Center of USC, Los Angeles, CA
*Purpose: Opportunistic infections remain a significant burden after liver transplantation, particularly cytomegalovirus (CMV) infection. With the use of valganciclovir (VGCV), the incidence of CMV infection…
2021 American Transplant Congress
Clinical Consequences in Patients Experiencing Leukopenia and Neutropenia After Solid Organ Transplant
A. Diamond¹, N. Diehl², K. Hiryak³, K. Mortia¹, J. Au¹, C. Ruggia-Check¹, H. Clauss⁴
¹Pharmacy, Temple University Hospital, Philadelphia, PA, ²Pharmacy, UPMC Pinnacle Health, Harrisburg, PA, ³Pharmacy, Temple University School of Pharmacy, Philadelphia, PA, ⁴Infectious Diseases, Temple University Hospital, Philadelphia, PA
*Purpose: The incidence of leukopenia and neutropenia in solid organ transplant (SOT) recipients can be influenced by medications required after transplant for immunosuppression and infection…
2021 American Transplant Congress
Risk Factors and Outcomes of Neutropenia in Kidney Transplant Recipients
R. Avery¹, J. Motter¹, S. Sae-Tia², N. Lu¹, W. Cochran¹, A. Massie¹, D. Brennan¹, F. Akinwande¹, S. Shoham¹, E. Kraus¹, N. Alachkar¹, S. Alasfar¹, F. Naqvi¹, F. Al Ammary¹, K. Marr¹, S. Mehta Steinke¹, N. Desai¹, O. Ezennia¹, P. Plummer¹, C. Durand¹, W. Werbel¹, M. Y. Kim¹, D. Segev¹, J. Garonzik Wang¹, B. Trollinger¹, L. Lees¹, L. Toman¹, S. Shulder³, K. Dzintars¹, D. Ostrander¹
¹Johns Hopkins, Baltimore, MD, ²Stony Brook University, Stony Brook, NY, ³University of Rochester, Rochester, NY
*Purpose: Neutropenia is a common side effect of valganciclovir and may pose increased risk for post-transplant infections. Medications such as mycophenolate and infections such as…
2021 American Transplant Congress
Characteristics, Risk Factors, and Outcomes of Neutropenia for the First Year After Liver or Kidney Transplantation in Children
C. Jarasvaraparn¹, S. Choudhury², C. Rusch², K. Liss¹, J. Stoll¹, S. Hmiel³, S. Kulkarni¹
¹Pediatric Gastroenterology, Washington University School in St Louis, Saint Louis, MO, ²Pediatric, Washington University School in St Louis, Saint Louis, MO, ³Pediatric Nephrology, Washington University School in St Louis, Saint Louis, MO
*Purpose: Prior studies in adults have shown that approximately 20-38 % of subjects undergoing solid organ transplant develop neutropenia. In the current study, we characterized…