2018 American Transplant Congress
T Cell-Mediated Rejection Poses Greater Risk to Graft Survival Than Antibody-Mediated Rejection in Heart Transplants
University of Alberta, Edmonton, Canada.
Purpose: In kidney transplants, failure post-biopsy is associated with acute injury transcript expression reflecting the histologically silent tissue response-to-wounding (JCI 120:1862) and antibody-mediated rejection (ABMR),…2018 American Transplant Congress
Livers from Diabetic Donors Can Safely Be Used in Donation after Circulatory Death Liver Transplantation
Liver grafts from donors with a history of diabetes mellitus (DM) have been associated with reduced graft survival after liver transplantation. Transplantation centers are often…2018 American Transplant Congress
Direct-Acting Antiviral Therapy Immune-Mediated Graft Dysfunction in Liver Transplant Recipients with Hepatitis C
Background and Aims:Interferon (IFN) treatment of hepatitis C virus (HCV) infection after liver transplantation (LT) can result in severe immune-mediated graft dysfunction (IGD). The occurrence…2018 American Transplant Congress
Serum Cytokines as Markers of Influenza Infection Outcomes after Transplantation
Background:Influenza infection in transplant patients can be severe but factors predictive of outcome in this setting are unclear. The aim of the study was to…2018 American Transplant Congress
Factor Analysis (FA) Identifies 5 Major Axes of Kidney Transplant Biopsy (KTxBx) Pathology
Definitions for acute rejection (ACR) and antibody mediated rejection (AMR) in KTxBx exist, but no data driven methods exist for quantitative analysis of all Banff,…2018 American Transplant Congress
Effect of Acute Vascular Inflammation (v) on Death Censored Graft Failure (DCGF) Following Kidney Transplant (KTx)
The impact of acute vascular inflammation in acute cellular or humoral rejection following KTx, and the effect of isolated vascular inflammatory lesions on late DCGF,…2018 American Transplant Congress
Factor Analysis (FA) of Renal Transplant Biopsy (KTxBx) Data Enables Objective Assessment of Risk for Subsequent Death Censored Graft Failure (DCGF)
We examined the impact of five axes of injury identified by FA in the KTxBx on the hazard for subsequent DCGF in two DeKAF cohorts.Methods:…2018 American Transplant Congress
Population-Based Modeling of Prototypes and Determinants of Allograft Function Trajectories after Kidney Transplantation: Implications for Patient Monitoring and Risk Stratification
Paris Transplant Group, Paris, France.
Background:Although the current gold standard of monitoring kidney allograft patients relies primarily on GFR assessment, little is known about long-term eGFR trajectories prototypes and their…2018 American Transplant Congress
Unique Gene Expression Signatures in Urine Distinguish BK Virus Nephropathy from Acute Rejection in Kidney Transplant Patients with Graft Dysfunction
Acute cellular rejection and BK virus nephropathy both cause deteriorating graft function that can lead to graft loss. Distinguishing the two conditions rapidly and accurately…2018 American Transplant Congress
Identification of Noninvasive and Mechanistically-Informative Biomarkers Predictive of Reversal of Acute Cellular Rejection (ACR) in Kidney Allografts
1University of Michigan, Ann Arbor, MI; 2Weill Cornell Medical College, New York City, NY.
Objective: We determined whether urinary cell mRNAs predict response to anti-rejection therapy in kidney allograft recipients with Banff grade IA or higher ACR biopsies.Methods: We…
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