Articles tagged "Nephropathy"

2016 American Transplant Congress
Novel Nuclear Factor-κB Activation Inhibitor, Dehydroxymethylepoxyquinomicin, Prevents the Development of Chronic Cyclosporine Nephropathy in Rats.
S. Morita,¹ K. Shinoda,¹ S. Tamaki,¹ H. Kono,² Y. Kanno,³ K. Umezawa,⁴ K. Nakagawa,² M. Oya.¹
¹Urology, Keio University School of Medicine, Tokyo, Japan; ²Urology, Tokyo Dental College Ichikawa General Hospital, Ichikawa, Chiba, Japan; ³Nephrology, Tokyo Medical University, Tokyo, Japan; ⁴Molecular Target Medicine Screening, Aichi Medical University, Nagakute, Aichi, Japan.
Purpose:The nephrotoxicity of the calcineurin inhibitors including cyclosporine is a major problem in the kidney transplantation. We investigated the effect of a novel nuclear factor-κB…
2016 American Transplant Congress
Slipping Through the Cracks: Late Onset BK Viremia.
J. Gandhi,¹ M. Mackenzie,¹ D. DeWolfe,² F. Cardarelli,³ M. Pavlakis,³ C. Tan.^1,4
¹Center for Virology & Vaccine Research, Beth Israel Deaconess Medical Center (BIDMC), Boston, MA; ²Division of Nephrology, BIDMC, Boston, MA; ³The Transplant Institute, BIDMC, Boston, MA; ⁴Division of Infectious Disease, BIDMC, Boston, MA.
Introduction: Most studies indicate that viremia caused by BK virus (BKV), the step preceding BKV associated nephropathy (BKVN) in kidney transplant recipients (KTRs), occurs within…
2016 American Transplant Congress
Urinary CXCL9 Protein as Biomarker for BK Polyoma Viremia.
N. Sarabu,¹ R. El-Rifai,² J. Augustine,¹ A. Padiyar,¹ A. Huml,¹ T. Young,¹ V. Rodriguez,¹ D. Hricik.¹
¹Division of Nephrology, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, OH; ²Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, IL.
Introduction: BK infection is common in kidney transplant patients and can result in accelerated loss of allografts. Management involves empiric lowering of immunosuppression, which can…
2016 American Transplant Congress
Evaluation of Polyomavirus (BK) Treatment and Clinical Outcomes in Pediatric Kidney Transplant Recipients: A >10 Year Single Center Retrospective Experience.
R. Liverman,¹ E. Kraus,¹ R. Garro,² B. Warshaw,² P. Winterberg,² R. George.²
¹Children's Healthcare of Atlanta, Atlanta, GA; ²Division of Pediatric Nephrology, Emory University School of Medicine, Atlanta, GA.
BK viremia (BKV) is a serious infectious complication after kidney transplantation and can lead to BK nephropathy (BKN) and allograft loss. We reviewed our experience…
2016 American Transplant Congress
Comparison of Efficacy of Different Regimens for Treating Recurrent IgA Nephropathy After Kidney Transplantation.
G. Chen, C. Wang, L. Chen, J. Qiu, C. Wang, J. Fei, S. Deng, J. Li, G. Huang, Q. Fu.
Organ Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.
Background Recurrent IgA nephropathy is a common complication after kidney transplantation. How to treat recipients with recurrent IgA nephropathy is still controversial. There are two…
2016 American Transplant Congress
Potential Biomarkers and Treatment for BK Virus Associated Nephropathy.
M. Borkar,¹ V. Srivastava,² R. Cunnington,¹ T. Sharma,¹ L. Tibbles.¹
¹Faculty of Mediicne, University of Calgary, Calgary, AB, Canada; ²CSIR-Indian Institute of Toxicology Research, Lucknow, Uttar Pradesh, India.
Background: BK polyomavirus assoiciated nephropathy (BKVAN) is one of the major complications in renal transplants, and is associated with significant fibrosis It is important to…
2015 American Transplant Congress
The Role of Quantitative Assay of Urinary Decoy Cells as a Screening and Follow-Up Tool in Renal Transplant Recipients With Polyomavirus BK Infection
G. Huang, J. Qiu, C.-X. Wang, J.-G. Fei, S.-X. Deng, J. Li, G.-D. Chen, Q. Fu, R.-H. Deng, L.-Z. Chen.
Department of Organ Transplantation, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Polyomavirus BK nephropathy (BKVN) is an important infectious complication in kidney transplant patients. Urinary cytology is effective for early diagnosis of BKVN. However, quantitative assay…
2015 American Transplant Congress
Isotype Switching of Antibodies to Vimentin Following Transplantation Is Associated With Development of Transplant Glomerulopathy Following Renal Transplantation
M. Gunasekaran,¹ T. Maw,³ R. Santos,³ J. Wellen,¹ S. Shenoy,¹ T. Mohanakumar.^1,2
¹Surgery, Washington Univ Sch of Med, St. Louis, MO; ²Pathology & Immunology, Washington Univ Sch of Med, St. Louis, MO; ³Medicine, Washington Univ Sch of Med, St. Louis, MO.
Background: Immune responses to tissue restricted self antigens have been proposed to play a role in transplant glomerulopathy (TG). The goal of this study is…
2015 American Transplant Congress
Experimental Study Using Contrast-Enhanced Ultrasonography to Evaluate Rat Chronic Allograft Nephropathy Model and the Relationship Between Hemodynamic Parameters and Renal Allograft Fibrosis
Q. Zhang,¹ Z. Yu,² Y. Xu,¹ S. Zeng,¹ W. Xue,¹ X. Hu.¹
¹Urology Department, Beijing ChaoYang Hospital Capital Medical University, Beijing, China; ²Ultrasound Department, Beijing ChaoYang Hospital Capital Medical University, Beijing, China.
Objectives:To quantitatively analyze the changes of hemodynamic characteristics in renal allograft at different stages of a rat chronic allograft nephropathy [CAN]model and the relationship between…